European urology最新文献

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Challenges and Opportunities in Establishing Appropriate Intermediate Endpoints Reflecting Patient Benefit: A Roadmap for Research and Clinical Application in Nonmetastatic Prostate Cancer 建立反映患者获益的适当中间终点的挑战与机遇:非转移性前列腺癌研究与临床应用路线图。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.04.024
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引用次数: 0
Cabozantinib Plus Nivolumab in Patients with Non–Clear Cell Renal Cell Carcinoma: Updated Results from a Phase 2 Trial Cabozantinib联合Nivolumab治疗非透明细胞肾细胞癌患者:2期试验的最新结果。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.04.025
{"title":"Cabozantinib Plus Nivolumab in Patients with Non–Clear Cell Renal Cell Carcinoma: Updated Results from a Phase 2 Trial","authors":"","doi":"10.1016/j.eururo.2024.04.025","DOIUrl":"10.1016/j.eururo.2024.04.025","url":null,"abstract":"<div><p><span>Treatment options are limited for patients with non–clear cell renal cell carcinoma (nccRCC). Patients with nccRCC experienced a favorable objective response rate (ORR) in a phase 2 trial of cabozantinib plus </span>nivolumab. We now report updated efficacy and safety results at median follow-up of 34 mo for patients with papillary, unclassified, or translocation-associated RCC. Cabozantinib and nivolumab were administered at standard doses to patients with metastatic nccRCC that had progressed on zero or one line of systemic therapy. The primary endpoint was the ORR according to Response Evaluation Criteria in Solid Tumors v1.1. Secondary endpoints included progression-free survival (PFS), overall survival (OS), and adverse events. Forty patients were treated. At median follow-up of 34 mo for survivors, the ORR was 48% (95% confidence interval [CI] 31.5–63.9%). Median PFS was 13 mo (95% CI 7–16); the 12-mo and 24-mo PFS rates were 51% (95% CI 34–65%) and 23% (95% CI 11–37%), respectively. Median OS was 28 mo (95% CI 23–43); the 18-mo and 36-mo OS rates were 70% (95% CI 53–82%) and 44% (95% CI 28–60%), respectively. No new safety signals were seen with cabozantinib and nivolumab. This extended follow-up analysis demonstrates promising efficacy, and highlights the potential for sustained responses with cabozantinib plus nivolumab in patients with metastatic nccRCC.</p></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic and Tumor-directed Therapy for Oligometastatic Prostate Cancer: The SOLAR Phase 2 Trial in De Novo Oligometastatic Prostate Cancer 针对寡转移性前列腺癌的全身和肿瘤导向疗法:新寡转移性前列腺癌的 SOLAR 2 期试验。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.02.008
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引用次数: 0
Re: Targeted Inhibition of CYP11A1 in Castration-Resistant Prostate Cancer 关于在阉割耐药前列腺癌中靶向抑制 CYP11A1。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.03.030
{"title":"Re: Targeted Inhibition of CYP11A1 in Castration-Resistant Prostate Cancer","authors":"","doi":"10.1016/j.eururo.2024.03.030","DOIUrl":"10.1016/j.eururo.2024.03.030","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Stereotactic Ablative Body Radiotherapy for Primary Kidney Cancer (TROG 15.03 FASTRACK II): A Non-randomised Phase 2 Trial 关于立体定向消融体放射治疗原发性肾癌(TROG 15.03 FASTRACK II):非随机 2 期试验。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.04.003
{"title":"Re: Stereotactic Ablative Body Radiotherapy for Primary Kidney Cancer (TROG 15.03 FASTRACK II): A Non-randomised Phase 2 Trial","authors":"","doi":"10.1016/j.eururo.2024.04.003","DOIUrl":"10.1016/j.eururo.2024.04.003","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Humanitarian Impact of Telesurgery and Remote Surgery in Global Medicine 远程手术和远程外科在全球医学中的人道主义影响。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.04.029
{"title":"The Humanitarian Impact of Telesurgery and Remote Surgery in Global Medicine","authors":"","doi":"10.1016/j.eururo.2024.04.029","DOIUrl":"10.1016/j.eururo.2024.04.029","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate-specific Antigen Screening in Limbo: How Low Should We Go? 前列腺特异性抗原筛查陷入困境:我们应该降低到什么程度?
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.05.005
{"title":"Prostate-specific Antigen Screening in Limbo: How Low Should We Go?","authors":"","doi":"10.1016/j.eururo.2024.05.005","DOIUrl":"10.1016/j.eururo.2024.05.005","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: EV-301 Long-term Outcomes: 24-month Findings from the Phase III Trial of Enfortumab Vedotin Versus Chemotherapy in Patients with Previously Treated Advanced Urothelial Carcinoma 关于EV-301 的长期疗效: Enfortumab Vedotin 与化疗对比治疗既往接受过治疗的晚期尿路上皮癌患者的 III 期试验的 24 个月结果。
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.03.011
{"title":"Re: EV-301 Long-term Outcomes: 24-month Findings from the Phase III Trial of Enfortumab Vedotin Versus Chemotherapy in Patients with Previously Treated Advanced Urothelial Carcinoma","authors":"","doi":"10.1016/j.eururo.2024.03.011","DOIUrl":"10.1016/j.eururo.2024.03.011","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Michael Eppler, Conner Ganjavi, Lorenzo Storino Ramacciotti, et al. Awareness and Use of ChatGPT and Large Language Models: A Prospective Cross-sectional Global Survey in Urology. Eur Urol 2024;85:146–53 Re:Michael Eppler、Conner Ganjavi、Lorenzo Storino Ramacciotti 等:对 ChatGPT 和大型语言模型的认识和使用:泌尿外科前瞻性横断面全球调查》。Eur Urol 2024;85:146-53.
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.02.029
{"title":"Re: Michael Eppler, Conner Ganjavi, Lorenzo Storino Ramacciotti, et al. Awareness and Use of ChatGPT and Large Language Models: A Prospective Cross-sectional Global Survey in Urology. Eur Urol 2024;85:146–53","authors":"","doi":"10.1016/j.eururo.2024.02.029","DOIUrl":"10.1016/j.eururo.2024.02.029","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Giancarlo Marra, Marco Oderda, Paolo Gontero, and Lorenzo Richiardi’s Letter to the Editor re: Jim C. Hu, Melissa Assel, Mohamad E. Allaf, et al. Transrectal Magnetic Resonance Imaging–targeted and Systematic Prostate Biopsy to Prevent Infectious Complications: The PREVENT Randomized Trial. Eur Urol. 2024;86:61–68 回复 Giancarlo Marra、Marco Oderda、Paolo Gontero 和 Lorenzo Richiardi 致编辑的信:Jim C. Hu、Melissa Assel、Mohamad E. Allaf 等:《经直肠磁共振成像靶向和系统性前列腺活检以预防感染性并发症》:PREVENT 随机试验》。Eur Urol.https://doi.org/10.1016/j.eururo.2023.12.015.
IF 25.3 1区 医学
European urology Pub Date : 2024-08-01 DOI: 10.1016/j.eururo.2024.02.015
{"title":"Reply to Giancarlo Marra, Marco Oderda, Paolo Gontero, and Lorenzo Richiardi’s Letter to the Editor re: Jim C. Hu, Melissa Assel, Mohamad E. Allaf, et al. Transrectal Magnetic Resonance Imaging–targeted and Systematic Prostate Biopsy to Prevent Infectious Complications: The PREVENT Randomized Trial. Eur Urol. 2024;86:61–68","authors":"","doi":"10.1016/j.eururo.2024.02.015","DOIUrl":"10.1016/j.eururo.2024.02.015","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":null,"pages":null},"PeriodicalIF":25.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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