European urology最新文献

{"title":"Prognostic Value of Interim PSMA-PET Total Tumor Volume for Overall Survival Within ENZA-p, A Randomized Phase 2 Trial of Enzalutamide Versus Enzalutamide Plus [177Lu] Lu-PSMA-617 (ANZUP1901)","authors":"Louise Emmett,&nbsp;Nathan Papa,&nbsp;Oliver Sartor,&nbsp;Michael J. Morris,&nbsp;Shalini Subramaniam,&nbsp;Megan Crumbaker,&nbsp;Narjess Ayati,&nbsp;Jeffrey Chen,&nbsp;Ken Herrmann,&nbsp;Andrei Gafita,&nbsp;Mina Swiha,&nbsp;Anthony M. Joshua,&nbsp;Andrew Weickhardt,&nbsp;Sze-Ting Lee,&nbsp;Siobhan Ng,&nbsp;Roslyn J. Francis,&nbsp;Jeffrey C. Goh,&nbsp;David A. Pattison,&nbsp;Bao Ho,&nbsp;Sobia Khan,&nbsp;Ian D. Davis","doi":"10.1016/j.eururo.2026.03.026","DOIUrl":"10.1016/j.eururo.2026.03.026","url":null,"abstract":"<div><h3>Background and objective</h3><div>Interim [⁶⁸Ga]Ga-prostate-specific membrane-antigen positron emission tomography/computed tomography (PSMA-PET/CT) has prognostic potential for overall survival (OS) in metastatic castrate-resistant prostate cancer (mCRPC), although evidence is limited. This ENZA-p sub-study evaluated 3-mo PSMA-total-tumor-volume (PSMA-TTV) as a prognostic biomarker for OS with enzalutamide ± [¹⁷⁷Lu]Lu-PSMA-617.</div></div><div><h3>Methods:</h3><div>ENZA-p is a randomized, phase 2 trial. Participants with mCRPC and risk factors for early treatment failure with enzalutamide were randomized (1:1) to enzalutamide or enzalutamide + [¹⁷⁷Lu]Lu-PSMA-617. Participants underwent baseline and 3-mo [⁶⁸Ga]Ga-PSMA-11-PET/CT, quantified to derive PSMA-TTV. We evaluated the prognostic value of PSMA-TTV change, and residual PSMA-TTV at 3-mo for OS (NCT04419402).</div></div><div><h3>Key findings and limitations:</h3><div>This sub-study included 152/162 (94%) randomized participants with a 3-mo PSMA-PET. Median OS was 27 mo (95% confidence interval [CI] 23–30). Baseline median PSMA-TTV 230 ml (interquartile range [IQR] 75–635) and 3-mo PSMA-TTV 103 ml (IQR 24–457). The median change in PSMA-TTV from baseline was –34% (IQR –76% to 16%) with 50/152 (33%) participants with increase in PSMA-TTV. Any increase versus decrease in PSMA-TTV at 3-mo was associated with shorter OS (HR 2.52, 95% CI 1.65–3.85) and decreased 2-yr survival 30% (95% CI 17–43) versus 67% (95% CI 56–75) (log-rank <em>p</em> &lt; 0.0001). Residual 3-mo PSMA-TTV higher versus lower than the median (103 ml) was associated with shorter OS (HR 3.76, 95% CI 2.39–5.92) and lower 2-yr survival 34% (95% CI 23–45) versus 76% (95% CI 64–84) (log-rank <em>p</em> &lt; 0.0001). This association was independent of treatment arm and prostate-specific antigen (PSA) response.</div></div><div><h3>Conclusions and clinical implications:</h3><div>PSMA-TTV at 3 mos was prognostic for OS independent of study treatment and PSA response in ENZA-p, warranting further prospective validation of interim PSMA-PET response criteria.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Pages 333-343"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Adverse Cardiovascular Events in Men with High-risk Localized or Metastatic Prostate Cancer Starting Long-term Hormone Therapy in the STAMPEDE Trial","authors":"Omar El-Taji,Peter Dutey-Magni,Mick Brown,Macey Murray,Claire Amos,Duncan Gilbert,Max Parmar,Louise Brown,Matthew Sydes,Gert Attard,Nicholas James,Noel W. Clarke,Ashwin Sachdeva","doi":"10.1016/j.eururo.2026.09.001","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.09.001","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"36 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Microultrasonography-guided Versus MRI-guided Biopsy for Prostate Cancer Diagnosis: The OPTIMUM Randomized Clinical Trial","authors":"Rossano Girometti,Francesco Giganti","doi":"10.1016/j.eururo.2026.09.007","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.09.007","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"1 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Daoyuan Li’s Words of Wisdom re: Bacillus Calmette-Guérin Plus Mitomycin Versus Bacillus Calmette-Guérin Alone for Bacillus Calmette Guérin–naïve Non–Muscle-Invasive Bladder Cancer: A Randomised Phase 3 Trial (ANZUP 1301). Eur Urol 2026;90:176","authors":"Dickon Hayne,&nbsp;Alison Y. Zhang,&nbsp;Hayley Thomas,&nbsp;Andrew D. Redfern,&nbsp;Ian D. Davis,&nbsp;Martin R. Stockler","doi":"10.1016/j.eururo.2026.04.033","DOIUrl":"10.1016/j.eururo.2026.04.033","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Page 435"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147990189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Antonio Cigliola, Andrea Necchi, and Umberto Capitanio’s Letter to the Editor Re: Metastasis-directed Therapy with or Without Pembrolizumab for Oligometastatic Clear Cell Renal Cell Carcinoma: Pooled Analysis of Two Prospective Single-arm Phase 2 Trials. Eur Urol 2026;90:13–18","authors":"Alexander D. Sherry,&nbsp;Van To,&nbsp;Pavlos Msaouel,&nbsp;Paul Neeson,&nbsp;Chad Tang,&nbsp;Shankar Siva","doi":"10.1016/j.eururo.2026.06.024","DOIUrl":"10.1016/j.eururo.2026.06.024","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Pages e93-e94"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-Year Patient-Reported Outcomes After SBRT for Prostate Cancer: A Benchmark for Radiotherapy, but How Far Across Modalities?","authors":"Pierre Blanchard,&nbsp;Chiara Sighinolfi,&nbsp;Mario Terlizzi,&nbsp;Bernardo Rocco","doi":"10.1016/j.eururo.2026.07.023","DOIUrl":"10.1016/j.eururo.2026.07.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Pages 328-329"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA-PET Total Tumor Volume Response: Ready for Prime Time or a Work in Progress?","authors":"Joseph R. Osborne,&nbsp;Tobechukwu Joseph Okobi,&nbsp;Valentina Marulanda-Corzo,&nbsp;Scott T. Tagawa","doi":"10.1016/j.eururo.2026.04.031","DOIUrl":"10.1016/j.eururo.2026.04.031","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Pages 344-346"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Paolo Zaurito’s Letter to the Editor re: Robert M. Meier, Nima Aghdam, Alan C. Beckman, et al. 10-yr Survival and Toxicity Outcomes of Stereotactic Body Radiotherapy for Prostate Cancer: A Nonrandomized Clinical Trial. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2026.04.029","authors":"Robert Meier,Nima Aghdam,Irving Kaplan","doi":"10.1016/j.eururo.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.08.018","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"8 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Aldo Brassetti, Gabriele Tuderti, Umberto Anceschi, et al. Sutureless Purely Off-clamp Robotic Partial Nephrectomy: Evidence from a Randomized Controlled Noninferiority Trial. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2026.04.019","authors":"Yan Huang,Yang Liu","doi":"10.1016/j.eururo.2026.06.019","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.06.019","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"34 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: McKay RR, Pal S, Xie W, et al. Advanced Urologic Cancer Consensus Conference (AUC3) 2025: Expert Consensus on the Management of Renal Cell and Urinary Tract Cancers. CA Cancer J Clin 2026;76:e70052","authors":"Giuseppe Di Lorenzo,&nbsp;Massimo Di Maio","doi":"10.1016/j.eururo.2026.06.014","DOIUrl":"10.1016/j.eururo.2026.06.014","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 4","pages":"Pages e91-e92"},"PeriodicalIF":29.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}