{"title":"Non-conventional diagnostic methods for invasive fungal infections.","authors":"K Rosam, S Steixner, A Bauer, C Lass-Flörl","doi":"10.1080/14737159.2025.2509026","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Biomarkers have transformed fungal diagnostics by enabling early detection, risk assessment and treatment monitoring. Their clinical value depends on factors e.g. sensitivity, specificity, host immune status and technical standardization.</p><p><strong>Area covered: </strong>This review covers antigen- and DNA-based methods for detecting invasive fungal infections, focusing on <i>Aspergillus</i> spp., <i>Candida</i> spp. and Mucorales.</p><p><strong>Expert opinion: </strong>The selection of fungal biomarkers should be tailored to patient populations, clinical setting, and suspected infections. Combining biomarkers enhances diagnostic accuracy, particularly in high-risk patients. While biomarkers indicate fungal presence, they support diagnosis and guide decisions, but must be interpreted alongside clinical context and guidelines (EORTC/MSG). [Figure: see text].</p>","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"313-327"},"PeriodicalIF":3.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Molecular Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14737159.2025.2509026","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Biomarkers have transformed fungal diagnostics by enabling early detection, risk assessment and treatment monitoring. Their clinical value depends on factors e.g. sensitivity, specificity, host immune status and technical standardization.
Area covered: This review covers antigen- and DNA-based methods for detecting invasive fungal infections, focusing on Aspergillus spp., Candida spp. and Mucorales.
Expert opinion: The selection of fungal biomarkers should be tailored to patient populations, clinical setting, and suspected infections. Combining biomarkers enhances diagnostic accuracy, particularly in high-risk patients. While biomarkers indicate fungal presence, they support diagnosis and guide decisions, but must be interpreted alongside clinical context and guidelines (EORTC/MSG). [Figure: see text].
期刊介绍：
Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting.
Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy.
Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.
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