2006 IEEE International Symposium on MicroNanoMechanical and Human Science最新文献_第4页

The reconstruction of bioengineered organ by cell manipulation 利用细胞操作技术重建生物工程器官

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320294

K. Nakao, R. Morita, Y. Saji, K. Ishida, M. Ogawa, Y. Tomooka, T. Tsuji

{"title":"The reconstruction of bioengineered organ by cell manipulation","authors":"K. Nakao, R. Morita, Y. Saji, K. Ishida, M. Ogawa, Y. Tomooka, T. Tsuji","doi":"10.1109/MHS.2006.320294","DOIUrl":"https://doi.org/10.1109/MHS.2006.320294","url":null,"abstract":"It has been expected that technology for reconstitution of an entire organ from single cells for application to organ replacement strategies in regenerative therapy. In our current study, we show that the artificial organ germ, which generates a structurally correct organ, could be reconstituted by cell manipulation. Bioengineered tooth germ was reconstituted from epithelial and mesenchymal single cells, which were separated from E14.5 incisor tooth germ under stereoscopic microscope. Explants reconstituted with the compartmentalization between epithelial and mesenchymal cells at high-cell density could generate structurally correct teeth. Furthermore, individual primordia, which were dissected from the bioengineered tooth germ on day 2 of the organ culture, could generate a single tooth. These observations indicate that the initial cell density and the compartmentalization between cell types, which mimics epithelial mesenchymal cell interaction, are essential for the development of a bioengineered organ germ. Our results have a potential for the application of bioengineered organ in future regenerative therapies","PeriodicalId":121329,"journal":{"name":"2006 IEEE International Symposium on MicroNanoMechanical and Human Science","volume":"61 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116833514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coding the Environment in Tactile Maps for Real-Time Guidance of the Visually Impaired 用触觉地图编码环境，为视障人士提供即时指引

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320235

R. Velázquez, E. Fontaine, E. Pissaloux

引用次数: 33

Fabrication of a Tapered Structure by Means of Exposure to Diffracted UV Light 用衍射紫外光曝光的方法制造锥形结构

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320297

T. Tanaka, T. Nomura, Y. Funabiki, T. Kitadani, K. Idei, K. Yamashita, D. Noda, T. Hattori

{"title":"Fabrication of a Tapered Structure by Means of Exposure to Diffracted UV Light","authors":"T. Tanaka, T. Nomura, Y. Funabiki, T. Kitadani, K. Idei, K. Yamashita, D. Noda, T. Hattori","doi":"10.1109/MHS.2006.320297","DOIUrl":"https://doi.org/10.1109/MHS.2006.320297","url":null,"abstract":"Demands for personal digital assistants (PDA) call for them to be additionally low profile, lightweight, and low power. To fulfil these demands, it is necessary to develop a backlight unit that features low-power consumption, high brightness, and high efficiency. The light source in a backlight unit has a light guide plate, which is a highly important component. The light guide plate has dots to reflect light. It is known that the smaller the dots and the higher the aspect ratio, the brighter the screen. The result of a simulation revealed that it is possible to improve the brightness of light guide plate by forming the shape of a truncated cone with a taper angle of 68 to 78 degrees. However, using the existing machining technology, it is difficult to form the dots into such a shape. Producing a desired shape, like a tapered shape, in the depthwise direction is difficult even with lithography, although using an elaborate mask pattern, this technique can produce a sophisticated shape on a two-dimensional plane. We have produced a tapered microstructure with a high aspect ratio, devising an innovative method of diffracted light exposure based on a lithography technique making use of UV light source. Furthermore, we controlled the taper angle and fabricated a light guide plate through a mold master, Ni-electroforming, and an injection molding by using UV-LIGA process","PeriodicalId":121329,"journal":{"name":"2006 IEEE International Symposium on MicroNanoMechanical and Human Science","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116896268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Direct Visualization of Instability Phenomena of Molecularly Thin Liquid Films 分子薄液体薄膜不稳定现象的直接可视化

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320268

K. Fukuzawa, T. Shimuta, T. Yoshida, H. Zhang, Y. Mitsuya

引用次数: 0

A Two-axis Bimorph Piezoelectric Actuator for Pressure and Slippage Force Presentation 一种用于压力和滑移力表示的两轴双晶圆压电驱动器

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320223

M. Ohka, Y. Sawamoto, S. Matsukawa, T. Miyaoka, Y. Mitsuya

{"title":"A Two-axis Bimorph Piezoelectric Actuator for Pressure and Slippage Force Presentation","authors":"M. Ohka, Y. Sawamoto, S. Matsukawa, T. Miyaoka, Y. Mitsuya","doi":"10.1109/MHS.2006.320223","DOIUrl":"https://doi.org/10.1109/MHS.2006.320223","url":null,"abstract":"We are studying a two-axis micro-actuator to enhance the presentation reality of a tactile display that is capable of presenting pressure distribution and shearing force. We develop two types of actuators; Actuator A is composed of sequentially connected x- and y-directional actuators; each actuator is comprised of bimorph piezoelectric actuators. The x- and y-directional actuators are independently controlled by changing the applied voltage to position a probe that is attached to the tip of a two-axis actuator. The maximum displacement and force generated by the x-directional actuator are 1.1 mm and 0.03 N, respectively. Those generated by y-directional actuator are 1.0 mm and 0.06 N, respectively. Actuator B is composed of two bimorph actuators making an angle, two small links and three joints. At the present, we confirm that the actuator can move along x and y-axes of two-dimensional coordinate. Finally, since relationship between applied voltage and displacement caused by the voltage shows a hysteresis loop in the bimorph actuator used as components of the two-axis actuator, we produce a control system for the two-axial actuator based on a multi-layered artificial neural network to compensate the hysteresis","PeriodicalId":121329,"journal":{"name":"2006 IEEE International Symposium on MicroNanoMechanical and Human Science","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127108988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Energy Efficient Swing-Back Control for Brachiation Robot 臂式机器人的节能后摆控制

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320273

T. Fukuda, S. Kojima, K. Sekiyama, Y. Hasegawa

引用次数: 3

Development of Micro Perfusion Cell Culture Device to Create In Vivo-Like Environments for Long-Period and Real-Time Monitoring of Cells Activities 微灌注细胞培养装置的研制，为长时间和实时监测细胞活动创造类似体内环境

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320262

H. Kimura, H. Sakai, T. Yamamoto, Y. Sakai, T. Fujii

{"title":"Development of Micro Perfusion Cell Culture Device to Create In Vivo-Like Environments for Long-Period and Real-Time Monitoring of Cells Activities","authors":"H. Kimura, H. Sakai, T. Yamamoto, Y. Sakai, T. Fujii","doi":"10.1109/MHS.2006.320262","DOIUrl":"https://doi.org/10.1109/MHS.2006.320262","url":null,"abstract":"Although enormous efforts have been consumed to improve in vitro cell-based assays for life science, environmental assessment, medical applications, etc., conventional methods still have many problems, such as large dead volumes, difficulty to maintain constant concentration of nutrition and to remove accumulating waste products in static dish-based culture, etc. In order to solve these problems, it would be a breakthrough to realize miniaturized perfusion cell culture system, which continuously supply nutrition and remove metabolic waste products during cell culture. Such a system would be possible to culture cells for a long period and could monitor chemical response at real-time. This scheme of culture system could innovatively be advanced by coupling the recent microfabrication technology. Here, we have developed and experimentally demonstrated a micro cell culture device embedded with a stirrer-type micropump for on-chip perfusion of culture medium and optical fiber connectors for on-chip and real-time fluorescent detection. The cell culture chamber was separated into two compartments by a polyester-made semi-permeable membrane, which can realize polarized cell culture condition and detect a fluorescent signal movement in-between the two-compartments. As an evaluation of the device, Caco-2 cells were successfully cultured over a period up to 26 days and investigated the activity of P-glycoprotein using a fluorescent dye of Rhodamine-123 as a substrate of P-glycoprotein","PeriodicalId":121329,"journal":{"name":"2006 IEEE International Symposium on MicroNanoMechanical and Human Science","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133308905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Vision for a Power Distribution Line Maintenance Robot -Environments Input 配电线路维护机器人的视觉-环境输入

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320237

K. Tsukahara, Y. Tanaka, N. Takasu, R. Hori, Yingxin He, H. Tatematsu, K. Tatsuno

引用次数: 4

Quartz tuning-fork type AFM probe operated in Anti-phase Vibration Mode 石英音叉式AFM探针工作在反相位振动模式下

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320245

Hirotaka Hida, M. Shikida, K. Fukuzawa, A. Ono, Sato Kenji, K. Asaumi, Y. Iriye

引用次数: 2

Fabrication and Characterization of 4-DOF Soft-Contact Tactile Sensor and Application to Robot Fingers 四自由度软接触触觉传感器的制作、表征及在机器人手指上的应用

2006 IEEE International Symposium on MicroNanoMechanical and Human Science Pub Date : 2006-11-01 DOI: 10.1109/MHS.2006.320271

D. Dao, S. Sugiyama

{"title":"Fabrication and Characterization of 4-DOF Soft-Contact Tactile Sensor and Application to Robot Fingers","authors":"D. Dao, S. Sugiyama","doi":"10.1109/MHS.2006.320271","DOIUrl":"https://doi.org/10.1109/MHS.2006.320271","url":null,"abstract":"This paper describes the development and application of a 4-DOF (degree of freedom) soft-contact tactile (SCT) sensor using 6-DOF micro force moment sensing (MFMS) chip. The 6-DOF MFMS chip is working based on the piezoresistive effect in single crystalline silicon and has been fabricated and calibrated completely. The MFMS chip has been packaged to produce a 4-DOF soft-contact tactile sensor, which has the contact part made of silicone rubber. The sensor can independently detect three components of force (Fx', Fy', Fz') and one components of moment (Mz'). The MFMS chip and the SCT sensor have been calibrated. The calibrated sensitivities to Fx, Fy, Fz, Mx, My and Mz components are SFx =0.06(mV/mN), SFy =0.054(mV/mN), SFz = 0.136 (mV/mN), SMx = 1.449 (mV/mum), SMy = 1.451(mV/N|im), and SMz = 0.751(mV/N|im), respectively, (bias voltage Vin = 2V). The sensitivities of the SCT sensor to the forces Fz', Fx' (or Fy') and moment Mz' are 0.085 (mV/mN), 0.039 (mV/mN) and 0.004 (mV/mum), respectively. The outputs were linear and the crosstalk was small. The sensor has been mounted onto robot fingers to sense the forces from gripping operation","PeriodicalId":121329,"journal":{"name":"2006 IEEE International Symposium on MicroNanoMechanical and Human Science","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125472820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5