European urology最新文献

{"title":"Re: Guohua Zeng, Kehua Jiang, Shusheng Liu, et al. Flexible Ureteroscopy with a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2–3 cm Renal Stones: An International, Multicenter, Randomized, Noninferiority Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.06.001","authors":"Awais Ayub, Numair Tariq, Shahroz Baloch","doi":"10.1016/j.eururo.2025.08.030","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.08.030","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"71 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CaboPoint: A Phase 2 Study of Second-line Cabozantinib After Checkpoint Inhibitor–based Combination Therapy in Patients with Metastatic Renal Cell Carcinoma","authors":"Laurence Albiges, Thomas Powles, Anand Sharma, Balaji Venugopal, Jens Bedke, Angelika Borkowetz, Gwenaelle Gravis, Berna C. Özdemir, Marco Julius Schnabel, Pascale Dutailly, Bryan Qvick, Valerie Perrot, Viktor Grünwald","doi":"10.1016/j.eururo.2025.07.018","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.07.018","url":null,"abstract":"<h3>Background and objective</h3>Data are limited regarding pure second-line cabozantinib use after standard first-line checkpoint inhibitor (CPI)-based combination therapy for advanced renal cell carcinoma (aRCC). We report the final results from the prospective CaboPoint study.<h3>Methods</h3>The phase 2, multicentre, open-label CaboPoint study (NCT03945773) evaluated the efficacy and safety of second-line cabozantinib in adults with aRCC, after prior ipilimumab plus nivolumab (IpiNivo; cohort A) or CPI therapy plus vascular endothelial growth factor-targeted therapy (cohort B). The primary endpoint was objective response rate (ORR) as per Response Evaluation Criteria in Solid Tumors 1.1, evaluated by independent central review (ICR) in cohort A. The secondary endpoints included ORR by ICR in cohort B, ORR by investigator review, progression-free survival, overall survival, and safety.<h3>Key findings and limitations</h3>Overall, 127 patients were enrolled from 2020 to 2023 across 40 institutions. The median follow-up was 19.3 mo. ORRs (95% confidence interval [CI]) by ICR were 40.5% (29.6–52.1%) in cohort A (statistically significant and clinically meaningful) and 27.5% (14.6–43.9%) in cohort B; according to the investigator review, ORRs were 49.4% (38.4–60.5%) in cohort A and 33.3% (19.6–49.5%) in cohort B. The median (95% CI) progression-free survival was 10.9 (8.2–14.2) mo in cohort A and 8.3 (5.6–11.1) mo in cohort B. The median (95% CI) overall survival was similar between cohorts (24.3 [18.5–31.8] and 24.1 [17.1–not calculable] mo, respectively). There were no new safety concerns.<h3>Conclusions and clinical implications</h3>CaboPoint is the first study of pure second-line cabozantinib after first-line CPI-based combinations, providing a benchmark for future second-line aRCC studies.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"96 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-assisted Kidney Autotransplantation for Nutcracker Syndrome: Surgical Technique and Results","authors":"Pierre-Vincent Campello, Emilien Seizilles de Mazancourt, Sacha Hollanders, Nicolas Terrier, Nadia Abid, Xavier Matillon, Lionel Badet, Sébastien Crouzet","doi":"10.1016/j.eururo.2025.08.016","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.08.016","url":null,"abstract":"<h3>Background and objective</h3>The nutcracker syndrome is a rare condition that occurs in young patients and can cause severe flank pain. The available surgical techniques often carry a risk of complications or morbidity. This study aims to describe robotic-assisted kidney autotransplantation for nutcracker syndrome and show its efficacy and safety.<h3>Methods and surgical procedure</h3>A retrospective study of all patients managed in our center by robotic-assisted kidney autotransplantation for symptomatic nutcracker syndrome was carried out. Patient demographics, operative time, hospitalization time, complications, management of postoperative pain, and patient-reported outcome measures (PROMs) were assessed.<h3>Key findings and limitations</h3>Thirty-four patients (30 female and four male) underwent surgery between January 2015 and December 2024, with a median age of 35 (Q1–Q3: 27–43) yr and a median body mass index of 20 kg/m². The median operative time was 314 (Q1–Q3: 265–350) min, and the median hospital stay was 3 d. One procedure was converted to open surgery. Seven patients (21%) experienced complications within 3 mo, including five minor (Clavien-Dindo grade &lt;3) and two major (Clavien-Dindo ≥3) complications, one of which required a nephrectomy. The median follow-up was 15 (Q1–Q3: 6–30) mo. PROMs were available for 29 patients. Nine patients (31%) reported complete symptom relief, 17 (59%) partial improvement, and three (10%) partial worsening of their symptoms.<h3>Conclusions and clinical implications</h3>Robotic-assisted kidney autotransplantation can be a therapeutic option for the treatment of nutcracker syndrome, but it should be performed in an expert center for transplantation and robotic surgery. Further studies and long-term follow-up are needed.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"157 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic Intensity-modulated Radiotherapy After Radical Prostatectomy (SCIMITAR): 4-Year Outcomes of a Phase 2 Clinical Trial","authors":"Amar U. Kishan, Jesus E. Juarez Casillas, Paul Sargos, Tahmineh Romero Kalbasi, Sylvie Chabaud, Meryem Brihoum, Ankush Sachdeva, John N. Nikitas, T.Martin Ma, Danielle Karasik, Leslie K. Ballas, Derrick Lock, Luca Valle, Kekoa Taparra, Robert E. Reiter, Christopher Saigal, Karim Chamie, Nicholas Donin, Arnold I. Chin, Matthew Rettig, Michael L. Steinberg","doi":"10.1016/j.eururo.2025.09.4149","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.09.4149","url":null,"abstract":"In the phase 2 SCIMITAR trial, stereotactic body radiotherapy (SBRT; 30–34 Gy in 5 fractions) was delivered to the prostatic fossa after radical prostatectomy in 100 patients requiring postoperative RT, with or without nodal RT and androgen deprivation therapy (ADT). The primary endpoint was 4-yr biochemical recurrence (BCR)-free survival (BCR-FS), with events defined as BCR (prostate-specific antigen ≥0.2 ng/ml above nadir), salvage ADT, or death. Outcomes were compared to individual patient data (IPD) from a phase 3 trial of conventionally fractionated RT (CFRT) using inverse probability of treatment weighting and Fine-Gray models. At median follow-up of 53 mo, the 4-yr BCR-FS rate was 60% (95% confidence interval [CI] 50–70%). The IPD analysis revealed that for men not receiving ADT, the risk of BCR was lower with SBRT than with CFRT (subdistribution hazard ratio [sHR] 0.49, 95% CI 0.29–0.84; <em>p</em> = 0.008). For men receiving ADT, there was no significant difference in BCR risk between SBRT and CFRT (sHR 1.58, 95% CI 0.81–3.11; <em>p</em> = 0.18), although the asymmetrically broad 95%CI and directionality of the point estimate suggest that a higher BCR risk with SBRT cannot be ruled out. The 4-yr cumulative incidence rates for late grade ≥2 gastrointestinal and genitourinary toxicities were 6.6% and 32%, respectively. At 48 mo, the proportion of patients reporting a decline of more than two times the minimal clinically important difference in urinary incontinence, urinary irritative/obstructive, bowel, and sexual domains was 23%, 6.7%, 13%, and 9.7%, respectively. SBRT to the prostatic fossa appears to be safe and effective through 4 yr.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"1 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Lars Holmberg, Hans Garmo, Sven-Olov Andersson, et al. Time Dependence of Outcomes in the SPCG-4 Randomized Trial Comparing Radical Prostatectomy and Watchful Waiting in Early Prostate Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.07.001","authors":"Yafei Wang, Qianting Lu, Xin Zhao","doi":"10.1016/j.eururo.2025.08.034","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.08.034","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"5 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Single- and Multiport Robot-assisted Approaches in Prostate and Renal Surgery: A Systematic Review and Meta-analysis","authors":"Vincenzo Ficarra, Ilaria Romito, Gabriele Sorce, Debora Maravigna, Angelo De Stefano, Alexander Mottrie, Firas Abdollah, Silvia Viganò, Armando Stabile, Andrea Salonia, Gianluca Giannarini, Fabio Crocerossa, Giorgio Gandaglia, Francesco Montorsi, Marta Rossanese","doi":"10.1016/j.eururo.2025.08.010","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.08.010","url":null,"abstract":"<h3>Background and objective</h3>The aim of this systematic review with meta-analysis was to assess the perioperative, functional, and oncological outcomes of single-port (SP) robotic procedures in the surgical management of prostate and renal diseases.<h3>Methods</h3>A systematic review was conducted using the MEDLINE and Scopus databases, covering literature published up to December 2024. Studies were included if these compared SP versus multiport (MP) approaches in robot-assisted procedures, specifically radical prostatectomy (RARP), simple prostatectomy (RASP), partial nephrectomy (RAPN), radical nephrectomy (RARN), and pyeloplasty (RAP; PROSPERO registration number: CRD42025616519). Perioperative outcomes were assessed across all procedures. Functional and oncological outcomes were analysed specifically in patients undergoing RARP, while warm ischaemia time (WIT), off-clamp rates, and positive surgical margin rates were evaluated in those undergoing RAPN.<h3>Key findings and limitations</h3>A total of 26, three, nine, one, and two studies evaluated RARP, RASP, RAPN, RARN, and RAP, respectively. Compared with MP-RARP, SP-RARP was associated with lower estimated blood loss (standardised mean difference [SMD] = 0.51; 95% confidence interval [CI]: 0.16–0.87), shorter length of stay (SMD = 1.12; 95% CI: 0.63–1.62), and reduced postoperative pain (SMD = 0.12; 95% CI: 0.04–0.35). The only difference between SP- and MP-RASP was represented by the use of a higher morphine milligram equivalent in the MP group (SMD = 0.59; 95% CI: 0.01–1.16). In patients undergoing RAPN, SP was associated with a significantly higher WIT than MP (SMD = –0.32; 95% CI: –0.58 to –0.06). However, the length of hospital stay (SMD = 0.31; 95% CI: 0.03–0.59) and pain score on postoperative day 1 (SMD = 0.22; 95% CI: 0.01–0.43) were significantly in favour of SP-RAPN. Limitations were the lack of randomised trials, and the across-study heterogeneity in surgical techniques and outcome definitions.<h3>Conclusions and clinical implications</h3>Compared with the MP approach, SP robotic surgery offers advantages in terms of reduced postoperative pain and hospital stay. In patients undergoing RARP, functional and oncological outcomes were comparable between the two approaches. In patients undergoing RAPN, the SP approach was associated with a longer WIT.","PeriodicalId":12223,"journal":{"name":"European urology","volume":"5 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Pietro Scilipoti, Eugenio Ventimiglia, Luca Villa, Alberto Briganti, Andrea Salonia, and Francesco Montorsi’s Letter to the Editor re: Guohua Zeng, Kehua Jiang, Shusheng Liu, et al. Flexible Ureteroscopy with a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2–3 cm Renal Stones: An International, Multicenter, Randomized, Noninferiority Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.06.001","authors":"Steffi Kar Kei Yuen, Vineet Gauhar, Guohua Zeng, Wei Zhu","doi":"10.1016/j.eururo.2025.09.4143","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.09.4143","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"15 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Arvin K. George, Ranko Miocinovic, Amit R. Patel, et al. Irreversible Electroporation for Prostate Tissue Ablation in Patients with Intermediate-risk Prostate Cancer: Results from the PRESERVE Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2025.06.003","authors":"Hongquan Liu, Fengze Sun, Jitao Wu","doi":"10.1016/j.eururo.2025.08.029","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.08.029","url":null,"abstract":"No Abstract","PeriodicalId":12223,"journal":{"name":"European urology","volume":"52 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Changhong Xu, Hanxue Zheng, Yun Deng, and Li Yang’s Letter to the Editor re: W. Marston Linehan, Cathy Anne Pinto, Yangang Liu, et al. Longitudinal Evaluation of Clear-cell Renal cell Carcinoma in von Hippel-Lindau Disease. Eur Urol 2025:88:56–63","authors":"W. Marston Linehan, Mark Ball, Ramaprasad Srinivasan","doi":"10.1016/j.eururo.2025.09.4139","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.09.4139","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"4 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Zhihao Lei’s Letter to the Editor re: Oliver Wiseman, Daron Smith, Kathryn Starr, et al. The PUrE Randomised Controlled Trial 1: Clinical and Cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for Lower Pole Stones ≤10 mm. Eur Urol 2025;88:179–89","authors":"Oliver Wiseman, Daron Smith, Kathryn Starr, Lorna Aucott, Rodolfo Hernández, Ruth Thomas, Steven MacLennan, Charles Terry Clark, Graeme MacLennan, Dawn McRae, Victoria Bell, Seonaidh Cotton, Zara Gall, Ben Turney, Sam McClinton","doi":"10.1016/j.eururo.2025.09.4141","DOIUrl":"https://doi.org/10.1016/j.eururo.2025.09.4141","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"29 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}