The Ceylon medical journal最新文献_第3页

Risk factors for deliberate self-harm in young people in rural Sri Lanka: a prospective cohort study of 22,000 individuals. 斯里兰卡农村年轻人故意自残的风险因素:一项22,000人的前瞻性队列研究。

The Ceylon medical journal Pub Date : 2021-06-30 DOI: 10.4038/cmj.v66i2.9469

K. Fernando, S. Jayamanna, M. Weerasinghe, C. Priyadarshana, R. Ratnayake, M. Pearson, D. Gunnell, Andrew Dawson, K. Hawton, F. Konradsen, M. Eddleston, C. Metcalfe, D. Knipe

{"title":"Risk factors for deliberate self-harm in young people in rural Sri Lanka: a prospective cohort study of 22,000 individuals.","authors":"K. Fernando, S. Jayamanna, M. Weerasinghe, C. Priyadarshana, R. Ratnayake, M. Pearson, D. Gunnell, Andrew Dawson, K. Hawton, F. Konradsen, M. Eddleston, C. Metcalfe, D. Knipe","doi":"10.4038/cmj.v66i2.9469","DOIUrl":"https://doi.org/10.4038/cmj.v66i2.9469","url":null,"abstract":"Background\u0000Over 90% of youth suicide deaths occur in low- and middle-income countries. Despite this relatively little is known about risk factors in this context.\u0000\u0000\u0000Aims\u0000Investigate risk factors for deliberate self-harm (non-fatal) in young people in rural Sri Lanka.\u0000\u0000\u0000Methods\u0000A prospective cohort study of 22,401 individuals aged 12-18 years with complete data on sex, student status, household asset score, household access to pesticides and household problematic alcohol use. Deliberate self-harm was measured prospectively by reviewing hospital records. Poisson regression estimated incidence rate ratios (IRRs) for the association of risk factors with deliberate self-harm.\u0000\u0000\u0000Results\u0000Females were at higher risk of deliberate self-harm compared to males (IRR 2.05; 95%CI 1.75 - 2.40). Lower asset scores (low compared to high: IRR 1.46, 95%CI 1.12 - 2.00) and having left education (IRR 1.61 95%CI 1.31 - 1.98) were associated with higher risks of deliberate self-harm, with evidence that the effect of not being in school was more pronounced in males (IRR 1.94; 95%CI 1.40 - 2.70) than females. There was no evidence of an association between household pesticide access and deliberate self-harm risk, but problematic household alcohol use was associated with increased risk (IRR 1.23; 95%CI 1.04 - 1.45), with evidence that this was more pronounced in females than males (IRR for females 1.42; 95%CI 1.17 - 1.72). There was no evidence of deliberate self-harm risk being higher at times of school exam stress.\u0000\u0000\u0000Conclusion\u0000Indicators of lower socioeconomic status, not being in school, and problematic alcohol use in households, were associated with increased deliberate self-harm risk in young people.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129474241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Oral Misoprostol for 48 hours Versus a Supra Cervical Foley Catheter for 48 Hours for Induction of Labour in Post Dated Pregnancies: A Randomized Control Trial. 口服米索前列醇48小时与颈上Foley导尿管48小时引产:一项随机对照试验。

The Ceylon medical journal Pub Date : 2021-06-30 DOI: 10.4038/cmj.v66i2.9468

Buddika Asela Amarasena, M. Goonewardene, R. Perera, F. Rameez

{"title":"Oral Misoprostol for 48 hours Versus a Supra Cervical Foley Catheter for 48 Hours for Induction of Labour in Post Dated Pregnancies: A Randomized Control Trial.","authors":"Buddika Asela Amarasena, M. Goonewardene, R. Perera, F. Rameez","doi":"10.4038/cmj.v66i2.9468","DOIUrl":"https://doi.org/10.4038/cmj.v66i2.9468","url":null,"abstract":"Aims\u0000To assess the feasibility of administration of three doses of oral misoprostol (OM) 50 µg four hourly per day for 48 hours versus the insertion of a supra cervical Foley catheter for 48 hours, in women at 40 weeks + 5 days gestation, and compare the effectiveness of the two methods for induction of labour (IOL).\u0000\u0000\u0000Method\u0000An investigator blinded, randomized controlled trial was conducted at the academic obstetric unit, Teaching Hospital Mahamodara, Galle from 13.10.2016 to 30.04.2017. Consecutive women (n=144) with singleton uncomplicated pregnancies having Modified Bishop Score (MBS) <5 at 40weeks + 5days gestation were allocated by stratified (primigravidae/ multigravidae) block randomization to receive three doses of OM 50µg four hourly per day for 48 hours or a supra cervical Foley catheter for 48 hours.\u0000\u0000\u0000Results\u0000Compared to the Foley, OM resulted in higher rates of successful IOL (67% vs 47%, RR 1.4, 95% CI 1.1 - 2.0, p =0.029), more vaginal deliveries within 24 hours and 48 hours, shorter mean induction delivery intervals and greater mean increase in MBS in those not in labour after 48 hours. There was non-significant increased frequency of excessive uterine activity, cardiotocograph abnormalities and meconium stained liquor after OM but no differences in the rates of caesarean deliveries and maternal or neonatal morbidity or mortality between the two groups.\u0000\u0000\u0000Conclusion\u0000The administration of three doses oral misoprostol (OM) 50 µg four hourly per day for 48 hours as well as the insertion of a supra cervical Foley catheter for 48 hours were feasible for women at 40 weeks + 5 days gestation, but OM was more effective than the Foley catheter for IOL.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124721499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undiagnosed diabetes, hypertension, and hypercholesterolaemia in an overweight or obese population: implications for cardiovascular disease risk screening programme. 超重或肥胖人群中未确诊的糖尿病、高血压和高胆固醇血症:对心血管疾病风险筛查计划的影响

The Ceylon medical journal Pub Date : 2020-09-30 DOI: 10.4038/cmj.v65i3.9185

U. Senarath, P. Katulanda, D. Fernando, N. Kalupahana, Kunarathinam Partheepan, G. Katulanda, M. Dibley

{"title":"Undiagnosed diabetes, hypertension, and hypercholesterolaemia in an overweight or obese population: implications for cardiovascular disease risk screening programme.","authors":"U. Senarath, P. Katulanda, D. Fernando, N. Kalupahana, Kunarathinam Partheepan, G. Katulanda, M. Dibley","doi":"10.4038/cmj.v65i3.9185","DOIUrl":"https://doi.org/10.4038/cmj.v65i3.9185","url":null,"abstract":"Introduction\u0000Establishing the burden of undiagnosed CVD risk factors is critical to monitoring public health efforts related to screening and diagnosis.\u0000\u0000\u0000Objective\u0000To assess the proportion and determinants of undiagnosed diabetes, hypertension, and hypercholesterolaemia, among overweight or obese adults.\u0000\u0000\u0000Methods\u0000A sample of 1200 participants aged 35-64 years with a BMI ≥25 kg/m2 was selected from the Colombo district. Data were collected through a questionnaire, anthropometry, blood pressure measurement, and blood sampling for fasting plasma glucose, HbA1c, and lipid profile. Undiagnosed diabetes, hypertension, and hypercholesterolaemia were defined as fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%; systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg; total cholesterol ≥240 mg/dl respectively, in a person without a previous diagnosis. Multiple logistic regression analyses were carried out to identify determinants.\u0000\u0000\u0000Results\u0000The prevalence (95%CI) of diabetes was 28% (25.5, 30.5), hypertension, 33.4% (30.7, 36.1) and hypercholesterolaemia, 31.9% (29.2, 34.5). The proportion of undiagnosed diabetes was 13.8% (11.9, 15.8), undiagnosed hypertension 11.3% (9.5, 13.1), and undiagnosed hypercholesterolaemia 17.8% (15.6, 19.9). Undiagnosed cases accounted for almost half of all diabetes cases, one-third of all hypertension cases, and more than half (56%) of all high cholesterol cases. The key determinants for undiagnosed CVD risk were: male sex, low or middle income, rural residence, and relatively younger age.\u0000\u0000\u0000Conclusion\u0000CVD screening programmes should be tailored to target populations based on these determinants and provide basic diagnostic facilities in all health centres. The 'proportion undiagnosed' in the population may be a useful indicator to evaluate their effectiveness.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"271 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115301081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What's in a Name? 名字里有什么?

The Ceylon medical journal Pub Date : 2020-09-10 DOI: 10.1007/978-3-642-14577-3_10

Joseph Bonneau, Mike Just, Greg Matthews

引用次数: 542

Professor Colvin Goonaratna - an Academic Professional with Loads of Talent. Colvin Goonaratna教授——一位才华横溢的学术专家。

The Ceylon medical journal Pub Date : 2020-06-30 DOI: 10.4038/cmj.v65i1-2.9129

A. Abeygunasekera

引用次数: 0

Prostatic leiomyoma in a young man 青年人前列腺平滑肌瘤

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8893

A. Abeygunasekera, M. Kumara, A. Ambegoda, D. Ranasingha, C. Sosai

引用次数: 1

New forms of induction of apoptosis in aggressive lymphoma using peptides that interrupt the RAS / RAF interaction 利用中断RAS / RAF相互作用的肽诱导侵袭性淋巴瘤细胞凋亡的新形式

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8890

C. Bergna, G. Marín, M. Maíz, H. Bruzzoni Giovanelli, C. Ponzinibbio, G. Schinella, J. Errecalde, A. Rebollo

{"title":"New forms of induction of apoptosis in aggressive lymphoma using peptides that interrupt the RAS / RAF interaction","authors":"C. Bergna, G. Marín, M. Maíz, H. Bruzzoni Giovanelli, C. Ponzinibbio, G. Schinella, J. Errecalde, A. Rebollo","doi":"10.4038/CMJ.V64I2.8890","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8890","url":null,"abstract":"Interpretation\u0000RAS-RAF-MEK-ERK is a key pathway for apoptosis regulation in cancer cells. B-Raf-inhibitors such as PLX4032 peptide was developed by Institute Curie-Université Pierre et Marie Curie in order to induce apoptosis in cancer cells.\u0000\u0000\u0000Objectives\u0000To demonstrate pro-apoptotic properties and survival outcome of EP2014/064243 peptide in murine aggressive lymphoma.\u0000\u0000\u0000Material and Methodology\u0000BALBc mice with T-lymphoma were randomized assigned either in Group A (peptide+cyclophosphamide-CFM); Group B (peptides), Group C (CFM-control) or Control D (Cl-Na 0.9%-SF control group). Survival probability was calculated by Kaplan-Meier analysis. Apoptosis was detected using TUNEL technique. The protocol was approved by the Institutional Committee for Animal Care (CICUAL: T04-01-2015)\u0000\u0000\u0000Results\u0000The median survival was 24 days (21.6-26.4) for placebo, 33 days (28.0-35.4) for the CFM monotherapy group, 33 (27.1-35.8) for the peptide group and 34 days (24,4-40) for CFM-peptide combined treatment (p<0.05). In lymph node tissue the mean TUNEL positive cells per field for each treatment group was 2, 12 and 13 and 35 for SF, CFM, peptide and combined therapy (p<0.05).\u0000\u0000\u0000Conclusion\u0000These findings suggest that in murine aggressive lymphoma treated by an experimental peptide in addition with CFM, had an exponentially pro-apoptotic effect than CFM alone, suggesting that the peptide potentiated the anti-tumoural effect of CFM.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116264543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Fetal Doppler reference values in women with a normal body mass index 正常体重指数妇女胎儿多普勒参考值

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8888

T. Dias, S. Abeykoon, P. Mendis, C. Gunawardena, G. Pragasan, T. Padeniya, A. Pathmeswaran, S. Kumarasiri

{"title":"Fetal Doppler reference values in women with a normal body mass index","authors":"T. Dias, S. Abeykoon, P. Mendis, C. Gunawardena, G. Pragasan, T. Padeniya, A. Pathmeswaran, S. Kumarasiri","doi":"10.4038/CMJ.V64I2.8888","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8888","url":null,"abstract":"Objectives\u0000To construct gestation specific reference limits for fetal umbilical (UA), middle cerebral artery (MCA) pulsatility indices (PI) and the cerebroplacental ratio (CPR) in singleton pregnancies with normal BMI between 16 and 40 weeks of gestation.\u0000\u0000\u0000Methods\u0000We ultrasonographically examined 596 fetuses from women with normal nutritional and health status and minimal environmental constraints on fetal growth. Each mother was considered only once for measurement of fetal Doppler indices, at gestations between 16 and 40 weeks in a prospective cross-sectional study. Gestational age was confirmed by fetal crown-rump length measurement between 11 and 14 weeks. Pulsatility indices of umbilical and middle cerebral arteries were measured by real time and Doppler ultrasonography. CPR ratio was calculated by dividing MCA PI by UA PI. The fetal Doppler measurements obtained from the current study were compared with commonly used reference charts. For each parameter separate polynomial regression models were fitted to estimate the gestation specific means and standard deviations, assuming that the measurements have a normal distribution at each gestational age.\u0000\u0000\u0000Results\u0000A significant difference of fetal Doppler indices was observed between our study and previously published reference charts for most gestational weeks. The fitted 10th, 50th and 90th centiles at 40 weeks of gestation were 0.65, 0.87 and 1.08 for UA PI; 0.93, 1.32 and 1.71 MCA PI; 1.02, 1.58 and 2.13 for CPR.\u0000\u0000\u0000Conclusions\u0000These charts can be used for better defining the normal range of fetal arterial Doppler indices. This will be useful in the diagnosis and management of fetuses with abnormal fetal growth.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131106223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Systematic approach for benign liver lesions in non - cirrhotic livers 非肝硬化肝良性病变的系统方法

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8892

C. Amaraweera, M. Niriella, A. Dassanayaka, N. Ranaweera, R. Siriwardana

{"title":"Systematic approach for benign liver lesions in non - cirrhotic livers","authors":"C. Amaraweera, M. Niriella, A. Dassanayaka, N. Ranaweera, R. Siriwardana","doi":"10.4038/CMJ.V64I2.8892","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8892","url":null,"abstract":"Introduction\u0000Focal liver lesions are increasingly diagnosed in non-cirrhotic livers with widespread use of imaging. Arriving at an accurate diagnosis is challenging. Management of indeterminate lesions is not clearly defined. This paper looks at 101 non - malignant cases on the initial assessment and the outcome after three years of follow up.\u0000\u0000\u0000Objectives\u0000To assess the outcome of 101 benign liver lesions on initial assessment.\u0000\u0000\u0000Methods\u0000136 lesions in non-cirrhotic patients underwent triphasic CT(Computed Tomography )scan in all, MRI in 56 cases, biopsy in 5 patients and all discussed in multidisciplinary meeting. After initial evaluation 101/136 were benign or likely to be benign. These were divided as having benign asymptomatic lesions (n = 59), benign symptomatic lesions (n = 9), benign but indeterminate lesions (n = 33). Surgery was offered for symptomatic and potentially progressive lesions. Collective decision was taken in indeterminate lesions for surgery or follow up for three years.\u0000\u0000\u0000Results\u0000Overall, 37% had haemangiomas, 24% had liver cysts, 8% had focal nodular hyperplasia (FNH), 5% had adenomas. 25% underwent surgery. These included 7/59 diagnosed lesions, nine symptomatic lesions and 8/33 indeterminate lesions. Of the 33 indeterminate lesions six turned out to be FNH after surgery. 24 lesions, which were followed up for three years, did not increase in size. None of the 101 benign lesions turned out to be malignant after surgery or follow- up.\u0000\u0000\u0000Conclusion\u0000Benign lesions can be diagnosed safely with currant imaging. Strong recommendation for follow up appears to be a safe strategy for indeterminate lesions.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124856431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitudes, and Practices of Responsive Feeding in Rural Sri Lanka (A Qualitative Study) 斯里兰卡农村响应性喂养的知识、态度和实践(一项定性研究)

The Ceylon medical journal Pub Date : 2019-07-26 DOI: 10.4038/CMJ.V64I2.8894

P. Pallewaththa, S. Agampodi, T. Agampodi, S. Siribaddana

{"title":"Knowledge, Attitudes, and Practices of Responsive Feeding in Rural Sri Lanka (A Qualitative Study)","authors":"P. Pallewaththa, S. Agampodi, T. Agampodi, S. Siribaddana","doi":"10.4038/CMJ.V64I2.8894","DOIUrl":"https://doi.org/10.4038/CMJ.V64I2.8894","url":null,"abstract":"Introduction\u0000Responsive Feeding has been proven to be an effective feeding method for children who are at early stages of development. The concept is not popular at the primary health care level and it is reported as a missing link in the current nutrition program in Sri Lanka.\u0000\u0000\u0000Objective\u0000To explore responsive feeding practices among caregivers who have an infant aged between 6 to 12 months and residing in rural Anuradhapura.\u0000\u0000\u0000Methods\u0000A qualitative approach was adopted. The study was carried out in Padaviya Medical Officer of Health area. Study participants were 18 mothers and all ten Public Health Midwives. Diary studies, interviews and focus group discussion were conducted to collect data. The framework approach was used to analyze the data.\u0000\u0000\u0000Results\u0000Pleasant and healthy feeding environment is non-existent. Identification of hunger and satiety cues was poor and hunger sensitive schedule to feed the child was absent. Feeding situations commenced in an emotionally supportive manner, but were not optimally utilized to promote psycho-social stimulation. During the feeding caregivers neglect emotional support and ultimately moves to forceful feeding.\u0000\u0000\u0000Conclusions\u0000The knowledge, attitude and practices are poor on responsive feeding among caregivers and health workers. This may contribute to poor growth and development in children. Action is needed to implement RF practices in the community.","PeriodicalId":122256,"journal":{"name":"The Ceylon medical journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131498614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7