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Re: Preventative Function-sparing Radical Prostatectomy: Experience in a Tertiary Referral Centre 关于:保留功能的预防性根治性前列腺切除术:三级转诊中心的经验
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.05.009
Jan Adamowicz, Krzysztof Koper, Tomasz Drewa
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引用次数: 0
The Critical Role of FLCN, TFE3, and TFEB in Bioenergetic and Nutrient Sensing, Renal Cancer Tumorigenesis and Metabolic Health FLCN、TFE3和TFEB在生物能量和营养感知、肾癌肿瘤发生和代谢健康中的关键作用
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.05.003
W. Marston Linehan, Christopher J. Ricketts, Daniel R. Crooks, Laura S. Schmidt
{"title":"The Critical Role of FLCN, TFE3, and TFEB in Bioenergetic and Nutrient Sensing, Renal Cancer Tumorigenesis and Metabolic Health","authors":"W. Marston Linehan, Christopher J. Ricketts, Daniel R. Crooks, Laura S. Schmidt","doi":"10.1016/j.eururo.2025.05.003","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.003","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>FLCN function</h2>FLCN is an ancient cellular bioenergetic and nutrient sensor that controls activation of the TFE3 and TFEB transcription factors and regulates lysosomal and mitochondrial biogenesis and function. FLCN, and its binding partner FNIP1, act as a GTP-activating protein (GAP) for the small GTPase Ras-related GTP-binding protein C (RagC). FLCN and FNIP activate a noncanonical mTORC1 signaling pathway that leads to phosphorylation of members of the microphthalmia/transcription factor E (MiT/TFE) family</section></section><section><section><h2><em>FLCN</em> mutation in BHD RCC</h2>BHD-associated hybrid RCC, chromophobe RCC, and oncocytoma tumors are characterized by biallelic inactivation of <em>FLCN</em> due to a combination of the germline pathogenic variation and somatic loss of function of the remaining allele via “second hit” mutation or deletion events. FLCN loss in BHD renal tumors leads to dephosphorylation and nuclear translocation of TFE3 [7] and TFEB, resulting in increased lysosomal and mitochondrial biogenesis (Fig. 1D). This is reflected in immunohistochemical</section></section><section><section><h2>Dysregulation of MiT/TFE transcription factors in renal cancer</h2>Activation of TFE3 and/or TFEB is recognized as an important driver event in many different types of renal cancer, including sporadic RCC's resulting from somatic TFE3/TFEB translocation or amplification of TFEB, as well as hereditary RCCs caused by germline variants in <em>MITF</em>, <em>TSC1</em>, <em>TSC2</em>, and <em>PRDM10</em>. These tumor types demonstrate overlapping histologies with BHD-associated RCCs, with TFE3/TFEB translocation RCC and PRDM10-associated RCC strongly reflecting the rarer but more aggressive</section></section><section><section><h2>Clinical management and therapy</h2>Identification of the <em>FLCN</em> gene, which was made possible by studying patients affected by BHD, has enabled clinicians to improve clinical management and surgical care for these patients. It also provides a foundation for the development of therapeutic or preventive approaches for BHD using small molecules that target TFE3/TFEB stability, agents targeting PGC1α transcriptional activity, antibody-drug conjugates and CAR-T cell therapies targeting cell-surface GPNMB expression.</section></section><section><section><h2>Implications of the physiologic role of FLCN on metabolic health</h2>As a sensor of bioenergetic and nutrient stress, FLCN is thought to potentially have significant importance in human health. FLCN is likely to play a critical role in the body’s response to exercise and restriction of caloric intake on long-term health. Gosis et al [8] showed that a decrease in FLCN in the liver could reverse nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in animals fed a diet high in fructose, cholesterol, and trans fats. Zhang et al [9] demonstrated that</section></section>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"30 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision Radiotherapy for Kidney Cancer: A Rising Ally in Multidisciplinary Care 精确放疗治疗肾癌:多学科治疗的新兴领域
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.04.027
Barbara Alicja Jereczek-Fossa, Federico Mastroleo, Giulia Marvaso
{"title":"Precision Radiotherapy for Kidney Cancer: A Rising Ally in Multidisciplinary Care","authors":"Barbara Alicja Jereczek-Fossa, Federico Mastroleo, Giulia Marvaso","doi":"10.1016/j.eururo.2025.04.027","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.04.027","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"44 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Assessment of a Polygenic Risk Score in Screening for Prostate Cancer 多基因风险评分在前列腺癌筛查中的评估
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.05.012
Guangdi Chu, Zhiqiang Li, Haitao Niu
{"title":"Re: Assessment of a Polygenic Risk Score in Screening for Prostate Cancer","authors":"Guangdi Chu, Zhiqiang Li, Haitao Niu","doi":"10.1016/j.eururo.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.012","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"127 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Belzutifan in Europe: A New Targeted Therapy for Clear Cell Renal Cancer 贝尔祖替芬在欧洲:透明细胞肾癌的一种新的靶向治疗
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.04.009
Catherine Graham, Laurence Albiges, Marc-Oliver Grimm, Thomas Powles
{"title":"Belzutifan in Europe: A New Targeted Therapy for Clear Cell Renal Cancer","authors":"Catherine Graham, Laurence Albiges, Marc-Oliver Grimm, Thomas Powles","doi":"10.1016/j.eururo.2025.04.009","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.04.009","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"54 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subtypes and Sequencing in Bladder Cancer: Powering Personalised Treatment or Extraneous Information? 膀胱癌的亚型和测序:个性化治疗还是外来信息?
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.05.001
Ella Schofield, James W.F. Catto, Jon Griffin
{"title":"Subtypes and Sequencing in Bladder Cancer: Powering Personalised Treatment or Extraneous Information?","authors":"Ella Schofield, James W.F. Catto, Jon Griffin","doi":"10.1016/j.eururo.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.001","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"30 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Local Anaesthetic Transperineal Biopsy Versus Transrectal Prostate Biopsy in Prostate Cancer Detection (TRANSLATE): A Multicentre, Randomised, Controlled Trial 局部麻醉经会阴活检与经直肠前列腺活检在前列腺癌检测中的对比:一项多中心、随机、对照试验
IF 23.4 1区 医学
European urology Pub Date : 2025-05-16 DOI: 10.1016/j.eururo.2025.05.010
David Hennes, Abdullah Al-Khanaty, David C. Chen, Eoin Dineen, Christa Babst, Nathan Lawrentschuk, Marlon L. Perera, Declan G. Murphy
{"title":"Re: Local Anaesthetic Transperineal Biopsy Versus Transrectal Prostate Biopsy in Prostate Cancer Detection (TRANSLATE): A Multicentre, Randomised, Controlled Trial","authors":"David Hennes, Abdullah Al-Khanaty, David C. Chen, Eoin Dineen, Christa Babst, Nathan Lawrentschuk, Marlon L. Perera, Declan G. Murphy","doi":"10.1016/j.eururo.2025.05.010","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.010","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"18 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management Dilemma for Very High-risk Non–muscle-invasive Bladder Cancer: Real-World Data Challenge the Guideline Recommendation for Upfront Radical Cystectomy 高危非肌浸润性膀胱癌的治疗困境:现实世界数据对预先根治性膀胱切除术指南建议的挑战
IF 23.4 1区 医学
European urology Pub Date : 2025-05-14 DOI: 10.1016/j.eururo.2025.05.005
José Daniel Subiela, Pietro Scilipoti, Roberto Contieri, Nijati Lobo, Renate Pichler, Ashish M. Kamat
{"title":"Management Dilemma for Very High-risk Non–muscle-invasive Bladder Cancer: Real-World Data Challenge the Guideline Recommendation for Upfront Radical Cystectomy","authors":"José Daniel Subiela, Pietro Scilipoti, Roberto Contieri, Nijati Lobo, Renate Pichler, Ashish M. Kamat","doi":"10.1016/j.eururo.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.005","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"41 3 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Development of Prediction Models for Severe Pain and Urinary Symptoms After Ureteroscopy with Ureteral Stent Placement: Results from the STENTS Study and Initial Validation of Pain Interference 输尿管镜下输尿管支架置入后严重疼痛和泌尿系统症状预测模型的建立:来自支架研究的结果和疼痛干扰的初步验证
IF 23.4 1区 医学
European urology Pub Date : 2025-05-10 DOI: 10.1016/j.eururo.2025.04.023
Palle Osther
{"title":"Re: Development of Prediction Models for Severe Pain and Urinary Symptoms After Ureteroscopy with Ureteral Stent Placement: Results from the STENTS Study and Initial Validation of Pain Interference","authors":"Palle Osther","doi":"10.1016/j.eururo.2025.04.023","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.04.023","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"1 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should We Incorporate Urinary Tumour DNA Status in Treatment Decisions for Patients with Non–muscle-invasive Bladder Cancer? 非肌肉浸润性膀胱癌患者的治疗决策是否应纳入泌尿肿瘤DNA状态?
IF 23.4 1区 医学
European urology Pub Date : 2025-05-10 DOI: 10.1016/j.eururo.2025.04.025
Douglas G. Ward, Richard T. Bryan
{"title":"Should We Incorporate Urinary Tumour DNA Status in Treatment Decisions for Patients with Non–muscle-invasive Bladder Cancer?","authors":"Douglas G. Ward, Richard T. Bryan","doi":"10.1016/j.eururo.2025.04.025","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.04.025","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"126 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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