European urology最新文献

{"title":"Varicocele Treatment in Azoospermia Before Artificial Reproductive Techniques: Critical Considerations by the EAU Guidelines Panel on Sexual and Reproductive Health","authors":"Luca Boeri , Marij Dinkelman-Smit , Christian Fuglesang S. Jensen , Suks Minhas , Andrea Salonia , European Association of Urology Guidelines Panel on Sexual and Reproductive Health","doi":"10.1016/j.eururo.2025.12.017","DOIUrl":"10.1016/j.eururo.2025.12.017","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 391-393"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Gonglin Tang and Hongwei Zhao’s Letter to the Editor re: Nikhil Mayor, Alexander Light, Anna Silvanto, et al. IP8-FLUORESCE: A Prospective Paired Cohort Study Evaluating the Diagnostic Accuracy of Fluorescence Confocal Microscopy for Real-time Assessment of Surgical Margins in Radical Prostatectomy. Eur Urol. 2026;89:223–32","authors":"Nikhil Mayor , Anna Silvanto , Greg Shaw , Hashim U. Ahmed , Francesca Fiorentino , Mathias Winkler","doi":"10.1016/j.eururo.2025.12.018","DOIUrl":"10.1016/j.eururo.2025.12.018","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages e125-e126"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less Is More? How Much Bacillus Calmette-Guérin (BCG) Is Enough for BCG-naïve High-risk Non–muscle invasive Bladder Cancer?","authors":"David J. Nusbaum , Roger Li , Charles C. Peyton , Philippe E. Spiess","doi":"10.1016/j.eururo.2026.01.032","DOIUrl":"10.1016/j.eururo.2026.01.032","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 454-456"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence for Risk Prediction in Non–muscle-invasive Bladder Cancer: From Complexity to Clinical Clarity","authors":"Zine-Eddine Khene , Karim Bensalah , Morgan Rouprêt","doi":"10.1016/j.eururo.2025.11.010","DOIUrl":"10.1016/j.eururo.2025.11.010","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 414-415"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Laurence Albiges, Thomas Powles, Anand Sharma, et al. CaboPoint: A Phase 2 Study of Second-line Cabozantinib After Checkpoint Inhibitor-based Combination Therapy in Patients with Metastatic Renal Cell Carcinoma. Eur Urol. 2026;89:210–19","authors":"Wenhao Xu , Dingwei Ye , Hailiang Zhang","doi":"10.1016/j.eururo.2025.10.023","DOIUrl":"10.1016/j.eururo.2025.10.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Page e122"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Functional Reactivity of Expanded Tumor-infiltrating Lymphocytes from Non–clear-cell Renal Cell Carcinoma","authors":"Marine Potez , Seyed Behzad Jazayeri , Christopher Guske , Justin Miller , Johannes Ali , Michael Carter , Fatema Khambati , Jasreman Dhillon , Wade Sexton , Logan Zemp , Brandon Manley , Gabriel Roman Souza , Philippe E. Spiess , Matthew Beatty , Shari Pilon-Thomas , Jad Chahoud","doi":"10.1016/j.eururo.2025.09.002","DOIUrl":"10.1016/j.eururo.2025.09.002","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 469-471"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacillus Calmette-Guérin Plus Mitomycin Versus Bacillus Calmette-Guérin Alone for Bacillus Calmette-Guérin–naïve Non–muscle-invasive Bladder Cancer: A Randomised Phase 3 Trial (ANZUP 1301)","authors":"Dickon Hayne ,&nbsp;Alison Y. Zhang ,&nbsp;Hayley Thomas ,&nbsp;Laurence Krieger ,&nbsp;Joseph Ischia ,&nbsp;Paul Anderson ,&nbsp;Ratnesh K. Srivastav ,&nbsp;William Green ,&nbsp;Jeremy Grummet ,&nbsp;Patricia A. Bastick ,&nbsp;Emma K. Beardsley ,&nbsp;Alison Blatt ,&nbsp;Manish Patel ,&nbsp;Lewis Chan ,&nbsp;Andrew Mitterdorfer ,&nbsp;Matthew Roberts ,&nbsp;Shomik Sengupta ,&nbsp;Matthew Winter ,&nbsp;Gavin Marx ,&nbsp;Conrad Bishop ,&nbsp;Martin R. Stockler","doi":"10.1016/j.eururo.2026.01.009","DOIUrl":"10.1016/j.eururo.2026.01.009","url":null,"abstract":"<div><h3>Background and objective</h3><div>Intravesical bacillus Calmette-Guérin (BCG) plus mitomycin (MM) had not been compared rigorously with BCG alone in BCG-naïve, non–muscle-invasive bladder cancer (NMIBC) patients.</div></div><div><h3>Methods</h3><div>Participants with BCG-naïve NMIBC (high-grade pTa or any grade pT1; concurrent carcinoma in situ [CIS] allowed) were assigned randomly (1:1) to either the BCG + MM or the BCG-alone group after maximal transurethral resection. The primary endpoint was disease-free survival (DFS); the secondary endpoints included a complete response on cystoscopy at 3 mo (CR3mos), recurrence, progression, adverse events (AEs), and deaths from any cause.</div></div><div><h3>Key findings and limitations</h3><div>We randomised 501 participants (249 to BCG + MM and 252 to BCG alone), with pTa in 53%, pT1 in 47%, and concurrent CIS in 28%. The median follow-up was 48 mo. DFS was not superior for BCG + MM versus BCG alone (2-yr DFS rate: 75% vs 71%; hazard ratio 0.87, 95% confidence interval 0.65–1.16; <em>p</em> = 0.3). The numbers of events for BCG + MM versus BCG alone were as follows: 214 versus 210 (CR3mos), 79 versus 86 (recurrence), 28 versus 44 (progression), and 26 versus 23 (death). Those assigned BCG + MM had more instillations (4033 vs 3383) but fewer doses of BCG (total 2056 vs 3383; median nine vs 16) than BCG alone. Grade 3–5 AEs occurred in 43 assigned BCG + MM versus 37 assigned BCG alone. A higher number of participants assigned BCG + MM than those assigned BCG alone had ≥75% of their planned doses (78% vs 68%, <em>p</em> = 0.02).</div></div><div><h3>Conclusions and clinical implications</h3><div>BCG + MM was not proved superior to BCG alone, but required 39% fewer doses of BCG and fewer treatment discontinuations. These findings support consideration of BCG + MM as a pragmatic alternative to BCG alone, which could mitigate the global shortage of BCG.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 446-453"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Marcio Covas Moschovas, Mischa Dohler, Mohamad Omar Al Kalaa, and Vipul Patel’s Letter to the Editor re: Bhaskar K. Somani, Jens Rassweiler, Evangelos Liatsikos, et al. European Association of Urology Policy on Telesurgery. Eur Urol 2025;88:318–24","authors":"Bhaskar K. Somani ,&nbsp;Jens Rassweiler ,&nbsp;Evangelos Liatsikos ,&nbsp;Alexandre Mottrie ,&nbsp;Thomas Knoll ,&nbsp;Jens Bedke ,&nbsp;Giampaolo Bianchi ,&nbsp;Kemal Sarica ,&nbsp;Alberto Briganti ,&nbsp;Ton Brouwers ,&nbsp;Alberto Breda","doi":"10.1016/j.eururo.2025.11.012","DOIUrl":"10.1016/j.eururo.2025.11.012","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages e117-e118"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Disitamab Vedotin plus Toripalimab in HER2-Expressing Advanced Urothelial Cancer","authors":"Giandomenico Roviello ,&nbsp;Silvia Mancini ,&nbsp;Lorenzo Antonuzzo","doi":"10.1016/j.eururo.2026.01.006","DOIUrl":"10.1016/j.eururo.2026.01.006","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 476-477"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145956248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: ctDNA-guided Adjuvant Atezolizumab in Muscle-invasive Bladder Cancer","authors":"Giandomenico Roviello ,&nbsp;Ismaela Anna Vascotto ,&nbsp;Lorenzo Antonuzzo","doi":"10.1016/j.eururo.2026.01.005","DOIUrl":"10.1016/j.eururo.2026.01.005","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"89 5","pages":"Pages 475-476"},"PeriodicalIF":25.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145956223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}