Expert Review of Molecular Diagnostics最新文献_第2页

Peripheral blood biomarkers in monitoring treatment response in breast cancer patients. 外周血生物标志物监测乳腺癌患者治疗反应。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1080/14737159.2025.2467965

Andres A Ocampo, Xiaopeng Sun, Justin M Balko

引用次数: 0

Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors. 探讨细菌生物标志物在非胃肠道实体瘤中的预后和预测潜力。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI: 10.1080/14737159.2025.2465743

Caoimbhe Burke, Thomas Glynn, Chowdhury Jahangir, Clodagh Murphy, Niamh Buckley, Mark Tangney, Arman Rahman, William M Gallagher

{"title":"Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors.","authors":"Caoimbhe Burke, Thomas Glynn, Chowdhury Jahangir, Clodagh Murphy, Niamh Buckley, Mark Tangney, Arman Rahman, William M Gallagher","doi":"10.1080/14737159.2025.2465743","DOIUrl":"10.1080/14737159.2025.2465743","url":null,"abstract":"Introduction: Standard clinical parameters like tumor size, age, lymph node status, and molecular markers are used to predict progression risk and treatment response. However, exploring additional markers that reflect underlying biology could offer a more comprehensive understanding of the tumor microenvironment (TME). The TME influences tumor development, progression, disease severity, and survival, with tumor-associated bacteria posited to play significant roles. Studies on tumor-associated microbiota have focused on high bacterial-load sites such as the gut, oral cavity, and stomach, but interest is growing in non-gastrointestinal (GI) solid tumors, such as breast, lung, and pancreas. Microbe-based biomarkers, including Helicobacter pylori, human papillomavirus (HPV), and hepatitis B and C viruses, have proven valuable in predicting gastric, cervical, and renal cancers.Areas covered: Potential of prognostic and predictive bacterial biomarkers in non-GI solid tumors and the methodologies used.Expert opinion: Advances in techniques like 16S rRNA gene sequencing, qPCR, immunostaining, and in situ hybridization have enabled detailed analysis of difficult-to-culture microbes in solid tumors. However, to ensure reliable results, it is critical to standardize protocols, accurately align reads, address contamination, and maintain proper sample handling. This will pave the way for developing reliable bacterial markers that enhance prognosis, prediction, and personalized treatment planning.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"117-128"},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homologous recombination deficiency: a reliable biomarker or a misleading indicator? 同源重组缺陷：一个可靠的生物标志物还是一个误导性的指标？

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-03-25 DOI: 10.1080/14737159.2025.2485212

Hisamitsu Takaya, Shiro Takamatsu, Hidekatsu Nakai, Noriomi Matsumura

引用次数: 0

Screening for oropharyngeal cancer: the time is now. 口咽癌筛查：现在正是时候。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-03-24 DOI: 10.1080/14737159.2025.2478999

Kristina R Dahlstrom, Erich M Sturgis, Karen S Anderson

引用次数: 0

Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment. 轻度行为障碍和神经退行性变：基于生物标志物的评估时间。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-03-20 DOI: 10.1080/14737159.2025.2479627

Maria Francesca Beatino, Lorenzo Lattanzi, Camilla Elefante, Roberto Ceravolo, Filippo Baldacci, Giulio Perugi

引用次数: 0

The value of molecular features in predicting efficacy of immuno-combinations in kidney cancer: just a drop in the ocean? 分子特征在预测免疫联合治疗肾癌疗效中的价值：只是沧海一粟？

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-03-12 DOI: 10.1080/14737159.2025.2478996

Matteo Rosellini, Elisa Tassinari, Linda Danielli, Andrea Marchetti, Costantino Ricci, Matteo Santoni, Veronica Mollica, Francesco Massari

引用次数: 0

From detection to action: new diagnostic insights into antifungal resistance. 从检测到行动：抗真菌耐药性的新诊断见解。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-03-10 DOI: 10.1080/14737159.2025.2477027

Renu Chaudhary, Zoozeal Thakur

引用次数: 0

Early diagnostics of fibromyalgia: an overview of the challenges and opportunities. 纤维肌痛的早期诊断：挑战和机遇的概述。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-01-01 Epub Date: 2025-01-12 DOI: 10.1080/14737159.2025.2450793

Natalie Malluru, Youssef Abdullah, Kevin V Hackshaw

{"title":"Early diagnostics of fibromyalgia: an overview of the challenges and opportunities.","authors":"Natalie Malluru, Youssef Abdullah, Kevin V Hackshaw","doi":"10.1080/14737159.2025.2450793","DOIUrl":"10.1080/14737159.2025.2450793","url":null,"abstract":"Introduction: Fibromyalgia is a common pain disorder with features of widespread musculoskeletal pain, fatigue, disrupted sleep, cognitive dysfunction, autonomic dysfunction, and mood disorders. Despite its high prevalence and significant impact on quality of life, the diagnosis and management of fibromyalgia remain challenging. Advancements in classification and diagnostics in broad areas have improved our understanding and treatment approach for this condition. We culminate with a discussion of future directions for research into early diagnostics in fibromyalgia.Areas covered: This perspective examines the current landscape of fibromyalgia biomarker discovery, highlighting challenges that must be addressed and opportunities that are presented as the field evolves.Expert opinion: Advances in fibromyalgia diagnostics provide an opportunity to dramatically reduce the cost burden placed on health resources for fibromyalgia once we have discovered a reliable reproducible biomarker that is widely accepted among practitioners and patients. Promising results in a number of fields may lead to point of care technologies that will be applicable in the office or bedside without the need for transport to specialized centers. Future research should focus on integrating these various diagnostic approaches to develop a comprehensive, multi-modal diagnostic tool for fibromyalgia.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"21-31"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of progress in establishing a diagnostic tool for non-celiac gluten sensitivity.

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.1080/14737159.2025.2458469

Giulia Catassi, Carlo Catassi

{"title":"An overview of progress in establishing a diagnostic tool for non-celiac gluten sensitivity.","authors":"Giulia Catassi, Carlo Catassi","doi":"10.1080/14737159.2025.2458469","DOIUrl":"10.1080/14737159.2025.2458469","url":null,"abstract":"Introduction: Non-Celiac Gluten Sensitivity (NCGS) is a common disorder characterized by symptoms resembling those of irritable bowel syndrome. In recent years there has been progress in the understanding of the pathogenic pathways and data suggest that NCGS has a distinct immunological profile that differs from celiac disease (CeD). This has fostered the search for a specific biomarker of NCGS.Areas covered: In this review we will firstly update on pioneer NCGS diagnostic tools, particularly the gluten challenge, serum IgG class antigliadin antibodies, and certain histological characteristics seen at the small intestinal biopsy. Then we will examine the most recent research on potential biomarkers of NCGS, specifically focusing on markers of damage to enterocytes, of translocation of bacteria from the gut into the bloodstream, intestinal permeability, and inflammation.Expert opinion: So far, no specific biomarker of NCGS has been detected. The diagnosis of NCGS still relies on clinical criteria. A gluten challenge may be useful for diagnostic purposes, however a strong nocebo effect limits the efficacy of this procedure. Additional investigation is necessary to identify biomarkers for NCGS, that may be useful to investigate the epidemiology, clinical spectrum, and natural history of this common disorder.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"59-66"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational trophoblastic disease: STR genotyping for precision diagnosis. 妊娠滋养细胞疾病：STR基因分型用于精确诊断。

IF 3.9 3区医学

Expert Review of Molecular Diagnostics Pub Date : 2025-01-01 Epub Date: 2025-01-19 DOI: 10.1080/14737159.2025.2453506

Krasimira A Rozenova, Natalia Buza, Pei Hui

{"title":"Gestational trophoblastic disease: STR genotyping for precision diagnosis.","authors":"Krasimira A Rozenova, Natalia Buza, Pei Hui","doi":"10.1080/14737159.2025.2453506","DOIUrl":"10.1080/14737159.2025.2453506","url":null,"abstract":"Introduction: Gestational trophoblastic disease (GTD) encompasses a constellation of rare to common gynecologic conditions stemming from aberrant gestations with distinct genetic backgrounds and variable degrees of trophoblast proliferation of either neoplastic or non-neoplastic nature. GTD is categorized into hydatidiform moles and gestational trophoblastic neoplasms, and their clinical outcomes vary widely across different subtypes. Prompt and accurate diagnosis plays a pivotal role in the effective management and prognostication of patients. Short tandem repeats (STRs) are repetitive DNA sequences dispersed throughout the human genome and inherit a tremendous genetic polymorphism among individuals. Widely recognized for its applications in forensic identity and paternity testing, the relevance of STR genotyping in the diagnosis of GTD has emerged as an essential ancillary test in the classification and management of GTD of both non-neoplastic hydatidiform moles and gestational trophoblastic tumors.Area covered: This review discusses fundamental principles, laboratory operation, and diagnostic interpretations of STR genotyping in the context of diagnosis and differential diagnosis of GTD. PubMed was searched for all references up to 2024.Expert opinion: STR genotyping is the gold standard in the diagnosis and subclassification of hydatidiform moles and has an important application in diagnostic workup and risk stratifications of gestational trophoblastic tumors as well.","PeriodicalId":12113,"journal":{"name":"Expert Review of Molecular Diagnostics","volume":" ","pages":"1-19"},"PeriodicalIF":3.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0