European Thyroid Journal最新文献

MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing? 甲状腺滤泡结节病和甲状腺癌中的微RNA调控基因突变：时机是否决定一切？

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-19 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0298

Vincenzo Condello, C Christofer Juhlin

{"title":"MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?","authors":"Vincenzo Condello, C Christofer Juhlin","doi":"10.1530/ETJ-24-0298","DOIUrl":"10.1530/ETJ-24-0298","url":null,"abstract":"In recent years, germline mutations in the microRNA (miRNA) processor genes DICER1 and DGCR8 have been coupled to the development of thyroid follicular nodular disease (TFND), thereby casting new light on the etiology of this enigmatic, benign condition in non-iodine-deficient regions. Moreover, DICER1 and DGCR8 mutations have also been reported in rare subsets of follicular cell-derived thyroid carcinomas. Specifically, truncating germline or missense somatic DICER1 mutations have been reported in small subsets of pediatric and adolescent follicular thyroid carcinoma (FTC) and poorly differentiated thyroid carcinoma (PDTC). Similarly, a recurrent somatic mutation of the DGCR8 gene has been observed in highly aggressive FTCs and in some indolent cases of encapsulated follicular variant of papillary thyroid carcinoma. The reason why identical mutations in the same miRNA processor gene can lead to such a myriad of thyroid conditions, ranging from benign TFND to FTCs and PDTCs, remains unclear. This review highlights key features of miRNA regulator gene mutations in thyroid disease and explores their potential roles as drivers or progression events in tumor development.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiposity is associated with a higher number of thyroid nodules and worse FNA outcomes.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-01 DOI: 10.1530/ETJ-24-0176

Elpida Demetriou, Aliki Economides, Maria Fokou, Demetris Lamnisos, Stavroula A Paschou, Panagiotis Papageorgis, Panayiotis A Economides

{"title":"Adiposity is associated with a higher number of thyroid nodules and worse FNA outcomes.","authors":"Elpida Demetriou, Aliki Economides, Maria Fokou, Demetris Lamnisos, Stavroula A Paschou, Panagiotis Papageorgis, Panayiotis A Economides","doi":"10.1530/ETJ-24-0176","DOIUrl":"https://doi.org/10.1530/ETJ-24-0176","url":null,"abstract":"Background: Adiposity may be associated with thyroid nodularity. However, its impact on the number of nodules and the risk of malignancy is unclear.Aim: To evaluate the impact of adiposity on thyroid nodules using Body Mass Index (BMI), ultrasonographic (US) and cytological data.Methods: A retrospective cohort study of 310 patients with thyroid nodules was performed. Patients were categorized based on their BMI, and grayscale US data and fine-needle aspiration (FNA) cytology results were evaluated.Results: Patients with BMI ≥25 Kg/ m² were found to have a higher number of thyroid nodules compared to those with BMI <25 Kg/ m² (4.25 ±2.42 vs. 3.66 ± 1.93) (P value=0.05). Patients with BMI ≥25 Kg/ m² had more suspicious and malignant cytology than those with BMI <25 Kg/ m² (P value = 0.029). Patients with BMI ≥25 Kg/m² had more nodules with intermediate and high suspicion sonographic patterns. However, this did not reach statistical significance.Conclusion: Overweight and obese patients have a trend for more thyroid nodules and have a higher risk of being diagnosed with thyroid malignancy.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A national survey of physicians regarding active surveillance for low-risk thyroid cancer in Korea.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-01 DOI: 10.1530/ETJ-24-0281

Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-Hoon Kim, Woojin Lim, KyungSik Kim, Sue K Park, Young Joo Park

{"title":"A national survey of physicians regarding active surveillance for low-risk thyroid cancer in Korea.","authors":"Min Joo Kim, Jae Hoon Moon, Eun Kyung Lee, Young Shin Song, Kyong Yeun Jung, Ji Ye Lee, Ji-Hoon Kim, Woojin Lim, KyungSik Kim, Sue K Park, Young Joo Park","doi":"10.1530/ETJ-24-0281","DOIUrl":"https://doi.org/10.1530/ETJ-24-0281","url":null,"abstract":"Objective: Active surveillance (AS) has emerged as a viable alternative to immediate surgery for low-risk thyroid cancer. However, several barriers still hinder its widespread adoption and implementation by physicians.Methods: In 2024, an email survey was conducted among members of the Korea Thyroid Association to assess their perspectives on AS. The survey comprised questions about clinical case scenarios, perceptions of the benefits and risks associated with AS, factors influencing the consideration of AS, and unmet needs for the implementation of AS.Results: Among the 287 physicians surveyed, 40.8% were endocrinologists, followed by general surgeons at 20.9%, and otolaryngologists at 19.9%. The majority worked in tertiary hospitals and had over 10 years of experience. Regarding a 65-year-old man with a 0.7-cm low-risk thyroid cancer, 74.6% of the respondents considered AS. Endocrinologists, physicians with higher self-assessment and experience explaining AS to patients were more inclined to consider AS. Although the respondents recognized the benefits of AS, such as avoiding surgery and reducing surgical complications, they expressed concerns about potential risks, including the possibility of patient lawsuits due to disease progression and patient worry and anxiety about the disease. Challenges in screening candidates for AS were highlighted, especially in detecting recurrent laryngeal nerve involvement and lymph node metastases. Additionally, physicians noted unmet needs in AS implementation, specifically regarding psychological support for patients and reimbursement for long-term follow-up costs.Conclusions: The survey underscored the need for further research and initiatives to overcome the barriers and implement AS for the management of low-risk thyroid cancer.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Influence Factors of Quality of Life in Thyroid Eye Disease: Insights from Machine Learning Approaches.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-01 DOI: 10.1530/ETJ-24-0292

Haiyang Zhang, Shuo Wu, Lehan Yang, Chengjing Fan, Huifang Chen, Hui Wang, Tianyi Zhu, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou, Terry J Smith, Xianqun Fan

{"title":"Investigating the Influence Factors of Quality of Life in Thyroid Eye Disease: Insights from Machine Learning Approaches.","authors":"Haiyang Zhang, Shuo Wu, Lehan Yang, Chengjing Fan, Huifang Chen, Hui Wang, Tianyi Zhu, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou, Terry J Smith, Xianqun Fan","doi":"10.1530/ETJ-24-0292","DOIUrl":"https://doi.org/10.1530/ETJ-24-0292","url":null,"abstract":"Aims: Thyroid eye disease (TED) is an autoimmune orbital disorder that diminishes the quality of life (QOL) for affected individuals. The Graves' ophthalmopathy (GO)-QOL questionnaire effectively assesses TED's impact on patients. This study aims to investigate factors influencing visual functioning (QOL-VF) and physical appearance (QOL-AP) scores in Chinese TED patients using innovative data analysis methods.Methods: This cross-sectional study included 211 TED patients whose initial visit to our clinic was from July 2022 to March 2023. Patients with previous ophthalmic surgery or concurrent severe diseases were excluded. GO-QOL questionnaires, detailed medical histories, and clinical examinations were collected. The distribution of GO-QOL scores was analyzed, and linear regression and machine learning algorithms were utilized.Results: The median QOL-VF and QOL-AP scores were 64.29 and 62.5, respectively. Multivariate linear regression analysis revealed age (p=0.013), ocular motility pain (p=0.012), vertical strabismus (p<0.001), and diplopia scores as significant predictors for QOL-VF. For QOL-AP, gender (p=0.013) and clinical activity (p=0.086) were significant. The XGBoost model demonstrated superior performance, with an R2 of 0.872 and an Root Mean Square Error (RMSE) of 11.083. SHapley Additive exPlanations (SHAP) analysis highlighted the importance of vertical strabismus, diplopia score, and age in influencing QOL-VF, and age, clinical activity, and sex in QOL-AP.Conclusion: TED significantly impacts patient QOL. The study highlights the efficacy of XGBoost and SHAP analyses in identifying key factors influencing QOL in TED patients. Identifying impactful interventions and considering specific demographic characteristics are essential to improving the QOL of patients with TED.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid response to blocking sympathetic activity in chronic cold exposed hunters in East Greenland: a case-control study.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-01 DOI: 10.1530/ETJ-24-0272

Mette Motzfeldt Jensen, Charlotte Almasi, Hans Christian Florian Sørensen, Stine Linding Andersen, Stig Andersen

{"title":"Thyroid response to blocking sympathetic activity in chronic cold exposed hunters in East Greenland: a case-control study.","authors":"Mette Motzfeldt Jensen, Charlotte Almasi, Hans Christian Florian Sørensen, Stine Linding Andersen, Stig Andersen","doi":"10.1530/ETJ-24-0272","DOIUrl":"https://doi.org/10.1530/ETJ-24-0272","url":null,"abstract":"Background: Thyroid hormones and sympathetic stimulation are needed for activating Brown adipose tissue (BAT) during cold exposure. Studies of human cold exposure have demonstrated both increased production and raised clearance of triiodothyronine (T3). Greenlandic hunters provide a unique model for evaluating metabolic effects of cold exposure.Aim: We aimed to explore the dynamics of thyroid hormones when blocking sympathetic activity in Greenlandic hunters during winter to inspire knowledge on mechanisms of BAT activation.Methods: We conducted a 7-day field study of Greenlandic hunters (n=7) in East Greenland in February. The sympathetic system was blocked using a non-selective beta blocker for seven consecutive days. A group of non-hunter Greenlanders (n = 8) from the same settlement were included for parallel sampling. All participants were healthy men. Blood samples were drawn daily for measurement of TSH, thyroid hormone levels, and thyroglobulin.Results: Hunters had higher serum thyroglobulin, TSH, and high fT3/fT4 ratio compared to controls. Blocking the sympathetic activity was followed by changes in serum thyroglobulin and fT3 with an initial decrease and subsequent restoration of levels, while TSH and fT4 showed a gradual increase over the course of the study. The fT3/fT4 ratio showed a continuous and marked decrease.Conclusion: We hypothesise that when blocking the sympathetic system, TSH increases to uphold the production of T3 needed for maintaining BAT activity. Additionally, alterations of fT3/fT4-ratio support a hypothesis of adrenergic stimulation promoting T3 over T4 secretion from the thyroid via the adrenergic nerve terminals in the thyroid.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of the AmpliSeq NGS Panel in Thyroid Nodules with Indeterminate Cytology.

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-12-01 DOI: 10.1530/ETJ-24-0160

Wiame Potonnier, Erell Guillerm, Claude Bigorgne, Cécile Ghander, Malanie Roy, Florence Coulet, François Ansart, Fabrice Menegaux, Laurence Leenhardt, Isabelle Brocheriou, Gabrielle Deniziaut, Camille Buffet

{"title":"Performance of the AmpliSeq NGS Panel in Thyroid Nodules with Indeterminate Cytology.","authors":"Wiame Potonnier, Erell Guillerm, Claude Bigorgne, Cécile Ghander, Malanie Roy, Florence Coulet, François Ansart, Fabrice Menegaux, Laurence Leenhardt, Isabelle Brocheriou, Gabrielle Deniziaut, Camille Buffet","doi":"10.1530/ETJ-24-0160","DOIUrl":"https://doi.org/10.1530/ETJ-24-0160","url":null,"abstract":"Objective: Fine needle aspiration (FNA) cytological analysis fails to confirm the benignity or malignancy of Bethesda III, IV and V thyroid nodules. Molecular tests performed on FNA samples have demonstrated interesting results in improving the diagnosis of these nodules. The aim of this study was to assess the performance of a large next-generation sequencing (NGS) panel in thyroid nodules with indeterminate cytology (Bethesda III, IV, V).Methods: Retrospective, monocentric study including 121 patients with cytologically indeterminate thyroid nodules (Bethesda III, IV and V), which underwent a routine FNA procedure for molecular testing, using the AmpliSeq general cancer NGS panel, with available final histological diagnosis. The main objective was to estimate the negative predictive value (NPV) of malignancy of the AmpliSeq panel in Bethesda III, and IV thyroid nodules. Performance assessment (sensitivity, specificity, positive predictive value (PPV) and NPV) was carried out in the grouped categories III and IV, in the overall cohort, and in each Bethesda category. The final histological diagnosis was used as the designated gold standard.Results: Histologically, 86 nodules were benign and 35 malignant. Molecular analysis yielded a positive result in 40 nodules. Panel performances assessed in the grouped categories Bethesda III and IV, demonstrated a 55.0% (CI95% [31.5;76.9]) sensitivity, a 76.9% (CI95% [66.0;85.7]) specificity, a 37.9% (CI95% [25.7;51.9]) PPV and an 87.0% (CI95% [80.2;91.7]) NPV, considering a 20 % prevalence of malignancy.Conclusions: The performances of the AmpliSeq panel are promising, however, the NPV is not sufficient to avoid diagnostic surgery in cytologically indeterminate thyroid nodules.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an enzyme-linked immunosorbent assay for newborns dried blood spot thyroglobulin. 为新生儿干血斑甲状腺球蛋白开发酶联免疫吸附试验。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-25 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0142

Camilo Fuentes Peña, María Cecilia Opazo, Luis Méndez, Claudia Riedel, Bernard Hauquier, Lionel Marcelis, Frédéric Cotton, Rodrigo Moreno-Reyes

{"title":"Development of an enzyme-linked immunosorbent assay for newborns dried blood spot thyroglobulin.","authors":"Camilo Fuentes Peña, María Cecilia Opazo, Luis Méndez, Claudia Riedel, Bernard Hauquier, Lionel Marcelis, Frédéric Cotton, Rodrigo Moreno-Reyes","doi":"10.1530/ETJ-24-0142","DOIUrl":"10.1530/ETJ-24-0142","url":null,"abstract":"Background: Thyroglobulin (Tg) is a biomarker of iodine status. Newborn Tg is a more sensitive marker than neonatal TSH in detecting variations in iodine intake. This study aims to validate an enzyme-linked immunosorbent assay (ELISA) for Tg determination on dried blood spots (DBS) in newborns. This study also sets out to assess the stability of Tg and the influence of newborns' hematocrit on Tg determination.Methods: A commercially available ELISA Tg assay was adapted for use on DBS. DBS-Tg in cord blood was measured in 209 newborns delivered from healthy euthyroid pregnant women. Sensitivity, linearity, repeatability, and intermediate fidelity were determined using the appropriate standards and quality control materials.Results: The limit of detection of the DBS-Tg assay was 2.4 µg/L, and the limit of quantification was 5.8 µg/L. Repeatability and intermediate fidelity were 7.7-8.3% and 11.0-11.2%, respectively. The median cord plasma Tg and DBS-Tg values in newborns were not significantly different, 30.2 (21.3-44.4) µg/L and 31.6 (19.3-48.7) µg/L (P = 0.48) with the ELISA, respectively, and 76.5 (40.0-101.5) µg/L with the Elecsys assay with an R = 0.88. DBS-Tg concentrations decrease with increasing hematocrit values (P < 0.05). DBS-Tg values were stable at a concentration of 25 µg/L for 12 months at -20ºC and 4ºC.Conclusion: This DBS-Tg assay demonstrated good analytical performance over a wide range of Tg concentrations, suggesting it is well suited to detecting variations in Tg concentrations. Studies comparing populations with different prevalence of anemia should consider the effect of hematocrit on DBS-Tg determination. The availability of a DBS-Tg assay for newborns makes it possible to integrate iodine status monitoring with newborn screening for inherited metabolic diseases.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a treatment for thyroid hormone transporter MCT8 deficiency - achievements and challenges. 治疗甲状腺激素转运体 MCT8 缺乏症：成就与挑战。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-20 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0286

Boyka Markova, Steffen Mayerl, Heike Heuer

引用次数: 0

Real word outcomes of cabozantinib therapy in poorly differentiated thyroid carcinoma. 卡博替尼治疗分化不良甲状腺癌的真实疗效。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-20 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0225

Omar Elghawy, Adam Barsouk, Jessica Xu, Simon Chen, Roger B Cohen, Lova Sun

{"title":"Real word outcomes of cabozantinib therapy in poorly differentiated thyroid carcinoma.","authors":"Omar Elghawy, Adam Barsouk, Jessica Xu, Simon Chen, Roger B Cohen, Lova Sun","doi":"10.1530/ETJ-24-0225","DOIUrl":"10.1530/ETJ-24-0225","url":null,"abstract":"Objective: Poorly differentiated thyroid carcinomas (PDTCs) are rare and aggressive head and neck malignancies with a poor prognosis. Systemic treatment for incurable PDTC consists of multi-kinase inhibitors (MKIs) based on extrapolation from the experience with radioiodine refractory differentiated thyroid cancer (DTC). Cabozantinib is an approved second-line MKI therapy for DTC, but there are limited data regarding the safety and efficacy of cabozantinib for PDTC.Methods: We conducted a single-institution, retrospective analysis of patients with PDTC who received cabozantinib in any line of therapy. Baseline demographics, disease characteristics, treatment history, toxicity, and clinical outcomes were abstracted from the electronic medical record. Median progression-free survival (PFS) and overall survival (OS) were primary endpoints and estimated using Kaplan-Meier methodology.Results: Seven patients with PDTC who received cabozantinib were included. 4/7 (57%) patients had a partial response to cabozantinib, while 2/7 (29%) had stable disease (SD) as their best response. The median time on treatment for cabozantinib was 10.53 months. The median PFS from the start of cabozantinib was 12.9 months, and median OS was 14.21 months. Most adverse events to treatment (5/6) were low grade. Two (29%) patients were alive at the date of the last follow-up.Conclusion: Cabozantinib is an effective and reasonably well-tolerated treatment option for patients with PDTC. Prospective studies are needed to further investigate the role of cabozantinib in the treatment of PDTC, alone and in combination with other agents, including checkpoint inhibitors.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyrotoxic periodic paralysis - a retrospective study from Southern India. 甲亢性周期性麻痹--来自印度南部的回顾性研究。

IF 3.5 2区医学

European Thyroid Journal Pub Date : 2024-11-11 Print Date: 2024-12-01 DOI: 10.1530/ETJ-24-0164

Jinson Paul, Aneez Joseph, Felix Jebasingh, Atul Ramachandra More, Julie Hephzibah, Kripa Elizabeth Cherian, Nitin Kapoor, Hesarghatta Shyamsunder Asha, Nihal Thomas

{"title":"Thyrotoxic periodic paralysis - a retrospective study from Southern India.","authors":"Jinson Paul, Aneez Joseph, Felix Jebasingh, Atul Ramachandra More, Julie Hephzibah, Kripa Elizabeth Cherian, Nitin Kapoor, Hesarghatta Shyamsunder Asha, Nihal Thomas","doi":"10.1530/ETJ-24-0164","DOIUrl":"10.1530/ETJ-24-0164","url":null,"abstract":"Objective: Thyrotoxic periodic paralysis is a rare manifestation of thyrotoxicosis. Here, we describe the clinical and biochemical features and treatment outcomes of this disorder.Methods: This retrospective study was conducted at a tertiary care centre in southern India. The clinical and biochemical features, treatment received, and therapeutic outcomes of all patients with thyrotoxicosis and acute flaccid paralysis without any other identifiable causes (cases for the study) were compared with an equal number of consecutively selected patients who presented with thyrotoxicosis but without features of paralysis (controls for the study) during the same period.Results: In total, 41 cases and controls were included in this study. The proportion of males was 92.6% and 43.9% in the cases and controls, respectively. The mean age was 32.8 (±7.6) years (cases) and 39.7 (±11.3) years (controls). In the cases, 20% of patients presented without clinical thyrotoxic features. Graves' disease was the most common aetiology of thyrotoxicosis in both groups (92.6% of cases and 87.8% of controls). The prevalence of goitre was significantly higher among controls (90.2%) than among cases (53.7%). The mean serum potassium, free T4, total T4 and total T3 levels were significantly lower in the cases than in the controls. In these cases, two patients had an additional aetiology for persistent hypokalaemia, likely Gitelman's syndrome.Conclusion: This is one of the largest series of thyrotoxic periodic paralysis cases in India. In subjects with thyrotoxicosis, serum potassium, free T4, total T4 and total T3 levels were significantly lower in those with periodic paralysis than in those without.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11623255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0