European urology最新文献_第6页

Effects of Enzalutamide on the Sexual Activity of Patients with Biochemically Recurrent Prostate Cancer: A Post Hoc Analysis of Patient-reported Outcomes in the EMBARK Study

IF 25.3 1区医学

European urology Pub Date : 2025-02-27 DOI: 10.1016/j.eururo.2025.02.006

Stephen J. Freedland , John P. Mulhall , Martin Gleave , Ugo De Giorgi , Fred Saad , Antti Rannikko , Jasmina I. Ivanova , Anchen F. Nasr , Arlene L. Reisman , Arijit Ganguli , Pavol Kral , James Turnbull , Neal Shore

{"title":"Effects of Enzalutamide on the Sexual Activity of Patients with Biochemically Recurrent Prostate Cancer: A Post Hoc Analysis of Patient-reported Outcomes in the EMBARK Study","authors":"Stephen J. Freedland , John P. Mulhall , Martin Gleave , Ugo De Giorgi , Fred Saad , Antti Rannikko , Jasmina I. Ivanova , Anchen F. Nasr , Arlene L. Reisman , Arijit Ganguli , Pavol Kral , James Turnbull , Neal Shore","doi":"10.1016/j.eururo.2025.02.006","DOIUrl":"10.1016/j.eururo.2025.02.006","url":null,"abstract":"<div><div>EMBARK demonstrated prolonged metastasis-free survival with enzalutamide ± leuprolide versus leuprolide alone for patients with high-risk biochemical recurrence of prostate cancer, with health-related quality of life (HRQoL) maintained. To evaluate treatment effects on sexual activity (SA), item-level analyses of SA-related HRQoL were performed. HRQoL was assessed (baseline, every 12 wk) until metastasis or death. Time to confirmed clinically meaningful deterioration (TTCD; confirmed at next visit) and longitudinal changes in HRQoL were examined using Cox regression and mixed-model repeated measures analyses, respectively. In comparison to leuprolide alone, enzalutamide monotherapy delayed TTCD in interest in sex (8.5 vs 5.6 mo; hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.57–0.87; <em>p</em> < 0.001), extent of SA (5.7 vs 3.0 mo; HR 0.69, 95% CI 0.54–0.90; <em>p</em> = 0.004), satisfaction with sex life (11.1 vs 5.4 mo; HR 0.61, 95% CI 0.45–0.84; <em>p</em> = 0.001), and erectile function (5.5 vs 2.9 mo; HR 0.67, 95% CI 0.50–0.88; <em>p</em> = 0.003). TTCD in SA-related HRQoL was similar with enzalutamide + leuprolide and leuprolide alone, except TTCD in erectile function was shorter by a statistically significant median of 0.1 mo (3 d), which is not clinically meaningful. Longitudinally, no clinically meaningful changes for any SA-related item were observed from baseline to week 205 in any group. SA-related HRQoL preservation seems to be better with enzalutamide monotherapy than with leuprolide alone.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"87 5","pages":"Pages 507-511"},"PeriodicalIF":25.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}