European urology最新文献

{"title":"Lenvatinib plus Pembrolizumab Following Immune Checkpoint Inhibitor Treatment in Patients with Metastatic Clear Cell Renal Cell Carcinoma: Results from Study 111/KEYNOTE-146","authors":"Chung-Han Lee , Amishi Yogesh Shah , Arpit Rao , Matthew H. Taylor , Christopher Di Simone , James J. Hsieh , Alvaro Pinto , Regina Gironés Sarrió , Allen Lee Cohn , Mehmet Asim Bilen , Sara Gunnestad Ribe , Øyvind Krohn Tennøe , Donald Richards , Randy F. Sweis , Jay Courtright , Daniel Heinrich , Rodolfo Perini , Peter Kubiak , Daena Bock , Chinyere E. Okpara , Robert J. Motzer","doi":"10.1016/j.eururo.2024.05.003","DOIUrl":"10.1016/j.eururo.2024.05.003","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 470-473"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Identification of the Optimal Candidates for Nodal Staging with Extended Pelvic Lymph Node Dissection Among Prostate Cancer Patients Who Underwent Preoperative Prostate-specific Membrane Antigen Positron Emission Tomography. External Validation of the Memorial Sloan Kettering Cancer Center and Briganti Nomograms and Development of a Novel Tool","authors":"Petr Macek, Lara Rodriguez-Sanchez, Xavier Cathelineau","doi":"10.1016/j.eururo.2024.05.021","DOIUrl":"10.1016/j.eururo.2024.05.021","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 478-479"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Kuo-Chin Hung and Chia-Ter Chao’s Letter to the Editor re: Jennifer Kranz, Riccardo Bartoletti, Franck Bruyère, et al. European Association of Urology Guidelines on Urological Infections: Summary of the 2024 Guidelines. Eur Urol. 2024;86:27–41","authors":"Jennifer Kranz , Gernot Bonkat","doi":"10.1016/j.eururo.2024.06.021","DOIUrl":"10.1016/j.eururo.2024.06.021","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Page e116"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Sandra P. García Nader, Cesar A. Díaz Ritter, and Valentina Garcia Perez’s Letter to the Editor re: Carlotta Nedbal, Patrick Juliebø-Jones, Eamonn Rogers, et al. Improving Patient Information and Enhanced Consent in Urology: The Impact of Simulation and Multimedia Tools. A Systematic Literature Review from the European Association of Urology Patient Office. Eur Urol. 2024;86:457–469","authors":"Carlotta Nedbal , Bhaskar Kumar Somani","doi":"10.1016/j.eururo.2024.08.019","DOIUrl":"10.1016/j.eururo.2024.08.019","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e124-e125"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-VEGF and -PD-1 Combinations in Renal Cell Carcinoma: When Are Treatment Breaks Safe?","authors":"J.C. Wells , Laurence Albiges , Thomas Powles","doi":"10.1016/j.eururo.2024.06.005","DOIUrl":"10.1016/j.eururo.2024.06.005","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 420-421"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Transurethral En Bloc Resection Versus Standard Resection of Bladder Tumour: A Randomised, Multicentre, Phase 3 Trial","authors":"Stefano Mancon , Francesco Soria , Benjamin Pradere , David D’Andrea","doi":"10.1016/j.eururo.2024.06.013","DOIUrl":"10.1016/j.eururo.2024.06.013","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 481-482"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world Uptake of Enfortumab Vedotin plus Pembrolizumab after US Food and Drug Administration Approval Among Patients with Advanced Urothelial Cancer","authors":"Ronac Mamtani , Ernesto Ulloa-Pérez , Ravi B. Parikh , Khilna Patel , Blanca Homet Moreno , Chethan Ramamurthy , Haojie Li , Rebecca A. Hubbard","doi":"10.1016/j.eururo.2024.08.012","DOIUrl":"10.1016/j.eururo.2024.08.012","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 474-476"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum Hall of Fame","authors":"","doi":"10.1016/j.eururo.2024.09.002","DOIUrl":"10.1016/j.eururo.2024.09.002","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e103-e113"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Microsatellite Instability/DNA Mismatch Repair Deficiency and Tumor Mutational Burden as Biomarkers in Predicting Response to Immunotherapy in Castration-resistant Prostate Cancer","authors":"Niklas Klümper , Viktor Grünwald , Arndt Hartmann , Michael Hölzel , Markus Eckstein","doi":"10.1016/j.eururo.2024.04.026","DOIUrl":"10.1016/j.eururo.2024.04.026","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 388-390"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140924123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047)","authors":"Chris C. Parker ,&nbsp;Noel W. Clarke ,&nbsp;Adrian D. Cook ,&nbsp;Peter M. Petersen ,&nbsp;Charles N. Catton ,&nbsp;William R. Cross ,&nbsp;Howard Kynaston ,&nbsp;Raj A. Persad ,&nbsp;Fred Saad ,&nbsp;John Logue ,&nbsp;Heather Payne ,&nbsp;Claire Amos ,&nbsp;Lorna Bower ,&nbsp;Rakesh Raman ,&nbsp;Ian Sayers ,&nbsp;Jane Worlding ,&nbsp;Wendy R. Parulekar ,&nbsp;Mahesh K.B. Parmar ,&nbsp;Matthew R. Sydes ,&nbsp;RADICALS Investigators","doi":"10.1016/j.eururo.2024.07.026","DOIUrl":"10.1016/j.eururo.2024.07.026","url":null,"abstract":"<div><h3>Background and objective</h3><div>The use and duration of androgen deprivation therapy (ADT) with postoperative radiotherapy (RT) have been uncertain. RADICALS-HD compared adding no (“None”), 6-months (“Short”), or 24-mo (“Long”) ADT to study efficacy in the long term.</div></div><div><h3>Methods</h3><div>Participants with prostate cancer were indicated for postoperative RT and agreed randomisation between all durations. ADT was allocated for 0, 6, or 24 mo. The primary outcome measure (OM) was metastasis-free survival (MFS). The secondary OMs included freedom from distant metastasis, overall survival, and initiation of nonprotocol ADT. Sample size was determined by two-way comparisons. Analyses followed standard time-to-event approaches and intention-to-treat principles.</div></div><div><h3>Key findings and limitations</h3><div>Between 2007 and 2015, 492 participants were randomised one of three groups: 166 None, 164 Short, and 162 Long. The median age at randomisation was 66 yr; Gleason scores at surgery were as follows: &lt;7 = 64 (13%), 3+4 = 229 (47%), 4+3 = 127 (26%), and 8+ = 72 (15%); T3b was 112 (23%); and T4 was 5 (1%). The median follow-up was 9.0 yr and, with MFS events reported for 89 participants (32 None, 31 Short, and 26 Long), there was no evidence of difference in MFS overall (logrank <em>p</em> = 0.98), and, for Long versus None, hazard ratio = 0.948 (95% confidence interval 0.54–1.68). After 10 yr, 80% None, 77% Short, and 81% Long patients were alive without metastatic disease. The three-way randomisation was not powered to conventional levels for assessment, yet provides a fair comparison.</div></div><div><h3>Conclusions and clinical implications</h3><div>Long-term outcomes after radical prostatectomy are usually favourable. In those indicated for postoperative RT and considered suitable for no, short-term, or long-term ADT, there was no evidence of improvement with addition of ADT. Future research should focus on patients at a higher risk of metastases in whom improvements are required more urgently.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 422-430"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}