Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth.

IF 5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert Opinion on Drug Delivery Pub Date : 2023-07-01 Epub Date: 2023-08-08 DOI:10.1080/17425247.2023.2244413

Yanjun Zhou, Luan Jia, Guangshuai Zhang, Gang Chen, Di Zhou, Xianbao Shi, Qiang Fu, Ning Li

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引用次数: 1

Abstract

Objectives: The dissolvable microneedles loaded with cedrol based on flexible backing were developed to deliver cedrol directly and continuously to the dermis, where the drug concentration in the hair follicle can be increased locally.

Methods: The tip-layer matrix solution was prepared by mixing cedrol and polyvinylpyrrolidone K25 (PVP K25), and the pedestal matrix solution was prepared with aqueous hyaluronic acid. The cedrol-loaded dissolvable microneedles (cedrol-DMNs) were prepared under vacuum conditions. The mechanical properties, pig skin penetration efficiency, in vitro cutaneous permeation test, and the amount of drug in the skin and receptor chamber were evaluated. Pharmacodynamical studies were performed with C57BL/6 mice.

Results: The mechanical properties of cedrol-DMNs were good. In vitro cutaneous permeation tests and pharmacodynamical studies demonstrated that cedrol-DMN could efficiently deliver the drug to the deep dermis and effectively promote hair growth.

Conclusions: The cedrol-DMNs offer a promising strategy for treating patients suffering from hair loss.

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基于弹性背衬的雪松负载可溶性微针，可促进头发生长。

目的：开发了基于柔性背衬的负载雪松醇的可溶性微针，将雪松醇直接连续地输送到真皮，在真皮中可以局部增加毛囊中的药物浓度。方法：将香髓和聚乙烯吡咯烷酮K25（PVP K25）混合制备尖端层基质溶液，并用透明质酸水溶液制备基座基质溶液。在真空条件下制备了负载雪松醇的可溶性微针（雪松醇DMNs）。对力学性能、猪皮渗透效率、体外皮肤渗透试验以及皮肤和受体室中的药物量进行了评估。用C57BL/6小鼠进行药效学研究。结果：雪松醇DMNs具有良好的力学性能。体外皮肤渗透试验和药效学研究表明，雪松醇DMN可以有效地将药物输送到真皮深处，并有效地促进头发生长。结论：cedrol DMNs为治疗脱发患者提供了一种有前景的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Drug Delivery 医学-药学

CiteScore

11.10

自引率

3.00%

发文量

104

审稿时长

3 months

期刊介绍： Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.