European review for medical and pharmacological sciences最新文献

{"title":"Assessment of the acceptability of effervescent oxycodone/paracetamol in the management of moderate-to-severe pain: the FirAlgos study.","authors":"R Vellucci, E Tur, A Lepri, S Gasperoni, L Dodaro, C Simoni, Z Momirovic, S Romagnoli","doi":"10.26355/eurrev_202605_37822","DOIUrl":"10.26355/eurrev_202605_37822","url":null,"abstract":"<p><strong>Objective: </strong>Chronic pain affects approximately one quarter of the Italian adult population and represents a major public health burden, significantly impairing quality of life and functional capacity. When first-line analgesics are insufficient, opioid combinations such as oxycodone/paracetamol (OXY/PAR) are recommended. The effervescent formulation of OXY/PAR was developed to improve administration and acceptability, particularly in frail patients or those with swallowing difficulties. The FirAlgos study evaluated its real-world effectiveness and patient-reported acceptability.</p><p><strong>Materials and methods: </strong>This retrospective observational study included adult patients treated with effervescent OXY/PAR for moderate-to-severe pain (NRS >5) at a tertiary Pain Therapy Center (2022-2023). Assessments were performed at baseline (T0), Day 7 (T1), and Day 14 (T2). Outcomes included pain intensity (Numeric Rating Scale, NRS), pain interference (Brief Pain Inventory, BPI), Patient Global Impression of Change (PGIC), and treatment satisfaction. Longitudinal changes were analyzed using Friedman's Chi-Square test with Wilcoxon post-hoc correction.</p><p><strong>Results: </strong>Ninety-four patients were included (mean age 69.3 ± 13.3 years; 59.6% female; 75.5% non-oncologic pain). Significant reductions in NRS scores were observed between T0 and T1 across all pain dimensions in both oncologic and non-oncologic groups (p < 0.05), with stabilization at T2. PGIC scores showed a rapid upward shift toward higher perceived improvement categories, maintained at follow-up. BPI analyses demonstrated significant early improvements in functional domains, particularly general activity, mobility, and work capability, with sustained benefit over time.</p><p><strong>Conclusions: </strong>In real-world clinical practice, the effervescent OXY/PAR formulation provided rapid, clinically meaningful, and sustained pain relief, with parallel improvements in functional outcomes and patient-perceived benefit. Its high acceptability supports its use in patients requiring flexible and easily administrable analgesic options for moderate-to-severe pain.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 5","pages":"181-191"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a new diagnostic tool for detecting cervical cancer using a TCR-like antibody targeting the HPV 16 oncoprotein E7.","authors":"R Selva Rajan, S A Dass, B A Sachit, G J Tye, V Balakrishnan","doi":"10.26355/eurrev_202605_37821","DOIUrl":"10.26355/eurrev_202605_37821","url":null,"abstract":"<p><strong>Objective: </strong>Persistent Human Papillomavirus (HPV) infection causes 84% of cervical cancers (CC) worldwide. The current gold standard, Pap smear, has a high false-negative rate, highlighting the need for a specific and sensitive molecular method for early diagnosis. T cell receptor (TCR)-like antibodies offer a promising platform for cancer immunodiagnostics and immunotherapy.</p><p><strong>Materials and methods: </strong>Using the phage display technique, a monoclonal TCR-like antibody (16 Ab) against HPV 16 oncoprotein E7 for human leukocyte antigen (HLA)-A2 was produced in this study. 16 Ab was selected from a single-domain antibody (sDAb) library via biopanning, an affinity-selection method. Once the clone of 16 Ab was selected, it was sequenced, and the result was analyzed using IMGT/V-Quest and VBase2 databases before proceeding with 16 Ab protein expression and purification. The purified 16 Ab was evaluated for its binding capability towards its target peptide-major histocompatibility complex (pMHC) by Western blot and Enzyme-Linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>A target pMHC complex was generated and panned against a phage display library. Highly enriched antibody phages from the 3rd biopanning round were chosen for phage ELISA analyses. Of the nine clones selected and sequenced, only two had proper sequences, and 16 Ab was chosen for the downstream process because it shows higher specificity for the target pMHC complex than the other clones. The dot blot showed that the soluble protein from 16 Ab was successfully expressed. The binding of 16 Ab towards the target pMHC complex (OD405 nm: 1.06) significantly differs from the non-target pMHC complex (OD405 nm: 0.09).</p><p><strong>Conclusions: </strong>This study demonstrates the potential of 16 Ab as a companion diagnostic to reduce the rate of false-negative Pap smears. Further research is needed to assess its therapeutic potential, expand coverage to all HPV variants and HLA types, and evaluate its performance in cervical cancer cell lines before clinical testing.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 5","pages":"164-180"},"PeriodicalIF":3.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Putative underlying mechanisms of lipid emulsion treatment for aluminum phosphide poisoning&#8221.","authors":"M Singh Bhatia, R Attri, A Saroch, A Kumar Pannu, N Singla, S Chandrabhan Sharda","doi":"10.26355/eurrev_202604_37750","DOIUrl":"https://doi.org/10.26355/eurrev_202604_37750","url":null,"abstract":"","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"131-132"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Antisepsis regimen in the surgical treatment of HPV generated cervical lesions: polyhexamethylene biguanide vs chlorhexidine. A randomized, double blind study.","authors":"S Gerli, F Bavetta, G C Di Renzo","doi":"10.26355/eurrev_202604_37746","DOIUrl":"https://doi.org/10.26355/eurrev_202604_37746","url":null,"abstract":"<p><p>The article \"Antisepsis regimen in the surgical treatment of HPV generated cervical lesions: polyhexamethylene biguanide vs chlorhexidine. A randomized, double blind study\" by S. Gerli, F. Bavetta, G.C. Di Renzo, published in European Review for Medical and Pharmacological Sciences 2012; 16: 1994-1998-PMID: 23242728, has been retracted by the Publisher and the Editor in Chief. Following concerns raised by a whistleblower regarding the statistical analysis and the reliability of the reported results, the journal initiated an editorial investigation in accordance with ethical policies. The authors were contacted and provided a response. An independent statistical expert was also appointed to reassess the methodology and data analysis. The evaluation identified significant methodological and statistical concerns that affect the validity and interpretation of the study findings. In light of these issues, the Editor-in-Chief has concluded that the reliability of the results and the conclusions of the article are compromised. The article is therefore retracted. This article has been retracted. The Publisher apologizes for any inconvenience this may cause.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"126"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the impact of post-emergency visit on diagnostic and therapeutic changes in orthopedics.","authors":"A Laudat, T Stoclet, N Kloek, M Leplomb, L-M Joly, M Taalba, M Lalevée","doi":"10.26355/eurrev_202604_37752","DOIUrl":"10.26355/eurrev_202604_37752","url":null,"abstract":"<p><strong>Objective: </strong>Musculoskeletal trauma accounts for more than a third of emergency department visits, and accurate diagnosis and treatment can be challenging in the acute setting. The objective of our study was to evaluate the impact of a post-emergency orthopedic visit on diagnostic and therapeutic changes in patients with minor trauma.</p><p><strong>Materials and methods: </strong>We conducted a prospective observational study in two French university hospitals. Adult patients referred to a post-emergency orthopedic visit for minor upper or lower limb trauma were included. Exclusion criteria included immediate surgical indication or injuries outside the limbs. Data collected during both initial and follow-up visits were compared to identify diagnostic changes (DCs) and therapeutic modifications (TMs), with TMs classified as resulting in either more or less intensive care.</p><p><strong>Results: </strong>A total of 547 patients were included. DCs occurred in 14.4% patients (n=79), and TMs were made in 23.2% (n=127). Among patients with TMs, 61.4% (n=78) received less intensive treatment, while 38.6% (n=49) required more intensive care. The highest rates of DCs were observed for knee contusions (31.9%, n=15/47), wrist sprains (36.4%, n=4/11), and ankle sprains (18.8%, n=12/64). TMs leading to less intensive care were most frequently noted in ankle sprains (21.9%, n=14/64), knee contusions (21.3%, n=10/47), foot fractures (11.3%, n=7/62), and wrist fractures (10.6%, n=9/85). More intensive care was frequently required for wrist sprains (63.6%, n=7/11) and foot contusions (25%, n=3/12). Injuries such as shoulder dislocations (TM: 0%) and shoulder fractures (DC: 6.9%, TM: 10.3%) rarely led to modifications during the post-emergency visit.</p><p><strong>Conclusions: </strong>The post-emergency visit is of interest when targeting trauma pathologies at risk of diagnostic change or therapeutic modification.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"143-151"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative and arts-based interventions in oncology supportive care: a narrative review of evidence and implications for bridging the distress screening-response gap.","authors":"S Cafarotti, P Perretta, D Salafia","doi":"10.26355/eurrev_202604_37751","DOIUrl":"10.26355/eurrev_202604_37751","url":null,"abstract":"<p><p>Psychological distress is a core dimension of oncology care and has long been described as the \"sixth vital sign\". Although distress screening is widely recommended and increasingly embedded in oncology services, translation of screening results into structured supportive responses remains inconsistent. The aim of the study is to synthesize the literature on narrative and arts-based interventions in adult oncology supportive care and to examine how implementation science can clarify the persistent gap between distress screening and timely supportive action. This manuscript was developed as a targeted narrative review. PubMed and Scopus were searched for systematic reviews, meta-analyses, landmark randomized trials, and implementation science papers relevant to distress screening, narrative medicine, art therapy, creative arts therapy, music interventions, dignity therapy, meaning-centered psychotherapy, and participatory visual methods in oncology. Priority was given to high-quality secondary evidence, seminal conceptual papers, and practice guidelines. Across visual art therapy, creative arts therapy, music interventions, dignity therapy, meaning-centered psychotherapy, and participatory visual approaches, the literature generally shows modest but consistent improvements in anxiety, emotional well-being, quality of life, existential outcomes, and patient experience. However, the same literature repeatedly reveals structural limitations: specialist dependency, multi-session intensity, heterogeneous outcome measurement, short follow-up, and sparse reporting of adoption, fidelity, penetration, cost, and sustainability. These constraints help explain why many psychosocial and arts-based interventions remain peripheral to routine oncology pathways despite favorable therapeutic signals. The central challenge in supportive oncology is no longer only whether distress can be detected, but whether detected distress is followed by a visible, scalable, and person-centered response. The literature supports renewed attention to brief, identity-centered conceptual models that can complement specialist psycho-oncology services and strengthen the connection between screening and supportive care within multidisciplinary cancer systems.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"133-142"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review.","authors":"Y Ahmad, S Kissling, C Torrent, J-D Chiche, L Liaudet, Z Ltaief","doi":"10.26355/eurrev_202604_37747","DOIUrl":"https://doi.org/10.26355/eurrev_202604_37747","url":null,"abstract":"<p><p>Correction to: Y. Ahmad, S. Kissling, C. Torrent, J.-D. Chiche, L. Liaudet, Z. Ltaief. The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review. Eur Rev Med Pharmacol Sci 2021; 25 (20): 6295-6299-DOI: 10.26355/eurrev_202110_26999-PMID: 34730209, published online on October 27, 2021. Following an editorial quality check, we have determined that incorrect references from another article were inadvertently inserted into the final PDF during production. The error was not detected by the authors prior to publication, and the PDF file was approved for publication. The erratum is issued to correct the whole list of references. 1. Kraut JA, Mullins ME. Toxic Alcohols. N Engl J Med 2018; 378: 270-280. 2. Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 2008; 3: 208-225. 3. Ross JA, Borek HA, Holstege CP. Toxic Alcohols. Crit Care Clin 2021; 37: 643-656. 4. Iqbal A, Glagola JJ, Nappe TM. Ethylene Glycol Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021. 5. Worthley LI, Guerin M, Pain RW. For calculating osmolality, the simplest formula is the best. Anaesth Intensive Care 1987; 15: 199-202. 6. Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol 2007; 2: 162-174. 7. Kruse JA. Methanol and ethylene glycol intoxication. Crit Care Clin 2012; 28: 661-711. 8. McStay CM, Gordon PE. Images in clinical medicine. Urine fluorescence in ethylene glycol poisoning. N Engl J Med 2007; 356: 611. 9. Sagar AS, Jimenez CA, McKelvy BJ. Lactate gap as a tool in identifying ethylene glycol poisoning. BMJ Case Rep 2018; 2018: bcr2018224243. 10. Poirier-Blanchette L, Simard C, Schwartz BC. Spurious point-of-care lactate elevation in ethylene glycol intoxication: rediscovering a clinical pearl. BMJ Case Rep 2021; 14: e239936. 11. Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD, Kennedy JR, Daws DE, Brignall JL. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med 2009; 53: 439-450. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"127"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Efficacy of intravenous lipid emulsion as an adjunctive therapy for acute aluminum phosphide poisoning: a randomized, open-label, pilot clinical trial.","authors":"M Singh Bhatia, R Attri, A Saroch, A Kumar Pannu, N Singla, S Chandrabhan Sharda","doi":"10.26355/eurrev_202604_37748","DOIUrl":"10.26355/eurrev_202604_37748","url":null,"abstract":"<p><p>Correction to: M. Singh Bhatia, R. Attri, A. Saroch, A. Kumar Pannu, N. Singla, S. Chandrabhan Sharda. Efficacy of intravenous lipid emulsion as an adjunctive therapy for acute aluminum phosphide poisoning: a randomized, open-label, pilot clinical trial. Eur Rev Med Pharmacol Sci 2026; 30 (1): 27-36-DOI: 10.26355/eurrev_202601_37646-PMID: 41636291, published online on January 20, 2026. This erratum serves to correct the calculation and reporting of the relative risk for the primary outcome, as well as a typographical error in the title. The authors regret a statistical error in the relative risk calculation for the primary outcome. Due to an inadvertent software parameter assignment during the statistical analysis, the Relative Risk (RR) was calculated and reported for survival (Control vs. Intervention) rather than the standard clinical metric of mortality (Intervention vs. Control). In the original publication, the RR was incorrectly reported as 0.493 (95% CI: 0.335-0.725). When properly analyzed to calculate the relative risk of mortality comparing the intravenous lipid emulsion group to the control group, the correct relative risk is 0.370 (95% CI: 0.211-0.649). The chi-square test statistic (χ² = 15.3, df = 1) and the statistical significance (p < 0.01) remain unchanged. Additionally, due to production error, a typo is displayed in the title, which is corrected as follows: Efficacy of intravenous lipid emulsion as an adjunctive therapy for acute aluminum phosphide poisoning: a randomized, open-label, pilot clinical trial This correction does not alter the fundamental findings of the study. There are amendments to this paper. The Publisher apologizes for any inconvenience this may cause.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"128"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Putative underlying mechanisms of lipid emulsion treatment for aluminum phosphide poisoning.","authors":"J-T Sohn","doi":"10.26355/eurrev_202604_37749","DOIUrl":"10.26355/eurrev_202604_37749","url":null,"abstract":"","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 4","pages":"129-130"},"PeriodicalIF":3.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Expression of miR-1294 is downregulated and predicts a poor prognosis in gastric cancer.","authors":"Y-X Shi, B-L Ye, B-R Hu, X-J Ruan","doi":"10.26355/eurrev_202603_37717","DOIUrl":"https://doi.org/10.26355/eurrev_202603_37717","url":null,"abstract":"<p><p>The article \"Expression of miR-1294 is downregulated and predicts a poor prognosis in gastric cancer\" by Y.-X. Shi, B.-L. Ye, B.-R. Hu, X.-J. Ruan, published in Eur Rev Med Pharmacol Sci 2018; 22 (17): 5525-5530-DOI: 10.26355/eurrev_201809_15813-PMID: 30229824, has been retracted in accordance with the Publisher and the Editor in Chief. Following a previously published Expression of Concern, the Editor-in-Chief and the Publisher have completed an investigation into the issues raised in relation to this article. The investigation confirmed concerns regarding non-verifiable nucleotide sequence reagents and the use of inadequately authenticated cell lines, which undermine the reliability of the findings reported. The authors did not respond to correspondence regarding these concerns. The Editor-in-Chief and the Publisher have therefore decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":"30 3","pages":"94"},"PeriodicalIF":3.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}