European urology最新文献

{"title":"Magnetic Resonance Imaging–based Biopsy Strategies in Prostate Cancer Screening: A Systematic Review","authors":"Ivo G. Schoots, Hashim U. Ahmed, Peter Albers, Patrick Asbach, Roderick C.N. van den Bergh, Rebecka A. Godtman, Pim J. van Leeuwen, Tobias Nordström, Shonit Punwani, Jonas Wallström, Anwar R. Padhani","doi":"10.1016/j.eururo.2025.05.038","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.038","url":null,"abstract":"<h3>Background and objective</h3>Prostate cancer (PCa) screening using prostate-specific antigen (PSA) thresholding and systematic biopsies reduces advanced disease presentations and cancer-specific mortality, but also leads to overdiagnosis. Magnetic resonance imaging (MRI) integration may maintain screening benefits, while reducing overdiagnosis and unnecessary biopsies. This review analyses the benefit-harm balance when MRI is integrated as first-line and second-stage (after PSA &gt;3 ng/ml) test in PCa screening.<h3>Methods</h3>Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, we performed a PROSPERO-registered systematic review (CRD420251006926). Literature searches identified five first-line and four second-stage MRI screening studies. We assessed MRI strategies (first-line/second-stage and risk thresholds), biopsy avoidance, and biopsy methods (targeted/systematic) for histological outcomes (grade group [GG] ≥2/GG 1 cancer detection and benign biopsies). Benefit-to-harm ratios of &gt;1 suggest a positive net benefit.<h3>Key findings and limitations</h3>First-line MRI screening detects twice as many men with GG ≥2 cancer as second-stage MRI screening but has more MRI-negative men (range, 66–89% vs 56–61%). Second-stage MRI significantly reduced biopsy rates (range, 42–79%) compared with systematic biopsy rates in all PSA-positive men. Subsequently, GG ≥2/GG 1 cancer detection ratios increased in MRI-positive men undergoing targeted and systematic biopsies (range, 1.9–6.2) and targeted biopsies alone (range, 1.8–7.0), compared with systematic biopsies alone (range, 0.8–1.4). First-line and second-stage MRI screening allowed biopsy avoidance in three to 125 and two to 15 men, respectively, for each benign diagnosis. All benefit-to-harm ratios showed positive net benefits (&gt;1). Heterogeneity in the study protocols limits generalisability.<h3>Conclusions and clinical implications</h3>Targeted biopsies in second-stage MRI screening optimise clinically significant PCa detection, while reducing the number of biopsies. First-line MRI screening requires further assessments of its feasibility. PCa screening quality assurance requires standardised MRI interpretations and biopsy protocols.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"12 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Rajal B. Shah, Gladell P. Paner, Liang Cheng, et al. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.02.029","authors":"Matthew R. Cooperberg, Jeremy Grummet, Scott E. Eggener","doi":"10.1016/j.eururo.2025.05.032","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.032","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"150 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Histology Artificial Intelligence (CHAI) Enhances Risk Stratification of High-grade Ta Non–muscle-invasive Bladder Cancer in a Multicenter Cohort: Comparison to Current European Association of Urology and American Urological Association Stratification Schemes","authors":"Sam S. Chang, Bryn Launer, Vikram Narayan, Dattatraya Patil, Michael A. O’Donnell, Patrick J. Hensley, John A. Taylor, Roger Li, Mario I. Fernandez, Haochen Zhang, Viswesh Krishna, Damir Vrabac, Waleed M. Abuzeid, Vivek Nimgaonkar, Drew Watson, Trevor J. Royce, Lesli A. Kiedrowski, Anirudh Joshi, Badrinath R. Konety, Philippe E. Spiess, Siamak Daneshmand","doi":"10.1016/j.eururo.2025.05.035","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.035","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"6 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum Hall of Fame","authors":"","doi":"10.1016/j.eururo.2025.05.022","DOIUrl":"10.1016/j.eururo.2025.05.022","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"88 1","pages":"Pages e1-e12"},"PeriodicalIF":25.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Bladder-preserving Trimodality Treatment for High-grade T1 Bladder Cancer: Results from Phase II Protocol NRG Oncology/RTOG 0926","authors":"Melinda Z. Fu, Saum Ghodoussipour, Vignesh T. Packiam","doi":"10.1016/j.eururo.2025.05.027","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.027","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"4 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congress Calendar","authors":"","doi":"10.1016/j.eururo.2025.05.023","DOIUrl":"10.1016/j.eururo.2025.05.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"88 1","pages":"Pages e21-e22"},"PeriodicalIF":25.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Role of Androgen Deprivation Therapy After Radical Prostatectomy","authors":"Mutlay Sayan, Paul L. Nguyen","doi":"10.1016/j.eururo.2025.05.034","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.034","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"18 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Using Deep Learning To Differentiate Among Histology Renal Tumor Types in Computed Tomography Scans","authors":"Matteo Santoni, Francesco Massari","doi":"10.1016/j.eururo.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.028","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"46 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Veeru Kasivisvanathan, Vinson Wai-Shun Chan, Keiran D. Clement, et al. An Individual Patient Data Meta-analysis of Randomised Trials Comparing Magnetic Resonance Imaging Targeted Biopsy with Standard Transrectal Ultrasound Guided Biopsy in the Detection of Prostate Cancer. Eur Urol 2025;87:512–23","authors":"Sherryn Sherryn, Bagus Baskoro, Jie Sun","doi":"10.1016/j.eururo.2025.05.033","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.033","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"23 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Matthew R. Cooperberg, Jeremy Grummet, and Scott E. Eggener‘s Letter to the Editor re: Rajal B. Shah, Gladell P. Paner, Liang Cheng, et al. Genitourinary Pathology Society and International Society of Urological Pathology White Paper on Defining Indolent Prostate Cancer: Call for a Multidisciplinary Approach. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.02.029","authors":"Glen Kristiansen, Gladell P. Paner, Rajal B. Shah","doi":"10.1016/j.eururo.2025.05.031","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.031","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"34 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}