European urology最新文献

{"title":"Honing Stratification and Treatment for High-risk Prostate Cancer","authors":"Sophia C. Kamran, Jason A. Efstathiou","doi":"10.1016/j.eururo.2024.07.007","DOIUrl":"10.1016/j.eururo.2024.07.007","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 225-227"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Radical Prostatectomy Without Prior Biopsy in Selected Patients Evaluated by 18F-Labeled Prostate-specific Membrane Antigen–Ligand Positron Emission Tomography/Computed Tomography and Multiparameter Magnetic Resonance Imaging: A Single-center, Prospective, Single-arm Trial","authors":"Alice C.M. Thomson , David Chen , Elio Mazzone , Yao Zhu , Marlon Perera , Declan G. Murphy","doi":"10.1016/j.eururo.2024.08.003","DOIUrl":"10.1016/j.eururo.2024.08.003","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 269-271"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Evaluating the Safety of Retrograde Intrarenal Surgery (RIRS): Intra- and Early Postoperative Complications in Patients Enrolled in the Global Multicentre Flexible Ureteroscopy Outcome Registry (FLEXOR)","authors":"Arthur Peyrottes , Paul Meria","doi":"10.1016/j.eururo.2024.08.015","DOIUrl":"10.1016/j.eururo.2024.08.015","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 264-265"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membranous expression of target protein is required for ADC response in urothelial cancer","authors":"Niklas Klümper , Johannes Brägelmann , Veronika Bahlinger , Arndt Hartmann , Viktor Grünwald , Christoph Kuppe , Michael Hölzel , Markus Eckstein","doi":"10.1016/j.eururo.2024.06.023","DOIUrl":"10.1016/j.eururo.2024.06.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages e34-e36"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Iver Nordentoft, Sia Viborg Lindskrog, Karin Birkenkamp-Demtröder, et al. Whole-genome Mutational Analysis for Tumor-informed Detection of Circulating Tumor DNA in Patients with Urothelial Carcinoma. Eur Urol. 2024;86:301–311","authors":"Xiaoliang Wu , Xiangyang Yao , Zhong Chen , Hua Xu","doi":"10.1016/j.eururo.2024.07.021","DOIUrl":"10.1016/j.eururo.2024.07.021","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages e36-e37"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Prostate Cancers in the Prostate-specific Antigen Interval of 1.8-3 ng/ml: Results from the Göteborg-2 Prostate Cancer Screening Trial","authors":"Ola Bratt","doi":"10.1016/j.eururo.2024.08.006","DOIUrl":"10.1016/j.eururo.2024.08.006","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 268-269"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Gene Expression Classifier Testing on Adjuvant Treatment Following Radical Prostatectomy: The G-MINOR Prospective Randomized Cluster-crossover Trial","authors":"Todd M. Morgan ,&nbsp;Stephanie Daignault-Newton ,&nbsp;Daniel E. Spratt ,&nbsp;Rodney L. Dunn ,&nbsp;Udit Singhal ,&nbsp;Linda A. Okoth ,&nbsp;Felix Y. Feng ,&nbsp;Anna M. Johnson ,&nbsp;Brian R. Lane ,&nbsp;Susan Linsell ,&nbsp;Khurshid R. Ghani ,&nbsp;James E. Montie ,&nbsp;Rohit Mehra ,&nbsp;Brent K. Hollenbeck ,&nbsp;Thomas Maatman ,&nbsp;Kirk Wojno ,&nbsp;Frank N. Burks ,&nbsp;Daniel Bekong ,&nbsp;Jon Curry ,&nbsp;Paul Rodriguez ,&nbsp;Michael L. Cher","doi":"10.1016/j.eururo.2024.09.011","DOIUrl":"10.1016/j.eururo.2024.09.011","url":null,"abstract":"<div><h3>Background and objective</h3><div>Decipher is a tissue-based genomic classifier (GC) developed and validated in the post–radical prostatectomy (RP) setting as a predictor of metastasis. We conducted a prospective randomized controlled cluster-crossover trial assessing the use of Decipher to determine its impact on adjuvant treatment after RP.</div></div><div><h3>Methods</h3><div>Eligible patients had undergone RP within 9 mo of enrollment, had pT3–4 disease and/or positive surgical margins, and prostate-specific antigen &lt;0.1 ng/ml. Centers were randomized to a sequence of 3-mo periods of either GC-informed care or usual care (UC). Cancer of the Prostate Risk Assessment Postsurgical (CAPRA-S) recurrence risk scores were provided to treating physicians and patients in all periods.</div></div><div><h3>Key findings and limitations</h3><div>Impact of GC test results on adjuvant treatment were compared with UC alone. Longitudinal patient-reported urinary and sexual function was assessed. A total of 175 patients were enrolled in 27 periods with GC and 163 in 28 periods with UC. At 18 mo after RP, an average patient in the GC arm received adjuvant treatment 9.7% of the time compared with 8.7% for an average individual in the UC arm (0.99% mean difference, 95% confidence interval [CI] –7.6%, 9.6%, <em>p</em> = 0.8). While controlling for CAPRA-S score, higher GC scores tended to result in an increased likelihood of adjuvant treatment that was not statistically significant (odds ratio [OR] = 1.35 per 0.1 increase in GC score, 95% CI 0.98–1.85, <em>p</em> = 0.066). Using the GC risk groups, reflecting clinical use, a high GC risk was associated with significantly higher odds of receiving adjuvant treatment (OR = 6.9, 95% CI 1.8, 26, <em>p</em> = 0.005) compared with a low GC score, adjusted for CAPRA-S score. There were no differences in patient-reported urinary and sexual function between the study arms. As oncologic outcomes are immature, the present data cannot address whether GC testing provides any cancer control benefit.</div></div><div><h3>Conclusions and clinical implications</h3><div>GC testing impacts adjuvant therapy administration when viewed through the risk categories presented in the patient report; however, these data do not provide specific support for GC testing in the adjuvant treatment setting.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 228-237"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Despite an Abundance of Active Treatment Options for Renal Cell Carcinoma, Shadows Still Obscure the Light","authors":"Camillo Porta ,&nbsp;Carlo Ganini ,&nbsp;Mimma Rizzo","doi":"10.1016/j.eururo.2024.11.005","DOIUrl":"10.1016/j.eururo.2024.11.005","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 155-156"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biparametric Versus Multiparametric Magnetic Resonance Imaging in Prostate Cancer: A Choice or a Fine Balance?","authors":"Adriano B. Dias ,&nbsp;Caroline M. Moore ,&nbsp;Raphaële Renard-Penna ,&nbsp;Francesco Giganti","doi":"10.1016/j.eururo.2024.11.022","DOIUrl":"10.1016/j.eururo.2024.11.022","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 251-252"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncological Benefits of Extended Pelvic Lymph Node Dissection: More Fog or Clarity to the Debate?","authors":"Matthew J. Roberts ,&nbsp;Philip Cornford ,&nbsp;Derya Tilki","doi":"10.1016/j.eururo.2024.12.001","DOIUrl":"10.1016/j.eururo.2024.12.001","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 2","pages":"Pages 261-263"},"PeriodicalIF":25.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}