European review for medical and pharmacological sciences最新文献

{"title":"Retraction Note: Effect of miR-363 on the proliferation, invasion and apoptosis of laryngeal cancer by targeting Mcl-1.","authors":"W-T Feng, R Yao, L-J Xu, X-M Zhong, H Liu, Y Sun, L-L Zhou","doi":"10.26355/eurrev_202511_37514","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37514","url":null,"abstract":"<p><p>The article \"Effect of miR-363 on the proliferation, invasion and apoptosis of laryngeal cancer by targeting Mcl-1\" by W.-T. Feng, R. Yao, L.-J. Xu, X.-M. Zhong, H. Liu, Y. Sun, L.-L. Zhou published in Eur Rev Med Pharmacol Sci 2018; 22 (14): 4564-4572-DOI: 10.26355/eurrev_201807_15512-PMID: 30058689 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer, the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation confirmed figure duplication, specifically within panel A of Figure 4. The authors were contacted, informed of the ongoing investigation, and requested to provide the original data supporting the manuscript, but they remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15512.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"492"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value and concordance of endometrial thickness, smear, and biopsy results in women with abnormal uterine bleeding.","authors":"S B Torumtay Alic, H E Malatyalioglu","doi":"10.26355/eurrev_202511_37506","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37506","url":null,"abstract":"&lt;p&gt;&lt;p&gt;OBJECTIVE: This study was conducted to investigate whether an effective screening method for endometrial hyperplasia and endometrial cancer can be identified by comparing the results of transvaginal ultrasonography (TV-USG), liquid-based endometrial cytology, and endometrial biopsy. MATERIALS AND METHODS: The study included a total of 200 patients with a mean age of 50.04 ± 10.39 years (range: 33-85), who presented with abnormal uterine bleeding during the premenopausal and postmenopausal periods. Following a detailed clinical examination, endometrial thickness was measured using TV-USG in all cases. Subsequently, liquid-based endometrial cytology was obtained using an endometrial brush, followed by an endometrial biopsy using a Karman cannula. All patients were evaluated by the same clinician, and both the cytological and biopsy specimens were assessed by the same pathologist. RESULTS: No endometrial pathology was detected in cases with an endometrial thickness of ≤ 5 mm as measured by TV-USG. The mean endometrial thickness was found to be 12.66 mm for simple hyperplasia without atypia, 18 mm for complex atypical hyperplasia, and 17.00 mm for endometrial adenocarcinoma. A statistically significant difference was observed among these three groups with endometrial thicknesses (p &lt; 0.05). The endometrial thickness in cases with complex atypical hyperplasia and endometrial cancer was significantly higher compared to the others (p &lt; 0.05). While 58% of endometrial cytology samples and 34% of biopsy samples were found to be insufficient for evaluation, cytology still appeared to be a useful method for detecting malignant lesions. The high insufficiency rate observed in our series likely reflects the sampling technique employed, as an endocervical-type brush was used rather than a dedicated endometrial sampler, which may have reduced cellular yield and affected adequacy rates. For the diagnosis of malignant lesions, cytology demonstrated a sensitivity of 100%, a specificity of 96.9%, a positive predictive value of 71.43%, and a negative predictive value of 100%. CONCLUSIONS: Although TV-USG is not a method that provides a definitive diagnosis, it is highly effective in identifying cases that require further investigation. Moreover, due to its non-invasive nature, it should be considered the first-line diagnostic tool in patients suspected of having endometrial pathology. Despite the high diagnostic accuracy of endometrial cytology in detecting malignant lesions, the relatively high rate of insufficient sample both in premenopausal and postmenopausal patients compared to biopsy represents a notable disadvantage. Therefore, we do not consider endometrial cytology to be a standalone method suitable for screening endometrial cancer and its precursors. However, since malignant lesions were reliably detected when adequate cytology material was obtained, dedicated endometrial samplers and emerging molecular adjuncts should be evaluated in future prospec","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"539-549"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future direction: novel inflammatory markers to enhance deep vein thrombosis diagnostic specificity.","authors":"R Cohen, E Daniel, S Nemet, N Abu Hamdeh, A Mahamid, A Kirzhner, T Schiller, M Alnees, H Abu Khadija","doi":"10.26355/eurrev_202511_37507","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37507","url":null,"abstract":"<p><p>OBJECTIVE: Deep vein thrombosis (DVT) poses a critical health risk, especially among the elderly. This study aims to enhance the specificity of DVT diagnosis by integrating novel inflammatory ratios and hematological markers. MATERIALS AND METHODS: We conducted a retrospective cohort study at Kaplan Medical Center, analyzing data from 310 patients aged 65 and older, following strict inclusion and exclusion criteria. Hematological and biochemical parameters, including D-dimer, C-reactive protein (CRP), and various inflammatory markers, were evaluated. Statistical analyses involved logistic regression, Receiver operating characteristic (ROC) curve, and K-Nearest Neighbors (KNN) algorithm for missing data imputation, ensuring robust results for DVT diagnostics. RESULTS: Out of 500 patients aged 65 and older evaluated for DVT admitted to the Emergency room at Kaplan Medical Center between January 1, 2020, and January 30, 2023, 310 were included in the analysis, with 23.23% positive for DVT. The DVT group's mean age was significantly higher (78.6 ± 9.1 years) than the non-DVT group (76.4 ± 4.65 years, p < 0.01). Significant predictors of DVT included D-dimer (p < 0.01, OR 1.33) and the D-dimer to activated partial thromboplastin time (aPTT) ratio (p < 0.01, OR 1.07). While achieving 100% sensitivity for both markers comes with low specificity, D-dimer and the Dd:aPTT ratio demonstrated strong potential in identifying DVT. CONCLUSIONS: D-dimer to aPTT ratio is a promising diagnostic tool for DVT, warranting further investigation.</p><p><strong>Graphical abstract: </strong>https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-30.jpg.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"550-558"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: MiR-411-5p acts as a tumor suppressor in non-small cell lung cancer through targeting PUM1.","authors":"L-H Xia, Q-H Yan, Q-D Sun, Y-P Gao","doi":"10.26355/eurrev_202511_37517","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37517","url":null,"abstract":"<p><p>The article \"MiR-411-5p acts as a tumor suppressor in non-small cell lung cancer through targeting PUM1\" by L.-H. Xia, Q.-H. Yan, Q.-D. Sun, Y.-P. Gao published in Eur Rev Med Pharmacol Sci 2018; 22 (17): 5546-5553-DOI: 10.26355/eurrev_201809_15816-PMID: 30229827 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer, the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation confirmed several instances of Figure duplication with previously published articles, specifically in Figures 3 and 4. The authors were contacted, informed of the ongoing investigation, and requested to provide the original data supporting the manuscript, but they remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15816.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"490"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic and rehabilitative role of transcranial magnetic stimulation in multiple sclerosis.","authors":"T Abualait, S Mukhtar, G Murtaza, F Al-Hussain, E N Ali, S Bashir","doi":"10.26355/eurrev_202511_37503","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37503","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic, autoimmune and neurodegenerative disease characterized by inflammation, lesions, demyelination, and axonal damage. Approximately 2.8 million people globally have MS. Many pharmacological agents can reduce relapsing-remitting episodes, but are ineffective on secondary progressive MS, causing symptoms to worsen over time. MS patients have significant impairment in neurophysiological factors such as demyelination and the balance between inhibitory and excitatory synaptic interactions. These impairments disrupt normal communication between neurons in the cerebral cortex, which contributes to the symptoms and disease progression. Transcranial Magnetic Stimulation (TMS) can identify and measure such neurophysiological parameters, including cortical excitability, linked with progression and the severity of disease. Thus, TMS could serve as a potential surrogate marker to monitor MS activity and severity. The review highlights the potential of TMS in managing MS, including enhanced cognitive functions, reduced fatigue, and improved spasticity, balance, and gait. In addition, TMS contributes to reducing neuroinflammation and oxidative stress while promoting neuronal repair and remyelination. However, further research is required for a better understanding of the stimulation- and site-specific effects of TMS in MS.</p><p><strong>Graphical abstract: </strong>https://www.europeanreview.org/wp/wp-content/uploads/graphical-abstract-25.jpg.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"493-506"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation.","authors":"R Sferra, A Vetuschi, V Catitti, S Ammanniti, S Pompili, D Melideo, G Frieri, E Gaudio, G Latella","doi":"10.26355/eurrev_202511_37508","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37508","url":null,"abstract":"<p><p>The article \"Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation\" by R. Sferra, A. Vetuschi, V. Catitti, S. Ammanniti, S. Pompili, D. Melideo, G. Frieri, E. Gaudio, G. Latella published in Eur Rev Med Pharmacol Sci 2012; 16 (11): 1484-1498-PMID: 23111960 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer, the Journal has started an investigation to assess the validity of the results as well as possible figure and data manipulation. The authors were contacted and informed of the ongoing investigation. The authors stated that \"due to an inadvertent error that occurred during the preparation of the manuscript, some images and data were mistakenly selected from an incorrect file, resulting in the inclusion of material previously published in Liver International (2009)\". The article has been, therefore, retracted according to COPE guidelines. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/1806.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"489"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting suicidal behavior: a machine learning model.","authors":"A-M Vejnović, V Tatalović, M Vujović, N Janković, A Dickov, V M Jovin, V Knežević, I Kelečević","doi":"10.26355/eurrev_202511_37505","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37505","url":null,"abstract":"<p><p>OBJECTIVE: Timely response and identification of risk factors are critical components of suicide prevention, enabling appropriate intervention. By applying machine learning to clinical data analysis, predictive models can be developed to classify patients into high- and low-risk groups, which can help prevent loss of life. This study aims to develop a machine learning model to categorize patients based on their risk of suicide attempts. MATERIALS AND METHODS: We analyzed data from 301 respondents hospitalized at the Clinic of Psychiatry for either suicidal behavior or non-suicidal reasons. They were divided into two groups according to the presence of suicidal behavior. By using machine learning methods, we analyzed the influence of 18 observed features on the development of suicidal behavior. A predictive model was developed to classify individuals into two risk categories - high and low - for the observed population. The k-Nearest Neighbors (kNN) algorithm was used to train the model. RESULTS: The kNN-based model achieved a classification accuracy of 87%, with sensitivity at 87%, precision at 90% and an F-score of 85% for the tested sample. CONCLUSIONS: Early identification of risk factors for suicidal behavior remains the most effective strategy for prevention. Classification models may serve as valuable clinical tools for assessing suicide risk, potentially contributing to a reduction in suicide rates in Vojvodina. Expanding the database could improve the functions of the obtained classifier and enable its introduction into medical practice.</p><p><strong>Graphical abstract: </strong>https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-27.jpg.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"528-538"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion.","authors":"K-X Lou, Z-H Li, P Wang, Z Liu, Y Chen, X-L Wang, H-X Cui","doi":"10.26355/eurrev_202511_37512","DOIUrl":"https://doi.org/10.26355/eurrev_202511_37512","url":null,"abstract":"<p><p>The article \"Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion\" by K.-X. Lou, Z.-H. Li, P. Wang, Z. Liu, Y. Chen, X.-L. Wang, H.-X. Cui published in Eur Rev Med Pharmacol Sci 2018; 22 (5): 1358-1365-DOI: 10.26355/eurrev_201803_14479-PMID: 29565494 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer and whistleblowers, the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation identified several instances of figure duplication, specifically in Figure 2 (panels B and D), with previously published articles. The authors were contacted, informed of the ongoing investigation, and requested to provide the original data supporting the manuscript, but they remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14479.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 11","pages":"491"},"PeriodicalIF":3.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Long non-coding RNA MEG3 represses cholangiocarcinoma by regulating miR-361-5p/TRAF3 axis.","authors":"W-X Lu","doi":"10.26355/eurrev_202510_37461","DOIUrl":"https://doi.org/10.26355/eurrev_202510_37461","url":null,"abstract":"<p><p>The article \"Long non-coding RNA MEG3 represses cholangiocarcinoma by regulating miR-361-5p/TRAF3 axis\" by W.-X. Lu published in Eur Rev Med Pharmacol Sci 2019; 23 (17): 7356-7368-DOI: 10.26355/eurrev_201909_18842-PMID: 31539122 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer (https://pubpeer.com/publications/1CE3437CE3D1F5CA10D8494E9EFEE2), the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation identified multiple instances of figure duplication, specifically in panel C of Figure 9, with previously published articles. Additionally, a duplication was also found in the Western Blots of Figure 8 with a previously published article. The author was contacted and informed of the ongoing investigation, and was requested to provide the original data supporting the manuscript, but remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/18842.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 10","pages":"454"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of poor outcomes in status epilepticus: insights from a university hospital in Saudi Arabia.","authors":"B Aljafen, S Alwakeel, L Alwakeel, J Alghtani, Z Alkaff, W Philip","doi":"10.26355/eurrev_202510_37468","DOIUrl":"https://doi.org/10.26355/eurrev_202510_37468","url":null,"abstract":"<p><p>OBJECTIVE: Status epilepticus (SE) is a life-threatening neurological emergency. However, studies on the prognostic factors of adult patients with SE in the Middle East remain lacking. Therefore, the present study aimed to analyze the clinical presentation, causes, and complications of SE and determine predictors of poor outcomes in patients treated in a tertiary care university hospital in Saudi Arabia. MATERIALS AND METHODS: This retrospective cohort study was conducted in the Department of Medicine, Neurology Division, College of Medicine, King Saud University, Riyadh, Saudi Arabia. This study recruited 38 patients aged 14 years or older who met the diagnostic criteria for SE. The median age was 30, and males accounted for 60.5% of cases. The outcomes were assessed using the Glasgow Outcome Scale (GOS). RESULTS: A history of epilepsy was present among 78.9% of patients; generalized seizures were observed in 89.5%, and focal seizures were observed in 10.59%. The primary complications included respiratory problems (36.89%) and acute kidney injury (23.7%). Antiepileptic drug reduction or withdrawal was the most common etiology in patients with preexisting epilepsy. Systemic infection (42.1%) was the most common cause in the general population, followed by withdrawal or reduction of anti-epileptic drugs (39.5%) and cerebrovascular disease (23.7%). Overall, 36.8% of patients experienced poor outcomes. CONCLUSIONS: It was concluded that, overall, one-third of patients experienced poor outcomes. The mortality rate was 18.4%. The refractory SE, caused by cerebrovascular disease and respiratory/renal complications, was identified as a significant predictor of poor outcomes. This study highlights poor medication adherence and systemic infections as the primary causes of SE in Saudi Arabia. Refractory SE, respiratory complications, acute kidney injury, and SE due to cerebrovascular disease emerged as key predictors of poor outcomes, emphasizing the importance of addressing the underlying causes and the early recognition and management of complications.</p><p><strong>Graphical abstract: </strong>https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-24.jpg.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 10","pages":"481-488"},"PeriodicalIF":3.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}