{"title":"Decoding pharmacogenetics and metabolic panels in Jordanian women with polycystic ovary syndrome: a case-control study.","authors":"A Yehya, A M Rababa'h, J Hamadneh, C L Shaffer","doi":"10.26355/eurrev_202506_37276","DOIUrl":null,"url":null,"abstract":"<p><p>OBJECTIVE: This study aimed to assess the metabolic profiles and the frequency of the Serine/threonine kinase 11 (STK11) rs8111699 single-nucleotide polymorphism (SNP) among Jordanian women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS Ninety Jordanian women with PCOS and ninety healthy controls participated in the study. Metabolic characteristics were recorded, and direct sequencing was used to identify STK11 SNP genotypes. RESULTS: Among the PCOS patients, 23 (31.1%) had the wild-type (CC) genotype, while 39 (46.6%) and 28 (35.5%) had heterozygous (CG) and homozygous (GG) genotypes, respectively. There was no statistically significant difference in the genotype and allele distribution between the cases and controls (p=0.264 and p<0.702, respectively). Women carrying the minor G allele had poor metabolic profiles and more severe clinical features. CONCLUSIONS: The findings support the importance of early detection of PCOS, especially in high-risk populations, to enable timely preventive interventions. The interplay between genetic and metabolic profiles offers guidance for improving treatment outcomes in women with PCOS.</p><p><strong>Graphical abstract: </strong>https://www.europeanreview.org/wp/wp-content/uploads/Graphical-abstract-14056.jpg.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"29 6","pages":"339-346"},"PeriodicalIF":3.3000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European review for medical and pharmacological sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.26355/eurrev_202506_37276","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
OBJECTIVE: This study aimed to assess the metabolic profiles and the frequency of the Serine/threonine kinase 11 (STK11) rs8111699 single-nucleotide polymorphism (SNP) among Jordanian women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS Ninety Jordanian women with PCOS and ninety healthy controls participated in the study. Metabolic characteristics were recorded, and direct sequencing was used to identify STK11 SNP genotypes. RESULTS: Among the PCOS patients, 23 (31.1%) had the wild-type (CC) genotype, while 39 (46.6%) and 28 (35.5%) had heterozygous (CG) and homozygous (GG) genotypes, respectively. There was no statistically significant difference in the genotype and allele distribution between the cases and controls (p=0.264 and p<0.702, respectively). Women carrying the minor G allele had poor metabolic profiles and more severe clinical features. CONCLUSIONS: The findings support the importance of early detection of PCOS, especially in high-risk populations, to enable timely preventive interventions. The interplay between genetic and metabolic profiles offers guidance for improving treatment outcomes in women with PCOS.
期刊介绍:
European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research.
The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine.
European Review for Medical and Pharmacological Sciences includes:
-Editorials-
Reviews-
Original articles-
Trials-
Brief communications-
Case reports (only if of particular interest and accompanied by a short review)