European review for medical and pharmacological sciences最新文献

{"title":"Predictive factors for lack of neurological improvement in acute stroke patients without large vessel occlusion treated with low-dose thrombolysis and screened with 3T MRI.","authors":"S Q Huynh, C C Tran, T T H Nguyen, H M Le, B T Nguyen, T M Ngo, T M Le, D M Nguyen","doi":"10.26355/eurrev_202412_36975","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36975","url":null,"abstract":"<p><strong>Objective: </strong>The study evaluated the lack of neurological improvement and the factors influencing it in patients with acute ischemic stroke (AIS) without major arterial occlusion.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted on patients diagnosed with acute ischemic stroke without significant occlusion of major arteries, with imaging evidence from 3-tesla magnetic resonance imaging (MRI) scans at the S.I.S Hospital in Can Tho, Vietnam, from 2019 to 2023. Eligible patients received treatment with low-dose alteplase (a single dose of 0.6 mg/kg).</p><p><strong>Results: </strong>Among the 268 patients included in the study, a significant improvement in neurological function was observed in 195 patients (72.8%) [modified Rankin Scale (mRS): 0-1 points], while 73 patients (27.2%) demonstrated little or no improvement after 3 months of treatment. There were no recorded fatalities during the study period. Female patients accounted for 35.8% of the total sample. The average age of the participants was 62.9 years. The multivariate regression analysis identified several predictive factors associated with the risk of lack of improvement after 3 months, including advanced age, higher National Institute of Health Stroke Scale (NIHSS) scores, elevated blood glycemia levels (mmol/L), and elevated high-sensitive (hs) troponin I levels (ng/mL) (p < 0.05). Glycemia and hs troponin I levels were identified as biomarkers for predicting outcomes after ischemic stroke. No evidence was found linking sex, a history of chronic illness, and a lack of improvement.</p><p><strong>Conclusions: </strong>Predicting prognostic factors for lack of neurological improvement will assist neurologists in developing personalized treatment plans for patients, reducing complications, and promoting patient recovery.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4646-4655"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term blood pressure control assessment using time spent in therapeutic range among Saudi patients.","authors":"M A Alshabeeb, R Alajlan, S Abohelaika, F A Alherz, A A Alqurain, F A Alomar","doi":"10.26355/eurrev_202412_36976","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36976","url":null,"abstract":"<p><strong>Objective: </strong>Time in therapeutic range (TTR) is a new approach to monitoring blood pressure (BP), providing a more accurate picture over time compared to the standard single BP measurement during a clinic visit. Currently, no study from Saudi Arabia has explored the use of TTR in assessing BP control and its related factors. Thus, we aimed to investigate them in this study.</p><p><strong>Patients and methods: </strong>Participants aged ≥ 18 years with at least three BP measurements from January 2016 to December 2020 were enrolled. Patient data were collected, including the date of hypertension (HTN) diagnosis, comorbidities, medication history, and laboratory test results. TTR values were calculated, and descriptive statistical analysis was applied to assess the differences between patients with TTR ≥ 50% and those with TTR < 50%. The Poisson regression model was used to describe the associations between patient characteristics and TTR values.</p><p><strong>Results: </strong>30,694 patients were included, with 74% identified as having TTR < 50%. Female gender, concomitant diabetes mellitus, or cardiovascular diseases were significantly associated with TTR ≥ 50% (p < 0.02). Conversely, increasing age, body mass index, years with HTN, or hyperlipidemia were associated with TTR < 50% (p < 0.001).</p><p><strong>Conclusions: </strong>According to the 2017 American College of Cardiology and the American Heart Association (ACC/AHA) guidelines, about three-quarters of the patients presented with TTR < 50% among the screened Saudi cohort. The results of this study may raise concerns about clinicians' adherence to the updated HTN management guidelines and patients' compliance with their treatment plans. This underscores the urgent need to improve HTN management and TTR attainment among Saudi patients.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4656-4665"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: MiR-5692a promotes the invasion and metastasis of hepatocellular carcinoma via MMP9.","authors":"S-J Sun, N Wang, Z-W Sun, J Chen, H-W Cui","doi":"10.26355/eurrev_202412_36973","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36973","url":null,"abstract":"<p><p>The article \"MiR-5692a promotes the invasion and metastasis of hepatocellular carcinoma via MMP9\" by S.-J. Sun, N. Wang, Z.-W. Sun, J. Chen, H.-W. Cui, published Eur Rev Med Pharmacol Sci 2018; 22 (15): 4869-4878-DOI: 10.26355/eurrev_201808_15623-PMID: 30070322 has been retracted by the Editor in Chief. Due to concerns raised by online readers regarding a set of articles published by different publishers sharing similarities in Kaplan-Meier survival plots, correlation plots, and overlapping images from wound-healing and transwell assays, the Editor-in-Chief has initiated an investigation to evaluate the validity of the results and potential figure manipulation. The journal's investigation revealed duplications between panels A of Figure 4 and panel B of Figure 5. Also, splicing was detected in panel A of Figure 4. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15623.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4644"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer.","authors":"W Jiang, P Jiang, R Yang, D-F Liu","doi":"10.26355/eurrev_202412_36974","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36974","url":null,"abstract":"<p><p>The article \"Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer\" by W. Jiang, P. Jiang, R. Yang, D.-F. Liu, published in Eur Rev Med Pharmacol Sci 2018; 22 (14): 4431-4439-DOI: 10.26355/eurrev_201807_15494-PMID: 30058682 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/B4079372E27EE32646DBD24D98E7DA), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation revealed duplications between panels A and B of Figure 1, between Figure 3 and a previously published article (link: https://doi.org/10.1371/journal.pone.0140918), and image duplication and rotation within panel Normal Control of Figure 6C. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. Consequently, the Editor in Chief has decided to retract the manuscript. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15494.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4645"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual analogue scale foot and ankle vs. short-form 36 quality of life scores: artificial intelligence using machine learning analysis with an external validation.","authors":"C Angthong, P Rajbhandari, W Angthong","doi":"10.26355/eurrev_202412_36977","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36977","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to utilize artificial intelligence (AI) via machine learning (ML) to analyze the relationship between visual analogue scale foot and ankle (VASFA) and short-form 36 (SF-36) quality of life scores and determine AI's performance over the aforementioned analysis.</p><p><strong>Materials and methods: </strong>We collected data from our registry of 819 data units or rows of datasets of foot and ankle patients with VASFA, SF-36 scores, and other demographic data. They were prepared and verified to be a proper input for building ML models using a web-based algorithm platform. After the first ML model was developed using random forest regression, the SF-36 percentage value was set as an endpoint. We developed a second ML model to evaluate it against the current algorithm. This new model employed a gradient-boosting regressor, where we omitted a key parameter, SF_Total, to correct the overfitting. We performed an external validation based on an unseen dataset from 42 data units of patients.</p><p><strong>Results: </strong>Internal validity showed an excellent relationship among the VASFA, SF-36 total score, and overall SF-36 percent values at a correlation coefficient (R2 score) of 1.000 based on the random forest regression model of ML (first model: 28XJ). The VASFA percent value of the total score (0=worst; 100=best) demonstrated the dynamic changes in the three zones of the score levels; these were unsatisfactory: ≤ 57.25; borderline: 57.26-80.99; satisfactory: ≥ 81 and could impact the levels of overall SF-36 percent value. A second ML model (model FK13) showed an R2 score of 0.977, which was a great performance. External validation showed no significant difference between the predicted and actual values, with a two-tailed p-value of 0.2136.</p><p><strong>Conclusions: </strong>Our ML models predicted excellent relationships among VASFA, with or without SF-36 total score and overall SF-36 percentage values, with evidence from external validation.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4666-4670"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the urinary microbiome on male benign prostatic hyperplasia (BPH) and its management using probiotic supplementation: a narrative review.","authors":"N Schifano, P Capogrosso, S Baldini, A Villano, G Antonini, F Deho'","doi":"10.26355/eurrev_202412_36978","DOIUrl":"https://doi.org/10.26355/eurrev_202412_36978","url":null,"abstract":"<p><p>Benign prostatic hyperplasia (BPH) is highly prevalent and associated with a significant impact on individuals' well-being. Initial management involves various medications, but their benefits can be limited by side effects, particularly concerning young people. In this context, novel and better-tolerated therapeutic strategies have been proposed, thus including the modulation of the gut microbiome through probiotic ingestion. We aimed to examine the available evidence linking the urinary microbiome to lower urinary tract symptoms (LUTS) and to evaluate the possible usefulness of probiotic supplementation as a novel treatment option for LUTS/BPH. A narrative review design was preferred to fulfill our purpose. The search strategy included a range of terms, e.g., \"microbiome,\" \"microbiota,\" \"urobiome,\" AND/OR \"probiotics\" AND \"benign prostatic hyperplasia,\" \"benign prostatic enlargement,\" \"lower urinary tract symptoms.\" A range of studies aimed to investigate the possible impact of urinary microbiome on BPH. Gut and/or urinary dysbiosis can alter the gut permeability and initiate/maintain inflammatory and oxidative processes in the prostate, which may contribute to the cell-hyper-proliferation leading to BPH. The modulation of the urinary and/or gut microbiome through probiotic supplementation seems to provide levels of clinical effectiveness in the management of BPH. Although different probiotics have been tested, a combination of B. Longum and F. Psychaerophilum seems to be particularly promising due to their capability of modulating both the inflammatory pathway and the intestinal barrier permeability. Gut and/or urinary microbiome dysbiosis is most likely contributing to the BPH pathogenesis. Even though only scarce evidence on the potential usefulness of probiotic supplementation in the management of BPH is currently available, the available studies seem to provide encouraging results. Further prospective trials are warranted in order to confirm these findings and to clarify which probiotic strains are more suitable for supplementation in this setting.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 23","pages":"4671-4679"},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diuretic activity of ethanolic extract and fraction enriched in saponins from Solanum sisymbriifolium Lam. root in rats.","authors":"W J Arrúa, J G Duarte, M C Hellión-Ibarrola, D A Ibarrola","doi":"10.26355/eurrev_202411_36911","DOIUrl":"10.26355/eurrev_202411_36911","url":null,"abstract":"<p><strong>Objective: </strong>Solanum sisymbriifolium Lam. is a native perennial plant with chemical characteristics of therapeutic importance. In Paraguayan traditional medicine, it is attributed to antihypertensive and diuretic activities. For this reason, the objective of the study was to evaluate the effect of acute oral administration of the ethanolic extract and fraction enriched in saponins obtained from the root of S. sisymbriifolium on the diuresis profile of rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats were used, randomly distributed in 6 groups to evaluate the diuretic activity. The control group received distilled water; the diuretic group was treated with 20 mg/kg of furosemide. Two groups were treated with 50 and 100 mg/kg of the ethanolic extract of S. sisymbriifolium, and two other groups were treated with 1 and 10 mg/kg with the fraction enriched in saponins. The animals were placed in individual metabolic cages for a period of 24 h. Urine volume was determined at 5 and 24 h, and urinary electrolytes, pH, and glomerular filtration rate at 24 h.</p><p><strong>Results: </strong>The findings indicated that both doses of the ethanolic extract and the saponin-enriched fraction significantly increased diuresis after 24 hours of treatment. Urinary pH was not affected. A significant increase in the urinary excretion of Na+ and Cl- was observed without affecting the elimination of K+ with both doses of the extracts. In addition, a significant increase in GFR was evidenced.</p><p><strong>Conclusions: </strong>Both ethanolic extract and saponins enriched fraction, presented natriuretic and saluretic effects with a possible mechanism of action mediated, at least partially, by the inhibition of carbonic anhydrase. Furthermore, it was possible to demonstrate the participation of the COX/PG pathway in the diuretic mechanism of the extracts in male rats.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 21","pages":"4526-4535"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible role of serum NGAL and MMP-9 in the assessment of kidney impairment and cardiovascular risk in children and adolescents with type 1 diabetes mellitus or obesity.","authors":"E Kostopoulou, D Kalavrizioti, P Davoulou, P Plotas, X Sinopidis, E Papachristou, D Goumenos, G Dimitriou, B E Spiliotis, M Papasotiriou","doi":"10.26355/eurrev_202411_36912","DOIUrl":"10.26355/eurrev_202411_36912","url":null,"abstract":"<p><strong>Objective: </strong>Type 1 diabetes mellitus (DM1) and obesity represent two chronic pediatric diseases characterized by increased risk for renal impairment and cardiovascular disease. The potential usefulness of neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9), two novel biomarkers, for predicting early kidney injury or increased cardiovascular risk in children and adolescents with DM1 or obesity, was investigated in this cross-sectional study.</p><p><strong>Patients and methods: </strong>Serum samples were obtained from children and adolescents aged 12.7 ± 3.8 years old with DM1 (n = 38) or obesity (n = 34) and normal renal function, as well as from healthy controls (n = 24). NGAL and MMP-9 concentrations were measured using commercially available sandwich ELISA kits (NGAL: DY1757-05, MMP-9: DMP900; R&D systems, Minneapolis, MN, USA).</p><p><strong>Results: </strong>NGAL serum values were found significantly higher in patients with obesity but not in those with DM1. A positive correlation was found in patients with DM1 with diabetes duration, and in the total population with body mass index (BMI) z-score. Also, serum MMP-9 levels were significantly increased in patients with DM1 and in patients with obesity compared to controls.</p><p><strong>Conclusions: </strong>Circulating NGAL and MMP-9 levels may prove useful as surrogate biomarkers to creatinine, glomerular filtration rate (GFR), and albumin excretion rate for early detection of kidney injury and cardiovascular complications in children and adolescents with DM1 or obesity.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 21","pages":"4536-4545"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloodstream infections caused by Staphylococcus aureus in patients admitted to King Abdulaziz University Hospital, Jeddah, Saudi Arabia.","authors":"A Albuhairy, D Attallah, S Qashqari, M Al-Rabia, R Kaki, S Harakeh, K Alkuwaity, T Abujamel, T Altorki, J Mokhtar, O Alharbi, M Ismail, M Mufrrih, A Sait, H Momin, I Abu, B Saleh, T Ekhmimi, A Alfadil, K A Ibrahem","doi":"10.26355/eurrev_202411_36956","DOIUrl":"https://doi.org/10.26355/eurrev_202411_36956","url":null,"abstract":"<p><strong>Objective: </strong>Currently, there is a limited amount of published data on the incidence of bloodstream infections (BSI) caused by both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) in most parts of the Arabian Peninsula. Thus, it is extremely important to have information concerning the distribution and prevalence of MRSA and MSSA to better handle and manage future epidemics.  This study aimed to investigate the correlation between MRSA and/or MSSA with BSI at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia.</p><p><strong>Patients and methods: </strong>This investigation took place at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, for four years. During this period, we meticulously collected and documented clinical data on blood cultures that tested positive for MRSA or MSSA.</p><p><strong>Results: </strong>BSI caused by S. aureus bacteria was found in 461 individuals; 232 (50.3%) of these patients had MSSA, and 229 (49.7%) had MRSA. The data showed that patients with diabetes, renal, and heart disease were most at risk of contracting S. aureus associated with BSI (at 46%, 37%, and 23%, respectively). Hospital-acquired (HA) MRSA was associated with higher rates of BSI compared to HA-MSSA. Device and procedure-related infections were mostly associated with HA-BSI, whereas superficial skin and soft-tissue infections were more commonly connected to community-acquired BSI (CA-BSI).</p><p><strong>Conclusions: </strong>Such information will probably lead to a reduction in hospital-acquired infections and will improve hospital infection-preventative procedures. Based on the data obtained, diabetic patients are most at risk of contracting S. aureus BSI.  To prevent the spread of MRSA infection among healthcare centers, patients with MRSA must undergo MRSA screening tests, appropriate therapeutic follow-up, and contact precautions. Moreover, appropriate therapeutic management of diabetes may protect the patients from getting infected with S. aureus.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 22","pages":"4621-4633"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring factors influencing COVID-19 severity: a matched case-control study.","authors":"G H Mansouri, F Darjiyani, F Karami Robati, L Allahqoli, H Mirzaei, H Salehiniya, I Alkatout","doi":"10.26355/eurrev_202411_36914","DOIUrl":"10.26355/eurrev_202411_36914","url":null,"abstract":"<p><strong>Objective: </strong>COVID-19, first identified in December 2019, quickly became a global pandemic and remains a significant public health concern. Robust data is rare, especially in pregnant women. The symptoms of this disease range from mild to severe respiratory distress syndrome and mortality. The present study aimed to evaluate the factors influencing COVID-19 severity in women to be better prepared in case of a new epidemic.</p><p><strong>Patients and methods: </strong>This retrospective matched case-control study based on body mass index, smoke, and drug use was conducted on all women hospitalized with COVID-19 at Afzalipour Hospital in Kerman, Iran from the beginning of 2020 to 2021. In this study, 130 female patients with COVID-19 were included, with 65 patients in the case group (moderate and severe cases of COVID-19) and 65 patients in the control group (mild cases of COVID-19). The data were entered into the Stata software, and to determine the effective risk factors for the severity of COVID-19 disease, both univariate and multivariable conditional logistic regression analyses were utilized, assuming individual matching. Finally, the odds ratios (OR), along with 95% confidence intervals (CI), were estimated.</p><p><strong>Results: </strong>The average age of women in the case group was 36.92 ± 7.07 years, compared to 30.12 ± 6.27 years in the control group. Among all patients, 50% were pregnant, with a mean gestational age of 30.03 weeks. Significant factors affecting disease severity included age, education, employment status, place of residence, insurance coverage, comorbidities, and pregnancy status. The highest adjusted odds ratio for severe COVID-19 was associated with comorbidities (OR = 7.8, 95% CI: 2.3-11.1), while the lowest was associated with urban residence (OR = 2.8, 95% CI: 1.02-4.5). Overall, significant predictors of severe COVID-19 included age over 30, urban residence, lack of insurance, a short duration between diagnosis and hospitalization, comorbidities, and non-pregnancy.</p><p><strong>Conclusions: </strong>The study identified several significant predictors of severe COVID-19 among women, including age over 30, urban residency, lack of insurance coverage, presence of comorbidities, and non-pregnancy, all of which were associated with a heightened risk of severe illness. Notably, comorbidities emerged as the strongest predictor. These findings underscore the critical need for targeted interventions to protect vulnerable populations.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"28 21","pages":"4553-4560"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}