Federation proceedings最新文献_第10页

Biochemical characteristics of receptors for vasoactive intestinal polypeptide in nervous, endocrine, and immune systems. 血管活性肠多肽受体在神经、内分泌和免疫系统中的生化特性。

Federation proceedings Pub Date : 1987-01-01

M S O'Dorisio

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Molecular and cellular properties of human polymorphonuclear leukocyte receptors for leukotriene B4. 人白三烯B4多形核白细胞受体的分子和细胞特性。

Federation proceedings Pub Date : 1987-01-01

D W Goldman, L A Gifford, T Marotti, C H Koo, E J Goetzl

引用次数: 0

Overview of physiological and pathophysiological effects of thromboxane A2. 血栓素A2的生理和病理生理作用综述。

Federation proceedings Pub Date : 1987-01-01

M L Ogletree

{"title":"Overview of physiological and pathophysiological effects of thromboxane A2.","authors":"M L Ogletree","doi":"","DOIUrl":"","url":null,"abstract":"Thromboxane (Tx) A2 is a biologically potent and chemically unstable metabolite of prostaglandin endoperoxides. Recent developments in measurement techniques and the availability of both selective inhibitors of Tx synthetase and TxA2 receptor antagonists have facilitated the implication of TxA2 as a physiological modulator and as a mediator in thrombotic, vasospastic, and bronchospastic conditions. TxA2 is synthesized by platelets and contributes to platelet activation and irreversible platelet aggregation in physiological hemostasis and in thrombosis (e.g., unstable angina, stroke). TxA2 is also synthesized in intestinal, pulmonary, and renal tissues by cells other than platelets. Particularly in these tissues, TxA2 appears to act as a physiological modulator of changes in blood flow distribution and airway caliber. Strong stimuli for TxA2 release from these tissues may initiate ulcer, pulmonary hypertension, bronchoconstriction, and renal vasoconstriction. Evidence supports participation of TxA2 and/or TxA2 receptors in modulation of natural cytotoxic cell cytotoxicity, in tumor growth and metastasis, in complications of pregnancy (e.g., preeclampsia), and in the progression of ischemic injury after coronary artery occlusion. This evidence supports pivotal involvement of TxA2 in pathophysiology and provides a strong rationale for pursuing TxA2-blocking strategies in drug development.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 1","pages":"133-8"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14083485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic diastolic caliber changes as a determinant for complete aortic baroreceptor resetting. 主动脉舒张直径变化是主动脉压力感受器完全重置的决定因素。

Federation proceedings Pub Date : 1987-01-01

E M Krieger

引用次数: 0

Thromboxane A2 biosynthesis in human disease. 血栓素A2在人类疾病中的生物合成。

Federation proceedings Pub Date : 1987-01-01

G A FitzGerald, C Healy, J Daugherty

{"title":"Thromboxane A2 biosynthesis in human disease.","authors":"G A FitzGerald, C Healy, J Daugherty","doi":"","DOIUrl":"","url":null,"abstract":"Thromboxane A2 (TxA2), the predominant cyclooxygenase product of human platelets, is a potent vasoconstrictor and platelet agonist. Although its biological properties are readily appreciable in vitro, it has been difficult to define its biological importance in vivo. To a large extent this reflected the problems associated with efforts to monitor biosynthesis of this eicosanoid and the lack of selective pharmacological probes that prevented the synthesis of TxA2 or antagonized its biological action in vivo. Recently the analysis of urinary metabolites of TxB2 has become simplified so that the methodology is readily applicable to clinical studies. This provides a noninvasive, time-integrated index of Tx biosynthesis. Although one cannot definitively establish a tissue of origin for metabolites measured in urine, indirect evidence suggests that urinary TxB2 derives primarily from the kidney whereas its dinor metabolite predominantly reflects platelet biosynthesis under physiological conditions. Although plasma concentrations of TxB2 are readily confounded by platelet activation ex vivo, the enzymatic metabolites formed from TxB2 have recently been identified and appear to bypass this problem. Combined analysis of long-lived (e.g., 11-dehydro-TxB2) and short-lived (e.g., 2,3-dinor-TxB2) metabolites in plasma promise to more accurately localize phasic increases in the biosynthesis of TxA2 and have been paralleled by the development of antagonists of the TxA2/prostaglandin endoperoxide receptor and their study of humans. The use of such specific probes in conditions characterized by abnormal biosynthesis of TxA2 promises to define the biological role of this mediator for humans.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 1","pages":"154-8"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14231535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of the clotting system in the pathogenesis of neuroimmunologic disease. 凝血系统在神经免疫疾病发病机制中的作用。

Federation proceedings Pub Date : 1987-01-01

P Y Paterson, C S Koh, H C Kwaan

{"title":"Role of the clotting system in the pathogenesis of neuroimmunologic disease.","authors":"P Y Paterson, C S Koh, H C Kwaan","doi":"","DOIUrl":"","url":null,"abstract":"Experimental allergic encephalomyelitis (EAE) is a prototypic neuroautoimmune disease involving sensitization to central nervous system myelin basic protein (MBP). Our studies of the clotting system and ensuing fibrinolysis implicate coagulation and cleavage of fibrin within or on the luminal surface of the cerebrovasculature as events initiating the inflammation characterizing EAE. Among recipient rats injected with MPB-primed, cultured-activated lymph node cells, opening of the blood-brain barrier (BBB) and deposition of perivascular fibrin within the spinal cord occur in parallel 1 day before onset of clinical signs of EAE. Daily treatment of recipient rats with trans-4-(aminomethyl)cyclohexanecarboxylic acid, a synthetic product that specifically inhibits plasminogen activator derived from endothelial cells, results in marked reduction of increased permeability of the BBB and suppression of clinical signs of EAE. We postulate that the critical event precipitating EAE is binding of circulating MBP-reactive immune effector cells to MBP immunodeterminants on the surface of cerebrovascular endothelial cells. Coagulation and ensuing fibrinolysis occur at sites of binding of effector cells to cerebrovascular endothelium. Release of biologically active peptides cleaved from fibrin open the BBB, thereby setting the stage for the cascade of inflammatory events culminating in clinical manifestations of EAE.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 1","pages":"91-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13580445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binding of leukotriene C4 by glutathione transferase: a reassessment of biochemical and functional criteria for leukotriene receptors. 谷胱甘肽转移酶与白三烯C4的结合:白三烯受体生化和功能标准的重新评估。

Federation proceedings Pub Date : 1987-01-01

F F Sun, L Y Chau, K F Austen

引用次数: 0

Opioid regulation of food intake and body weight in humans. 阿片类药物对人类食物摄入和体重的调节。

Federation proceedings Pub Date : 1987-01-01

R L Atkinson

引用次数: 0

Baroreceptor mechanisms at the cellular level. 细胞水平的压力感受器机制。

Federation proceedings Pub Date : 1987-01-01

F Sachs

引用次数: 0

Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors. 血小板和血管平滑肌血栓素A2/前列腺素H2受体。

Federation proceedings Pub Date : 1987-01-01

P V Halushka, D E Mais, D L Saussy

{"title":"Platelet and vascular smooth muscle thromboxane A2/prostaglandin H2 receptors.","authors":"P V Halushka, D E Mais, D L Saussy","doi":"","DOIUrl":"","url":null,"abstract":"Thromboxane A2 (TxA2) and prostaglandin H2 (PGH2) aggregate platelets and contract vascular smooth muscle. Inasmuch as both compounds produce the same effects and presumably through the same receptor, their receptors have been referred to as TxA2/PGH2 receptors. Pharmacological studies of stable agonists and antagonists of the TxA2/PGH2 receptors have shown different rank order potencies for these compounds in platelets compared with blood vessels. These studies have provided evidence to support the hypothesis that the platelet TxA2/PGH2 receptor is different from the one found in vascular tissue. The vascular receptor has been named [TxA2/PGH2]tau and the platelet receptor has been named [TxA2/PGH2]alpha. In the past few years several radiolabeled antagonists and agonists have been developed and used in radioligand-binding studies, primarily in platelets. One of these ligands, 125I-labeled PTA-OH, a TxA2/PGH2 receptor antagonist, has been extensively used to characterize the human platelet TxA2/PGH2-binding site. It has been found to have a Kd of approximately 20 nM and a Bmax of 2500 binding sites/platelet. Through the combination of pharmacological and biochemical approaches, it should be possible to characterize platelet and vascular TxA2/PGH2 receptors.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 1","pages":"149-53"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14083487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0