Expert Review of Molecular Diagnostics最新文献_第4页

Neurofilament light chain as a biomarker for neuronal injury in CNS infections. 神经丝轻链作为中枢神经系统感染中神经元损伤的生物标志物。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-25 DOI: 10.1080/14737159.2025.2509023

Lars Hagberg, Henrik Zetterberg, Magnus Gisslén

引用次数: 0

hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy. hTERT rs2735940多态性影响铂类双重化疗肺癌患者的肺癌风险和总生存期

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-05 DOI: 10.1080/14737159.2025.2500657

Anjali Saini, Heena Kansal, Navneet Singh, Siddharth Sharma

{"title":"hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy.","authors":"Anjali Saini, Heena Kansal, Navneet Singh, Siddharth Sharma","doi":"10.1080/14737159.2025.2500657","DOIUrl":"https://doi.org/10.1080/14737159.2025.2500657","url":null,"abstract":"Background: The hTERT gene is an essential part of the telomerase enzyme, preserving telomere length and encouraging cellular immortality. The study aimed to investigate whether the TERT gene SNP was associated with an increased risk of lung cancer in the North Indian population.Research design and methods: 387 lung cancer patients undergoing platinum-based chemotherapy and 384 healthy controls were genotyped for the TERT variant rs2735940 (T>C) using PCR-RFLP. The study aimed to determine the significant association between the TERT genetic variant and lung cancer risk.Results: Patients carrying homozygous mutant genotype (CC) for rs2735940 showed a significant association (0 R = 2.4, p = 0.03). Furthermore, in dominant model, the combination genotype (TC+CC) showed an increased risk of lung cancer susceptibility with an AOR of 1.67 (p = 0.0016). For TERT rs2735940, individuals with SCLC carrying the mutant genotype (CC) were significantly more likely to develop lung cancer (p = 0.0004). Our results also showed that lung cancer patients carrying the TERT rs2735940 genetic variant who received a combination of docetaxel and cisplatin/carboplatin had better prognosis as compared to alternative chemotherapy regimens.Conclusion: Our study associates' chemotherapy toxicities in North Indian lung cancer patients and the TERT polymorphism rs2735940, delivering insights for improving biomarker development and individualized treatment.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"1-13"},"PeriodicalIF":3.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variant in LncRNA-NKILA associated with gastric cancer susceptibility and the binding with miR-6731-5p. LncRNA-NKILA基因变异与胃癌易感性及与miR-6731-5p的结合

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-02 DOI: 10.1080/14737159.2025.2499898

Qiuyu Sun, Ye Zhang, Qian Yang, Xiaolin Chen, Yiran Wang, Yuwei Hou, Yaodong Zhang, Kaijuan Wang

{"title":"Genetic variant in LncRNA-NKILA associated with gastric cancer susceptibility and the binding with miR-6731-5p.","authors":"Qiuyu Sun, Ye Zhang, Qian Yang, Xiaolin Chen, Yiran Wang, Yuwei Hou, Yaodong Zhang, Kaijuan Wang","doi":"10.1080/14737159.2025.2499898","DOIUrl":"https://doi.org/10.1080/14737159.2025.2499898","url":null,"abstract":"Background: This study aims to assess the association between lncRNA-NKILA single nucleotide polymorphisms (SNPs) and susceptibility to gastric cancer in the Chinese Han population.Research design and methods: Four functional SNPs (rs911157, rs16981280, rs2273534, and rs957313) were validated using bioinformatics analysis and genotyped in 490 patients and 490 controls. A case-control study was conducted to analyze the association between NKILA SNPs and gastric cancer risk. qRT-PCR was conducted to detect the NKILA expression in plasma of different rs911157 and rs16981280 genotypes. The effect of rs16981280 C>T mutation on the binding ability of NKILA and miR-6731-5p was verified by dual-luciferase experiment.Results: In this study, rs911157 CT genotype (OR:1.72, 95%CI:1.20-2.69) was associated with an increased risk of gastric cancer, whereas rs16981280 CG (OR:0.64, 95%CI:0.48-0.85) and GG genotypes (OR:0.56, 95%CI:0.36-0.87) were associated with a reduced risk. The population attributable risk percentage for rs911157 T-carriers was below 10%, while for the rs16981280 CC genotype was approximately 15%. Rs911157 C carried a binding site with miR-6731-5p while T allele might cause the target loss.Conclusions: In summary, NKILA polymorphism might be related to the susceptibility of gastric cancer. NKILA rs911157 C/T genotype probably affects the function of gastric cancer cells by modulating the interactions with of miR-6731-5p.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"1-7"},"PeriodicalIF":3.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for oropharyngeal cancer: the time is now. 口咽癌筛查：现在正是时候。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI: 10.1080/14737159.2025.2478999

Kristina R Dahlstrom, Erich M Sturgis, Karen S Anderson

引用次数: 0

Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment. 轻度行为障碍和神经退行性变：基于生物标志物的评估时间。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1080/14737159.2025.2479627

Maria Francesca Beatino, Lorenzo Lattanzi, Camilla Elefante, Roberto Ceravolo, Filippo Baldacci, Giulio Perugi

引用次数: 0

Advances in pediatric sepsis biomarkers - what have we learnt so far? 儿童脓毒症生物标志物的进展-到目前为止我们学到了什么？

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-05-05 DOI: 10.1080/14737159.2025.2500656

Wen Su, Miao Fan, Wei Shen, Xinyu Wang, Rubo Li, Lu Lu, Jie Wu, Kaihu Yao, Quan Wang, Suyun Qian, Dan Yu

{"title":"Advances in pediatric sepsis biomarkers - what have we learnt so far?","authors":"Wen Su, Miao Fan, Wei Shen, Xinyu Wang, Rubo Li, Lu Lu, Jie Wu, Kaihu Yao, Quan Wang, Suyun Qian, Dan Yu","doi":"10.1080/14737159.2025.2500656","DOIUrl":"https://doi.org/10.1080/14737159.2025.2500656","url":null,"abstract":"Introduction: Sepsis is a systemic immune dysregulation syndrome triggered by secondary infection in the host, with diagnosis based on the updated Phoenix criteria and characterized by multi-organ failure as its core pathological manifestation. It is a significant global health challenge due to its increasing incidence and high mortality rates. Recent advancements in biomarker research provide promising tools for improving early diagnosis and timely intervention, essential for better patient outcomes.Areas covered: This review examines the latest developments in pediatric sepsis biomarkers, categorized by inflammation, metabolism, organ damage, and non-coding RNAs (miRNAs, LncRNAs). We discuss the advancements in each category, highlighting the integration of diverse biomarkers and advanced technologies to enhance diagnostics, personalize therapy, and improve patient stratification.Expert opinion: Given the limited specificity and sensitivity of current markers like CRP and PCT, multicenter studies are crucial for validating new biomarkers and for developing comprehensive panel markers that combine multiple diagnostic indicators. It is also important to consider the variability in host responses to different pathogens when identifying biomarkers based on host-pathogen interactions. To advance personalized medicine, future research may prioritize the identification of specific diagnostic biomarkers for pediatric sepsis, tailored to different pathogens.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":"25 5","pages":"183-198"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of molecular features in predicting efficacy of immuno-combinations in kidney cancer: just a drop in the ocean? 分子特征在预测免疫联合治疗肾癌疗效中的价值：只是沧海一粟？

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI: 10.1080/14737159.2025.2478996

Matteo Rosellini, Elisa Tassinari, Linda Danielli, Andrea Marchetti, Costantino Ricci, Matteo Santoni, Veronica Mollica, Francesco Massari

引用次数: 0

Advances in biomarkers in multiple system atrophy. 多系统萎缩生物标志物研究进展。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-04-06 DOI: 10.1080/14737159.2025.2489729

Anastasia Bougea

{"title":"Advances in biomarkers in multiple system atrophy.","authors":"Anastasia Bougea","doi":"10.1080/14737159.2025.2489729","DOIUrl":"10.1080/14737159.2025.2489729","url":null,"abstract":"Introduction: In order to improve illness identification, monitoring, and patient outcomes, this special report emphasizes the revolutionary potential of fluid and imaging biomarkers using new diagnostic technologies in Multiple system atrophy (MSA).Areas covered: Innovations like multiplex seeding aggregation assays (SAA), 18FDG-Positron Emission Tomography (PET), and SPECT) are changing the diagnostic landscape. These techniques make it easier to detect MSA early and offer noninvasive monitoring choices. Although neurofilament light chain measurements in blood and cerebrospinal fluid (CSF), as well as α-synuclein-based diagnostic biomarkers in CSF, are recognized as both diagnostic and surrogatemarkers of disease progression in MSA, their application in clinical practiceis limited to research. Some efforts are being made in the development ofselective α- synucleinPET tracers despite numerous barriers in visualizing intracellular localization of α-synuclein. The primary drawbacks include the high expense of SAA and imaging technologies, the paucity of multicenter longitudinal investigations, and the lack of uniformity of the prοtocols. The research highlights that to successfully solve these restrictions, stakeholders must continue to collaborate.Expert opinion: A multi-dimensional biomarker system of MSA patients maximizes the power of contemporary diagnostics to enhance MSA care by prioritizing the ongoing evaluation of multi-omics data.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"151-155"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination. 宫颈癌筛查的演变和未来：从细胞学到原发性HPV检测和疫苗接种的影响。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.1080/14737159.2025.2486653

Mariam El-Zein, Eduardo L Franco

{"title":"Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination.","authors":"Mariam El-Zein, Eduardo L Franco","doi":"10.1080/14737159.2025.2486653","DOIUrl":"10.1080/14737159.2025.2486653","url":null,"abstract":"Introduction: Cervical cancer remains a significant global health challenge despite decades of progress in screening and prevention. Global cervical cancer screening practices vary substantially, with many countries still relying on cytology-based methods, despite evidence supporting the superior performance of human papillomavirus (HPV)-based screening.Areas covered: This review explores the historical evolution as well as current landscape and policies of cervical cancer screening, with a focus on Western countries. We discuss the gradual transition from cytology to HPV DNA testing as the primary screening method, while recognizing the continuing role of cytology as a triage method. We also argue that HPV vaccination will have a transformative impact on screening practices, necessitating the need for adapting screening strategies to a post-vaccination world.Expert opinion: The role of cytology in cervical cancer screening will become increasingly limited due to its diminished effectiveness post-HPV vaccination, as many abnormal cytology results will likely be false positives. This could lead to unnecessary procedures, underscoring the need for adjustments in screening strategies and HPV testing to align with the fact that cervical precancerous lesions will become exceedingly rare.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"157-164"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omic profiling in breast cancer: utility for advancing diagnostics and clinical care. 乳腺癌的多组学分析：推进诊断和临床护理的实用工具。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/14737159.2025.2482639

Emna El Gazzah, Scott Parker, Mariaelena Pierobon

{"title":"Multi-omic profiling in breast cancer: utility for advancing diagnostics and clinical care.","authors":"Emna El Gazzah, Scott Parker, Mariaelena Pierobon","doi":"10.1080/14737159.2025.2482639","DOIUrl":"10.1080/14737159.2025.2482639","url":null,"abstract":"Introduction: Breast cancer remains a major global health challenge. While advances in precision oncology have contributed to improvements in patient outcomes and provided a deeper understanding of the biological mechanisms that drive the disease, historically, research and patients' allocation to treatment have heavily relied on single-omic approaches, analyzing individual molecular dimensions such as genomics, transcriptomics, or proteomics. While these have provided deep insights into breast cancer biology, they often fail to offer a complete understanding of the disease's complex molecular landscape.Areas covered: In this review, the authors explore the recent advancements in multi-omic research in the realm of breast cancer and use clinical data to show how multi-omic integration can offer a more holistic understanding of the molecular alterations and their functional consequences underlying breast cancer.Expert opinion: The overall developments in multi-omic research and AI are expected to complement precision diagnostics through potentially refining prognostic models, and treatment selection. Overcoming challenges such as cost, data complexity, and lack of standardization is crucial for unlocking the full potential of multi-omics and AI in breast cancer patient care to enable the advancement of personalized treatments and improve patient outcomes.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"165-181"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0