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Food and cosmetics toxicology最新文献

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Handling Chemical Carcinogens in the Laboratory: Problems of Safety 在实验室处理化学致癌物:安全问题
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90322-9
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引用次数: 0
Asbestos Killer Dust. A Worker/Community Guide. How to fight the Hazards of Asbestos and its Substitutes 石棉杀手粉尘。工人/社区指南。如何对抗石棉及其替代品的危害
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90314-X
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引用次数: 2
Chromium and the kidneys 铬和肾脏
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90376-X
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引用次数: 0
Environmental Health Criteria 8. Sulfur Oxides and Suspended Particulate Matter 环境卫生标准硫氧化物和悬浮微粒物质
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90316-3
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引用次数: 0
Testicular responses of rats and dogs to cyclohexylamine overdosage 大鼠和狗睾丸对过量环己胺的反应
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90387-4
R.W. James , R. Heywood, D. Crook
{"title":"Testicular responses of rats and dogs to cyclohexylamine overdosage","authors":"R.W. James ,&nbsp;R. Heywood,&nbsp;D. Crook","doi":"10.1016/0015-6264(81)90387-4","DOIUrl":"10.1016/0015-6264(81)90387-4","url":null,"abstract":"<div><p>Cyclohexylamine (CHA), the principal metabolite of cyclamate, was given by oral gavage to male rats (200 mg/kg/day) and male Beagles (250 mg/kg/day) for 9 wk. Subsequently some of these animals were maintained undosed for 13 wk to assess recovery. CHA adversely affected body-weight gain and food consumption in both species. Although a degree of tolerance developed, vomiting tended to occur after CHA administration to dogs. Serum follicle stimulating hormone levels increased and testosterone levels decreased in rats given CHA. No effects were found on the serum luteinizing hormone and testosterone levels in dogs, but reversible effects on sperm morphology were induced in this species. There were no statistically significant (<em>P</em> &gt; 0·05) effects on the weight of the pituitaries, testes or secondary sex organs of either species. The only lesion detectable by conventional histological examination was focal atrophy of seminiferous tubules in one rat examined 13 wk after cessation of CHA treatment. Quantitative assessment of testicular spermatogenesis showed that CHA administration reduced the counts of pachytene spermatocytes, and of early and late spermatids, in both species. These effects were apparently reversible in dogs but not in rats.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 291-296"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90387-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18275627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Studies of the arylhydroxylation of monochlorophenylureas in the isolated perfused rat liver 单氯苯脲在离体灌注大鼠肝脏中芳基羟基化的研究
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90393-X
D. Westphal, K. Lucas, V. Hilbig
{"title":"Studies of the arylhydroxylation of monochlorophenylureas in the isolated perfused rat liver","authors":"D. Westphal,&nbsp;K. Lucas,&nbsp;V. Hilbig","doi":"10.1016/0015-6264(81)90393-X","DOIUrl":"10.1016/0015-6264(81)90393-X","url":null,"abstract":"<div><p>Biotransformation studies with phenylurea and the three isomers of monochlorophenylurea were performed using an isolated perfused rat-liver preparation. In the perfusate and the bile, ring-hydroxylation was detected only with phenylurea and with <em>o</em>- and <em>m</em>-chlorophenylurea, and yielded the corresponding <em>p</em>-hydroxylated compounds in each case, while with <em>p</em>-chlorophenylurea no ring hydroxylation was observed at the ortho or meta position. Similar results were obtained with the arylhydroxylation of the herbicide monolinuron (3-(4-chlorophenyl)-1-methoxy-1-methylurea) in the perfused rat liver. In contrast, studies of monolinuron biotransformation <em>in vivo</em> in rats, pigs and hens showed that ring hydroxylation at the ortho or meta position was the main degradation step. The possible reasons for the difference in biotransformation <em>in vivo</em> and <em>in vitro</em> are discussed.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 341-345"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90393-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18275631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
MSG—mainly reproductive effects 主要是生殖影响
Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90473-9
B. Phillips
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引用次数: 0
The cause of MBK neuropathy? MBK神经病的病因是什么?
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90334-5
{"title":"The cause of MBK neuropathy?","authors":"","doi":"10.1016/0015-6264(81)90334-5","DOIUrl":"https://doi.org/10.1016/0015-6264(81)90334-5","url":null,"abstract":"","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Page 133"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90334-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136778845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigenda 更正
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90348-5
{"title":"Corrigenda","authors":"","doi":"10.1016/0015-6264(81)90348-5","DOIUrl":"https://doi.org/10.1016/0015-6264(81)90348-5","url":null,"abstract":"","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Page 143"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90348-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136430763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Size-distribution analysis of respirable particulates in cosmetic aerosols: A methodological comparison 化妆品气雾剂中可吸入颗粒物的尺寸分布分析:方法比较
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90308-4
M.K. Halbert , M.K. Mazumder, R.L. Bond
{"title":"Size-distribution analysis of respirable particulates in cosmetic aerosols: A methodological comparison","authors":"M.K. Halbert ,&nbsp;M.K. Mazumder,&nbsp;R.L. Bond","doi":"10.1016/0015-6264(81)90308-4","DOIUrl":"10.1016/0015-6264(81)90308-4","url":null,"abstract":"<div><p>The size spectra of respirable particulates from five cosmetic aerosol products were determined using the methods of microscopy, cascade impaction, and single particle aerodynamic relaxationtime (SPART) analysis. In order to facilitate methodological comparisons, the same sampling apparatus was used in all phases of the study. The results obtained using the three methods were similar in most cases. The pressurized aerosol products produced particulates with count median diameters of 0·6-1·5 μm and mass median diameters of 2·2–3·2 μm as measured by all methods. The pump spray also yielded particulates with median diameters in these ranges in the microscope and SPART analyses, but in the cascade impaction analysis, the mass median diameter was determined to be 12·8 μm.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 85-88"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90308-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18275623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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