Redefining drug therapy: innovative approaches using catalytic compartments.

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Yasemin Leyla Mustafa,Arianna Balestri,Xinan Huang,Cornelia Palivan
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引用次数: 0

Abstract

INTRODUCTION Rapid excretion of drug derivatives often results in short drug half-lives, necessitating frequent administrations. Catalytic compartments, also known as nano- and micro-reactors, offer a solution by providing confined environments for in situ production of therapeutic agents. Inspired by natural compartments, polymer-based catalytic compartments have been developed to improve reaction efficiency and enable site-specific therapeutic applications. AREAS COVERED Polymer-based compartments provide stability, permeability control, and responsiveness to stimuli, making them ideal for generating localized compounds/signals. These sophisticated systems, engineered to carry active compounds and enable selective molecular release, represent a significant advancement in pharmaceutical research. They mimic cellular functions, creating controlled catalytic environments for bio-relevant processes. This review explores the latest advancements in synthetic catalytic compartments, focusing on design approaches, building blocks, active molecules, and key bio-applications. EXPERT OPINION Catalytic compartments hold transformative potential in precision medicine by improving therapeutic outcomes through precise, on-site production of therapeutic agents. While promising, challenges like scalable manufacturing, biodegradability, and regulatory hurdles must be addressed to realize their full potential. Addressing these will be crucial for their successful application in healthcare.
重新定义药物疗法:利用催化区的创新方法。
引言 药物衍生物的快速排泄往往导致药物半衰期较短,因此需要频繁给药。催化室(也称为纳米和微反应器)提供了一种解决方案,它为原位生产治疗药物提供了封闭的环境。受天然隔室的启发,我们开发了基于聚合物的催化隔室,以提高反应效率,实现特定部位的治疗应用。涵盖领域基于聚合物的隔室具有稳定性、渗透性控制和对刺激的响应性,是产生局部化合物/信号的理想选择。这些复杂的系统可携带活性化合物并实现选择性分子释放,是制药研究的一大进步。它们模仿细胞功能,为生物相关过程创造受控催化环境。本综述探讨了合成催化元件的最新进展,重点关注设计方法、构建模块、活性分子和关键生物应用。专家观点催化元件通过现场精确生产治疗剂来改善治疗效果,在精准医疗领域具有变革潜力。催化元件虽然前景广阔,但要充分发挥其潜力,还必须应对可扩展制造、生物降解性和监管障碍等挑战。解决这些问题对其在医疗保健领域的成功应用至关重要。
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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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