Expert Review of Clinical Immunology最新文献_第6页

The burden of mental health issues in Behçet's disease: implications for patient quality of life. 贝赫切特病的心理健康问题负担：对患者生活质量的影响。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-10-11 DOI: 10.1080/1744666X.2024.2412771

Carlos Eduardo Garcez Teixeira, Fabiano Reis, Marília Paula Souza Dos Santos, Marina Ferreira Simões, Ana Paula Toledo Del Rio, Ibsen Bellini Coimbra, Alisson Pugliesi, Eduardo de Paiva Magalhães, Zoraida Sachetto

{"title":"The burden of mental health issues in Behçet's disease: implications for patient quality of life.","authors":"Carlos Eduardo Garcez Teixeira, Fabiano Reis, Marília Paula Souza Dos Santos, Marina Ferreira Simões, Ana Paula Toledo Del Rio, Ibsen Bellini Coimbra, Alisson Pugliesi, Eduardo de Paiva Magalhães, Zoraida Sachetto","doi":"10.1080/1744666X.2024.2412771","DOIUrl":"10.1080/1744666X.2024.2412771","url":null,"abstract":"Introduction: Depression and anxiety are among the most prevalent mental health conditions in Brazil. Both are associated with poor quality of life (HRQoL) and challenges in disease management for chronic illnesses, including Behçet's disease (BD). This study aimed to evaluate depression, anxiety, and HRQoL in BD patients from a non-endemic area.Research design and methods: This case-control study included adult BD patients from Brazilian tertiary center and healthy controls (HC). All patients fulfilled the ISG and ICBD diagnostic criteria. Depression, anxiety and quality of life were assessed using BDI, HADS, SF-36, and physical capacity with the HAQ.Results: We enrolled 58 BD patients (60% female, mean age 46.1) and 96 HC (74% female, mean age 44). High rates of depression and anxiety were observed in BD patients, correlating with disease activity, younger age, absence of a partner, shorter disease duration, and lower income. BD patients showed significant HRQoL restrictions, particularly in physical and emotional roles, compared to HC. Longer disease duration was correlated with better HRQoL.Conclusion: High rates of depression and anxiety were observed in BD patients, negatively impacting HRQoL, particularly in those with higher disease activity. Further study and clinical attention are warranted to enhance patient care and outcomes.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"103-111"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pioglitazone as a potential modulator in autoimmune diseases: a review on its effects in systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and multiple sclerosis. 吡格列酮作为自身免疫性疾病的潜在调节剂：综述其对系统性红斑狼疮、银屑病、炎症性肠病和多发性硬化症的影响。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-09-16 DOI: 10.1080/1744666X.2024.2401614

Mohammad Esmail Nasrabadi, Ahmed Al-Harrasi, Saeed Mohammadi, Fateme Zarif Azam Kardani, Mina Rahmati, Ali Memarian

{"title":"Pioglitazone as a potential modulator in autoimmune diseases: a review on its effects in systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and multiple sclerosis.","authors":"Mohammad Esmail Nasrabadi, Ahmed Al-Harrasi, Saeed Mohammadi, Fateme Zarif Azam Kardani, Mina Rahmati, Ali Memarian","doi":"10.1080/1744666X.2024.2401614","DOIUrl":"10.1080/1744666X.2024.2401614","url":null,"abstract":"Introduction: Current medications for autoimmune disorders often induce broad-ranging side effects, prompting a growing interest in therapies with more specific immune system modulation. Pioglitazone, known for its anti-diabetic properties, is increasingly recognized for significant immunomodulatory potential. Beyond its traditional use in diabetes management, pioglitazone emerges as a promising therapeutic candidate for autoimmune disorders.Areas covered: This comprehensive review explores pioglitazone's impact on four prominent autoimmune conditions: systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and multiple sclerosis. We focus on pioglitazone's diverse effects on immune cells and cytokines in these diseases, highlighting its potential as a valuable therapeutic option for autoimmune diseases. Here we have reviewed the latest and most current research literature available on PubMed, based on research published in the last 15 years.Expert opinion: Pioglitazone as an immunomodulatory agent can regulate T cell differentiation, inhibit inflammatory cytokines, and promote anti-inflammatory macrophages. While further clinical studies are needed to fully understand its mechanisms and optimize treatment strategies, pioglitazone represents a potential therapeutic approach to improve outcomes for patients with these challenging autoimmune conditions. The future of autoimmune disease research may involve personalized treatment approaches, and collaborative efforts to improve patient quality of life.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"5-15"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol: immunological activity and possible application in children and adolescents with allergic rhinitis. 白藜芦醇：免疫活性及在儿童和青少年过敏性鼻炎患者中的可能应用。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-09-02 DOI: 10.1080/1744666X.2024.2399705

Matteo Naso, Chiara Trincianti, Lorenzo Drago, Maria Daglia, Giulia Brindisi, Francesco Paolo Brunese, Giulio Dinardo, Alessandra Gori, Cristiana Indolfi, Enrico Tondina, Attilio Varricchio, Anna Maria Zicari, Giorgio Ciprandi

引用次数: 0

Late effects following hematopoietic cell transplantation for severe combined immunodeficiency: critical factors and therapeutic options. 造血细胞移植治疗严重合并免疫缺陷症后的晚期效应：关键因素和治疗方案。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-09-22 DOI: 10.1080/1744666X.2024.2402948

Hesham Eissa, Morton J Cowan, Jennifer Heimall

{"title":"Late effects following hematopoietic cell transplantation for severe combined immunodeficiency: critical factors and therapeutic options.","authors":"Hesham Eissa, Morton J Cowan, Jennifer Heimall","doi":"10.1080/1744666X.2024.2402948","DOIUrl":"10.1080/1744666X.2024.2402948","url":null,"abstract":"Introduction: Severe combined immunodeficiency (SCID) is an inborn error of immunity that is fatal without hematopoietic cell transplantation (HCT) or gene therapy (GT). Survival outcomes have improved, largely due to implementation of SCID newborn screening. A better understanding of the long-term outcomes and late effects to address critical aspects of monitoring immune and general health life-long is needed.Areas covered: In a comprehensive review of PubMed indexed articles with publication dates 2008-2024 we describe the current knowledge of chronic and late effects (CLE) of HCT survivors for SCID as well as the role of GT and advances for specific SCID genotypes. We review factors affecting the development of CLE including disease related factors (genotype, trigger for diagnosis and presence of infection prior to HCT), transplant related factors (type of donor, conditioning regimen, immune reconstitution and graft versus host disease (GVHD) and describe causes and factors associated with higher risk for late mortality in this unique population. We further describe monitoring and potential therapeutic strategies for management of common CLE in this patient population.Expert opinion: Ongoing research efforts are needed to better describe CLE in survivors, to develop prospective clinical trials aimed at mitigating these CLE, and developing genotype-based approaches for management and follow-up of these patients.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"73-82"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL-10: the master immunomodulatory cytokine in allergen immunotherapy. IL-10：过敏原免疫疗法中的主要免疫调节细胞因子。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-09-25 DOI: 10.1080/1744666X.2024.2406894

Shixian Liu, Jingyun Li, Yuan Zhang, Chengshuo Wang, Luo Zhang

{"title":"IL-10: the master immunomodulatory cytokine in allergen immunotherapy.","authors":"Shixian Liu, Jingyun Li, Yuan Zhang, Chengshuo Wang, Luo Zhang","doi":"10.1080/1744666X.2024.2406894","DOIUrl":"10.1080/1744666X.2024.2406894","url":null,"abstract":"Introduction: Allergen immunotherapy (AIT) is the only disease-modifying treatment for patients with IgE-mediated allergic diseases. Successful AIT can induce long-term immune tolerance to the common allergen, which provides clinical benefits for years after discontinuation. The cytokine interleukin (IL)-10, as a key anti-inflammatory mediator with strong immunoregulatory functions, has drawn increasing attention over the past decades.Areas covered: After an extensive search of PubMed, EMBASE, and Web of Science databases, covering articles published from 1989 to 2024, our review aims to emphasize the key common information from previous reviews on the crucial involvement of IL-10 in allergen immunotherapy (AIT) induced immunological tolerance. In this review, we discuss the regulation of IL-10 expression and the molecular pathways associated with IL-10 function. We also further summarize mechanisms of immune tolerance induced by AIT, especially the indispensable role of IL-10 in AIT.Expert opinion: IL-10 plays an indispensable role in immune tolerance induced by AIT. Understanding the importance of the role of IL-10 in AIT would help us comprehend the mechanisms thoroughly and develop targeted therapeutics for allergic diseases.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"17-28"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell RNA sequencing: an emerging tool revealing dysregulated innate and adaptive immune response at single cell level in Kawasaki disease. 单细胞 RNA 测序：揭示川崎病单细胞水平先天和适应性免疫反应失调的新兴工具。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2025-01-01 Epub Date: 2024-09-13 DOI: 10.1080/1744666X.2024.2401105

Saniya Sharma, Sumit Goel, Taru Goyal, Rakesh Kumar Pilania, Ridhima Aggarwal, Taranpreet Kaur, Manpreet Dhaliwal, Amit Rawat, Surjit Singh

{"title":"Single-cell RNA sequencing: an emerging tool revealing dysregulated innate and adaptive immune response at single cell level in Kawasaki disease.","authors":"Saniya Sharma, Sumit Goel, Taru Goyal, Rakesh Kumar Pilania, Ridhima Aggarwal, Taranpreet Kaur, Manpreet Dhaliwal, Amit Rawat, Surjit Singh","doi":"10.1080/1744666X.2024.2401105","DOIUrl":"10.1080/1744666X.2024.2401105","url":null,"abstract":"Introduction: Kawasaki disease [KD] is a systemic disorder characterized by acute febrile illness due to widespread medium-vessel vasculitis, mainly affecting children. Despite the ongoing advanced research into the disease pathophysiology and molecular mechanisms, the exact etiopathogenesis of KD is still an enigma. Recently, single-cell RNA sequencing [scRNA-seq], has been utilized to elucidate the pathophysiology of KD at a resolution higher than that of previous methods.Area covered: In the present article, we re-emphasize the pivotal role of this high-resolution technique, scRNA-seq, in the characterization of immune cell transcriptomic profile and signaling/response pathways in KD and explore the diagnostic, prognostic, and therapeutic potential of this new technique in KD. Using combinations of the search phrases 'KD, scRNA-seq, CAA, childhood vasculitis' a literature search was carried out on Scopus, Google Scholar, and PubMed until the beginning of 2024.Expert opinion: scRNA-seq presents a transformative tool for dissecting KD at the cellular level. By revealing rare cell populations, gene expression alterations, and disease-specific pathways, scRNA-seq aids in understanding the intricacies of KD pathogenesis. This review will provide new insights into pathogenesis of KD and the field of applications of scRNA-seq in personalized therapeutics for KD in the future.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"83-92"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-12-12 DOI: 10.1080/1744666X.2024.2441538

引用次数: 0

Isolation and analysis of the exosomal membrane proteins in bullous pemphigoid. 牛皮癣外泌体膜蛋白的分离与分析。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI: 10.1080/1744666X.2024.2396155

Yangchun Liu, Jialing Zhang, Bingjie Zhang, Xuming Mao, Yiman Wang, Yanhong Wang, Meng Fan, Xuan Liu, Jin An, Hongzhong Jin, Li Li

{"title":"Isolation and analysis of the exosomal membrane proteins in bullous pemphigoid.","authors":"Yangchun Liu, Jialing Zhang, Bingjie Zhang, Xuming Mao, Yiman Wang, Yanhong Wang, Meng Fan, Xuan Liu, Jin An, Hongzhong Jin, Li Li","doi":"10.1080/1744666X.2024.2396155","DOIUrl":"10.1080/1744666X.2024.2396155","url":null,"abstract":"Background: Bullous pemphigoid (BP) is a severe autoimmune sub-epidermal bullous disease. Exosomes are small extracellular vesicles secreted by most cell types. The exosomal membrane proteins are implicated in various biological and pathological pathways. This study aims to explore the potential roles of exosomes in BP pathomechanism.Research design: We collected plasma samples from 30 BP patients and 31 healthy controls. Nanoparticle tracking analysis (NTA) was used to analyze the size and concentration of exosomes. The immunogold labelling experiment and extracellular vesicle (EV) array were performed to detect the content and distribution of exosomes.Results: The exosomes from both the BP and control groups' plasma were successfully extracted. EV Array showed that CD63 and CD9 levels were significantly higher in the BP group than in the control group (p < 0.05). Expression levels of the BP180 NC16A and intracellular domain (ICD) were higher in the anti-BP180 positive group versus the controls (p < 0.05). The active BP group exhibits higher CD63 and BP180 ICD protein concentrations than the control or inactive BP groups (p < 0.05).Conclusion: BP180 autoantigen fragments were expressed on the exosomal membrane in BP patients. The BP180 ICD and CD63 on exosomes could potentially be novel biomarkers for monitoring disease activity.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1493-1501"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of neurological manifestations, existence of diabetes mellitus, and 5-year mortality and cancer association outcomes in a cohort of Omani patients with positive anti- GAD autoimmunity. 一组抗 GAD 自身免疫阳性的阿曼患者的神经系统表现谱系、是否患有糖尿病以及 5 年死亡率和癌症相关性结果。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI: 10.1080/1744666X.2024.2395853

Ammar Alobaidy, Mulham Alsulaimi, Ameer Alajmi

{"title":"Spectrum of neurological manifestations, existence of diabetes mellitus, and 5-year mortality and cancer association outcomes in a cohort of Omani patients with positive anti- GAD autoimmunity.","authors":"Ammar Alobaidy, Mulham Alsulaimi, Ameer Alajmi","doi":"10.1080/1744666X.2024.2395853","DOIUrl":"10.1080/1744666X.2024.2395853","url":null,"abstract":"Objectives: There is scarce data in the literature concerning the anti-GAD65 antibodies (GAD-Abs) autoimmunity in the Omani population.Methods: Retrospective cohort study included GAD-Abs positive patients (n = 444) presented to a tertiary referral center in Oman from January 2005 until January 2018, with a five-year follow-up to study the cancer association and mortality outcomes.Results: Out of 444 patients, 27 patients (6.1%) showed GAD-Abs related neurological disorders. Adult age group was significantly associated with more GAD-Abs related neurological manifestations compared to pediatric and adolescents age group (p = 0.045). There was no association between the presence or absence of neurological manifestations with diabetes mellitus nor the titer level of GAD-Abs. Refractory status epilepticus and stiff person syndrome were the main causes of death in patients with neurological manifestations over five years and none of them found to have associated cancer.Conclusion: The GAD-Abs autoimmunity represents a spectrum of neurological manifestations with variable severity and outcome among Omanis with positive GAD-Abs testing. The results of this study will serve as a platform for future studies to address the impact of GAD-Abs autoimmunity on the morbidity, mortality and treatment efficacy in the Omani population.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1483-1492"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathophysiology of rejection in kidney transplantation. 肾移植排斥反应的病理生理学。

IF 3.9 3区医学

Expert Review of Clinical Immunology Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1080/1744666X.2024.2421310

David Cucchiari, Manuel Alfredo Podestà, Claudio Ponticelli

{"title":"Pathophysiology of rejection in kidney transplantation.","authors":"David Cucchiari, Manuel Alfredo Podestà, Claudio Ponticelli","doi":"10.1080/1744666X.2024.2421310","DOIUrl":"10.1080/1744666X.2024.2421310","url":null,"abstract":"Introduction: Rejection remains a major obstacle to successful kidney transplantation. The complex pathophysiology of rejection depends on a fine-tuned interplay between the innate and adaptive immune systems.Areas covered: This review provides a comprehensive analysis of the pathophysiology of rejection of kidney grafts, performed through careful selection of most relevant papers available on the topic in the PubMed database. The two types of rejection usually observed at the kidney biopsy, i.e. cellular and humoral rejection, are described with an accurate outline of the biological processes that lead to their development.Expert opinion: The incidence of T-cell-mediated rejection is decreasing, and most cases promptly respond to appropriate immunosuppression. However, late diagnosis or incomplete response to treatment may have deleterious consequences in the long term. The main issue is represented by antibody-mediated rejection, which unsatisfactorily responds to aggressive immunosuppression, especially when diagnosed late. Prevention of acute ABMR rests on HLA-specific antibody detection prior to transplantation, adequate immunosuppression, and optimal patients' compliance. Late diagnosis and poor response to treatment inevitably lead to chronic ABMR, for which no therapies are currently available.","PeriodicalId":12175,"journal":{"name":"Expert Review of Clinical Immunology","volume":" ","pages":"1471-1481"},"PeriodicalIF":3.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0