Experimental eye research最新文献

{"title":"Further evaluation of the effectiveness and superiority of hyaluronic acid combined preparations (trehalose, dexpanthenol and coenzyme Q10 & vitamin E) in experimental alkali model","authors":"Yucel Yigit ,&nbsp;Gozde Sahin Vural ,&nbsp;Yurdagul Girgin ,&nbsp;Basak Isildar ,&nbsp;Pakize Nur Akkaya ,&nbsp;Gamze Tanriverdi ,&nbsp;Muhammed Dara Tas ,&nbsp;Ozlem Barut Selver","doi":"10.1016/j.exer.2025.110357","DOIUrl":"10.1016/j.exer.2025.110357","url":null,"abstract":"<div><h3>Purpose</h3><div>The objective of this study was to undertake a more comprehensive evaluation of the efficacy and comparative advantage of hyaluronic acid (HA) combined preparations in an experimental alkali model.</div></div><div><h3>Method</h3><div>In the present study, experimental chemical burns were induced in the right eyes of 22 New Zealand rabbits. The eyes were then divided into four groups for subsequent analysis: Trehalose + HA (Group T, n = 6); dexpanthenol + HA (Group P, n = 6); coenzyme Q10+vitamin E + HA (Group V, n = 6); and one control group (CG, n = 4).</div></div><div><h3>Results</h3><div>There was no statistically significant difference in the size of the epithelial defect area between the groups on days 1, 3, and 5. However, a marked difference in the healing of epithelial defects was observed. Histologic analysis revealed optimal healing in terms of stromal edema, epithelial disruption, and lymphatic infiltration in group P. Alpha SMA (alpha smooth actin)-positive areas was higher in groups P and V. Electron microscopic examination revealed enhanced anterior surface epithelial formation and collagen arrangement in the treatment groups compared to the control group.</div></div><div><h3>Conclusion</h3><div>The findings of the present study are consistent with those of other studies in the literature, which have shown the superiority of trehalose, dexpanthenol, and coenzyme Q10 to the control group. Furthermore, histologic and immunohistochemical evaluations revealed that the P and V groups exhibited superior healing signs in comparison to the T group. Notably, our study is the first to comparatively analyze artificial tears with trehalose, dexpanthenol, and coenzyme Q10 in terms of epithelial defect healing, incorporating electron microscopic examination.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110357"},"PeriodicalIF":3.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a clock in the cornea?","authors":"Eric B. Papas ,&nbsp;Nuriye Gunler ,&nbsp;Shalini Nanayakkara ,&nbsp;Azadeh Tavakoli ,&nbsp;Sultan Alotaibi ,&nbsp;Vinod Maseedupally ,&nbsp;Nico Dames","doi":"10.1016/j.exer.2025.110356","DOIUrl":"10.1016/j.exer.2025.110356","url":null,"abstract":"<div><div>The overnight corneal swelling response is generally attributed to hypoxia but other factors, such as osmolarity, may contribute. A seldom considered alternative is that the response represents a biological rhythm instigated by the dark/light cycle. The purpose of this study was to investigate that possibility. Ten participants wore goggles designed to exclude light from one eye only, while allowing normal blinking and access to the external atmosphere. Measurements taken from both eyes, prior to and after 6 h of goggle wear, included corneal thickness (epithelial and stromal, centrally and in 4 concentric annuli), intraocular pressure and tear film osmolarity. Data were fitted by linear mixed models to assess the effect of light deprivation. Mean changes (SD) in central corneal thickness for light exposed eyes were 6.8 (8.1) μm in the epithelium and −4.0 (9.3) μm in the stroma. Corresponding values for light deprived eyes were −.1 (10.8) μm and 5.1 (10.6) μm. Corneal thickness changes (epithelial or stromal) between light deprived and light exposed eyes were not significant in any location (p &gt; 0.23). Neither intraocular pressure, nor tear film osmolarity altered significantly (p &gt; 0.6). These data show that monocular darkness does not generate corneal thickness changes, a finding which does not support the hypothesis that corneal thickness control is light mediated in humans. The possibility remains that such a mechanism does exist but contributes only a relatively minor portion to the response and/or has a triggering mechanism that is presently uncharacterised.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110356"},"PeriodicalIF":3.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Transformed bacterial ocular surface microbiome in diabetic mice and its Consequential influence on corneal wound healing restoration","authors":"Huifeng Wang ,&nbsp;Junfa Xue ,&nbsp;Yi Song ,&nbsp;Dewei Li ,&nbsp;Chao Wei ,&nbsp;Luqin Wan","doi":"10.1016/j.exer.2025.110350","DOIUrl":"10.1016/j.exer.2025.110350","url":null,"abstract":"<div><div>To obtain a profound understanding of microbiome variations and their associations with diabetic cornea wound healing, a type 1 diabetic mouse model and a corneal epithelial wound healing model were established. Corneal tissues from diabetic mice and healthy controls were collected. The 2bRAD sequencing for microbiome (2bRAD-M)technique was used to analyze the ocular microbiome profiles. Fifty-five distinct bacterial species were identified through alignment against the 2bRAD-M database. Among all the species identified on the corneal wound, 17 (30.91 %) unique species were discovered on the diabetic epithelium side, 13 (23.64 %) on the non-diabetic epithelium side, and 25 (45.45 %) species were common to both. The top five most abundant bacterial species on the non-diabetic side were <em>Exiguobacterium sibiricum</em> (26.50 %), <em>Enterobacter hormaechei</em> (13.37 %), <em>Brevibacillus agri</em> (6.24 %), <em>Ralstonia</em> sp. <em>UNC404CL21Col</em> (6.11 %), and <em>Cupriavidus pauculus</em> (5.71 %). On the diabetic side, the predominant five species were <em>Methylobacterium</em> sp. <em>MB200</em> (38.73 %), <em>Exiguobacterium sibiricum</em> (11.58 %), <em>Acinetobacter johnsonii</em> (9.80 %), <em>Corynebacterium glutamicum</em> (6.46 %), and <em>Corynebacterium stationis</em> (5.71 %). Increased levels of gram-negative bacilli, such as <em>Methylobacterium</em>, in the diabetic ocular surface microbiota may be involved in the delayed healing of corneal wounds. Gatifloxacin eye drops with antibacterial activity against gram-negative bacteria were applied to the ocular surface. The corneal epithelium of diabetic mice healed more rapidly after the application of gatifloxacin eye drops. The changes in the ocular surface microbiota of diabetic corneal wounds may be related to delayed healing of the corneal epithelium in diabetic mice, providing a new research target for the investigation of this pathology.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110350"},"PeriodicalIF":3.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide methylation analysis unveils genes and pathways with altered methylation profiles in pterygium","authors":"Mathan L ,&nbsp;Tejaswi Prasad ,&nbsp;Mohammed Hameed Aslam ,&nbsp;Aadhithiya T. Gr ,&nbsp;Bharanidharan Devarajan ,&nbsp;N. Venkatesh Prajna ,&nbsp;K. Dharmalingam ,&nbsp;Daipayan Banerjee","doi":"10.1016/j.exer.2025.110353","DOIUrl":"10.1016/j.exer.2025.110353","url":null,"abstract":"<div><div>Pterygium is a highly prevalent ocular surface disease, particularly in equatorial regions, with no pharmaceutical intervention available and surgical excision remaining the only treatment option. Ultraviolet (UV) radiation from sunlight is widely recognized as the primary cause of pterygium. While chronic UV exposure induces epigenetic changes in the skin contributing to skin cancer, comprehensive studies on epigenetic alterations in pterygium remain unpublished, and causal relationships have yet to be established. This study aimed to investigate genome-wide methylation changes in pterygium using the Illumina Infinium Epic v2.0 Methylation array. We identified 1052 hypermethylated CpGs (499 genes) and 687 hypomethylated CpGs (340 genes) in pterygium tissue compared to control conjunctival tissue from patients undergoing cataract surgery (Δβ&gt;|0.1|, P &lt; 0.05). Hypomethylated genes were mainly associated with PI3K-Akt and MAPK pathways, while hypermethylated genes were enriched in pathways related to oxidative stress, autophagy, DNA repair, and Wnt signaling inhibition. Comparing these findings with transcriptomic datasets revealed 28 hypermethylated genes with downregulated transcripts and 74 hypomethylated genes with upregulated transcripts. qPCR validation confirmed upregulation of hypomethylated genes (MMP2, FBLN5, ZEB1) and downregulation of hypermethylated genes (SAMSN1, CBX4) at the transcript level. These findings suggest that dysregulated DNA methylation may contribute to pterygium pathogenesis by upregulating genes involved in cell proliferation, survival, angiogenesis, fibrosis, and extracellular matrix remodeling, while silencing genes associated with oxidative stress response, autophagy, and DNA damage repair. These insights into the global methylation landscape of pterygium open avenues for detailed functional analysis, potentially guiding targeted therapeutic strategies.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110353"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet factor 4 attenuates inflammation of microglia and protects retinal ganglion cells in retinal excitotoxicity","authors":"Daowei Zhang ,&nbsp;Fangyuan Hu ,&nbsp;Ting Li ,&nbsp;Hongli Liu ,&nbsp;Qian Li ,&nbsp;Yun Cheng ,&nbsp;Xuejin Zhang ,&nbsp;Ping Xu ,&nbsp;Shenghai Zhang ,&nbsp;Jihong Wu","doi":"10.1016/j.exer.2025.110352","DOIUrl":"10.1016/j.exer.2025.110352","url":null,"abstract":"<div><div>Glaucoma, a progressive optic neuropathy characterized by RGC degeneration and irreversible vision loss, currently affects approximately 76 million individuals globally. Despite conventional therapeutic strategies primarily targeting IOP reduction, the ongoing progression of vision loss in normotensive patients highlights an urgent need for alternative neuroprotective interventions. We employed a comprehensive experimental paradigm that integrated both in vivo and in vitro approaches. The in vivo component was utilized by NMDA-induced excitotoxicity involving Sprague-Dawley rats. In vitro analyses were conducted using R28 and BV2 cells. Quantitative assessments encompassed electroretinography, RGC survival, axonal integrity measurements, inflammatory marker profiles, flow cytometry, as well as molecular pathway analyses through immunofluorescence microscopy, Western blot analysis. Administration of PF4 (500 ng/ml) exhibited significant neuroprotective efficacy via multiple cellular mechanisms. Quantitative analyses indicated substantial preservation of RGC density (p &lt; 0.001) alongside maintenance of inner plexiform layer thickness(p &lt; 0.05) within the NMDA-induced model. PF4 treatment markedly attenuated microglial activation (p &lt; 0.01) while modulating the inflammatory response—characterized by reduced expression of pro-inflammatory cytokines coupled with enhanced production of anti-inflammatory mediators. CTB tracing confirmed the preservation of both RGC axons and their projections. Molecular analyses revealed that PF4 may exerted its effects on RGC through different mechanisms: suppression of the Galectin-3/NLRP3-inflammasome/Caspase-1 pathway in microglia and enhancement of the CaMKII/CREB/BDNF neuroprotective cascade within RGCs; these protective effects can attenuate necroptosis independent from IOP modulation in retinal excitotoxicity. Our findings suggest that PF4 can protect RGCs through activate CaMKII/CREB/BDNF pathway induced by excitotoxicity. Moreover, it attenuates NLRP3 inflammasome activation via mediating Galectin-3 and thus decreasing necroptosis of RGCs. This study demonstrates that PF4 may possesses neuroprotective properties through simultaneous modulation across multiple cellular pathways in glaucomatous neurodegeneration, and emphasized the significance of immune-mediated mechanisms.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110352"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ripasudil does not induce phospholipid accumulation in human corneal epithelial cells","authors":"Fumiko Tazoe ,&nbsp;Yuichiro Watanabe ,&nbsp;Noriyuki Inoue ,&nbsp;Mizuho Kanazawa ,&nbsp;Atsushi Kasano ,&nbsp;Toshihiro Inoue","doi":"10.1016/j.exer.2025.110351","DOIUrl":"10.1016/j.exer.2025.110351","url":null,"abstract":"<div><div>Rho-associated coiled-coil-containing protein kinase (Rho kinase; ROCK) inhibitors represent a novel class of glaucoma medications that lower intraocular pressure by enhancing aqueous humor outflow through the conventional outflow pathway. Netarsudil, a ROCK inhibitor, is known to induce cornea verticillata as an adverse effect in clinical settings. Unlike systemic amiodarone and antimalarials, topical agents do not typically induce the development of this corneal condition. This study investigated whether ripasudil, another ROCK inhibitor, induces cornea verticillata using a Chinese hamster-derived ovary cell line (CHO-K1), SV40 transformed human corneal epithelial cell line (HCE-T), and normal human primary corneal epithelial cells (HCEC-2). CHO-K1, HCE-T, and HCEC-2 were treated with ripasudil, netarsudil, or Y-27632 with varying concentrations (0.1, 0.3, 1, 3, 10, or 30 μM). Ripasudil and Y-27632 did not alter intracellular phospholipid levels at any concentration tested. Conversely, intracellular phospholipid accumulation was observed in cells treated with netarsudil. Netarsudil possesses chemical characteristics similar to those of cationic amphiphilic drugs, which are known to cause phospholipidosis. In contrast, ripasudil and Y-27632 lack these structural features. Our results suggest that ripasudil has a low likelihood of inducing cornea verticillata.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110351"},"PeriodicalIF":3.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting BMP4 as a therapeutic strategy for neovascularization and fibrosis in age-related macular degeneration","authors":"Rong Luan ,&nbsp;Shuzhan Xu ,&nbsp;Manhong Xu,&nbsp;Manqiao Wang,&nbsp;Xinyuan Huang,&nbsp;Jie Wang,&nbsp;Qingbo Li,&nbsp;Yi Gong,&nbsp;Juping Liu,&nbsp;Yan Shao,&nbsp;Xiaorong Li","doi":"10.1016/j.exer.2025.110348","DOIUrl":"10.1016/j.exer.2025.110348","url":null,"abstract":"<div><div>This study investigates the role of bone morphogenetic protein-4 (BMP4) in age-related macular degeneration (AMD), with a focus on its effects on subretinal fibrosis and choroidal neovascularization (CNV). Using a mouse model of laser-induced CNV, we found that BMP4 expression was significantly elevated in CNV lesions. BMP4 was shown to promote fibroblast proliferation and their differentiation into myofibroblasts, as indicated by increased expression of α-smooth muscle actin (α-SMA). Additionally, BMP4 promoted the transition of endothelial progenitor cells (EPCs) into endothelial cells (ECs), a process that was modulated by mitochondrial function. Intravitreal administration of Noggin, a BMP4 inhibitor, significantly reduced CNV lesion volume and decreased the expression of CD31 and α-SMA, suggesting a decrease in neovascularization and fibrosis. These findings underscore BMP4's critical role in AMD pathogenesis by driving both angiogenesis and fibrosis. Targeting BMP4 with Noggin presents a promising therapeutic approach for AMD, addressing both neovascularization and fibrosis in a single intervention, and highlights BMP4 as a potential novel target for AMD therapy.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110348"},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD24 is required for sustained transparency of the adult lens","authors":"Mahbubul H. Shihan ,&nbsp;Ramachandran Balasubramanian ,&nbsp;Yan Wang ,&nbsp;Rabiul Rafi ,&nbsp;Adam P. Faranda ,&nbsp;Justin Parreno ,&nbsp;Kulandaiappan Varadaraj ,&nbsp;Junyuan Gao ,&nbsp;Richard T. Mathias ,&nbsp;Xingju Nie ,&nbsp;Melinda K. Duncan","doi":"10.1016/j.exer.2025.110347","DOIUrl":"10.1016/j.exer.2025.110347","url":null,"abstract":"<div><div>Genes regulate, maintain, and fine-tune the structural organization and physiological homeostasis of the lens and therefore influence lens transparency. RNAseq profiling of the mouse lens revealed that the Cd24a gene, which encodes the mucin-like GPI-linked membrane protein CD24, is abundantly expressed in the lens. Immunolocalization revealed that CD24 protein is abundant at mouse lens fiber cell membranes from early lens development into adulthood, while in adult human lenses, CD24 protein was detected in both the lens epithelium and fibers. Analysis of mice lacking the Cd24a gene revealed that the lens develops normally and is transparent with normal morphology until 2 months of age. However, older Cd24a null mice have smaller than normal lenses which exhibit abnormal fiber cell structure, actin filament disorganization, and refractive defects that lead to premature cataract development by 1 year of age. By integrating RNA sequencing, immunofluorescence, and magnetic resonance imaging, we found that the aquaporin 1 gene that regulates lens epithelial water transport is downregulated and the protein gradient that mediates the lenses refractive properties is altered in aged Cd24a null lenses that exhibit cataract. However, experiments on intracellular gap junction coupling and hydrostatic pressure in 2 month old lenses found no differences between control and Cd24a null lenses, suggesting that the later lens defects do not arise from primary issues with the lens circulation. Overall, our study found that CD24 plays a key role in maintaining the structural organization and refractive properties of the adult lens.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110347"},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysophosphatidic acid receptor 3 (LPAR3) regulates ocular surface chloride transport via calcium signaling","authors":"Ethan S. Lindgren ,&nbsp;Rongshan Yan ,&nbsp;Yien-Ming Kuo ,&nbsp;Qi Gao ,&nbsp;Livia de Souza Goncalves ,&nbsp;Feeling Y. Chen ,&nbsp;Matilda F. Chan ,&nbsp;Alan S. Verkman ,&nbsp;Onur Cil ,&nbsp;Neel D. Pasricha","doi":"10.1016/j.exer.2025.110346","DOIUrl":"10.1016/j.exer.2025.110346","url":null,"abstract":"<div><div>Dry eye is a multifactorial disease associated with impaired tear film homeostasis, damaging the ocular surface epithelium. Lysophosphatidic acid receptors (LPARs) are G-protein coupled receptors involved in Ca²⁺ and cAMP signaling via PLC and adenylyl cyclase activation. LPAR activation is involved in cell proliferation and wound healing in human corneal epithelial cells (HCECs) and in neuropathic pain. This study investigates the expression and functions of LPARs in ocular surface epithelial cells. Functional measurements of ocular surface potential difference (OSPD) were done in mice with topically applied, selective LPAR modulators. LPAR3 immunostaining was performed in mouse and human cornea and conjunctiva, and mouse lacrimal gland. LPAR-induced Ca²⁺ signaling was studied in primary and immortalized HCECs. The general LPAR agonist, linoleoyl LPA, and the LPAR3 selective agonist, 2S-OMPT, stimulated ocular surface Cl⁻ secretion via Ca²⁺-activated Cl⁻ channels (CaCCs). LPAR3 was expressed in the corneal and conjunctival epithelia of mice and humans, as well as in mouse lacrimal gland. Activation of LPAR and LPAR3 in HCECs transiently elevated intracellular Ca²⁺ through the G<em>q</em>/PLC signaling pathway. LPAR3 agonists may potentially have therapeutic efficacy in ocular surface diseases, including dry eye disease.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110346"},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking Bruch's: How changes in Bruch's membrane influence retinal homeostasis","authors":"Simon J. Clark ,&nbsp;Christine Curcio ,&nbsp;Andrew D. Dick ,&nbsp;Sarah Doyle ,&nbsp;Malia Edwards ,&nbsp;Miguel Flores-Bellver ,&nbsp;Daniel Hass ,&nbsp;Rachel Lennon ,&nbsp;Christopher B Toomey ,&nbsp;Bärbel Rohrer","doi":"10.1016/j.exer.2025.110343","DOIUrl":"10.1016/j.exer.2025.110343","url":null,"abstract":"","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"255 ","pages":"Article 110343"},"PeriodicalIF":3.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}