Wojciech Kozieł, Katarzyna Kulińska, Małgorzata Dobrowolska, Piotr Malisz
{"title":"Application of dual-energy computed tomography in neuroradiology -a review of literature.","authors":"Wojciech Kozieł, Katarzyna Kulińska, Małgorzata Dobrowolska, Piotr Malisz","doi":"10.24425/fmc.2024.153286","DOIUrl":"https://doi.org/10.24425/fmc.2024.153286","url":null,"abstract":"<p><p>Imaging diagnostics, supported by advances in medical equipment and software, is a dynamically evolving field of medicine. Methods that improve the precision of disease detection are currently in high demand. This paper discusses spectral computed tomography (CT), specifically dual-energy computed tomography (DECT), which is a modern and advanced imaging technique offering significant advantages over conventional single-energy CT (SECT). DECT provides additional diagnostic information and reduces the effective dose of ionizing radiation to the patient. A key benefit of DECT is its ability to reduce image artifacts compared to SECT. The article explains the operating principles of DECT and reviews its clinical indications, with a focus on neuroradiology. Special attention is given to the differentiation of intracranial hemorrhage from calcifications and distinguishing fresh blood from iodinated contrast media - especially in overlapping areas - through the interpretation of base pair images. DECT also plays an important role in evaluating the progression of intracerebral hematomas and detecting the \"spot sign\" in CT angiography (CTA) of the brain. Another application is in imaging the vascular system of the head and neck using DECTA, where bone removal and virtual non-contrast image reconstruction are particularly useful. The final section of the paper addresses artifact reduction methods in neuroradiology and outlines the key advantages and limitations of DECT in clinical practice.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"55-67"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mast cells as pivotal players in atherogenesis. Review.","authors":"Jacek Jawień, Magdalena Bartuś","doi":"10.24425/fmc.2024.153285","DOIUrl":"https://doi.org/10.24425/fmc.2024.153285","url":null,"abstract":"<p><p>The mast cell is an immune cell involved primary in host defense of organism. Moreover, it plays an important role in atopic diseases. Recently, accumulating evidence established the contribution of the mast cell in atherogenesis. Through its release of mediators, activated mast cells can have proatherogenic effects on its surroundings in the vessel wall. In this review, we will discuss the current knowledge on mast cell function in atherogenesis and atherosclerosis - caused cardiovascular diseases.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamil Możdżeń, Konrad Kaleta, Agnieszka Murawska, Edward Pędziwiatr, Julia Hypnar, Ilie Lastovetskyi, Mateusz Kęska, Barbara Lorkowska-Zawicka, Beata Bujak-Giżycka
{"title":"Investigating the incidence of false positive outcomes in drug detection assays.","authors":"Kamil Możdżeń, Konrad Kaleta, Agnieszka Murawska, Edward Pędziwiatr, Julia Hypnar, Ilie Lastovetskyi, Mateusz Kęska, Barbara Lorkowska-Zawicka, Beata Bujak-Giżycka","doi":"10.24425/fmc.2024.153287","DOIUrl":"https://doi.org/10.24425/fmc.2024.153287","url":null,"abstract":"<p><p>Immunoassays are widely utilized in urine drug screens due to their simplicity, ease of automation, and rapid results, making them the standard for clinical and workplace drug testing, as well as in rehabilitation programs and legal systems. However, the potential for cross-reactivity with both structurally related and unrelated compounds increases the risk of false-positive results. This poses significant challenges for healthcare professionals, especially in populations undergoing routine drug testing, such as those in recovery or court-ordered monitoring programs. The ongoing opioid epidemic in the United States, which has resulted in countless deaths from both prescription and illicit opioids, underscores the critical importance of accurate drug detection methods. This review evaluates specialized drug assays, highlighting their effectiveness and limitations. While immunoassays are highly sensitive, they often lack specificity, increasing the risk of false positives, which can affect clinical and legal decisions. This research also details substances prone to causing false positives, aiding clinicians in making informed diagnostic and therapeutic decisions.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"69-84"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monika Kabzińska-Turek, Marta Balajewicz-Nowak, Tomasz Piskorz, Violetta Hosiawa
{"title":"Pregnancy of unknown location - still diagnostics and therapeutic problem.","authors":"Monika Kabzińska-Turek, Marta Balajewicz-Nowak, Tomasz Piskorz, Violetta Hosiawa","doi":"10.24425/fmc.2025.156118","DOIUrl":"https://doi.org/10.24425/fmc.2025.156118","url":null,"abstract":"<p><p>Pregnancy of unknown location is still a significant diagnostic and therapeutic problem in the population of women of reproductive age. The management of women with PUL can vary widely, as there are still no standardized guidelines for the diagnosis and treatment of such a clinical situation. The diagnostic effort in this initial diagnosis should be directed both to the exclusion of ectopic pregnancy, which carries a significant risk to the patient, as well as a properly implanted pregnancy, since the implementation of treatment may be associated with adverse effects on its subsequent fate. The authors reviewed the literature on this issue, taking into account their own experience in the management of pregnancies of unknown location. They conducted a critical analysis of the literature on PUL found in MEDLINE, Google Scholar, the Cochrane Central Register of Controlled Trials, and Clinical Trials.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"157-168"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Saliva - the gatekeeper at the entrance to the gastrointestinal tract - a remarkable biofluid, its proteins, and the upper part of the alimentary tract.","authors":"Marcin Pasternak, Maria Mituś-Kenig, Maciej Suski","doi":"10.24425/fmc.2025.156115","DOIUrl":"https://doi.org/10.24425/fmc.2025.156115","url":null,"abstract":"<p><p>Saliva, a seemingly unpretentious secretion, is actually a multifaceted and multipurpose biofluid. Performing numerous functions, far exceeding only lubrication of oral mucosa, it is essential for general health. Saliva's remarkable properties are primarily due to its constituents, mainly peptides and proteins. Excreted at the entrance to the gastrointestinal tract, this biofluid-active in the oral cavity-also affects other sections of the canal alike, particularly esophagus, where its active components do not undergo degradation. Animal models employing sialoadenectomy consistently with clinical data of patients afflicted with issues related to insufficient salivation, clearly demonstrate how indispensable proper saliva secretion is. In this paper we briefly summarize current perspectives on saliva, with a focus on its protein components and its impact on the upper part of the alimentary tract, particularly on oral and esophageal mucosa. The practical aspects of the modern proteomic research of saliva being at the forefront of salivaomics progress are also discussed, and the current state-of-the-art proteomic methodology is outlined.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"121-132"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aneta Suder, Julia Nawrot, Małgorzata Kulesa-Mrowiecka, Joanna Zyznawska, Agnieszka Gniadek
{"title":"Diagnostic tools used to assess the functional development of 2-year-old children born prematurely.","authors":"Aneta Suder, Julia Nawrot, Małgorzata Kulesa-Mrowiecka, Joanna Zyznawska, Agnieszka Gniadek","doi":"10.24425/fmc.2024.153289","DOIUrl":"https://doi.org/10.24425/fmc.2024.153289","url":null,"abstract":"<p><p>In Poland, preterm infants account for 6-7% of all births. Preterm deliveries are associated with a number of short- and long-term health conditions and therefore pose a major public health challenge. Monitoring the psychomotor development of children born prematurely is a significant challenge for pediatricians and neonatologists. Early diagnosis of delayed functional development enables timely therapeutic intervention by developmental specialists, such as physiotherapists, educators, psychologists, and speech therapists. Currently, monitoring the development of preterm infants during the first year of life is common practice. However, due to the significant percentage of late preterm infants in the population of prematurely born newborn population, there is a justified need to focus on the periodic assessment of their functional development also beyond the first year of life. Regular and multidimensional developmental monitoring in this group of patients is crucial due to the increased risk of subtle but clinically significant developmental delays that may manifest at later stages of life.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improving the quality of childbirth care: a questionnaire-driven evaluation of women experiences.","authors":"Julia Nawrot, Aneta Suder, Agnieszka Gniadek","doi":"10.24425/fmc.2025.156116","DOIUrl":"https://doi.org/10.24425/fmc.2025.156116","url":null,"abstract":"<p><strong>Introduction: </strong>Childbirth, regardless of its course, is one of the most significant events in a woman's life. In perinatal care, both medical aspects and the woman's needs for choice, information, and support are crucial. The fulfillment of these needs influences satisfaction, which is an element of care quality evaluation. The aim of this study was to analyze tools for measuring women's experiences in perinatal care, considering the subjective nature of satisfaction and factors affecting care quality.</p><p><strong>Review methods: </strong>A literature review was conducted on validated tools and questionnaires used to assess patient-reported outcomes. Systematic searches in PubMed, Scopus, and Google Scholar databases included keywords such as \"satisfaction of care,\" \"maternal satisfaction,\" and \"questionnaires\" in Polish and English. The analysis was part of research conducted within the doctoral dissertation of one of the authors.</p><p><strong>Conclusions: </strong>Publications highlight the use of diverse measurement tools, ranging from general satisfaction surveys to specialized questionnaires. These tools address aspects such as the quality of communication with medical staff, pain management effectiveness, and respect for patient autonomy. However, most tools have not been adapted or validated for use in Poland. The importance of employing verified measurement tools in evidence-based practices and their role in improving patient-provider relationships was also discussed.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"133-142"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryszard W Gryglewski, Uliana Pidvalna, Michał Chlipała, Leo Schaukal, Lesya Mateshuk-Vatseba, Wolfgang J Weninger
{"title":"Henryk Kadyi's preparatory techniques - exploring anatomical traditions of Vienna, Krakow and Lviv.","authors":"Ryszard W Gryglewski, Uliana Pidvalna, Michał Chlipała, Leo Schaukal, Lesya Mateshuk-Vatseba, Wolfgang J Weninger","doi":"10.24425/fmc.2024.153280","DOIUrl":"https://doi.org/10.24425/fmc.2024.153280","url":null,"abstract":"<p><p>Henryk Kadyi's (1851-1912) work in anatomical research is closely related to researching fundamental problems of preserving anatomic specimens for science and teaching. The goal of this study is to describe the professional life of Henryk Kadyi, to highlight his achievements for modern anatomy and to use his story to demonstrate the importance of mentoring, international scientific communication and cross border cooperations for scientific success. The development of novel conservation methods gained him enormous respect of the scientific community and secured him a place in the history of medicine. Kadyi was educated in Vienna and shaped by Hyrtl and Langer. He then started residency in Krakow, where he was supervised by Teichmann, a disciple of Hyrtl. There, he received a call for professorship in Lviv. At each location, he was influence by local conditions, which improved his anatomical skills. This is a good example of the interconnection of knowledge, skills, scholarship, and scientific tradition between academic centers - in this case, Vienna, Krakow, and Lviv in the second half of the 19th century. Our paper focuses on Kadyi's preparatory techniques with a particular emphasis on the influence that the education and skills acquired in Vienna and Krakow had on them and how they were shaped when Kadyi was already an independent researcher in Lviv.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Conservative treatment of finger and metacarpal fractures: a narrative review.","authors":"Andrzej Żyluk","doi":"10.24425/fmc.2025.156114","DOIUrl":"https://doi.org/10.24425/fmc.2025.156114","url":null,"abstract":"<p><strong>Background: </strong>Hand (finger and metacarpal) fractures are common in surgical practice, usually affecting adolescents and young adults. Treatment of these injuries is generally conservative, with generally good results. However, since the end of the 20th century, as a result of the offensive of manufacturers of implants, surgical treatment have attracted increasing popularity, although there was no scientific basis for it. Objective of this study was literature review focused on outcomes of conservative treatment of hand (metacarpal and phalangeal) fractures.</p><p><strong>Methods: </strong>Articles from PubMed and Medline databases on the methods and outcomes of conservative treatment of hand fractures published in last 10 years were reviewed.</p><p><strong>Results: </strong>A total of 10 studies meeting inclusion criteria were identified. Three were focused on finger fractures, two - on metacarpal shaft fractures and five - on the fifth metacarpal neck fractures. Results of this review have demonstrated that vast majority of finger and metacarpal fractures can be successfully treated conservatively. Conservative treatment is preferably performed with a buddy taping or a splint allowing free mobilization of fingers. Treatment without any immobilization, according to special protocol is also an acceptable and safe option.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"107-119"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bilateral ossification of the carotico clinoid ligament: clinical and surgical considerations.","authors":"Dibakar Borthakur, Jayanta Biswas","doi":"10.24425/fmc.2024.153283","DOIUrl":"https://doi.org/10.24425/fmc.2024.153283","url":null,"abstract":"<p><strong>Introduction: </strong>The carotico clinoid foramen (CCF) is an anomalous foramen that is formed due to ossification of carotico clinoid ligament (CCL) in the sphenoid bone with a reported prevalence of around 8%. Ossified CCL is of tremendous clinical relevance considering its intimate relationship with important neurovascular structures in the parasellar region such as internal carotid artery, cavernous sinus, optic nerve and the pituitary gland.</p><p><strong>Case presentation: </strong>This report describes a case of bilateral ossification of CCL that was incidentally observed in a dry human skull during routine demonstration to medical undergraduate students. In the present case, ossified CCLs were observed spanning the tips of the anterior and the middle clinoid processes bilaterally and they formed two distinct oval CCF on either side.</p><p><strong>Discussion: </strong>Variable incidence of ossified CCL has been reported in anatomical studies. The exact reason for the ossification of CCL and other periclinoid ligaments are not known. Developmental anomalies of the sphenoid bone, ossification of fibrous tissue of the ligaments or the folds of dura mater bridging the interclinoid region are thought to be underlying reasons. The presence of a complete or partially ossified CCL can affect the internal carotid artery (ICA), cavernous sinus, its contents and the pituitary gland etc. Ossified CCL and CCF can lead to misinterpretation in radiological investigations and might pose difficulty in neurosurgical access and interventions in the skull base.</p><p><strong>Conclusions: </strong>Considering the modest prevalence of carotico clinoid ligament across all major races, preoperative recognition of the same in imaging studies is warranted before approaching any parasellar intra- cranial lesions.</p>","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"65 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}