European urology最新文献

{"title":"Congress Calendar","authors":"","doi":"10.1016/j.eururo.2026.08.004","DOIUrl":"10.1016/j.eururo.2026.08.004","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages e66-e67"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Versus Robot-assisted Kidney Transplantation in Adults with End-stage Kidney Disease (ORAKTx): A Randomised Open-label Trial","authors":"Milla Ortved,&nbsp;Julia Dagnæs-Hansen,&nbsp;Hein V. Stroomberg,&nbsp;Camilla Vejlstrup,&nbsp;Birgitte Ruhnau,&nbsp;Thomas Kistorp,&nbsp;Vladimir Karas,&nbsp;Malene Rohrsted,&nbsp;Søren S. Sørensen,&nbsp;Andreas Røder","doi":"10.1016/j.eururo.2026.04.022","DOIUrl":"10.1016/j.eururo.2026.04.022","url":null,"abstract":"<div><h3>Background and objective</h3><div>We investigated whether robot-assisted kidney transplantation (KTx) could reduce short-term surgical complications compared to open KTx.</div></div><div><h3>Methods</h3><div>We conducted a randomised, parallel, open-label trial at the Copenhagen University Hospital – Rigshospitalet, Denmark. Adult patients with end-stage kidney disease and no contraindication to robotic surgery, scheduled to undergo living or deceased donor KTx, were randomly assigned to receive either open or robot-assisted surgery. Primary outcomes were the 30-d post-transplant rates of vascular and major surgical complications. All participants who underwent transplantation were analysed according to assigned intervention.</div></div><div><h3>Key findings and limitations</h3><div>A total of 54 participants were assigned to robot-assisted KTx and 53 were assigned to open KTx. Fifty-three participants in each arm underwent transplantation and completed follow-up. Major surgical complications occurred in 13 patients (25%) in the open arm and in seven patients (13%) in the robotic arm (risk difference: −11%, 95% confidence interval [CI]: −26 to 3.4, <em>p</em> = 0.2). Vascular complications occurred in 10 patients (19%) in the open arm and in five patients (9.4%) in the robotic arm (risk difference: −9.4%, 95% CI: −23 to 3.7, <em>p</em> = 0.3). Limitations include single-centre design, lack of blinding, and a modest sample size.</div></div><div><h3>Conclusions and clinical implications</h3><div>ORAKTx is the first randomised trial to compare robot-assisted KTx with open KTx surgery. Although the primary endpoint was not met, the observed reduction in complications suggests a potentially meaningful decrease in postoperative morbidity with robot-assisted surgery.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages 202-209"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EAU–EANM–ESTRO–ESUR–ISUP–SIOG Guidelines on Prostate Cancer—2026 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent","authors":"Philip Cornford,&nbsp;Roderick C.N. van den Bergh,&nbsp;Erik Briers,&nbsp;Peter Chiu,&nbsp;Daniel Eberli,&nbsp;Adina Epure,&nbsp;Andrea Farolfi,&nbsp;Valérie Fonteyne,&nbsp;Giorgio Gandaglia,&nbsp;Silke Gillessen,&nbsp;Nikolaos Grivas,&nbsp;Ann M. Henry,&nbsp;Geert J.L.H. van Leenders,&nbsp;Estefania Linares Espinos,&nbsp;Bo Matsen,&nbsp;Jan Oldenburg,&nbsp;Inge M. van Oort,&nbsp;Daniela E. Oprea-Lager,&nbsp;Matthew J. Roberts,&nbsp;Olivier Rouvière,&nbsp;Derya Tilki","doi":"10.1016/j.eururo.2026.04.013","DOIUrl":"10.1016/j.eururo.2026.04.013","url":null,"abstract":"<div><h3>Background and objective</h3><div>To present a summary of the 2026 version of the European Association of Urology (EAU)–European Association of Nuclear Medicine (EANM)–European Society for Radiotherapy and Oncology (ESTRO)–European Society of Urogenital Radiology (ESUR)–International Society of Urological Pathology (ISUP)–International Society of Geriatric Oncology (SIOG) guidelines on screening, diagnosis, and treatment of clinically localised prostate cancer (PCa).</div></div><div><h3>Methods</h3><div>The Panel performed a literature review of all new data published in English, covering the time frame between May 2023 and 2025. The Guidelines were updated, and a strength rating for each recommendation was added based on a systematic review of the evidence.</div></div><div><h3>Key findings</h3><div>A risk-adapted strategy for identifying men who may develop PCa is advised, generally commencing at 50 yr of age and based on individualised life expectancy. The use of multiparametric magnetic resonance imaging to avoid unnecessary biopsies is recommended. When a biopsy is considered, a combination of targeted and regional biopsies should be performed. A new five-tier EAU classification has been introduced. Prostate-specific membrane antigen positron emission tomography imaging is the most sensitive technique for identifying metastatic spread. Active surveillance is the appropriate management for men with low-risk PCa, as well as for patients with selected favourable intermediate-risk ISUP grade group 2 lesions. Local therapies are addressed, as well as the management of persistent prostate-specific antigen after surgery. A recommendation to consider hypofractionated radiotherapy in intermediate-risk patients is provided. Patients with cN1 PCa should be offered radiotherapy to the primary tumour combined with long-term intensified hormonal treatment.</div></div><div><h3>Conclusions and clinical implications</h3><div>The evidence in the field of diagnosis, staging, and treatment of localised PCa is evolving rapidly. These PCa Guidelines reflect the multidisciplinary nature of PCa management.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages 254-269"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148458182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Renate Pichler and José Daniel Subiela’s Letter to the Editor re: Can Aydogdu, Laura Bukavina, Liang Cheng, et al. Histological Subtypes and Divergent Differentiation of Urothelial Carcinoma: Histology, Genomics, and Management Implications. Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2026.05.030","authors":"Can Aydogdu,Ashish Kamat,Philippe E. Spiess,Roger Li","doi":"10.1016/j.eururo.2026.09.016","DOIUrl":"https://doi.org/10.1016/j.eururo.2026.09.016","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"47 1","pages":""},"PeriodicalIF":23.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Advanced and Metastatic Prostate Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment, and Follow-up","authors":"Bram De Laere,&nbsp;Ashkan Mortezavi,&nbsp;Martin Eklund,&nbsp;Henrik Grönberg,&nbsp;for the ProBio Investigators","doi":"10.1016/j.eururo.2026.04.028","DOIUrl":"10.1016/j.eururo.2026.04.028","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Page e61"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PROSA trial: Some Prosaic Comments","authors":"Rebecka Arnsrud Godtman,&nbsp;Jonas Wallström,&nbsp;Ola Bratt","doi":"10.1016/j.eururo.2026.03.036","DOIUrl":"10.1016/j.eururo.2026.03.036","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages e58-e59"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Perioperative enfortumab vedotin and pembrolizumab in bladder cancer","authors":"Giandomenico Roviello,&nbsp;Lorenzo Antonuzzo","doi":"10.1016/j.eururo.2026.04.023","DOIUrl":"10.1016/j.eururo.2026.04.023","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages 307-308"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ProBIOPSY: A Multidisciplinary International Consensus on Standards for Prostate Biopsy","authors":"Daria Chernysheva,&nbsp;Francesco Di Bello,&nbsp;Giulio Avesani,&nbsp;Michael Baboudjian,&nbsp;Eric Barret,&nbsp;Alberto Breda,&nbsp;Alberto Briganti,&nbsp;Lars Budäus,&nbsp;Eva Comperat,&nbsp;Romain Diamand,&nbsp;Gert De Meerleer,&nbsp;Maarten De Rooij,&nbsp;Francesco Giganti,&nbsp;Gianluca Giannarini,&nbsp;Karolien Goffin,&nbsp;Jonathan Hernández Mancera,&nbsp;Barbara Alicja Jereczek-Fossa,&nbsp;Veeru Kasivisvanathan,&nbsp;Claudia Kesch,&nbsp;Laurence Klotz,&nbsp;Francesco Sanguedolce","doi":"10.1016/j.eururo.2026.06.012","DOIUrl":"10.1016/j.eururo.2026.06.012","url":null,"abstract":"<div><h3>Background</h3><div>Prostate biopsy is a complex, multi-step procedure lacking standardisation across patient selection, tools, technique, and biopsy strategy, potentially influencing local treatment planning. An international consensus project was initiated to harmonise these aspects.</div></div><div><h3>Methods and analysis</h3><div>A systematic review informed statement development. A modified Delphi process involving 34 international experts was conducted over three rounds. Panellists evaluated 96, 99, and 112 statements in Rounds 1–3, respectively, grouped into 36 stems. Statements were iteratively revised based on feedback and discussion. Consensus was assessed using a modified RAND appropriateness method.</div></div><div><h3>Key findings and limitations</h3><div>All experts completed the three rounds. Consensus was achieved for 29 of 36 stems (81%). Both biparametric and multiparametric magnetic resonance imaging were endorsed within the diagnostic pathway, provided imaging quality is adequate. Key elements of a targeted plus perilesional biopsy scheme were harmonised. For treatment planning, a targeted ± perilesional biopsy scheme was considered sufficient for most aspects of local treatment planning. However, additional contralateral sampling still seems necessary for specific indications, notably focal therapy candidate selection. Limitations include imbalances in specialty representation and heterogeneity in expertise across topics.</div></div><div><h3>Conclusion and clinical implications</h3><div>The ProBIOPSY consensus defines a contemporary, standardised framework for prostate biopsy. While targeted-based strategies are sufficient for most clinical scenarios, no single biopsy approach provides complete information for all treatment decisions, underscoring the need for indication-specific biopsy tailoring.</div></div>","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages 212-224"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148414335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining ctDNA and utDNA as a Dual Biomarker-driven Strategy for Bladder-sparing Therapy in Muscle-invasive Bladder Cancer: Neither Alone Is Sufficient","authors":"José Daniel Subiela,&nbsp;Daniel A. González-Padilla,&nbsp;Renate Pichler,&nbsp;Pietro Scilipoti,&nbsp;Benjamin Pradere","doi":"10.1016/j.eururo.2026.04.030","DOIUrl":"10.1016/j.eururo.2026.04.030","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Pages 191-195"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Khan S, Papa N, Kneebone A, et al. Prospective Comparison of 64Copper [64Cu]SAR-bisPSMA vs 68Gallium[68Ga] PSMA-11 PET/CT for Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy (Co-PSMA Trial). Eur Urol. 2026;89:512–520","authors":"Guixin Ding,&nbsp;Jipeng Wang,&nbsp;Jitao Wu","doi":"10.1016/j.eururo.2026.04.034","DOIUrl":"10.1016/j.eururo.2026.04.034","url":null,"abstract":"","PeriodicalId":12223,"journal":{"name":"European urology","volume":"90 3","pages":"Page e64"},"PeriodicalIF":29.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}