The Ceylon medical journal最新文献_第4页

Genetic association between antipsychotic induced weight gain and FTO gene in a Sri Lankan population 斯里兰卡人群抗精神病药物诱导体重增加与FTO基因的遗传关联

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8889

V. D. de Silva, K. Muneeswaran, S. Ratnatunga, I. Ranwala, S. Gamage, R. Hanwella, C. Wijeyaratne, N. Chandrasekharan

{"title":"Genetic association between antipsychotic induced weight gain and FTO gene in a Sri Lankan population","authors":"V. D. de Silva, K. Muneeswaran, S. Ratnatunga, I. Ranwala, S. Gamage, R. Hanwella, C. Wijeyaratne, N. Chandrasekharan","doi":"10.4038/CMJ.V64I2.8889","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8889","url":null,"abstract":"Background\u0000About 30% of patients treated with second generation antipsychotics (SGA) experience weight gain. Although there is evidence that the FTO gene is associated with obesity its role in antipsychotic induced weight gain is not so clear.\u0000\u0000\u0000Methods\u0000A genetic association study was carried out to identify the association between FTO rs9939609 and antipsychotic induced weight gain. Sample consisted of 180 cases and 120 controls. Cases were patients diagnosed with schizophrenia or schizoaffective disorder, treated with second-generation antipsychotics for a minimum of 3 months, and had gained at least 10% of body weight. Controls were patients with schizophrenia treated with second-generation antipsychotics for a minimum of 3 months but had not gained ≥10% of body weight. Genomic DNA was extracted from whole blood. Polymerase chain reaction of the samples was done. Real-time quantitative PCR (qPCR) was carried out using BIO-RAD CFX96 Touch TM PCR detection system.\u0000\u0000\u0000Results\u0000Females were significantly more among cases (58.3%) than controls (35%). Cases (52.4%) were significantly more likely to be overweight or obese than controls (13.8%). Genotype distribution was in Hardy-Weinberg equilibrium (p=0.43). Cochran-Armitage trend test was not significant. Risk of antipsychotic induced weight gain in the AA genotype [OR 1.69 (95% CI 0.74-3.86)] and AT genotype [OR 1.1 (95% CI 0.67-1.79)] were not significantly higher than the TT genotype. Recessive model showed that AA/AT genotypes were at significantly higher risk of being obese/overweight [OR 1.84 (95% CI 1.05-3.2)].\u0000\u0000\u0000Conclusions\u0000There was no significant association between FTO rs9939609 and antipsychotic induced weight gain. AA/AT genotypes had significantly higher risk of overweight/obesity.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114962562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Perplexing issues in the management of thyroid nodules 甲状腺结节治疗中令人困惑的问题

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8896

Ranil Fernando

引用次数: 0

Construct validity and reliability of EQ-5D-3L for stroke survivors in a lower middle income setting EQ-5D-3L对中低收入地区脑卒中幸存者的结构效度和信度

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8891

P. Mahesh, M. W. Gunathunga, S. Jayasinghe, S. M. Arnold, S. Senanayake, C. Senanayake, L. S. D. D. Silva, S. Kularatna

{"title":"Construct validity and reliability of EQ-5D-3L for stroke survivors in a lower middle income setting","authors":"P. Mahesh, M. W. Gunathunga, S. Jayasinghe, S. M. Arnold, S. Senanayake, C. Senanayake, L. S. D. D. Silva, S. Kularatna","doi":"10.4038/CMJ.V64I2.8891","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8891","url":null,"abstract":"Introduction\u0000Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lower-middle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descriptive questions and a visual analogue scale (VAS) value.\u0000\u0000\u0000Objectives\u0000To assess the validity and reliability of EQ-5D-3L for stroke patients in Sri Lanka, which is a LMI setting.\u0000\u0000\u0000Methods\u0000A descriptive cross sectional study was done among 100 stroke survivors among whom 50 each were managed at an ambulatory setting and an in-ward setting. A second wave of data collection was done for reliability analysis among one half of participants. The validity of EQ-5D-3L was assesses with five a-priori hypotheses. Reliability was assessed with test-retest method and with internal consistency. Non parametric Mann Whitney U test and Spearman correlation coefficients were used in the analysis.\u0000\u0000\u0000Results\u0000The EQ-5D index scores had significant positive correlation with SF-36 domain scores (p<0.001). The EQ-5D VAS scores had significant positive correlation with SF-36 domain scores (p<0.01). Index and VAS values of the EQ-5D were proved to be valid in known-group comparison (p<0.001). Participants reporting some kind of impairment for EQ-5D-3L dimensions had lower SF-36 domain scores. All the kappa values in the analysis of test-retest method were significant (p<0.001). For the VAS score, the Spearman correlation coefficient in test-reter analysis was 0.993 (p<0.001). Cronbach’s alpha value was 0.928.\u0000\u0000\u0000Conclusions\u0000and Recommendations EQ-5D-3L questionnaire demonstrates construct validity and a is a reliable toolin measuring QOL among stoke survivors in Sri Lanka.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116388448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Biorhythms. Biorhythms。

The Ceylon medical journal Pub Date : 2019-07-10 DOI: 10.1090/spec/019/31

K. Tennekoon

{"title":"Biorhythms.","authors":"K. Tennekoon","doi":"10.1090/spec/019/31","DOIUrl":"https://doi.org/10.1090/spec/019/31","url":null,"abstract":"The best ebooks about Biorhythms that you can get for free here by download this Biorhythms and save to your desktop. This ebooks is under topic such as biorhythms and pineal gland neuroendocrinology letters biorhythms department of biology biorhythms c4oh biorhythms washington university in st louis lab 1: biorhythms whitman people biological rhythms cornell university ergonomics web biorhythms & the sine graph wikispaces biorhythms texas instruments biorhythms and the sine wave lab week 4: biorhythms whitman college biorhythms and law school performance sleep, biorhythms and human performance trig name: biorhythms project background information april 2017 washington university in st louis biorhythms ms schroeder's math 2/3 biorhythms and erythromelalgia: why em symptoms worsen in weather, biorhythms, beliefs and stock returnsÃ¢Â€Â”some modeling your biorhythm name(s): what are biorhythms? secondary biorhythm chart for 28 days starting from 0 0 biorhythm: a biologically-inspired audio-visual installation biology is rhythmical!! york college of pennsylvania the relationship between biorhythms and injuries in female chronic diseases and biorhythmÃ¢Â€ÂTMs phase-shift dynamic biorhythms of functional activity of phagocytes in iron the impact of birthdate biorhythms on aviation accidents biorhythms and swimming performances ithaca college biorhythms goddess flight biorhythms canyon isd biorhythms in your life repol biorhythms in your life smcars biorhythms a step by step guide repol ms biorhythms }ftv fk eating a your biorhythm maintain or lose weight in synch biological rhythms: implications for the worker sine curves and biorhythms cpalms download and read biorhythms biorhythms biorhythms biorhythms at your fingertips edtree biorhythms cardinal star systems study of biorhythms effect on the incidence of lost time biorhythms a step by step guide ehlady biorhythms a step by step guide voippe endogenous biorhythms of the mass specific rate of oxygen cp precalculus project biorhythms wikispaces","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115151622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Acute neurotoxicity following Fenpyroximate poisoning 芬吡肟中毒后的急性神经毒性

The Ceylon medical journal Pub Date : 2018-12-31 DOI: 10.4038/CMJ.V63I4.8770

A. N. Kuruppuarachchi, K. Sundaresan, M. Umakanth, T. Thivakaran

{"title":"Acute neurotoxicity following Fenpyroximate poisoning","authors":"A. N. Kuruppuarachchi, K. Sundaresan, M. Umakanth, T. Thivakaran","doi":"10.4038/CMJ.V63I4.8770","DOIUrl":"https://doi.org/10.4038/CMJ.V63I4.8770","url":null,"abstract":"Fenpyroximate is a potent inhibitor of mitochondrial proton-translocating NADH-quinoneoxidoruductase (complex 1) [1]. It is used in the agricultural sector as an acaricide. Acute and chronic toxicity studies of fenpyroximate in laboratory animals have been conducted by oral lavage. There were no treatment-related deaths and neuropathological evaluation in rats did not reveal any treatment-related lesions [2]. Laboratory testing has documented limited toxicities particularly irritation to the skin and eyes. LD50 for this product is 245 mg/kg for mammalians [3]. Laboratory studies have classified fenpyroximate (along with rotenone) as a Complex I inhibiting pesticide that is neurotoxic to astrocytes when cultured by in vitro bioassays [4]. Despite its worldwide usage as an insecticide, there are only few reported cases of its human toxicity. Lee et al [5] reported a case of near fatal fenpyroximate poisoning that resulted in severe lactic acidosis and cardiac arrest needing percutaneous cardiopulmonary support and therapeutic hypothermia. The authors were unable to find any case of acute neurotoxicity as a presentation following fenpyroximate poisoning in either Poisoning Center data base in Sri Lanka or in a search of the published literature using the PUBMED data base.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131217690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Environmental pollution. 环境污染。

The Ceylon medical journal Pub Date : 2018-10-04 DOI: 10.19080/artoaj.2018.18.556049

Eman Abdelrazek Abdelhady Ahmed

{"title":"Environmental pollution.","authors":"Eman Abdelrazek Abdelhady Ahmed","doi":"10.19080/artoaj.2018.18.556049","DOIUrl":"https://doi.org/10.19080/artoaj.2018.18.556049","url":null,"abstract":"The Environmental Pollution book series includes current, comprehensive texts on critical national and global environmental issues useful to scientists in academia, industry and government from diverse disciplines. These include water, air, and soil pollution, organic and inorganic pollution, risk assessment, human and environmental health, environmental biotechnology, global ecology, mathematics and computing as related to environmental pollution, environmental modelling, environmental chemistry and physics, biology, toxicology, conservation and biodiversity, agricultural sciences, pesticides, environmental engineering, bioremediation/biorestoration, and environmental economics. Environmental problems and solutions are complex and interrelated. Complex problems often require complex solutions. The linkage of many disciplines can result in new approaches to old and new environmental problems as well as pollution prevention. This knowledge will assist in understanding, maintaining and improving the biosphere in which we live. Proposals for this book series can be sent the Series Editor: Jack Trevors at jtrevors@uoguelph.ca or the Publishing Editor Sherestha Saini at Sherestha.Saini@springer.com","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130619719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SLMA GUIDELINES AND INFORMATION ON VACCINES 关于疫苗的Slma指南和信息

The Ceylon medical journal Pub Date : 2018-03-31 DOI: 10.4038/CMJ.V63I1.8632

H T Wickramasinghe

引用次数: 5

Validation of the Sinhala version of the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) 僧伽罗语版本的神经心理状态评估可重复测试(rban)的验证

The Ceylon medical journal Pub Date : 2016-12-30 DOI: 10.4038/CMJ.V61I4.8383

C. Suraweera, D. Anandakumar, D. Dahanayake, M. Subendran, U. Perera, R. Hanwella, V. de Silva

{"title":"Validation of the Sinhala version of the Repeatable Battery for Assessment of Neuropsychological Status (RBANS)","authors":"C. Suraweera, D. Anandakumar, D. Dahanayake, M. Subendran, U. Perera, R. Hanwella, V. de Silva","doi":"10.4038/CMJ.V61I4.8383","DOIUrl":"https://doi.org/10.4038/CMJ.V61I4.8383","url":null,"abstract":"Introduction\u0000Only the Mini mental state examination (MMSE) and Montreal Cognitive Assessment scale have been validated in a Sri Lankan population for the assessment of cognitive functions. Both tests are deficient in the number of domains assessed. Therefore validation of Repeatable Battery for Assessment of Neuropsychological Status is important as it assesses most of the cognitive domains.\u0000\u0000\u0000Objectives\u0000To culturally adapt RBANS and investigate the validity and reliability of culturally adapted RBANS (RBANS-S).\u0000\u0000\u0000Methods\u0000Fifty four participants with major neurocognitive disorder and 60 normal controls aged >50 were administered with RBANS-S at the Cognitive Assessment Unit, Faculty of Medicine, Colombo and National Hospital of Sri Lanka. The participants were selected after a detailed clinical assessment according to Diagnostic and Statistical Manual – 5 criteria. Data were analysed using SPSS data package.\u0000\u0000\u0000Results\u0000The mean age of the sample was 69.5 years. RBANS-S total scale correlated highly with MMSE total score, (Pearson correlational coefficient = 0.793 p=0.01). Criterion validity was assessed using receiver operating curve characteristic analysis and the area under the curve was 0.937. RBANS-S showed strong concurrent validity us indicated by its significant correlations with the MMSE. All of the RBANS-S subtests demonstrated significant correlations with the MMSE subsets. The sensitivity and specificity for RBANS-S was 89% and 85% respectively at a totals score of 80.5. The RBANS-S yielded a reliability coefficient of 0.929.\u0000\u0000\u0000Conclusions\u0000Culturally adapted RBANS-S is a valid and reliable instrument which can be used in assessment of cognitive functions.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121926103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Re: HLA– B27 allele frequency in Sri Lankan patients with spondyloarthritides 斯里兰卡脊柱关节炎患者的HLA - B27等位基因频率

The Ceylon medical journal Pub Date : 2016-12-30 DOI: 10.4038/cmj.v61i4.8397

S. Goonawardena

引用次数: 0

Effect of body mass index on pulmonary function in children 体重指数对儿童肺功能的影响

The Ceylon medical journal Pub Date : 2016-12-30 DOI: 10.4038/CMJ.V61I4.8382

G. Liyanage, B. Jayamanne, M. Aaqiff, D. Sriwardhana

引用次数: 9