Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations.

IF 3.6 3区 医学 Q1 PATHOLOGY
Dorsa Safari, Sepideh Razi, Nima Rezaei
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引用次数: 0

Abstract

Introduction: In the management of breast cancer, the need for assessment of axillary status has been questionable in recent years. However, it is still applicable for making a decision on adjuvant therapy and evaluating the prognosis. Molecular tests have been widely used for intraoperative detection of axillary lymph node metastases and have prevented a second surgery for dissection of the lymph nodes in at least 20% of the cases. Unlike histopathological examination, molecular tests do not need a specialized technologist to provide the results.

Areas covered: We have reviewed recent advancements in the assessment of axillary nodes by molecular studies such as one-step nucleic acid amplification (OSNA) assay and metasin test. Our work concentrated on reported thresholds for the tests, economical aspects, and newly developed devices throughout the current literature.

Expert opinion: Well-designed clinical trials on molecular assays could lead to individualized management of the axillary, while preventing additional surgical operations in a large proportion of women with breast cancer.

术中检测乳腺癌腋窝转移的核酸扩增方法:优势与局限性综述。
简介:在乳腺癌的治疗中,近年来是否需要评估腋窝状态一直存在争议。但仍可用于辅助治疗的决策和预后的评价。分子检测已广泛用于术中腋窝淋巴结转移的检测,并在至少20%的病例中避免了第二次淋巴结清扫手术。与组织病理学检查不同,分子检查不需要专门的技术人员提供结果。涵盖领域:我们回顾了腋窝淋巴结的分子研究的最新进展,如一步核酸扩增(OSNA)测定和metasin试验。我们的工作集中在目前文献中报道的测试阈值、经济方面和新开发的设备。专家意见:精心设计的分子检测临床试验可能导致腋窝的个体化治疗,同时防止大部分乳腺癌妇女进行额外的外科手术。
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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
71
审稿时长
1 months
期刊介绍: Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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