European Thyroid Journal最新文献_第2页

Effects of iodine contrast media on thyroid function - a prospective study. 碘造影剂对甲状腺功能的影响--一项前瞻性研究。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-11 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0244

Jeanette Carlqvist, Ulf Nyman, John Brandberg, Helena Filipsson Nyström, Mikael Hellström

{"title":"Effects of iodine contrast media on thyroid function - a prospective study.","authors":"Jeanette Carlqvist, Ulf Nyman, John Brandberg, Helena Filipsson Nyström, Mikael Hellström","doi":"10.1530/ETJ-24-0244","DOIUrl":"10.1530/ETJ-24-0244","url":null,"abstract":"Objectives: When exposed to iodine contrast medium (ICM), thyroid dysfunction may develop, due to excess amounts of iodide. The incidence of contrast-induced thyroid dysfunction has been difficult to interpret, because of the observational and retrospective designs of most previous studies. With the Swedish CArdioPulmonary bioImage Study (SCAPIS), where randomly selected individuals aged 50-65 years, underwent contrast-enhanced coronary CT angiography (CCTA), we were able to prospectively assess the incidence, magnitude and clinical impact of contrast-induced thyroid dysfunction.Methods: In 422 individuals, thyroid hormone levels were analysed before and 4-12 weeks after CCTA. Thyroid-related patient-reported outcome questionnaires (ThyPRO) at the time of pre and post-CCTA blood samplings were provided by 368 of those individuals. Thyroid peroxidase antibodies (TPOab) were analysed and an ultrasound of the thyroid gland was performed to detect any thyroid nodules.Results: There was a small statistically significant effect on thyroid hormone levels but no cases of overt hypo- or hyperthyroidism after ICM. Subclinical hypo- or hyperthyroidism or isolated low/high levels of free thyroxine (fT4) developed in 3.5% of the population with normal hormone levels pre-CCTA but without any increased thyroid-related symptoms compared to the remaining cohort. Elevated TPOab and being born outside Sweden were risk factors for developing subclinical hypothyroidism. The presence of thyroid nodules was not associated with ICM-induced thyroid dysfunction.Conclusion: The results of this prospective study support the notion that in iodine-sufficient countries, ICM-associated thyroid dysfunction is rare, usually mild, self-limiting and oligo/asymptomatic in subjects aged 50-65 years.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graves' hyperthyroidism treated with potassium iodide: early response and after 2 years of follow-up. 用碘化钾治疗巴塞杜氏甲状腺功能亢进症：早期反应和两年随访。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-08 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0085

Megumi Fujikawa, Ken Okamura

{"title":"Graves' hyperthyroidism treated with potassium iodide: early response and after 2 years of follow-up.","authors":"Megumi Fujikawa, Ken Okamura","doi":"10.1530/ETJ-24-0085","DOIUrl":"10.1530/ETJ-24-0085","url":null,"abstract":"Objective: As thionamide is associated with various adverse effects, we re-evaluated the practical efficacy of potassium iodide (KI) therapy for Graves' hyperthyroidism (GD).Methods: We administered KI (mainly 100 mg/day) to 324 untreated GD patients and added methimazole (MMI) only to those remaining thyrotoxic even at 200 mg/day. When the patient became hypothyroid, MMI, if taken was stopped, then levothyroxine (LT4) was added without reducing the KI dose. Radioactive iodine (RI) therapy or thyroidectomy was performed whenever required. We evaluated the early effects of KI at 2-4 weeks and followed patients for 2 years.Results: At 2 weeks, serum thyroid hormone levels decreased in all 324 patients. At 4 weeks, fT4, fT3, and both fT4 and fT3 levels became normal or low in 74.7%, 50.6%, and 50.6% of patients, respectively. In a cross-sectional survey over 2 years, GD was well-controlled with KI or KI + LT4 (KI-effective) in >50% of patients at all time points. Among 288 patients followed for 2 years, 42.7% remained 'KI-effective' throughout the 2 years (KI Group), 30.9% were well-controlled with additional MMI given for 1-24 months, and 26.4% were successfully treated with ablative therapy (mainly RI). Among 'KI-effective' patients at 4 weeks, 76.5% were classified into the KI Group. No patients experienced adverse effects from KI.Conclusion: KI therapy was useful in the treatment of GD. A sufficient dose of KI was effective in >50% of GD patients from 4 weeks to 2 years, and 42.7% (76.5% of 'KI-effective' patients at 4 weeks) remained 'KI-effective' throughout the 2 years.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echogenicity as a standalone nodule characteristic is not inferior to the TIRADS systems in the 10-20 mm nodule diameter range in patient selection for fine needle aspiration: a pilot study. 在选择患者进行细针穿刺时，在结节直径为 10 至 20 毫米的范围内，作为独立结节特征的回声不劣于 TIRADS 系统；一项试点研究。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-06 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0149

Karoly Rucz, Laszlo Hegedűs, Steen Joop Bonnema, Andrea Frasoldati, Laszlo Jambor, Gabor Laszlo Kovacs, Enrico Papini, Gilles Russ, Zsolt Karanyi, Endre V Nagy, Tamas Solymosi

{"title":"Echogenicity as a standalone nodule characteristic is not inferior to the TIRADS systems in the 10-20 mm nodule diameter range in patient selection for fine needle aspiration: a pilot study.","authors":"Karoly Rucz, Laszlo Hegedűs, Steen Joop Bonnema, Andrea Frasoldati, Laszlo Jambor, Gabor Laszlo Kovacs, Enrico Papini, Gilles Russ, Zsolt Karanyi, Endre V Nagy, Tamas Solymosi","doi":"10.1530/ETJ-24-0149","DOIUrl":"10.1530/ETJ-24-0149","url":null,"abstract":"Objective: The ultrasound evaluation of thyroid nodules (TNs) in patient selection for fine needle aspiration (FNA) requires both uniformly accepted definitions of each nodule characteristic and extensive experience from the examiner. We hypothesized that nodule echogenicity alone may provide comparable performance to more complex approaches in patient selection for FNA.Patients and methods: Seven highly experienced investigators from four countries evaluated, online, the ultrasound (US) video recordings of 123 histologically verified TN by answering 17 nodule characteristics-related questions. The diagnostic performances of five TN image reporting and data systems (TIRADS) were compared to making decisions based solely on the echogenicity of the nodule for indicating FNA in 110 nodules ≥10 mm.Results: In the 10-20 mm size range, the sensitivities and specificities of the five TIRADS systems in identifying malignant nodules were 80.5-91.0% and 31.4-50.9%, respectively. Had FNA been recommended for all hypoechoic nodules, disregarding other US characteristics, comparable sensitivity and specificity (87.5% and 43.4%, respectively) were obtained. Compared to nodules >20 mm, a higher proportion of cancers were hypoechoic in the 10-20 mm size range (87.2% vs 77.8%, P = 0.05). In the 10-20 mm size range, compared to hypoechoic nodules, a significantly lower proportion of isoechoic nodules demonstrated suspicious findings (70.7% vs 30.0%, P < 0.05).Conclusion: In contrast to >20 mm diameter nodules, the recommendation of FNA may rely on a single US feature, echogenicity, in the 10-20 mm size range. If independently confirmed in larger cohorts, this may simplify nodule evaluation in this size range.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of genetics and epigenetics in Graves' orbitopathy. 遗传学和表观遗传学在巴塞杜氏眶病中的作用。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-06 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0179

Michele Marinò, Giovanna Rotondo Dottore, Francesca Menconi, Simone Comi, Giada Cosentino, Roberto Rocchi, Francesco Latrofa, Michele Figus, Ferruccio Santini

{"title":"Role of genetics and epigenetics in Graves' orbitopathy.","authors":"Michele Marinò, Giovanna Rotondo Dottore, Francesca Menconi, Simone Comi, Giada Cosentino, Roberto Rocchi, Francesco Latrofa, Michele Figus, Ferruccio Santini","doi":"10.1530/ETJ-24-0179","DOIUrl":"10.1530/ETJ-24-0179","url":null,"abstract":"Objectives: The pathogenesis of Graves' orbitopathy (GO) remains to be fully elucidated. Here, we reviewed the role of genetics and epigenetics.Design: We conducted a PubMed search with the following keywords: GO, thyroid eye disease; or Graves' ophthalmopathy; or thyroid-associated ophthalmopathy; and: genetic, or epigenetic, or gene expression, or gene mutation, or gene variant, or gene polymorphism, or DNA methylation, or DNA acetylation. Articles in which whole DNA and/or RNA sequencing, proteome, and methylome analyses were performed were chosen.Results: The different prevalence of GO in the two sexes, as well as racial differences, suggest that genetics play a role in GO pathogenesis. In addition, the long-lasting phenotype of GO and patient-derived orbital fibroblasts suggests a genetic or epigenetic mechanism. Although no genes have been found to confer a specific risk for GO, differential gene expression has been reported in orbital fibroblasts from GO patients vs control fibroblasts, suggesting that an epigenetic mechanism may be involved. In this regard, a different degree of DNA methylation, which affects gene expression, has been found between GO and control fibroblasts, which was confirmed by whole methylome analysis. Histone acetylation and deacetylation, which also affect gene expression, remain to be investigated.Conclusions: Although no pathogenic gene variants have been reported, epigenetic mechanisms elicited by an initial autoimmune insult seem to be needed for differential gene expression to occur and, thus, for GO to develop and persist over time.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and gender difference of brain metastases in newly diagnosed follicular thyroid cancer patients. 新确诊滤泡型甲状腺癌患者脑转移的发生率和性别差异

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-01 DOI: 10.1530/ETJ-24-0093

Ruiguo Zhang, Weijian Li, Hui Wang, Wenxin Zhang, Jinyan Chai, Pengpeng Chang, Qiang Jia, Wei Zheng

{"title":"Incidence and gender difference of brain metastases in newly diagnosed follicular thyroid cancer patients.","authors":"Ruiguo Zhang, Weijian Li, Hui Wang, Wenxin Zhang, Jinyan Chai, Pengpeng Chang, Qiang Jia, Wei Zheng","doi":"10.1530/ETJ-24-0093","DOIUrl":"https://doi.org/10.1530/ETJ-24-0093","url":null,"abstract":"Background: Population-based estimates of brain metastases in follicular thyroid cancer (FTC) patients with or without distant metastases (DMs) at diagnosis are lacking.Objective: To study the prevalence of brain metastases in FTC patients and compare gender disparity.Methods: DMs are defined as bone, lung, and brain metastases. Using the SEER database, we identified 5116 patients diagnosed with FTC between 2010 and 2019. The incidences of brain metastases were calculated for the entire cohort and among patients with bone/lung metastases. Cohorts were stratified by gender and age.Results: 4.8% (245) had DMs at diagnosis, primarily in the form of bone metastases (3.6%), followed by lung metastases (2.4%). The incidence of brain metastases at initial diagnosis was only 0.37% (17 females and 2 males), but occurred in 8.2% and 6.1% of patients with bone metastases and lung metastases, respectively. Median survival for patients with brain metastases was only 8.0 months (95% CI, 4.1-11.9). Interestingly, female patients with bone metastases exhibited a significantly higher incidence of brain metastases compared to males (12.0% vs. 1.5%), with a notable odds ratio of 8.971 (95% CI:1.152-69.835) in univariate analysis. Multivariate logistic regression analysis confirmed that being female (odds ratio, 10.08; 95% CI:1.243-81.748) was the sole statistically significant risk factor for brain metastases in FTC patients with bone metastases at diagnosis.Conclusion: An incidence of brain metastases is observed in newly diagnosed FTC patients with DMs, especially in females with bone involvement. Our findings advocate for the early detection of brain metastases in female FTC patients with concurrent bone metastases at diagnosis.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New diagnostic approach to central hypothyroidism after traumatic brain injury in children and adolescents.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-01 DOI: 10.1530/ETJ-24-0184

Geraldo Miranda Graça, Luiz Roberto Aguiar, Luiz De Lacerda

{"title":"New diagnostic approach to central hypothyroidism after traumatic brain injury in children and adolescents.","authors":"Geraldo Miranda Graça, Luiz Roberto Aguiar, Luiz De Lacerda","doi":"10.1530/ETJ-24-0184","DOIUrl":"10.1530/ETJ-24-0184","url":null,"abstract":"Background: Pituitary lesions after traumatic brain injury (TBI) are frequent in children and adolescents, but the rate of post-TBI central hypothyroidism (CH) remains uncertain.Objective: To identify the long-term incidence of post-TBI CH and the clinical and laboratory characteristics of this complication in children and adolescents.Methods: The analysis included 31 patients with a history of TBI with at least 1 year of follow-up. Patients were evaluated at hospital admission and every 3 months thereafter. Assessments included clinical evaluation, brain CT, and hormone assessments (basal fT4, IGF-1, cortisol, and ACTH; ITT/TRH test with TSH, GH, and cortisol measurement; and CRH test, if indicated). The CH diagnosis was based on clinical and laboratory findings and a therapeutic trial with levothyroxine.Results: Overall, 5 patients (16%) developed CH (3 with associated adrenal insufficiency). At 3 and 12 months, median fT4 values were lower in patients with CH compared with those without anterior pituitary dysfunction (n=18; p=0.01). Patients with CH received levothyroxine and progressed with clinical resolution and increased median fT4 (from 0.92 to 1.47 ng/dL) and IGF-1 (from -2.08 to -0.22 standard deviation scores [SDS]) levels. Temporary suspension of levothyroxine was accompanied by decreased median fT4 (1.02 ng/dL) and IGF-1 (-1.07 SDS) levels and reappearance of clinical symptoms, which resolved once levothyroxine was reinitiated.Conclusions: The longer follow-up, valorization of clinical manifestations, nontraditional laboratory approach, and therapeutic trial with levothyroxine in the present study revealed a higher rate of post-TBI CH in children and adolescents than that reported in the literature.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto's thyroiditis via the complement pathway. IgG4 糖基化通过补体途径促进了 IgG4 桥本氏甲状腺炎的发病机制。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-10-24 Print Date: 2024-10-01 DOI: 10.1530/ETJ-24-0156

Chenxu Zhao, Zhiming Sun, Shuaihang Wang, Jixin Zhang, Jumei Liu, Lei Chen, Guizhi Lu, Yang Yu, Ying Gao

{"title":"IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto's thyroiditis via the complement pathway.","authors":"Chenxu Zhao, Zhiming Sun, Shuaihang Wang, Jixin Zhang, Jumei Liu, Lei Chen, Guizhi Lu, Yang Yu, Ying Gao","doi":"10.1530/ETJ-24-0156","DOIUrl":"10.1530/ETJ-24-0156","url":null,"abstract":"Background: To explore whether IgG4 is involved in the pathogenesis of IgG4 HT.Methods: Serum TgAb IgG4 and TPOAb IgG4 were measured in IgG4 HT and non-IgG4 HT. C1q, mannose-binding lectin (MBL), Bb, C3d, C4d, and membrane attack complex (MAC) in thyroid tissues from IgG4 HT, non-IgG4 HT, and controls were examined by immunohistochemistry. We assessed IgG4 and MAC deposition in mouse thyroid by immunohistochemistry after injecting purified IgG4 into mice. The glycosylation patterns of TgAb IgG4 from IgG4 HT were identified by MALDI-TOF-MS. The ability of IgG4 to bind to MBL before and after deglycosylation was assessed by ELISA. MBL and MAC fluorescence were detected in thyrocytes after the addition of IgG4 or deglycosylated IgG4.Results: Serum TgAb IgG4 and TPOAb IgG4 levels were significantly higher in the IgG4 HT group. MBL, Bb, C3d, C4d, and MAC levels were significantly higher in the thyroid tissues of IgG4 HT than in non-IgG4 HT (all P < 0.001). IgG4 colocalized with MBL by immunofluorescence. In mice, follicular cell structure disruption was observed after the injection of IgG4 from IgG4 HT, as well as the colocalization of IgG4 with MAC. High levels of TgAb IgG4 glycosylation patterns, including monogalactose glycan (G1F), galactose-deficient glycan (G0F), and high-mannose glycan (M5), were detected in IgG4 HT. After deglycosylation, IgG4 reduced its ability to bind to MBL, and there was low MBL and MAC activation in thyrocytes.Conclusion: High levels of IgG4 glycosylation patterns, including G1F, G0F, and M5, may activate the complement lectin pathway, thereby participating in the pathogenesis of IgG4 HT.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apalutamide-induced severe hypothyroidism: case series and practice recommendations for thyroid management. 阿帕鲁胺诱发的严重甲状腺功能减退症：系列病例和甲状腺管理实践建议。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-10-16 Print Date: 2024-10-01 DOI: 10.1530/ETJ-24-0158

Karel David, Paul Van Crombrugge, Anne-Marie Van der Biest, Frederiek D'Hondt, Frank Claessens, Alexander Giesen, Steven Joniau, Brigitte Decallonne

引用次数: 0

Management of follicular thyroid carcinoma. 甲状腺滤泡癌的治疗。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-10-16 Print Date: 2024-10-01 DOI: 10.1530/ETJ-24-0146

Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Wataru Kitagawa, Mitsuji Nagahama, Aya Saito, Koichi Ito

{"title":"Management of follicular thyroid carcinoma.","authors":"Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Wataru Kitagawa, Mitsuji Nagahama, Aya Saito, Koichi Ito","doi":"10.1530/ETJ-24-0146","DOIUrl":"10.1530/ETJ-24-0146","url":null,"abstract":"Follicular thyroid carcinoma (FTC) is the second most common histological type of thyroid carcinoma. This review aims to summarize the available evidence and guidelines and provide an updated consensus regarding the management of FTC. The cytoarchitectural features of FTC are similar to those of follicular adenoma (FA), and it is difficult to preoperatively distinguish between FA and FTC. For nodules with Bethesda class III-V cytology, molecular test results (if available) should be considered before the operation. However, it should be noted that molecular tests are not available in all countries. The goals of initial surgical therapy for patients with FTC are to improve overall and disease-specific survival, reduce the risk of persistent/recurrent disease and associated morbidity, and permit accurate disease staging and risk stratification while minimizing treatment-related morbidity and unnecessary therapy. Previous studies have reported some prognostic factors such as distant metastasis, age, tumor size, vascular invasion, TERT promoter mutation, and histological subtype. In particular, the degree of vascular invasion is becoming increasingly important. Evaluating these prognostic factors is essential for prognostic prediction and precise management of patients with FTC. Recurrence and distant metastasis of FTC are treated with radioactive iodine (RAI). However, some FTCs become refractory to RAI. Multi-tyrosine kinase inhibitors such as sorafenib and lenvatinib are utilized for treating RAI-refractory FTCs. In addition, given that renin-angiotensin system (RAS) is the most common driver gene for FTC, it is also important to develop RAS inhibitors.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":"13 5","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. 在两种人类肝细胞模型中，TBL1X 的功能紊乱对 T3 调控基因的表达有不同影响。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-10-14 Print Date: 2024-10-01 DOI: 10.1530/ETJ-24-0162

Yalan Hu, Lorraine Soares De Oliveira, Kim Falize, A S Paul van Trotsenburg, Eric Fliers, Joseph E Kaserman, Andrew A Wilson, Anthony N Hollenberg, Eveline Bruinstroop, Anita Boelen

{"title":"Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models.","authors":"Yalan Hu, Lorraine Soares De Oliveira, Kim Falize, A S Paul van Trotsenburg, Eric Fliers, Joseph E Kaserman, Andrew A Wilson, Anthony N Hollenberg, Eveline Bruinstroop, Anita Boelen","doi":"10.1530/ETJ-24-0162","DOIUrl":"10.1530/ETJ-24-0162","url":null,"abstract":"Background: Mutations in TBL1X, part of the NCOR1/SMRT corepressor complex, were identified in patients with hereditary X-linked central congenital hypothyroidism and associated hearing loss. The role of TBL1X in thyroid hormone (TH) action, however, is incompletely understood. The aim of the present study was to investigate the role of TBL1X on T3-regulated gene expression in two human liver cell models.Methods: A human hepatoma cell line (HepG2) wherein TBL1X was downregulated using siRNAs, and human-induced pluripotent stem cell-derived hepatocytes (iHeps) generated from individuals with a TBL1X N365Y mutation. Both cell types were treated with increasing concentrations of T3. The expression of T3-regulated genes was measured by qPCR.Results: KLF9, CPT1A, and PCK1 mRNA expression were higher upon T3 stimulation in the HepG2 cells with decreased TBL1X expression compared to controls, while DIO1 mRNA expression was lower. Hemizygous TBL1X N365Y iHeps exhibited decreased expression of CPT1A, G6PC1, PCK1, FBP1, and ELOVL2 compared to cells with the heterozygous TBL1X N365Y allele, but KLF9 and HMGCS2 expression was unaltered.Conclusion: Downregulation of TBL1X in HepG2 cells and the TBL1X N365Y variant in iHeps have differential effects on T3-regulated gene expression. This suggests that TBL1X may play a gene context role in TH action.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0