Food and cosmetics toxicology最新文献_第7页

Long-term effects of feeding aflatoxin-contaminated market peanut oil to Sprague-Dawley rats 给Sprague-Dawley大鼠饲喂黄曲霉毒素污染的花生油的长期影响

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90355-2

L.Y.Y. Fong, W.C. Chan

{"title":"Long-term effects of feeding aflatoxin-contaminated market peanut oil to Sprague-Dawley rats","authors":"L.Y.Y. Fong, W.C. Chan","doi":"10.1016/0015-6264(81)90355-2","DOIUrl":"10.1016/0015-6264(81)90355-2","url":null,"abstract":"<div><p>Peanut oils obtained from Hong Kong markets were frequently contaminated with aflatoxins. A ‘purified’ diet in which aflatoxin-contaminated market peanut oil (aflatoxin B<sub>1</sub> 110 ppb [μg/kg]) was used as the fat source was fed to Sprague-Dawley rats for 22 months from weaning. Its estimated aflatoxin B<sub>1</sub> content was 5–7 ppb. Controls were fed a diet of identical composition except that Mazola corn oil (aflatoxin-free) was used. At autopsy, three out of 76 aflatoxin-fed rats were found to have sarcomas—one in the liver, one in the wall of the colon and one in the subcutaneous tissue of the groin. Eighteen animals fed peanut oil showed parenchymal liver damage and varying degrees of fatty change and one showed pre-malignant changes in liver cells. Of 90 control rats, none developed malignant tumours. The liver-to-body weight ratios for experimental and control rats were 2·93 ± 0·46 and 2·62 ± 0·58, respectively (means ± 1 SD). The difference between these values was statistically significant (<em>P</em> < 0·01), reflecting the degree of fatty change in the livers of experimental rats compared with that in the controls. Over 90% of Hong Kong households use peanut oils for cooking purposes, and these data appear to indicate a possible health hazard in the use of peanut oils contaminated at the levels found.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 179-183"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90355-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18299022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Studies on liver microsomes of female rats fed purified diets varying in fat content and with and without propyl gallate 饲喂不同脂肪含量、含和不含没食子酸丙酯的纯化饲料的雌性大鼠肝微粒体的研究

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90297-2

M.M. King, P.B. McCay

引用次数: 17

Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate 邻苯苯钠对F344大鼠泌尿系统肿瘤的诱导作用

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90389-8

K. Hiraga, T. Fujii

{"title":"Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate","authors":"K. Hiraga, T. Fujii","doi":"10.1016/0015-6264(81)90389-8","DOIUrl":"10.1016/0015-6264(81)90389-8","url":null,"abstract":"<div><p>Sodium <em>o</em>-phenylphenate (OPP-Na), a fungicide approved as a food additive in Japan, was given in pellet diets at dietary levels of 0, 0·125, 0·25, 0·5, 1·0, 2·0 or 4·0% to groups of about 10 male and female F344/Du rats for 13 wk and to male F344/Du rats for 91 wk. In the 13-wk study, urinary bladder tumours developed in one out of ten male rats fed 1% OPP-Na, nine out of ten male rats fed 2% OPP-Na, one out of ten male rats fed 4% OPP-Na and two out of ten female rats fed 4% OPP-Na. Five transitional cell carcinomas were observed in male rats fed 2% OPP-Na and one such carcinoma was found in a male rat fed 4% OPP-Na. In the 91-wk study, tumours of the urinary bladder, renal pelvis and renal papilla developed in one out of 21 rats (5%) fed 0·5% OPP-Na, seven out of 21 rats (33%) fed 1% OPP-Na, 20 out of 21 rats (95%) fed 2% OPP-Na and 17 out of 21 rats (85%) fed 4% OPP-Na. These were all transitional cell carcinomas, except for one carcinosarcoma in the 2% group. A dose-related increase in the incidence of non-neoplastic lesions of the kidney were observed in treated rats. In the 13-wk study, slight to moderate pyelonephritis was observed in six out of ten male rats and one out of ten female rats fed 4% OPP-Na. In the 91-wk study, moderate to severe pyelonephritis was observed in four out of 21 rats (19%) fed 2% OPP-Na and in all of 20 rats fed 4% OPP-Na.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 303-310"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90389-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18275629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 93

Comparative metabolism of zearalenone and transmission into bovine milk 玉米赤霉烯酮的比较代谢及其在牛奶中的传播

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90299-6

C.J. Mirocha, S.V. Pathre, T.S. Robison

{"title":"Comparative metabolism of zearalenone and transmission into bovine milk","authors":"C.J. Mirocha, S.V. Pathre, T.S. Robison","doi":"10.1016/0015-6264(81)90299-6","DOIUrl":"10.1016/0015-6264(81)90299-6","url":null,"abstract":"<div><p>The metabolism of zearalenone in the urine of the cow, the pig, the rabbit, the rat and man was studied. Both free and conjugated zearalenone (63%), α-zearalenol (32%) and β-zearalenol (5%) were present in the urine of the pig; α-zearalenol was the predominant metabolized species. In the cow, free and conjugated (glucuronic and sulphate) zearalenone (29%), α-zearalenol (20%) and β-zearalenol (51%) were found; in contrast to swine, β-zearalenol was the predominant species. In rat urine, the major species was free zearalenone, which constituted over 90% of the total zearalenone and metabolites. In the rabbit, 46% of the urinary metabolites took the form of zearalenone conjugates, 29% were conjugates of α-zearalenol and 25% were conjugates of β-zearalenol. The distribution of metabolites in the faeces was similar to that in the urine. In man, zearalenone and α-zearalenol were the major metabolites followed by β-zearalenol; all were in the glucuronide form.</p><p>Free and conjugated forms of zearalenone and diastereomeric zearalenols were present in cows' milk. The total concentration of zearalenone and its metabolites was 1·3 ppm (after receiving 25 ppm dietary zearalenone for 7 days); zearalenone constituted 35%, α-zearalenol, 31% and β-zearalenol, 34% of the free metabolites. α-Zearalenol is three times more oestrogenic than zearalenone.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 25-30"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90299-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17513915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 194

Chronic toxicity of 2,3,7,8-tetrachlorodibenzofuran for rhesus macaques 2,3,7,8-四氯二苯并呋喃对恒河猴的慢性毒性

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90304-7

W.P. McNulty, I. Pomerantz, T. Farrell

引用次数: 28

Catalyst for polyurethane foam causes bladder dysfunction 聚氨酯泡沫催化剂导致膀胱功能障碍

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90337-0

引用次数: 0

Books received for review 接受评审的书籍

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90323-0

引用次数: 0

Mutagenicity of fumigants 熏蒸剂的致突变性

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90375-8

引用次数: 0

Carcinogenicity of piperonyl butoxide still uncertain 胡椒酰丁醇的致癌性仍不确定

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90374-6

引用次数: 0

Carcinogenicity of dyestuff intermediates 染料中间体的致癌性

Food and cosmetics toxicology Pub Date : 1981-01-01 DOI: 10.1016/0015-6264(81)90382-5

引用次数: 0