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Food and cosmetics toxicology最新文献

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Monographs on fragrance raw materials 香精原料专著
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90311-4
D.L.J. Opdyke
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引用次数: 113
Chronic toxicity of butylated hydroxytoluene in Wistar rats 丁基羟基甲苯对Wistar大鼠的慢性毒性
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90350-3
M. Hirose, M. Shibata, A. Hagiwara, K. Imaida, N. Ito
{"title":"Chronic toxicity of butylated hydroxytoluene in Wistar rats","authors":"M. Hirose,&nbsp;M. Shibata,&nbsp;A. Hagiwara,&nbsp;K. Imaida,&nbsp;N. Ito","doi":"10.1016/0015-6264(81)90350-3","DOIUrl":"10.1016/0015-6264(81)90350-3","url":null,"abstract":"<div><p>Groups of 57 Wistar rats of each sex were maintained on diet containing 0.25 or 1% butylated hydroxytoluene (BHT) for 104 wk; control groups comprised 36 rats of each sex. Treated rats of both sexes showed reduced body-weight gain, relative spleen weight and white-blood-cell count while in the males there was also a reduction in serum triglyceride. BHT-treated animals of both sexes showed increased relative liver weight and total blood cholesterol but increases in red-blood-cell count could be seen only in females and only the males showed increased γ-glutamyltransferase. No significant histological changes were observed in the liver or haematopoietic system to explain these haematological and biochemical changes. Tumours were found in the liver, pancreas, mammary glands, uterus, pituitary gland, adrenal glands and in some other organs of some of the treated rats, but their incidence was not significantly different from that in controls. This experiment showed no carcinogenic effect of BHT on rats.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 147-151"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90350-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18299017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 75
Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats 丁基羟基甲苯对大鼠的发育性神经行为毒性
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90351-5
C.V. Vorhees , R.E. Butcher , R.L. Brunner , T.J. Sobotka
{"title":"Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats","authors":"C.V. Vorhees ,&nbsp;R.E. Butcher ,&nbsp;R.L. Brunner ,&nbsp;T.J. Sobotka","doi":"10.1016/0015-6264(81)90351-5","DOIUrl":"10.1016/0015-6264(81)90351-5","url":null,"abstract":"<div><p>Butylated hydroxytoluene (BHT) was fed to rats throughout development (from before conception through to day 90 of postnatal life) at levels of 0, 0·125, 0·25 or 0·5% (w/w) in the diet. A similarly treated positive control group was injected on day 12 of gestation with 550 mg/kg of the antimitotic/embryotoxic drug hydroxyurea for reference. Offspring from all groups were reared by their natural dams and were evaluated in a battery of behavioural tests from day 3 to day 90 after birth. BHT at 0·5% in the diet reduced the body weights of dams and of offspring during early development and increased offspring mortality (to 39%) up to 30 days of age. This dose delayed eyelid opening, surface-righting development and limb co-ordination in swimming in males, and reduced female open-field ambulation; however, no significant effects were found after weaning. The lower doses of BHT produced some irregularities in maternal weight (0·25% an increase and 0·125% a decrease) but had no effect on the body weights of offspring. BHT at 0·25% of the diet increased pre- and periweaning mortality (23%), but neither this dose nor the 0·125% dose had any effect on physical or behavioural development or on post-weaning behavioural performance. The positive control group treated with hydroxyurea showed reduced growth prior to weaning, reduced adult brain weight and a slight but nonsignificant increase in pre- and periweaning mortality (10%). This group also exhibited delayed eyelid opening, delayed forward locomotor development and limb co-ordination during swimming, but showed no effects on postweaning behavioural performance. The BHT findings are consistent with the existing toxicological literature that BHT is toxic to growing rodents at doses of 0·25 or 0·5% of the diet with marginal effects at 0·125% of the diet. The behavioural data expand the picture of BHT's toxicity, but do not suggest any disproportionate or special toxicity of BHT for the central nervous system.</p></div>","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 153-162"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90351-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18299018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Effect of dietary tin on zinc, copper and iron utilization by rats 日粮锡对大鼠锌、铜、铁利用的影响
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90352-7
J.L. Greger, M.A. Johnson
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引用次数: 31
Metabolism of aspartate and aspartame 天冬氨酸和阿斯巴甜的代谢
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90326-6
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引用次数: 0
Immunopathology. Sixth international convocation on immunology 免疫病理反应。第六届国际免疫学大会
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90367-9
{"title":"Immunopathology. Sixth international convocation on immunology","authors":"","doi":"10.1016/0015-6264(81)90367-9","DOIUrl":"https://doi.org/10.1016/0015-6264(81)90367-9","url":null,"abstract":"","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 265-266"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90367-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136819158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Electron Microscopy of Tumours 肿瘤诊断电镜
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90318-7
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引用次数: 243
Pulmonary haemorrhage from trimellitic anhydride 三苯三酸酐引起的肺出血
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90338-2
{"title":"Pulmonary haemorrhage from trimellitic anhydride","authors":"","doi":"10.1016/0015-6264(81)90338-2","DOIUrl":"https://doi.org/10.1016/0015-6264(81)90338-2","url":null,"abstract":"","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Page 135"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90338-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136807906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlorinated insecticides and the diet 氯化杀虫剂和饮食
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90373-4
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引用次数: 0
Books received for review 接受评审的书籍
Food and cosmetics toxicology Pub Date : 1981-01-01 Epub Date: 2004-04-26 DOI: 10.1016/0015-6264(81)90370-9
{"title":"Books received for review","authors":"","doi":"10.1016/0015-6264(81)90370-9","DOIUrl":"https://doi.org/10.1016/0015-6264(81)90370-9","url":null,"abstract":"","PeriodicalId":12197,"journal":{"name":"Food and cosmetics toxicology","volume":"19 ","pages":"Pages 266-267"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0015-6264(81)90370-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136818929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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