European Thyroid Journal最新文献

pT1a Papillary Thyroid Carcinomas in Pediatric Patients. 儿科患者的pT1a乳头状甲状腺癌。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-10-09 DOI: 10.1530/ETJ-25-0119

Sin-Ting Tiffany Lai, Mya Bojarsky, Julia Baran, Amber Isaza, Lindsay Sisko, Stephanie Gonzales, Brianna Spatz, Tricia Bhatti, Lea F Surrey, Zubair W Baloch, N Scott Adzick, Ken Kazahaya, Sogol Mostoufi-Moab, Andrew Bauer

{"title":"pT1a Papillary Thyroid Carcinomas in Pediatric Patients.","authors":"Sin-Ting Tiffany Lai, Mya Bojarsky, Julia Baran, Amber Isaza, Lindsay Sisko, Stephanie Gonzales, Brianna Spatz, Tricia Bhatti, Lea F Surrey, Zubair W Baloch, N Scott Adzick, Ken Kazahaya, Sogol Mostoufi-Moab, Andrew Bauer","doi":"10.1530/ETJ-25-0119","DOIUrl":"https://doi.org/10.1530/ETJ-25-0119","url":null,"abstract":"Background: Observational studies in adults suggest that incidental PTC (iPTC) and non-incidental PTC (niPTC) are distinct entities. We examine the incidence of iPTC in pediatric patients undergoing thyroidectomy for benign conditions and compare clinical and histopathologic findings, as well as outcomes, of iPTC with those of niPTC.Methods: A retrospective chart review was conducted at the Children's Hospital of Philadelphia between August 2010 and February 2023 to identify pediatric patients who underwent thyroidectomy and were diagnosed with pT1a PTC.Results: iPTC was identified in 23 of 453 (5.1%) patients undergoing thyroidectomy for benign conditions. Within a cohort of 66 patients diagnosed with pT1a PTC, 23 (34.8%) were classified as iPTC, and 43 (65.2%) were classified as niPTC. Compared to niPTC, iPTC had a significantly smaller median greatest dimension (iPTC: 3 mm, niPTC: 7 mm, p < 0.001), a lower rate of lymphatic invasion (iPTC: 0%, niPTC: 60.5%, p < 0.001), and AJCC N1 disease (iPTC: 0%, niPTC: 55.8%, p < 0.001). Most iPTC (22 out of 23 [95.7%]) were classified as ATA pediatric low-risk, while 6 out of 43 (14.0%) niPTC were categorized as intermediate/high-risk. Patients with iPTC and niPTC were followed for a median of 3.3 and 5.7 years, respectively. There was no evidence of persistent or recurrent disease in any patient with iPTC during this time frame.Conclusions: iPTC may be found in 5.1% of pediatric patients undergoing thyroidectomy for benign conditions. Similar to adults, iPTC in pediatric patients appears to be indolent with a minimal risk for invasive features and a low risk for persistent or recurrent disease. In contrast to iPTC, niPTC exhibits the potential for invasive behavior and should be regarded as a distinct entity.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lenvatinib as an urgent initial therapy in thyroid cancer with remarkable laryngotracheal invasion. Lenvatinib作为甲状腺癌喉气管明显侵犯的紧急初始治疗。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-10-08 Print Date: 2025-10-01 DOI: 10.1530/ETJ-25-0212

Hiroshi Katoh, Riku Okamoto, Yuka Ozawa, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai

{"title":"Lenvatinib as an urgent initial therapy in thyroid cancer with remarkable laryngotracheal invasion.","authors":"Hiroshi Katoh, Riku Okamoto, Yuka Ozawa, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai","doi":"10.1530/ETJ-25-0212","DOIUrl":"10.1530/ETJ-25-0212","url":null,"abstract":"Objectives: In thyroid cancer with marked laryngotracheal invasion, life-threatening airway stenosis necessitates urgent procedures such as extensive curative surgery, tracheostomy, stenting, or laser bronchoscopy. These interventions are invasive and may significantly compromise quality of life. In anaplastic thyroid cancer (ATC), the delay during genetic testing turnaround time before initiating targeted therapy poses an additional therapeutic challenge. This study aimed to assess lenvatinib (LEN) as an initial and bridging treatment to rapidly alleviate airway stenosis and avoid emergency invasive interventions.Methods: This retrospective study analyzed 14 patients with remarkable laryngotracheal invasion among 69 thyroid cancer patients treated with multikinase inhibitor(s). All 14 patients received LEN as first-line or post-paclitaxel treatment. Response was assessed by CT imaging per RECIST 1.1, with particular attention to changes in tumor size and airway diameter. Symptom improvement and adverse events, such as fistula formation, were also recorded.Results: Of the 14 patients, 13 showed tumor reduction and airway improvement on initial CT post-LEN induction. Median response rate was 28.4%, with airway diameter improving by 15.9% on the initial CT. Airway symptoms resolved in a median of 3 days. One patient developed a tumor-tracheal fistula, managed with LEN dose adjustment. LEN was also successfully used as a bridging therapy before BRAF-targeted treatment in ATC cases.Conclusions: Initial LEN therapy rapidly alleviates airway stenosis in advanced thyroid cancer with laryngotracheal invasion, offering a non-invasive alternative to emergency procedures under careful monitoring for fistula formation. LEN is especially valuable as a bridging therapy during the genetic testing period in ATC.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NSD3::NUTM1 fusion evidenced on RNA sequencing in poorly differentiated thyroid cancer: a report of two cases. RNA测序证实NSD3::NUTM1融合在低分化甲状腺癌中：附两例报告

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-10-06 Print Date: 2025-10-01 DOI: 10.1530/ETJ-25-0100

Renaud Ciappuccini, Virginie Saguet-Rysanek, Paul-Antoine Bompain, Jacques Balosso, Raphaël Leman, Laurent Castera, Stéphane Bardet

{"title":"NSD3::NUTM1 fusion evidenced on RNA sequencing in poorly differentiated thyroid cancer: a report of two cases.","authors":"Renaud Ciappuccini, Virginie Saguet-Rysanek, Paul-Antoine Bompain, Jacques Balosso, Raphaël Leman, Laurent Castera, Stéphane Bardet","doi":"10.1530/ETJ-25-0100","DOIUrl":"10.1530/ETJ-25-0100","url":null,"abstract":"Background: Nuclear protein in testis (NUT) carcinomas are aggressive, poorly or undifferentiated cancers, generally arising from midline structures. This subtype of squamous cell carcinoma is rare and has a poor prognosis. NUT cancers are defined by NUTM1 fusions. Rearrangements of the NUTM1 gene have rarely been described in primary thyroid cancer and are mainly reported in patients ≤45 years old. NSD3::NUTM1 translocation is the most common NUTM1 fusion transcript reported in thyroid cancer. As they are very infrequent, NUTM1 fusions are not routinely sought in poorly differentiated thyroid cancer (PDTC) or anaplastic thyroid cancer (ATC).Case presentation: We report two PDTC patients >65 years old with locally advanced disease and 18FDG-avid distant metastases. NSD3::NUTM1 translocation was evidenced in both patients by RNA sequencing using the next-generation sequencing panel of our institution.Conclusion: We suggest including the search for NUTM1 fusions in the RNA sequencing panel for advanced and refractory thyroid cancers.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GRAVES' DISEASE IN ECTOPIC THYROID TISSUE: A SCOPING REVIEW AND A CASE STUDY. 异位甲状腺组织中的Graves病：范围回顾和个案研究

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-10-03 DOI: 10.1530/ETJ-25-0135

Annick Van den Bruel, Pieter Drieskens, Helena Van Haecke, Frank De Geeter, Tatjana Sajevets, Maximilian Luffy, Arno Schad, George J Kahaly

{"title":"GRAVES' DISEASE IN ECTOPIC THYROID TISSUE: A SCOPING REVIEW AND A CASE STUDY.","authors":"Annick Van den Bruel, Pieter Drieskens, Helena Van Haecke, Frank De Geeter, Tatjana Sajevets, Maximilian Luffy, Arno Schad, George J Kahaly","doi":"10.1530/ETJ-25-0135","DOIUrl":"10.1530/ETJ-25-0135","url":null,"abstract":"Background: Persistent Graves' disease (GD) after total thyroidectomy is sporadic and may be explained by incomplete total thyroidectomy, GD in ectopic thyroid tissue (ETT) or struma ovarii.Methods: We present a novel case of ectopic GD in a giant paracardiac mass, including an in-depth histologic exam. We searched the Pubmed database on GD in ETT.Results: A 34-year-old woman presented with severe thyrotoxicosis, 4 months after total thyroidectomy, and 6 weeks after cessation of levothyroxine substitution. Persistently high thyrotropin receptor antibodies (TSH-R-Ab) (27 IU/l, normal <1.5 IU/l) and thyroglobulin > 5000 µg/l (normal <77 µg/l) suggested GD in ETT. A 99mTc-pertechnetate SPECT/CT scan showed uptake in a paracardiac mass. After surgical removal of the 13 cm paracardiac mass, euthyroidism was achieved. Histology was typically remarkable for a Graves' pattern in the ETT as opposed to a nodular pattern in the eutopic thyroid. The additional scoping review encompasses 29 reported ETT cases of which only 11 were in the mediastinum. Graves' eye disease was present in 11 / 29 subjects.Conclusion: This is the first report showing a markedly different histology between the thyroid and the ectopic tissue. Persistent systemic severe GD post-thyroidectomy led to the detection of a giant paracardiac ectopic thyroid. GD in ETT is rare and presents a diagnostic challenge.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study. 甲状腺毒症和甲状腺毒性周期性麻痹的20年趋势：一项基于人群的队列研究。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-09-25 Print Date: 2025-10-01 DOI: 10.1530/ETJ-25-0220

Gloria Hoi-Yee Li, Ching-Man Tang, Ray Shing-Hin Li, Grace Mengqin Ge, Annie Wai-Chee Kung, Kathryn Choon-Beng Tan, Elaine Yun-Ning Cheung, Ching-Lung Cheung

{"title":"Twenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study.","authors":"Gloria Hoi-Yee Li, Ching-Man Tang, Ray Shing-Hin Li, Grace Mengqin Ge, Annie Wai-Chee Kung, Kathryn Choon-Beng Tan, Elaine Yun-Ning Cheung, Ching-Lung Cheung","doi":"10.1530/ETJ-25-0220","DOIUrl":"10.1530/ETJ-25-0220","url":null,"abstract":"Objective: Thyrotoxic periodic paralysis (TPP) is a rare but potentially lethal complication of thyrotoxicosis. Absence of large cohorts limits the conduct of epidemiology studies. We aimed to establish a population-based registry of thyrotoxicosis and TPP in Hong Kong and evaluate their trend.Methods: We developed algorithms to identify thyrotoxicosis and TPP cases from a representative electronic medical database in Hong Kong. Of the potential cases (thyrotoxicosis:83,184; TPP:999), we reviewed clinical notes and laboratory test records of 200 randomly selected cases. Population-based registries of thyrotoxicosis and TPP were subsequently established. Their standardized incidence rate, TPP-associated hospitalization rate, length of stay (LOS), and trends from 2002 to 2021 were evaluated.Results: Positive predictive values for thyrotoxicosis and TPP were 0.86-0.97, respectively, enabling establishment of population-based cohorts of incident thyrotoxicosis (n = 77,856) and TPP (n = 994). Age- and sex-standardized incidence rate (per 100,000 person-years) of thyrotoxicosis increased from 41.31 in 2002 to 69.51 in 2021 (average annual percentage change: 4.77%), with a similar trend observed in both sexes. TPP patients were predominantly male (93.66%). In 2002 and 2021, the age-standardized incidence rate (per 100,000 person-years) of TPP in males was 1.43 and 1.18, respectively, while that in females was 0.11 and 0.13, without a significant trend observed. TPP-associated hospitalization rate (90.91-100%) and median LOS (2-3 days) were steady across the two decades.Conclusion: This is the first study establishing a TPP cohort based on validated clinical data from an electronic medical database. It is important to keep monitoring the increasing incidence rate of thyrotoxicosis.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the pathogenic mechanisms in Graves' orbitopathy. 揭示graves眼病的发病机制。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-09-24 Print Date: 2025-10-01 DOI: 10.1530/ETJ-25-0200

Alan Chun Hong Lee, George J Kahaly

{"title":"Unravelling the pathogenic mechanisms in Graves' orbitopathy.","authors":"Alan Chun Hong Lee, George J Kahaly","doi":"10.1530/ETJ-25-0200","DOIUrl":"10.1530/ETJ-25-0200","url":null,"abstract":"Graves' orbitopathy (GO) is characterized by orbital inflammatory infiltration, expansion of orbital tissues due to de novo adipogenesis and over-production of hydrophilic glycosaminoglycans, as well as myofibroblastic differentiation resulting in tissue fibrosis. Thyrotropin receptor antibody (TSH-R-Ab) is the major stimulus, which activates thyrotropin receptor (TSH-R)/insulin-like growth factor-1 receptor (IGF-1R) and its downstream signalling in orbital fibroblasts (OF). Clinical evaluation of TSH-R-Ab, the specific biomarker of Graves' disease (GD) and the associated orbitopathy, provides important clinical information concerning diagnosis, disease monitoring and prognosis of GO. TSH-R/IGF-1R crosstalk represents the principal mechanism of activation of OF, the key effector cells in GO. T cells and monocytes/macrophages predominate in the inflammatory infiltrates and B-T cell co-stimulation results in mutual activation. Mast cell-derived products also activate OF. In the presence of various pro-inflammatory molecules, activated OF and lymphocytes perpetuate orbital inflammation and mediate tissue remodelling. Enhanced oxidative stress drives various pathological processes in GO and many antioxidant agents have shown inhibitory effects on OF. Highly differential gene and protein expression exists between GO and normal subjects, as well as between active/severe and inactive/mild GO, providing important insights into the disease mechanisms. The lack of confirmed genetic susceptibility to GO development suggests that epigenetic mechanisms (e.g. DNA methylation and microRNAs) may play a role in regulating gene and protein expression, and hence disease phenotypes. The gut microbiome differs significantly between GO patients and healthy individuals. Modifying gut microbiota in GO animal models improves GO. Emerging evidence indicates that hypercholesterolaemia is associated with increased risk of developing GO, while statin use is a protective factor.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocality and bilaterality in medullary thyroid cancer: basis for a proof-of-concept safety of lobectomy. 甲状腺髓样癌的多灶性和双侧性：肺叶切除术概念安全性验证的基础。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-09-05 Print Date: 2025-10-01 DOI: 10.1530/ETJ-25-0074

Virginia Cappagli, Antonio Matrone, Valeria Bottici, Alessandro Prete, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Clara Ugolini, Liborio Torregrossa, Paolo Piaggi, Rossella Elisei

{"title":"Multifocality and bilaterality in medullary thyroid cancer: basis for a proof-of-concept safety of lobectomy.","authors":"Virginia Cappagli, Antonio Matrone, Valeria Bottici, Alessandro Prete, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Clara Ugolini, Liborio Torregrossa, Paolo Piaggi, Rossella Elisei","doi":"10.1530/ETJ-25-0074","DOIUrl":"10.1530/ETJ-25-0074","url":null,"abstract":"Objective: At present, total thyroidectomy and central neck dissection are the surgical approaches recommended for the initial treatment of medullary thyroid cancer (MTC) independently of the size, number of tumor foci, age of patients, and other demographic and clinico-pathological parameters. The aims of the present study were to assess the prevalence of multifocality in hereditary (hMTC) and sporadic (sMTC) patients and to correlate the presence of multifocality with clinico-pathological parameters to provide a proof of concept that lobectomy can be safely performed in selected cases.Methods: We analyzed the epidemiological, pathological, and clinical data of 389 MTC (311 sMTC and 78 hMTC) diagnosed in our center from 2005 to 2018.Results: Multifocality was found in 89/389 cases (22.9%), (45/311 (14.5%) sMTC and 44/78 (56.4%) hMTC). Bilaterality was detected in 27/311 (8.7%) of all sMTC, particularly in 27/45 (60%) of multifocal ones, and in 44/78 of hMTC (56.4%). Multifocality was correlated with a more aggressive phenotype in both sMTC and hMTC, and the multivariate analysis showed that it was statistically and independently associated with tumoral extrathyroidal extension and N1 status in sMTC and with N1 status and persistent disease in hMTC. However, none of the presurgical factors could predict the presence of both multifocality and bilaterality.Conclusions: Our study demonstrated that the rarity of multifocality and, in particular, of bilaterality, in sMTC represents the proof of concept for considering a more conservative surgical approach in selected sMTC cases. This approach cannot be considered in hMTC due to the high prevalence of multifocal and bilateral cases.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term exposure to PM1 and thyroid diseases in China. 中国长期暴露于PM1和甲状腺疾病

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-08-08 DOI: 10.1530/ETJ-25-0106

Jing Wang, Di Teng, Kaijie Yang, Siying Liu, Cihang Lu, Zhongyan Shan, Weiping Teng, Yongze Li

{"title":"Long-term exposure to PM1 and thyroid diseases in China.","authors":"Jing Wang, Di Teng, Kaijie Yang, Siying Liu, Cihang Lu, Zhongyan Shan, Weiping Teng, Yongze Li","doi":"10.1530/ETJ-25-0106","DOIUrl":"10.1530/ETJ-25-0106","url":null,"abstract":"Background: Globally prevalent, thyroid diseases are linked to environmental factors such as air pollution. This study examines the link between particulate matter (PM)1 exposure and thyroid disease rates in China.Methods: We analyzed data from 73,900 adults across 31 Chinese provinces, using a high-resolution spatial-temporal extremity tree model to estimate PM1 and PM2.5 levels, and thyroid function tests to assess disease prevalence. Multivariate-adjusted ORs evaluated PM1's link to thyroid disease. This cross-sectional study is adept at identifying associations but cannot establish causality due to its single-time data collection limitation.Results: Higher PM1 level exposure was significantly linked to an increased prevalence of thyroid diseases, including overt hypothyroidism, autoimmune thyroiditis (AIT), and TgAb positivity. A linear dose-response relationship was observed between PM1 concentration and both AIT and TgAb positivity. The study also revealed a significant association between PM1 exposure and autoimmune overt hypothyroidism, suggesting that thyroid dysfunction may be primarily mediated through autoimmune mechanisms. In addition, iodine status significantly influenced PM1's effects, with lower levels enhancing susceptibility to thyroid issues. Furthermore, every 1% increase in the PM1/PM2.5 ratio was related to the prevalence of overt hypothyroidism (OR = 1.03; 95% CI: 1.03-1.04) and subclinical hypothyroidism (OR = 1.03; 95% CI: 1.03-1.04).Conclusions: PM1 exposure is associated with thyroid diseases, particularly AIT and TgAb positivity, with iodine status playing a modifying role. PM1 may be a key factor in PM2.5-related thyroid disease risk. Further prospective cohort studies are warranted to validate these findings.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiated thyroid cancer in two European referral centres: impact of different diagnostic and therapeutic strategies. 两个欧洲转诊中心的分化甲状腺癌：不同诊断和治疗策略的影响。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-08-08 DOI: 10.1530/ETJ-25-0161

Daniele Ceruti, Petronella B Ottevanger, Simone De Leo, Han J Bonenkamp, Carla Colombo, Martin Gotthardt, Laura Fugazzola, Romana T Netea-Maier

{"title":"Differentiated thyroid cancer in two European referral centres: impact of different diagnostic and therapeutic strategies.","authors":"Daniele Ceruti, Petronella B Ottevanger, Simone De Leo, Han J Bonenkamp, Carla Colombo, Martin Gotthardt, Laura Fugazzola, Romana T Netea-Maier","doi":"10.1530/ETJ-25-0161","DOIUrl":"10.1530/ETJ-25-0161","url":null,"abstract":"Objective: To evaluate differences in the presentation, diagnostic/therapeutic approaches, and outcome of differentiated thyroid cancer (DTC) in an Italian and a Dutch referral centre.Methods: We retrospectively included 919 patients (586 Italian, 333 Dutch), and compared the two cohorts as a whole and according to ATA risk classes. Dynamic risk stratification (DRS) and Kaplan-Meier curves were used to compare progression-free survival (PFS) and disease-specific survival (DSS).Results: Several differences (P < 0.001) were found in clinicopathological features and in diagnostic/therapeutic modalities. The Dutch cohort had a higher age at diagnosis, a higher number of patients presenting with metastatic disease, and patients with stage III/IV. Most Italian patients showed a low/intermediate ATA risk, while high-risk patients represented half of the Dutch cohort. The Dutch cohort received a more intensive first treatment and more additional treatments during follow-up (i.e. surgery, radiotherapy, and systemic treatments). DRS analysis showed comparable excellent and biochemical incomplete responses, while the Dutch cohort had a lower rate of indeterminate and a higher rate of structural incomplete responses (P < 0.001). The Dutch cohort had a significantly worse 5-year PFS, and TC-related mortality was 10 and 1% for the Dutch and Italian cohorts, respectively, in line with the higher rate of advanced disease at presentation, with DSS still excellent for both.Conclusion: Data reported in the present comparison between two European countries highlight a different prevalence, presentation, and outcome of DTC, likely due to variabilities in healthcare systems, iodine nutritional status, and diagnostic and treatment approaches.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

50 YEARS OF NEWBORN SCREENING FOR CONGENITAL HYPOTHYROIDISM: EVOLUTION OF INSIGHTS IN ETIOLOGY, DIAGNOSIS AND MANAGEMENT: Transient or permanent congenital hypothyroidism: from milestones to current and future perspectives. 暂时性或永久性先天性甲状腺功能减退：从里程碑到现在和未来的观点。

IF 4.3 2区医学

European Thyroid Journal Pub Date : 2025-08-05 Print Date: 2025-08-01 DOI: 10.1530/ETJ-25-0019

Gaia Vincenzi, Ilenia Teresa Petralia, Marco Abbate, Maria Cristina Vigone

{"title":"50 YEARS OF NEWBORN SCREENING FOR CONGENITAL HYPOTHYROIDISM: EVOLUTION OF INSIGHTS IN ETIOLOGY, DIAGNOSIS AND MANAGEMENT: Transient or permanent congenital hypothyroidism: from milestones to current and future perspectives.","authors":"Gaia Vincenzi, Ilenia Teresa Petralia, Marco Abbate, Maria Cristina Vigone","doi":"10.1530/ETJ-25-0019","DOIUrl":"10.1530/ETJ-25-0019","url":null,"abstract":"Primary congenital hypothyroidism (CH) is the most common endocrinopathy of developmental age. In recent years, several studies from different countries have reported a significant increase in CH incidence detected by newborn screening programs, primarily 'mild' forms of CH with gland in situ (GIS). However, more than one-third of affected children with GIS present transient CH and recover endogenous thyroid function in early childhood, permitting the cessation of levothyroxine treatment by the end of the third year of life. Therefore, in CH patients with GIS, a clinical and biochemical reassessment is needed to determine whether the hypothyroidism is transient or permanent and to search for the underlying causes of the thyroid defect. Despite the presence of consensus guidelines for the management of CH in pediatric age, the screening strategy and management of the disease, especially at re-evaluation, differ significantly between centers and present some points of discussion. The following review summarizes the main pathophysiological mechanisms of transient and permanent forms of CH, also underlining the importance of new genetic tools in order to guarantee each patient the best diagnostic and therapeutic approach.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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