Experimental eye research最新文献

{"title":"Exosome-enriched extracellular vesicles versus serum in corneal epithelial wound healing: An exploratory preclinical study.","authors":"Nihat Furkan Eratilgan, Mehmet Gurdal, Meltem Kocamanoglu, Yilmaz Kadir Atsatan, Seyfi Anil Kanbur, Cansu Subasi Demir, Omer Faruk Dadas, Banu Yaman, Ozlem Barut Selver","doi":"10.1016/j.exer.2026.111195","DOIUrl":"10.1016/j.exer.2026.111195","url":null,"abstract":"<p><p>This study compared short-term epithelial and stromal responses associated with human umbilical cord mesenchymal stem cell (hucMSC)-derived exosome-enriched extracellular vesicle treatment and serum therapy in a rabbit corneal epithelial defect model. Three groups were evaluated: exosome-enriched extracellular vesicles, 20% pooled human serum, and preservative-free artificial tears as a supportive-care control. Exosome-enriched extracellular vesicle characterization included nanoparticle tracking analysis and CD9-based flow cytometry, while parental hucMSCs were characterized by phase-contrast morphology and flow cytometric expression of CD90, CD44, CD73, and CD105. Fifteen animals were analysed (exosome-enriched extracellular vesicle group n = 6, serum group n = 5, artificial tear control group n = 4). Mean epithelial closure time was 3.50 ± 0.54 days in the exosome-enriched extracellular vesicle group, 4.00 ± 0.70 days in the serum group, and 4.75 ± 0.96 days in the artificial tear control group; however, this difference did not reach statistical significance (p = 0.081). Post-hoc power for the primary endpoint was low, approximately 22%, indicating that the study was underpowered for efficacy or superiority conclusions. Stromal thickness was higher in the exosome-enriched extracellular vesicle group (p = 0.001), but this finding was not accompanied by significant differences in stromal oedema, fibrosis, or cellularity scores. Therefore, the increased stromal thickness remains mechanistically unexplained within the limits of the present dataset. These findings should be interpreted as exploratory observations from a small preclinical study. Larger, adequately powered studies incorporating expanded extracellular vesicle characterization, longer follow-up, and mechanistic endpoints are required before therapeutic efficacy can be inferred.</p>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":" ","pages":"111195"},"PeriodicalIF":3.1,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulated Retinal DPP10 Expression with Single Cell-based Next Genomic Sequencing Profiling in X-linked Juvenile Retinoschisis.","authors":"Han-Ping Cheng, Lo-Jei Ching, Chia-Hao Wang, Muhammad Reza Putra Mahardhika, Huan Ou-Yang, Chun-Yuan Lee, Yuh-Lih Chang, Der-Chong Tsai, Chih-Chien Hsu, De-Kuang Hwang, Shih-Hwa Chiou, Shih-Jen Chen, Tai-Chi Lin, Yi-Ping Yang","doi":"10.1016/j.exer.2026.111287","DOIUrl":"https://doi.org/10.1016/j.exer.2026.111287","url":null,"abstract":"<p><p>X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy resulting from mutations in the retinoschisin (RS1) gene, which lead to progressive structural abnormalities in the retina and consequent visual impairment. Despite this, the molecular mechanisms through which RS1 mutations induce cell type-specific transcriptional remodeling during disease progression remain inadequately elucidated. To delineate transcriptional changes associated with RS1 mutations, we conducted single-cell RNA sequencing (scRNA-seq) on a CRISPR/Cas9-engineered Rs1^emR209C knock-in mouse model. Integrative analysis with the Mouse Retina Cell Atlas demonstrated that rod photoreceptors exhibited the most significant transcriptional dysregulation among retinal cell types. Notably, dipeptidyl peptidase-like protein 10 (DPP10) was progressively and markedly upregulated, predominantly within photoreceptors, as the disease advanced. These findings were corroborated by immunofluorescence staining, quantitative PCR, and western blot analyses, which confirmed increased retinal DPP10 expression concurrent with a gradual decline in RS1 levels. To explore the functional implications of DPP10 dysregulation, we developed Y79 retinal cell models expressing either wild-type RS1 or the XLRS-associated RS1 R209C variant. Cells expressing the RS1 R209C mutation exhibited elevated DPP10 expression alongside reduced viability. Crucially, siRNA-mediated knockdown of DPP10 partially rescued cell viability and was associated with reduced GRP78/BiP expression in RS1 R209C-expressing cells, supporting potential functional relevance between DPP10 upregulation and mutant RS1-induced cellular stress. Furthermore, circulating DPP10 concentrations were significantly increased in patients with XLRS compared to control subjects. Collectively, these results identify DPP10 as a molecular alteration associated with RS1 mutation and suggest its potential as a circulating biomarker candidate for XLRS.</p>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":" ","pages":"111287"},"PeriodicalIF":3.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of exogenous relaxin on dry eye in an experimental Sjögren's disease (SS) mouse model.","authors":"Lucimeire N Carvalho, Taís H Wakamatsu, Cristiane D Gil, Gustavo B Gasparetto, Alex M Nasare, Eduarda de Oliveira, Larissa R Rosa, Priscila C Cristovam, José A P Gomes","doi":"10.1016/j.exer.2026.111280","DOIUrl":"10.1016/j.exer.2026.111280","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the potential of exogenous relaxin (RLX) as a treatment for dry eye disease (DED) in an experimental animal model of Sjögren's disease (SS).</p><p><strong>Methods: </strong>Nonobese diabetic female (NOD) mice with SS-associated DED received RLX-based or vehicle eye drops (100 ng/mL) four times daily for 30 days. Clinical evaluations included measurements of tear production, assessment of keratitis, and histological analysis of the exorbital lacrimal gland. Inflammatory cytokine expression was measured using PCR.</p><p><strong>Results: </strong>RLX-treated mice showed significant improvement in tear production and keratitis reversal. Qualitative histological analysis suggested better preservation of lacrimal gland architecture, with more evident acinar and ductal structures in the RLX-treated group. PCR analysis demonstrated reduced inflammatory cytokine expression (IL-1β, IL-6, IL-12a, IL-17a, TNFα, and IFNγ), and increased expression of RLX and its receptor RXFP1 in the RLX-treated group.</p><p><strong>Conclusions: </strong>Exogenous relaxin shows therapeutic potential for DED in SS, demonstrated by clinical improvements and reduced inflammatory markers in an animal model of SS.</p>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":" ","pages":"111280"},"PeriodicalIF":3.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Retinal and Choroidal Vascular Parameters in Healthy Rhesus Monkeys of Different Age Groups.","authors":"Lu Chang, Wei He, Yong Li, Fang Han, Xiaoyan Chen, Quankun Ji, Hong Wang, Yuqing He","doi":"10.1016/j.exer.2026.111246","DOIUrl":"https://doi.org/10.1016/j.exer.2026.111246","url":null,"abstract":"<p><strong>Background: </strong>Non-human primates are essential models in basic vision research due to their retinal structure and function being closely comparable to those of humans. Systematic Optical Coherence Tomography Angiography (OCTA) studies on retinal and choroidal vessels in rhesus monkeys of different ages will enhance our understanding of the underlying pathology of human retinal vascular diseases and offer valuable insights for preclinical translational research.</p><p><strong>Methods: </strong>Data were collected from 26 rhesus monkeys, categorized into infant, juvenile, adult, and geriatric groups based on age. OCTA measured vascular density (VD) in the superficial, deep, and inner retinal layers, as well as choroidal vascular density, using 1×1 mm, 3×3 mm, and 6×6 mm scans of the macular area. A one-way analysis of variance (ANOVA) with LSD post hoc tests was used for statistical analysis.</p><p><strong>Results: </strong>Significant age-related differences in VD were observed across all rhesus macaque groups in the three retinal layers and the choroid. In the superficial retina, the maximum VD values across all groups were observed in the 3-6 mm region. In all groups, the highest VD values for both the deep and inner retinal layers were observed in the 1-3 mm region. Furthermore, VD values across all retinal layers increased in the juvenile group compared with the infant group, whereas they decreased in the elderly group compared with the adult group. Results for the choroidal VD in the central region indicated that VD values across all groups were highest at 1-3 mm. The trend of age-related changes in choroidal VD corresponds with that of retinal VD.</p><p><strong>Conclusions: </strong>Superficial VD peaks at 3-6 mm, while deep, inner, and choroidal VD all reach their maximum at 1-3 mm. These values typically peak during adolescence and gradually decline with age.</p>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":" ","pages":"111246"},"PeriodicalIF":3.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets.","authors":"Xiaoyan Zhu, Tao Jin, Yu Zhang, Lulu Lian, Wanli Du","doi":"10.1016/j.exer.2026.111157","DOIUrl":"https://doi.org/10.1016/j.exer.2026.111157","url":null,"abstract":"<p><p>Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and remains a major cause of visual impairment and blindness in adults. Accumulating evidence indicates that DR is not merely a microvascular disorder, but a complex neurovascular disease driven by long-standing hyperglycemia, metabolic dysregulation, oxidative stress, chronic inflammation, neurodegeneration, and impaired neurovascular coupling. Mitochondria are central regulators of cellular energy metabolism and redox homeostasis, and mitochondrial dysfunction is increasingly recognized as a pivotal mechanism linking hyperglycemia-induced metabolic abnormalities to retinal neurovascular unit injury. Under persistent hyperglycemic conditions, excessive glucose flux and metabolic overload promote mitochondrial reactive oxygen species (ROS) overproduction, mitochondrial DNA (mtDNA) damage, impaired oxidative phosphorylation, mitochondrial fusion-fission imbalance, defective mitochondrial biogenesis, dysregulated mitophagy, metabolic reprogramming, and epigenetic alterations. These abnormalities lead to ATP depletion, inflammatory amplification, and activation of multiple forms of programmed cell death, including apoptosis, ferroptosis, pyroptosis, necroptosis, and poly(ADP-ribose) polymerase 1 (PARP1)-dependent cell death. Mitochondrial injury affects retinal endothelial cells, pericytes, Muller cells, microglia, retinal ganglion cells, photoreceptors, and retinal pigment epithelial cells in a cell-type-specific manner, ultimately contributing to blood-retinal barrier disruption, capillary occlusion, neurovascular coupling impairment, retinal neurodegeneration, and progression from non-proliferative to proliferative DR. This review summarizes recent advances in mitochondrial dysfunction in DR, focusing on oxidative stress, mtDNA injury, mitochondrial metabolic reprogramming, mitochondrial dynamics, mitochondrial biogenesis, mitophagy, epigenetic regulation, mitochondria-associated cell death, and neurovascular unit dysfunction. Emerging mitochondria-targeted therapeutic strategies, including mitochondrial antioxidants, modulation of mitochondrial biogenesis and dynamics, mitophagy regulation, mtDNA protection, ferroptosis and inflammasome inhibition, epigenetic intervention, are also discussed. A deeper understanding of mitochondrial mechanisms may provide new therapeutic targets and translational opportunities for DR prevention and treatment.</p>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":" ","pages":"111157"},"PeriodicalIF":3.1,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based diagnostic classification of multiple sclerosis using multicenter optical coherence tomography data","authors":"Zahra Khodabandeh ,&nbsp;Hossein Rabbani ,&nbsp;Neda Shirani Bidabadi ,&nbsp;Fereshteh Ashtari ,&nbsp;David H. Steel ,&nbsp;Jaume Bacardit ,&nbsp;Anya Hurlbert ,&nbsp;Raheleh Kafieh","doi":"10.1016/j.exer.2026.110916","DOIUrl":"10.1016/j.exer.2026.110916","url":null,"abstract":"<div><h3>Background</h3><div>Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, where timely and accurate diagnosis is essential for effective management. Optical coherence tomography (OCT) enables non-invasive evaluation of retinal changes that may serve as biomarkers for MS. Unlike other ophthalmologic diseases, raw cross-sectional OCT images in MS show subtle alterations often indistinguishable from healthy controls (HCs). Consequently, retinal layer thickness and boundary-derived surface features offer greater discriminatory power.</div></div><div><h3>Methods</h3><div>We investigated three categories of artificial intelligence (AI) models: (1) feature extraction with auto-encoder (AE) and shallow networks, (2) custom-designed deep networks, and (3) fine-tuned pre-trained networks. Retinal layer thickness and surface maps derived from OCT were analyzed to determine the most informative features, with channel-wise combination and mosaicing applied for feature integration. Model interpretability was assessed using occlusion sensitivity and Gradient-weighted Class Activation Mapping (Grad-CAM) visualizations. The dataset included 38 HC and 78 MS eyes obtained from independent public and local sources. Patient-wise partitioning was implemented to prevent data leakage.</div></div><div><h3>Results</h3><div>The proposed deep network using channel-wise combined thickness maps of retinal nerve fiber layer (RNFL), ganglion cell and inner plexiform layer (GCIPL), and inner nuclear layer (INL) layers achieved balanced accuracy of 97.3% (SD = 4.16; 95% CI: 92.3–100%), specificity of 97.3% (SD = 5.59; 95% CI: 92.6–100%), sensitivity of 97.4% (SD = 3.54; 95% CI: 92.6–100%), g-mean of 97.3% (SD = 4.18; 95% CI: 92.24-100%), F1-score of 98.0% (SD = 3.86; 95% CI: 92.6–100%), and an AUC of 0.96 (SD = 0.08; 95% CI: 0.95–1.00). Notably, the high performance observed in internal cross-validation was achieved when public and local datasets were combined. However, performance decreased substantially in cross-dataset evaluations, where models were trained on one dataset and tested on the other, indicating limited external generalizability, particularly when trained on public data and applied to local clinical data.</div></div><div><h3>Conclusions</h3><div>AI-based analysis of OCT-derived retinal layer features enables accurate and interpretable classification of MS, supporting its potential as a valuable clinical biomarker.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"266 ","pages":"Article 110916"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comments on “Circadian rhythm disruption induces myopia in mice”","authors":"Wei-Ling Bai ,&nbsp;Mei-Jun Wang ,&nbsp;Jia-He Gan ,&nbsp;Ying Huang ,&nbsp;Zi-Han Liu ,&nbsp;Cong-Ying Li ,&nbsp;Ning-Li Wang ,&nbsp;Shi-Ming Li","doi":"10.1016/j.exer.2026.110889","DOIUrl":"10.1016/j.exer.2026.110889","url":null,"abstract":"","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"266 ","pages":"Article 110889"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of NDUFS1 in mitochondrial dysfunction and oxidative stress in glaucomatous retinal ganglion cells","authors":"Jing Zhang ,&nbsp;Lin Jiang ,&nbsp;Xiao Zheng","doi":"10.1016/j.exer.2026.110913","DOIUrl":"10.1016/j.exer.2026.110913","url":null,"abstract":"<div><div>This study investigates the role of NDUFS1, a subunit of mitochondrial complex I, in glaucomatous retinal ganglion cell (RGC) injury and determines whether it mediates RGC apoptosis through regulating mitochondrial dysfunction and oxidative stress (OS). A microbead-induced glaucoma mouse model was established. Intraocular pressure (IOP) measurements, retinal whole-mount immunofluorescence staining, TUNEL assay, and OS marker detection were conducted to assess RGC survival, apoptosis, and OS. <em>In vitro</em>, NDUFS1 was knocked down or overexpressed in R28 retinal cells. JC-1 staining, adenosine triphosphate (ATP) assay, and flow cytometry were employed to analyze the impacts of NDUFS1 on mitochondrial membrane potential, energy metabolism, OS, and apoptosis. Finally, adeno-associated virus-mediated NDUFS1 overexpression (AAV-oe-NDUFS1) was delivered via intravitreal injection to validate its protective effects <em>in vivo</em>. <em>In vivo</em> experiments revealed downregulation of NDUFS1 expression in the retinas of glaucoma mice, accompanied by significant RGC loss, enhanced OS, and increased apoptosis. <em>In vitro</em>, NDUFS1 knockdown induced mitochondrial membrane depolarization, reduced ATP synthesis, exacerbated OS, and ultimately promoted apoptosis. Conversely, NDUFS1 overexpression effectively reversed these pathological phenotypes. Rescue experiments <em>in vivo</em> further demonstrated that NDUFS1 upregulation alleviated OS, suppressed apoptosis, and significantly improved RGC survival. NDUFS1 downregulation plays a critical role in glaucomatous RGC injury. Overexpression of NDUFS1 improves mitochondrial function, attenuates OS, and enhances cell survival. The study provides novel mechanistic insights into neuroprotection in glaucoma and suggests NDUFS1 as a potential therapeutic target.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"266 ","pages":"Article 110913"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of chemokine and chemokine-receptor gene polymorphisms on the development of diabetic retinopathy in the Turkish cohort","authors":"Ebru Alp ,&nbsp;Egemen Akgun ,&nbsp;Sibel Doguizi ,&nbsp;Fadime Mutlu Icduygu ,&nbsp;Mehmet Ali Sekeroglu ,&nbsp;Murat Atabey Ozer","doi":"10.1016/j.exer.2026.110912","DOIUrl":"10.1016/j.exer.2026.110912","url":null,"abstract":"<div><div>It is known that in many acute and chronic inflammatory diseases, chemokines are secreted into the environment and increase during the inflammation process. Inflammation is thought to be important in the pathogenesis of diabetic retinopathy (DR) and various cytokines and chemokines play a role. Accordingly, the aim of the present study is to determine the relationship between DR and chemokines and their receptor gene polymorphisms (CXCL12, CXCR4, CCL2, CCR2) in Turkish population. This study included 353 patients with type 2 diabetes mellitus (with and without retinopathy) and 204 controls. Genomic DNA was isolated from whole blood and genotype distribution of polymorphisms was determined by PCR-RFLP method. It was determined that the G allele of the CCL2 rs1024611 SNP could prevent the development of DR (1.42 fold) and PDR (proliferative diabetic retinopathy) (1.92 fold). Binary logistic regression analysis also showed that the TT genotype of CXCL12 rs1801157 SNP may have a protective effect (OR = 0.258) on the development of DR. In contrast, CXCR4/rs2228014 and CCR2/rs1799864 SNPs did not show a significant effect on DR in the Turkish population. Findings of the present study suggest that the CCL2 rs1024611 SNP may play a role in the etiology of DR and PDR, and the G allele has a protective effect in Turkish population. Furthermore, TT genotype of CXCL12 rs1801157 SNP may also provide protection against the development of DR. Large-scale studies including a large number of patients are recommended to confirm these results.</div></div>","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"266 ","pages":"Article 110912"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating “Circadian rhythm disruption induces myopia in mice”: The need to consider sex as a biological variable in translational myopia research","authors":"Gang Chen,&nbsp;Yixia Zhang","doi":"10.1016/j.exer.2026.110888","DOIUrl":"10.1016/j.exer.2026.110888","url":null,"abstract":"","PeriodicalId":12177,"journal":{"name":"Experimental eye research","volume":"266 ","pages":"Article 110888"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}