European urology最新文献

{"title":"Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data","authors":"Sarah Burdett, David J. Fisher, Jayne F. Tierney, Adrian D. Cook, Daniel E. Spratt, James J. Dignam, Wendy F. Seiferheld, Amar U. Kishan, Yilun Sun, Sylvie Chabaud, Jason A. Efstathiou, Christopher C. Parker, Alan Pollack, Paul Sargos, Igor Latorzeff, Meryem Brihoum, Charles N. Catton, Noel W. Clarke, Felix Y. Feng, Theodore G. Karrison, Claire L. Vale","doi":"10.1016/j.eururo.2025.05.013","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.013","url":null,"abstract":"<h3>Background and objective</h3>To better understand the role of hormone therapy (HT) with postoperative radiotherapy (RT) for nonmetastatic prostate cancer, the DADSPORT Collaboration planned a systematic review and meta-analysis of aggregate data from randomised controlled trials (RCTs).<h3>Methods</h3>RCTs evaluating HT with postoperative RT in people with nonmetastatic prostate cancer were identified. Methods were prespecified prior to results of recent trials being known (CRD42022325769). The primary outcome was overall survival (OS); metastasis-free survival (MFS) and prostate cancer–specific survival (PCSS) were the secondary outcomes. Summary results, including those by prespecified participant subgroups, were obtained from investigators and combined across trials using a fixed-effect meta-analysis. Sensitivity and network meta-analyses evaluated the consistency of findings.<h3>Key findings and limitations</h3>Five RCTs (six trial comparisons, 4411 participants; 96% of all eligible) were included in the primary analysis. There was no clear evidence that OS was improved with HT (hazard ratio [HR] = 0.86, 95% confidence interval [CI] = 0.74–1.00, <em>p</em> = 0.057; absolute effect 2% [0–3.5%] at 8 yr) or that effects varied by HT duration (<em>p</em> = 0.6). Any benefit of HT on OS appears to be confined to people with higher pre-RT prostate specific antigen levels (<em>p</em> = 0.07) and CAPRA-S scores (<em>p</em> = 0.09). HT significantly improved MFS (HR = 0.78, 95% CI = 0.69–0.88, <em>p</em> &lt; 0.001) and PCSS (HR = 0.61, 95% CI = 0.47–0.79, <em>p</em> &lt; 0.001), with 4% absolute improvements for both outcomes at 8 yr.<h3>Conclusion and clinical implications</h3>Short- or long-course HT after postoperative RT improves MFS and PCSS. Observed improvements in OS are small and may be limited to people with higher-risk factors.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"139 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Non-neurogenic Male Lower Urinary Tract Symptoms: Better Holistic than Sequential","authors":"Jean-Nicolas Cornu, Michael Baboudjian, Christopher Netsch, Hashim Hashim, Massimiliano Creta, Nikaolos Pyrgidis, Lisa Moris, Manuela Tutolo, Vasileios Sakalis, Malte Rieken, Sachin Malde, Markos Karavitalis, Thomas Herrmann, Cosimo De Nunzio, Nikita Bhatt, Natasha Schouten, Mauro Gacci","doi":"10.1016/j.eururo.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.010","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"17 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Early Detection: Magnetic Resonance Imaging Strategies for Smarter Prostate Cancer Screening","authors":"Sigrid V. Carlsson","doi":"10.1016/j.eururo.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.011","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"12 2 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active Surveillance for Screen-detected Low- and Intermediate-risk Prostate Cancer: Extended Follow-up up to 25 Years in the GÖTEBORG-1 Trial","authors":"Emmeli Palmstedt, Marianne Månsson, Jonas Hugosson, Rebecka Arnsrud Godtman","doi":"10.1016/j.eururo.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.012","url":null,"abstract":"<h3>Background and objective</h3>Active surveillance (AS) is used to postpone or avoid surgery or radiotherapy for prostate cancer (PC). While the risk of PC-related death remains low for patients deferring treatment, follow-up data have previously been limited to 15 yr. Since many men outlive this timeframe, studying long-term outcomes is crucial.<h3>Methods</h3>We included 488 men with screen-detected PC in the GÖTEBORG-1 screening trial managed with AS, of whom 251 were at a very low risk, 129 at a low risk, and 108 at an intermediate risk. Prostate-specific antigen (PSA) testing was performed every 6–12 mo, and repeated biopsies were indicated if there were signs of clinical progression. Treatment was recommended upon progression (PSA, grade, or stage). Kaplan-Meier analyses were performed for treatment-free, failure-free, and PC-specific survival, measuring time from diagnosis to an event or the last follow-up.<h3>Key findings and limitations</h3>During a median follow-up of 18 yr, a total of 232 men discontinued AS, 81 experienced failure, and 14 died from PC. The treatment-free survival rate at 22 yr was 38% for the entire cohort . At 19 yr, treatment-free survival rates were 55% for very-low-risk, 35% for low-risk, and 30% for intermediate-risk PC. The failure-free survival rate at 22 yr for all men was 68%, and at 19 yr, the rates were 85% for very-low-risk, 74% for low-risk, and 55% for intermediate-risk cases. The PC-specific survival rate at 25 yr for the entire cohort was 94%. At 24 yr, these rates were 99% for very-low-risk, 92% for low-risk, and 85% for intermediate-risk PC. The overall survival rate at 25 yr for all men was 32%, and at 24 yr, the rates were 38% for very-low-risk, 34% for low-risk, and 22% for intermediate-risk PC. The limitation was no predefined AS protocol.<h3>Conclusions and clinical implications</h3>This study confirms a low risk of PC death with a median follow-up of 18 yr. The risk of failure increased over time, highlighting the need for life-long monitoring. Providing men information about this risk is important.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"148 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Xin Rui, Xiaoming Xu, and Bo Dai’s Letter to the Editor re: Thomas Dreyer, Simone Brandt, Knud Fabrin, et al. Use of the Xpert Bladder Cancer Monitor Urinary Biomarker Test for Guiding Cystoscopy in High-grade Non–muscle-invasive Bladder Cancer: Results from the Randomized Controlled DaBlaCa-15 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.03.018","authors":"Thomas Dreyer, Jørgen Bjerggaard Jensen","doi":"10.1016/j.eururo.2025.05.040","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.040","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"16 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144371026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Zhengbo Pan, Run Shi, and Zhaokai Zhou’s Letter to the Editor - Re: Madeleine J. Karpinski, Kambiz Rahbar, Martin Bögemann, et al. Updated Prostate Cancer Risk Groups by Prostate-specific Membrane Antigen Positron Emission Tomography Prostate Cancer Molecular Imaging Standardized Evaluation (PPP2): Results from an International Multicentre Registry Study. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.04.017","authors":"Madeleine J. Karpinski, Boris A. Hadaschik, Wolfgang P. Fendler","doi":"10.1016/j.eururo.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.006","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"143 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"If the Treatment for Metastatic Hormone-sensitive Prostate Cancer Stops Working, What Next?","authors":"Ian D. Davis","doi":"10.1016/j.eururo.2025.06.009","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.009","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"5 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Current Surgical Anatomical Knowledge of Radical Prostatectomy: An Updated Review","authors":"Asher Mandel, Sneha Parekh, Manish Choudhary, Suichi Morizane, Coskun Kacagan, Neeraja Tillu, Ryutaro Shimizu, Adriana Pedraza, Thomas Bessede, Jochen Walz, Ash Tewari","doi":"10.1016/j.eururo.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.002","url":null,"abstract":"<h3>Background and objective</h3>New anatomical studies have emerged since the last prostatic surgical anatomy review published in 2016. Our goal is to present the latest periprostatic anatomical understanding.<h3>Methods</h3>PubMed was queried to identify articles covering prostate anatomy, emphasizing work published from 2016 to 2025.<h3>Key findings and limitations</h3>The endopelvic fascia partially engulfs the prostate laterally. Meanwhile, the prostatic fascia surrounds the medial aspect. The anterior fibromuscular stroma reinforces the prostatic stroma ventrally. The detrusor apron is continuous with anterior bladder muscle fibers, which anchors to the posterior pubis. Posterolaterally, the prostate is adjacent to a predominant neurovascular bundle. The external and internal sphincters, along with membranous urethra, are components of the urethral sphincter complex. At the prostatic base, the seminal vesicles are anteromedial to the adjoining proximal neurovascular plate. Autonomic and somatic fibers innervate the prostate, from T11-L2 and S2-S4 rami. In a spray-like pattern, autonomic fibers are distributed into the neurovascular bundle, the proximal plate, and accessory pathways. Synthesizing the most recent surgical anatomy research, we also created a three-dimensional animation.<h3>Conclusions and clinical implications</h3>The prostate is a dense organ with muscular and glandular features. Located within the true pelvis, the prostate is surrounded by several fascial planes that contain the neurovascular structures. Lumbosacral parasympathetic nerve root fibers of the pelvic plexus run posterolateral to the prostate gland in a neural hammock configuration. This anatomic understanding informs the nerve-sparing technique. Finally, the anterior ligamentous structures play a role in continence and possibly erectile function too.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"25 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Madeleine J. Karpinski, Kambiz Rahbar, Martin Bögemann, et al. Updated Prostate Cancer Risk Groups by Prostate-specific Membrane Antigen Positron Emission Tomography Prostate Cancer Molecular Imaging Standardized Evaluation (PPP2): Results from an International Multicentre Registry Study. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.04.017","authors":"Zhengbo Pan, Run Shi, Zhaokai Zhou","doi":"10.1016/j.eururo.2025.05.041","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.05.041","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"29 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Baris Turkbey, Henkjan Huisman, Andriy Fedorov, et al. Requirements for AI Development and Reporting for MRI Prostate Cancer Detection in Biopsy-Naïve Men: PI-RADS Steering Committee, Version 1.0. Radiology 2025;315:e24014","authors":"Masatomo Kaneko, Vasileios Magoulianitis, Vinay Duddalwar, Manju Aron, C.-C. Jay Kuo, Inderbir S. Gill, Andre Luis Abreu","doi":"10.1016/j.eururo.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.06.007","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"14 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}