Food and cosmetics toxicology最新文献_第8页

Testicular responses of rats and dogs to cyclohexylamine overdosage 大鼠和狗睾丸对过量环己胺的反应

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90387-4

R.W. James , R. Heywood, D. Crook

{"title":"Testicular responses of rats and dogs to cyclohexylamine overdosage","authors":"R.W. James , R. Heywood, D. Crook","doi":"10.1016/0015-6264(81)90387-4","DOIUrl":"10.1016/0015-6264(81)90387-4","url":null,"abstract":"<div><p>Cyclohexylamine (CHA), the principal metabolite of cyclamate, was given by oral gavage to male rats (200 mg/kg/day) and male Beagles (250 mg/kg/day) for 9 wk. Subsequently some of these animals were maintained undosed for 13 wk to assess recovery. CHA adversely affected body-weight gain and food consumption in both species. Although a degree of tolerance developed, vomiting tended to occur after CHA administration to dogs. Serum follicle stimulating hormone levels increased and testosterone levels decreased in rats given CHA. No effects were found on the serum luteinizing hormone and testosterone levels in dogs, but reversible effects on sperm morphology were induced in this species. There were no statistically significant (<em>P</em> > 0·05) effects on the weight of the pituitaries, testes or secondary sex organs of either species. The only lesion detectable by conventional histological examination was focal atrophy of seminiferous tubules in one rat examined 13 wk after cessation of CHA treatment. Quantitative assessment of testicular spermatogenesis showed that CHA administration reduced the counts of pachytene spermatocytes, and of early and late spermatids, in both species. These effects were apparently reversible in dogs but not in rats.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 291-296"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90387-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18275627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Studies of the arylhydroxylation of monochlorophenylureas in the isolated perfused rat liver 单氯苯脲在离体灌注大鼠肝脏中芳基羟基化的研究

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90393-X

D. Westphal, K. Lucas, V. Hilbig

引用次数: 3

Asbestos Killer Dust. A Worker/Community Guide. How to fight the Hazards of Asbestos and its Substitutes 石棉杀手粉尘。工人/社区指南。如何对抗石棉及其替代品的危害

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90314-X

引用次数: 2

Handling Chemical Carcinogens in the Laboratory: Problems of Safety 在实验室处理化学致癌物:安全问题

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90322-9

引用次数: 0

Chromium and the kidneys 铬和肾脏

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90376-X

引用次数: 0

Environmental Health Criteria 8. Sulfur Oxides and Suspended Particulate Matter 环境卫生标准硫氧化物和悬浮微粒物质

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90316-3

引用次数: 0

Size-distribution analysis of respirable particulates in cosmetic aerosols: A methodological comparison 化妆品气雾剂中可吸入颗粒物的尺寸分布分析:方法比较

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90308-4

M.K. Halbert , M.K. Mazumder, R.L. Bond

引用次数: 6

Monographs on fragrance raw materials 香精原料专著

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90311-4

D.L.J. Opdyke

引用次数: 113

Chronic toxicity of butylated hydroxytoluene in Wistar rats 丁基羟基甲苯对Wistar大鼠的慢性毒性

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90350-3

M. Hirose, M. Shibata, A. Hagiwara, K. Imaida, N. Ito

引用次数: 75

Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats 丁基羟基甲苯对大鼠的发育性神经行为毒性

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90351-5

C.V. Vorhees , R.E. Butcher , R.L. Brunner , T.J. Sobotka

{"title":"Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats","authors":"C.V. Vorhees , R.E. Butcher , R.L. Brunner , T.J. Sobotka","doi":"10.1016/0015-6264(81)90351-5","DOIUrl":"10.1016/0015-6264(81)90351-5","url":null,"abstract":"<div><p>Butylated hydroxytoluene (BHT) was fed to rats throughout development (from before conception through to day 90 of postnatal life) at levels of 0, 0·125, 0·25 or 0·5% (w/w) in the diet. A similarly treated positive control group was injected on day 12 of gestation with 550 mg/kg of the antimitotic/embryotoxic drug hydroxyurea for reference. Offspring from all groups were reared by their natural dams and were evaluated in a battery of behavioural tests from day 3 to day 90 after birth. BHT at 0·5% in the diet reduced the body weights of dams and of offspring during early development and increased offspring mortality (to 39%) up to 30 days of age. This dose delayed eyelid opening, surface-righting development and limb co-ordination in swimming in males, and reduced female open-field ambulation; however, no significant effects were found after weaning. The lower doses of BHT produced some irregularities in maternal weight (0·25% an increase and 0·125% a decrease) but had no effect on the body weights of offspring. BHT at 0·25% of the diet increased pre- and periweaning mortality (23%), but neither this dose nor the 0·125% dose had any effect on physical or behavioural development or on post-weaning behavioural performance. The positive control group treated with hydroxyurea showed reduced growth prior to weaning, reduced adult brain weight and a slight but nonsignificant increase in pre- and periweaning mortality (10%). This group also exhibited delayed eyelid opening, delayed forward locomotor development and limb co-ordination during swimming, but showed no effects on postweaning behavioural performance. The BHT findings are consistent with the existing toxicological literature that BHT is toxic to growing rodents at doses of 0·25 or 0·5% of the diet with marginal effects at 0·125% of the diet. The behavioural data expand the picture of BHT's toxicity, but do not suggest any disproportionate or special toxicity of BHT for the central nervous system.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 153-162"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90351-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18299018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27