European urology最新文献

{"title":"Systematic Review on the Cost Effectiveness of Prostate Cancer Screening in Europe","authors":"Pieter Vynckier ,&nbsp;Lieven Annemans ,&nbsp;Sarah Raes ,&nbsp;Cheïma Amrouch ,&nbsp;Peter Lindgren ,&nbsp;Ondřej Májek ,&nbsp;Katharina Beyer ,&nbsp;Renée C.A. Leenen ,&nbsp;Lionne D.F. Venderbos ,&nbsp;Frederique Denijs ,&nbsp;Meike J. van Harten ,&nbsp;Jozien Helleman ,&nbsp;Renata Chloupková ,&nbsp;Erik Briers ,&nbsp;Vera Vasilyeva ,&nbsp;Juan Gomez Rivas ,&nbsp;Partha Basu ,&nbsp;Arunah Chandran ,&nbsp;Roderick C.N. van den Bergh ,&nbsp;Sarah Collen ,&nbsp;Lisa Jelf Eneqvist","doi":"10.1016/j.eururo.2024.04.036","DOIUrl":"10.1016/j.eururo.2024.04.036","url":null,"abstract":"<div><h3>Background and objective</h3><div>In Europe, prostate cancer (PCa) is the most common cancer in men. Screening may therefore be crucial to lower health care costs, morbidity, and mortality. This systematic review aimed to provide a contemporary overview of the costs and benefits of PCa screening programmes.</div></div><div><h3>Methods</h3><div>A peer-reviewed literature search was conducted, using the PICO method. A detailed search strategy was developed in four databases based on the following key search terms: “PCa”, “screening”, and “cost effectiveness”. Any type of economic evaluation was included. The search strategy was restricted to European countries, but no restrictions were set on the year of publication.</div></div><div><h3>Key findings and limitations</h3><div>A total of 7484 studies were identified initially. Of these, 19 studies described the cost effectiveness of PCa screening in Europe. Among the studies using an initially healthy study population, most focussed on risk- and/or age- and/or magnetic resonance imaging (MRI)-based screening in addition to prostate-specific antigen (PSA) testing and compared this with no screening. Incremental cost ratios (ICERs) varied from €5872 per quality-adjusted life year (QALY) to €372 948/QALY, with a median of €56 487/QALY. Risk-based screening followed by MRI testing seemed to be a more cost-effective strategy than no screening.</div></div><div><h3>Conclusions and clinical implications</h3><div>This systematic review indicates that screening programmes incorporating a risk-based approach and MRI have the potential to be cost effective.</div></div><div><h3>Patient summary</h3><div>In this review, we looked at the cost effectiveness of prostate cancer screening in Europe. We found that a risk-based approach and incorporation of magnetic resonance imaging has the potential to be cost effective. However, there remains a knowledge gap regarding cost effectiveness of prostate cancer screening. Therefore, determinants of cost effectiveness require further investigation.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 400-408"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Ivan Mauricio Plata, Julián Azuero, and Valentina García’s Letter to the Editor re: Massimiliano Creta, Giorgio I. Russo, Naeem Bhojani, et al. Bladder Outlet Obstruction Relief and Symptom Improvement Following Medical and Surgical Therapies for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Systematic Review. Eur Urol. 2024;86:315–326","authors":"Massimiliano Creta ,&nbsp;Jean-Nicolas Cornu ,&nbsp;Ferdinando Fusco","doi":"10.1016/j.eururo.2024.07.011","DOIUrl":"10.1016/j.eururo.2024.07.011","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e121-e122"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Drug Screening and Multiomic Characterization of Patient-derived Bladder Cancer Organoids Reveal Novel Molecular Correlates of Gemcitabine Response","authors":"Nathan M. Merrill ,&nbsp;Samuel D. Kaffenberger ,&nbsp;Liwei Bao ,&nbsp;Nathalie Vandecan ,&nbsp;Laura Goo ,&nbsp;Athena Apfel ,&nbsp;Xu Cheng ,&nbsp;Zhaoping Qin ,&nbsp;Chia-Jen Liu ,&nbsp;Armand Bankhead ,&nbsp;Yin Wang ,&nbsp;Varun Kathawate ,&nbsp;Lila Tudrick ,&nbsp;Habib A. Serhan ,&nbsp;Zackariah Farah ,&nbsp;Chad Ellimoottil ,&nbsp;Khaled S. Hafez ,&nbsp;Lindsey A. Herrel ,&nbsp;Jeffrey S. Montgomery ,&nbsp;Todd M. Morgan ,&nbsp;Aaron M. Udager","doi":"10.1016/j.eururo.2024.05.026","DOIUrl":"10.1016/j.eururo.2024.05.026","url":null,"abstract":"<div><h3>Background and objective</h3><div>Predicting response to therapy for each patient’s tumor is critical to improving long-term outcomes for muscle-invasive bladder cancer. This study aims to establish <em>ex vivo</em> bladder cancer patient–derived organoid (PDO) models that are representative of patients’ tumors and determine the potential efficacy of standard of care and curated experimental therapies.</div></div><div><h3>Methods</h3><div>Tumor material was collected prospectively from consented bladder cancer patients to generate short-term PDO models, which were screened against a panel of clinically relevant drugs in <em>ex vivo</em> three-dimensional culture. Multiomic profiling was utilized to validate the PDO models, establish the molecular characteristics of each tumor, and identify potential biomarkers of drug response. Gene expression (GEX) patterns between paired primary tissue and PDO samples were assessed using Spearman’s rank correlation coefficients. Molecular correlates of therapy response were identified using Pearson correlation coefficients and Kruskal-Wallis tests with Dunn’s post hoc pairwise comparison testing.</div></div><div><h3>Key findings and limitations</h3><div>A total of 106 tumors were collected from 97 patients, with 65 samples yielding sufficient material for complete multiomic molecular characterization and PDO screening with six to 32 drugs/combinations. Short-term PDOs faithfully represent the tumor molecular characteristics, maintain diverse cell types, and avoid shifts in GEX-based subtyping that accompany long-term PDO cultures. Utilizing an integrative approach, novel correlations between <em>ex vivo</em> drug responses and genomic alterations, GEX, and protein expression were identified, including a multiomic signature of gemcitabine response. The positive predictive value of <em>ex vivo</em> drug responses and the novel multiomic gemcitabine response signature need to be validated in future studies.</div></div><div><h3>Conclusions and clinical implications</h3><div>Short-term PDO cultures retain the molecular characteristics of tumor tissue and avoid shifts in expression-based subtyping that have plagued long-term cultures. Integration of multiomic profiling and <em>ex vivo</em> drug screening data identifies potential predictive biomarkers, including a novel signature of gemcitabine response.</div></div><div><h3>Patient summary</h3><div>Better models are needed to predict patient response to therapy in bladder cancer. We developed a platform that uses short-term culture to best mimic each patient’s tumor and assess potential sensitivity to therapeutics.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 434-444"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Jennifer Kranz, Riccardo Bartoletti, Franck Bruyère, et al. European Association of Urology Guidelines on Urological Infections: Summary of the 2024 Guidelines. Eur Urol. 2024;86:27–41","authors":"Kuo-Chin Hung ,&nbsp;Chia-Ter Chao","doi":"10.1016/j.eururo.2024.05.032","DOIUrl":"10.1016/j.eururo.2024.05.032","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e114-e115"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Overall Survival with Adjuvant Pembrolizumab in Renal-cell Carcinoma","authors":"Zhenbang Liu ,&nbsp;Haidar AlSaffar ,&nbsp;Sachin Perera ,&nbsp;Elio Mazzone ,&nbsp;Nathan Lawrentschuk ,&nbsp;Renu Eapen ,&nbsp;Declan G. Murphy ,&nbsp;Marlon L. Perera","doi":"10.1016/j.eururo.2024.06.014","DOIUrl":"10.1016/j.eururo.2024.06.014","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 482-483"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Being Grade 3: A Plea for a Three-tier Hybrid Classification System for Grade in Primary Non–muscle-invasive Bladder Cancer","authors":"Irene J. Beijert ,&nbsp;Oskar Hagberg ,&nbsp;Truls Gårdmark ,&nbsp;Lars Holmberg ,&nbsp;Christel Häggström ,&nbsp;Allan Johnston ,&nbsp;Matthew Trail ,&nbsp;Sami Hamid ,&nbsp;Barend A. Dreyer ,&nbsp;Luisa Padovani ,&nbsp;Roberta Garau ,&nbsp;Rami Hasan ,&nbsp;Imran Ahmad ,&nbsp;David Hendry ,&nbsp;Eva M. Compérat ,&nbsp;Maximilian Burger ,&nbsp;Morgan Rouprêt ,&nbsp;Paolo Gontero ,&nbsp;Maria J. Ribal ,&nbsp;Theo H. van der Kwast ,&nbsp;Bas W.G. van Rhijn","doi":"10.1016/j.eururo.2024.08.013","DOIUrl":"10.1016/j.eururo.2024.08.013","url":null,"abstract":"<div><div>Grade is an important determinant of progression in non–muscle-invasive bladder cancer. Although the World Health Organization (WHO) 2004/2016 grading system is recommended, other systems such as WHO1973 and WHO1999 are still widely used. Recently, a hybrid (three-tier) system was proposed, separating WHO2004/2016 high grade (HG) into HG/grade 2 (G2) and HG/G3 while maintaining low grade. We assessed the prognostic performance of HG/G3 and HG/G2. Three independent cohorts with 9712 primary (first diagnosis) Ta-T1 bladder tumors were analyzed. Time to progression was analyzed with cumulative incidence functions and Cox regression models. Harrell’s C-index was used to assess discrimination. Time to progression was significantly shorter for HG/G3 than for HG/G2 in multivariable analyses (cohort 1: hazard ratio [HR] = 1.92; cohort 2: HR = 2.51, and cohort 3: HR = 1.69). Corresponding progression risks at 5 yr were 18%, 20%, and 18% for HG/G3 versus 7.3%, 7.5%, and 9.3% for HG/G2, respectively. Cox models using hybrid grade performed better than models with WHO2004/2016 (all cohorts; <em>p</em> &lt; 0.001). For the three cohorts, C-indices for WHO2004/2016 were 0.69, 0.62, and 0.75, while, for hybrid grade, C-indices were 0.74, 0.68, and 0.78, respectively. Subdividing the HG category into HG/G2 and HG/G3 stratifies time to progression and supports the recommendation to adopt the hybrid grading system for Ta/T1 bladder cancers.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 391-399"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congress Calendar","authors":"","doi":"10.1016/j.eururo.2024.09.010","DOIUrl":"10.1016/j.eururo.2024.09.010","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e128-e129"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer","authors":"Joep J. de Jong ,&nbsp;Yair Lotan ,&nbsp;Joost L. Boormans","doi":"10.1016/j.eururo.2024.07.023","DOIUrl":"10.1016/j.eururo.2024.07.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 480-481"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Massimiliano Creta, Giorgio I. Russo, Naeem Bhojani, et al. Bladder Outlet Obstruction Relief and Symptom Improvement Following Medical and Surgical Therapies for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: A Systematic Review. Eur Urol. 2024;86:315–326","authors":"Mauricio Plata,&nbsp;Julian Azuero,&nbsp;Valentina Garcia","doi":"10.1016/j.eururo.2024.07.010","DOIUrl":"10.1016/j.eururo.2024.07.010","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages e119-e120"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Randomized Data Confirming Minimal Benefit from the Addition of Hormone Therapy to Postoperative Radiotherapy","authors":"Daniel E. Spratt","doi":"10.1016/j.eururo.2024.08.024","DOIUrl":"10.1016/j.eururo.2024.08.024","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"86 5","pages":"Pages 431-433"},"PeriodicalIF":25.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}