Decoding pharmacogenetics and metabolic panels in Jordanian women with polycystic ovary syndrome: a case-control study.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-06-01 DOI:10.26355/eurrev_202506_37276

A Yehya, A M Rababa'h, J Hamadneh, C L Shaffer

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Abstract

OBJECTIVE: This study aimed to assess the metabolic profiles and the frequency of the Serine/threonine kinase 11 (STK11) rs8111699 single-nucleotide polymorphism (SNP) among Jordanian women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS Ninety Jordanian women with PCOS and ninety healthy controls participated in the study. Metabolic characteristics were recorded, and direct sequencing was used to identify STK11 SNP genotypes. RESULTS: Among the PCOS patients, 23 (31.1%) had the wild-type (CC) genotype, while 39 (46.6%) and 28 (35.5%) had heterozygous (CG) and homozygous (GG) genotypes, respectively. There was no statistically significant difference in the genotype and allele distribution between the cases and controls (p=0.264 and p<0.702, respectively). Women carrying the minor G allele had poor metabolic profiles and more severe clinical features. CONCLUSIONS: The findings support the importance of early detection of PCOS, especially in high-risk populations, to enable timely preventive interventions. The interplay between genetic and metabolic profiles offers guidance for improving treatment outcomes in women with PCOS.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-abstract-14056.jpg.

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解码约旦多囊卵巢综合征妇女的药物遗传学和代谢组：一项病例对照研究。

目的：本研究旨在评估约旦多囊卵巢综合征（PCOS）女性丝氨酸/苏氨酸激酶11 (STK11) rs8111699单核苷酸多态性（SNP）的代谢谱和频率。材料与方法90名约旦多囊卵巢综合征妇女和90名健康对照者参加了这项研究。记录代谢特征，直接测序鉴定STK11 SNP基因型。结果：PCOS患者中，野生型（CC） 23例（31.1%），杂合型（CG） 39例（46.6%），纯合型（GG） 28例（35.5%）。两组间基因型及等位基因分布差异无统计学意义（p=0.264, p= p）。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)