European urology最新文献

{"title":"Platinum Hall of Fame","authors":"","doi":"10.1016/j.eururo.2025.06.020","DOIUrl":"10.1016/j.eururo.2025.06.020","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"88 2","pages":"Pages e23-e34"},"PeriodicalIF":25.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Association of Urology Policy on Telesurgery","authors":"Bhaskar K. Somani, Jens Rassweiler, Evangelos Liatsikos, Alexandre Mottrie, Thomas Knoll, Jens Bedke, Giampaolo Bianchi, Kemal Sarica, Alberto Briganti, Ton Brouwers, Alberto Breda","doi":"10.1016/j.eururo.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.018","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"5 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Therapeutic Strategies for Metastatic Prostate Cancer Care","authors":"Alessia Cimadamore, Cristina Boixareu, Adam Sharp, Himisha Beltran, Johann S. de Bono","doi":"10.1016/j.eururo.2025.06.013","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.013","url":null,"abstract":"The elucidation of prostate cancer biology and genomics has led to new therapies improving disease outcomes with novel androgen receptor (AR) pathway inhibitors (ARPIs), taxanes, and targeted therapeutics that require disease molecular stratification.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"109 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-port Antegrade Robotic Lymphadenectomy: A Novel Minimally Invasive Approach to Treat Lymph Nodes in Men with Penile Cancer","authors":"Aldo Brassetti, Alfredo Maria Bove, Flavia Proietti, Umberto Anceschi, Eugenio Bologna, Silvia Cartolano, Giuseppe Chiacchio, Simone D’Annunzio, Mariaconsiglia Ferriero, Simone Rocco Flammia, Salvatore Guaglianone, Costantino Leonardo, Leslie Claire Licari, Riccardo Mastroianni, Leonardo Misuraca, Gabriele Tuderti, Giuseppe Simone","doi":"10.1016/j.eururo.2025.06.016","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.016","url":null,"abstract":"Lymph node (LN) dissection (LND) improves survival in penile cancer (PenC) patients, but it is largely underused due to high morbidity associated with it. We present a novel single-port antegrade robotic lymphadenectomy (SPARL) technique to treat both inguinal and pelvic LNs through a single abdominal incision.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"1 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irreversible Electroporation for Prostate Tissue Ablation in Patients with Intermediate-risk Prostate Cancer: Results from the PRESERVE Trial","authors":"Arvin K. George, Ranko Miocinovic, Amit R. Patel, Derek J. Lomas, Andres F. Correa, David Y.T. Chen, Ardeshir R. Rastinehad, Michael J. Schwartz, Abhinav Sidana, Kristian D. Stensland, Brian T. Helfand, Jeffrey C. Gahan, Xiaosong Meng, Alice Yu, Wayne G. Brisbane, Srinivas Vourganti, Al Baha Barqawi, Edward M. Uchio, James S. Wysock, Thomas J. Polascik, Timothy D. McClure, Jonathan Fainberg, Jonathan A. Coleman","doi":"10.1016/j.eururo.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.003","url":null,"abstract":"The PRESERVE study (NCT04972097) assessed the safety and effectiveness of irreversible electroporation (IRE) with the NanoKnife System to ablate prostate tissue in patients with intermediate-risk prostate cancer (PCa).","PeriodicalId":12223,"journal":{"name":"European urology","volume":"267 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Matthew J. Roberts, Philip Cornford, Derya Tilki. Oncological Benefits of Extended Pelvic Lymph Node Dissection: More Fog or Clarity to the Debate? Eur Urol 2025;87:261–3","authors":"Andrew J. Vickers, Karim A. Touijer","doi":"10.1016/j.eururo.2025.05.043","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.043","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"31 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Clinical Trials to Routine Practice: Are Urodynamics Still Useful?","authors":"Christopher R. Chapple, Adrian Wagg, Christopher Harding, Marcus J. Drake, Mohamed Abdel-Fattah, John Heesakkers, Enrico Finazzi Agrò, Sachin Malde, Alan J. Wein, Paul Abrams","doi":"10.1016/j.eururo.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.017","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"680 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How To Interpret Subgroup Analyses from Prospective Randomized Clinical Trials: What Clinicians Need To Know","authors":"Susan Halabi, Siyuan Guo","doi":"10.1016/j.eururo.2025.06.015","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.015","url":null,"abstract":"<h2>Section snippets</h2><section><section><section><h2>Inflated type I errors</h2>Most RCTs are designed to test the overall treatment effect and not for detection of effects in subgroups. With each additional subgroup comparison, the likelihood of a false-positive result increases. For example, testing five independent subgroups yields a 23% chance of observing at least one <em>p</em> value &lt;0.05 by chance alone, which rises to 40% with ten independent subgroups (Fig. 1A). Moreover, the probability of seeing a reversal of a treatment effect in at least one subgroup is surprisingly</section></section></section><section><section><h2>Levels of evidence and the role of meta-analysis</h2>The credibility of a subgroup claim depends on the study design and context. Prespecified analyses with adequate power, significant interaction tests, and a biological rationale carry more weight than post hoc findings (Fig. 2A). In the CHAARTED trial, a prespecified subgroup analysis showed that men with high-disease volume metastatic hormone-sensitive prostate cancer (mHSPC) had longer OS with androgen deprivation therapy (ADT) + docetaxel than with ADT alone (hazard ratio 0.60, 95%</section></section><section><section><h2>Traditional versus data-driven subgroup definitions</h2>Subgroup definitions have traditionally relied on clinical judgment and biological rationale, such as classification of patients by tumor stage, biomarker expression, or prior treatments. These categories are grounded in existing knowledge and are easier to interpret and communicate. However, they may overlook more complex predictors of treatment heterogeneity.By contrast, data-driven methods such as recursive partitioning, clustering, and machine-learning algorithms can uncover unrecognized</section></section><section><section><h2>Conclusions</h2>Subgroup analyses must be approached with caution. Unless such analyses are prespecified at the design stage, any findings should be considered exploratory and confirmed in future trials (Fig. 2B). Poorly designed subgroup analyses risk misleading interpretation and may erode trust among clinicians, regulators, and the public. Credible subgroup claims require safeguards such as prespecification, adequate power, formal interaction testing, and meta-analysis. Statistical reporting should</section></section>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"33 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Circulating Tumor DNA and Clinical Outcomes with Adjuvant Immune Checkpoint Blockade in Patients with Muscle-invasive Bladder Cancer Treated with Neoadjuvant Chemotherapy Followed by Cystectomy","authors":"Jonathan F. Anker, Menggang Yu, Matthew D. Galsky","doi":"10.1016/j.eururo.2025.05.039","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.039","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"19 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Surgery and Patient Safety: A Global Assessment of Technological Malfunctions During da Vinci X and Xi Procedures","authors":"Marco Paciotti, Andrea Piccolini, Alessandro Uleri, Stefano Moretto, Vittorio Fasulo, Massimo Lazzeri, Giovanni Lughezzani, Paolo Casale, Nicolò Maria Buffi","doi":"10.1016/j.eururo.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.014","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"152 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}