Folia medica Cracoviensia最新文献

Effects of Chronic Prenatal Alcohol Exposure on Nociceptive Responses to Mechanical and Thermal Stimuli in Rats. 产前长期接触酒精对大鼠机械和热刺激痛觉反应的影响

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150154

Magdalena Król, Michał Jurczyk, Paweł Skowron, Paulina Stach, Kamil Skowron, Aleksandra Midro, Agnieszka Baranowska-Chowaniec, Magdalena Kurnik-Łucka, Krzysztof Gil

{"title":"Effects of Chronic Prenatal Alcohol Exposure on Nociceptive Responses to Mechanical and Thermal Stimuli in Rats.","authors":"Magdalena Król, Michał Jurczyk, Paweł Skowron, Paulina Stach, Kamil Skowron, Aleksandra Midro, Agnieszka Baranowska-Chowaniec, Magdalena Kurnik-Łucka, Krzysztof Gil","doi":"10.24425/fmc.2024.150154","DOIUrl":"https://doi.org/10.24425/fmc.2024.150154","url":null,"abstract":"The present study sought to investigate the effects of chronic prenatal alcohol exposure (PAE) on nociceptive responses to mechanical and thermal stimuli in rats. The Von Frey and Hot Plate tests were employed to assess the nociceptive responses of 10 control rats and 7 experimental rats whose mothers had been administered ethanol from day 5 to day 20 of gestation. In healthy animals, a decrease in pain sensitivity was observed between days 28 and 70, which was not observed in the experimental group. The findings also indicated that rats with PAE exhibited diminished sensitivity to nociceptive stimuli during the early postnatal period, as evidenced by a higher threshold response to mechanical stimuli at day 28 than in the control group. However, those observations did not apply to thermal stimuli. It appears that this may be a result of distinctiveness in neural pain pathways for particular stimuli at the receptor or ion channel level, while a disruption in the equilibrium between the sympathetic and parasympathetic nervous systems may be a contributing factor. The results of this study highlight a critical aspect of the harmful systemic effects of alcohol, while also underscoring the need for further research to elucidate the underlying mechanisms, including the role of the hypothalamic-pituitary-adrenal axis and the serotonergic system in modulating pain responses in individuals prenatally exposed to alcohol.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between diet and the enteric nervous system in the pathophysiology of colorectal cancer. 饮食与肠道神经系统在结直肠癌病理生理学中的相互作用。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150147

Wojciech Michał Jankowski, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka

{"title":"The interplay between diet and the enteric nervous system in the pathophysiology of colorectal cancer.","authors":"Wojciech Michał Jankowski, Jakub Fichna, Aleksandra Tarasiuk-Zawadzka","doi":"10.24425/fmc.2024.150147","DOIUrl":"https://doi.org/10.24425/fmc.2024.150147","url":null,"abstract":"Colorectal cancer (CRC) represents the third most diagnosed cancer worldwide, with 1.9 million new cases reported annually. Notwithstanding the progress made in the field of therapeutic modalities and the advent of early diagnosis, CRC continues to represent the second most common cause of cancer-related mortality. The interactions between cancer cells and enteric nervous system (ENS) neurons are of great importance for the prevention and/or progression of CRC. Dietary factors play an important role in regulating both processes. The consumption of foods rich in polyphenols, omega-3 fatty acids, and the use of probiotics has been shown to promote proper ENS function, which in turn has been demonstrated to indirectly inhibit the development or progression of CRC. Conversely, a diet comprising a high proportion of saturated fats and refined sugars can induce oxidative stress and inflammation, which exacerbates the disease. Nutritional education and dietary modifications can reduce the incidence of new cases of CRC and improve prognosis. Further research into the potential anti- or pro-cancer effects of food substances is recommended.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ability assessment of the craniofacial structures radiological anatomy on panoramic radiography among dental student during pandemic of Covid-19. Ability assessment on OPG among dental student during pandemic of Covid-19. 在 Covid-19 大流行期间对牙科学生进行颅颌面结构全景放射解剖学能力评估。在 Covid-19 大流行期间对牙科学生进行 OPG 能力评估。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150149

Jakub Majewski, Dominika Qarashouli, Zuzanna Kazibudzka, Klaudia Ciach, Patrycja Kurzawa, Klaudia Orłowska, Julia Janas, Bartosz Ciapała, Jolanta E Loster, Aneta Wieczorek

{"title":"Ability assessment of the craniofacial structures radiological anatomy on panoramic radiography among dental student during pandemic of Covid-19. Ability assessment on OPG among dental student during pandemic of Covid-19.","authors":"Jakub Majewski, Dominika Qarashouli, Zuzanna Kazibudzka, Klaudia Ciach, Patrycja Kurzawa, Klaudia Orłowska, Julia Janas, Bartosz Ciapała, Jolanta E Loster, Aneta Wieczorek","doi":"10.24425/fmc.2024.150149","DOIUrl":"https://doi.org/10.24425/fmc.2024.150149","url":null,"abstract":"Orthopantomography (OPG) is a routine imaging method in dental practice and an essential di- agnostic tool in dentistry. However, OPGs are challenging to interpret due to many overlapping structures. Graduates of dental schools should be aware of image distortions caused by various factors and be able to distinguish them from typical structures to make an accurate diagnosis. The aim was to determine the correlation between the knowledge regarding the location of craniofacial structures of the 1st through 3rd- year dental students and the ability to recognized them on OPGs. The study was conducted in 2021 on 131 dental students using the Microsoft Teams program. Each participant had to determine the location of 4 anthropometric points on 4 OPGs. Using proprietary software, the authors determined the Articular angle between them. The researchers performed the statistical analysis. The Bioethics Committee approved the research. The results of students from particular years of studies did not show statistical significance. There was no statistically significant difference between males and females. Only the answers from third-year male students regarding the one Articular angle showed statistically significant differences compared to the rest of the participants. Recognizing joint structures on OPG is very important from the clinical point of view, although it is often overlooked in diagnostics. Students in the first years of dental school acquire the ability to assess and analyze TMJ on OPGs properly. OPGs have many advantages, including high availability, low cost and low radiation dose. In conclusion we can say that in the first three years of studies, dental students' image assessment skills in the craniofacial radiology field remain the same.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"29-40"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications after Gonioscopy-Assisted Transluminal Trabeculotomy in glaucoma treatment - literature review. 在青光眼治疗中进行球镜辅助透镜小梁切开术后的并发症--文献综述。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150151

Martyna Wrześniewska, Maciej Dyda, Paweł Skowron, Paulina Tomecka, Katarzyna Zontek, Kinga Brawańska, Hanna Zając-Pyrus, Magdalena Król

{"title":"Complications after Gonioscopy-Assisted Transluminal Trabeculotomy in glaucoma treatment - literature review.","authors":"Martyna Wrześniewska, Maciej Dyda, Paweł Skowron, Paulina Tomecka, Katarzyna Zontek, Kinga Brawańska, Hanna Zając-Pyrus, Magdalena Król","doi":"10.24425/fmc.2024.150151","DOIUrl":"https://doi.org/10.24425/fmc.2024.150151","url":null,"abstract":"Glaucoma is a disease that leads to optic nerve damage and irreversible loss of the visual field. Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive glaucoma surgery technique, where the surgeon opens the trabecular network and Schlemm's canal to improve the outflow of the aqueous humor. This method has shown efficacy in reducing intraocular pressure in patients with primary and secondary glaucoma. GATT has gained popularity due to its minimally invasive nature, compatibility with cataract surgery and relatively low cost. Despite its advantages, the procedure can be associated with many complications such as hyphema, intraocular pressure spikes and corneal edema. In rare cases, it can lead to Descemet's membrane detachment or cystoid macular edema. The success of GATT procedure mostly depends on the surgeon's skill and experience, but also on the patient's risk factors, including age and preoperative intraocular pressure levels. Further studies are required to understand long outcomes and identify the patients, who may be at higher risk of complications.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organizing pneumonia associated with Richter transformation in chronic lymphocytic leukemia: a case report and review of the literature. 慢性淋巴细胞白血病里氏转化相关的组织性肺炎：病例报告和文献综述。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150153

Wiktoria Grycuk, Renata Langfort, Grzegorz Rymkiewicz, Laretta Grabowska-Derlatka, Piotr Korczyński, Krzysztof Jamroziak, Joanna Drozd-Sokołowska

{"title":"Organizing pneumonia associated with Richter transformation in chronic lymphocytic leukemia: a case report and review of the literature.","authors":"Wiktoria Grycuk, Renata Langfort, Grzegorz Rymkiewicz, Laretta Grabowska-Derlatka, Piotr Korczyński, Krzysztof Jamroziak, Joanna Drozd-Sokołowska","doi":"10.24425/fmc.2024.150153","DOIUrl":"https://doi.org/10.24425/fmc.2024.150153","url":null,"abstract":"Organizing pneumonia (OP) is defined histologically by the presence of granulation tissue within alveolar ducts and alveoli. Recently, several lymphoid neoplasms have been implicated as a risk factor for OP, however, OP as a primary manifestation of malignancy transformation has not been widely reported in the literature. Here, we report a case of a patient with a history of chronic lymphocytic leukemia (CLL) who presented with weight loss, low-grade fever, lymphadenopathy, and bilateral pulmonary infiltrates revealed in imaging studies. Video-assisted thoracoscopic lung biopsy showed CLL cells within the pulmonary vessels and areas of OP in the lung parenchyma. Subsequent lymph nodes biopsies were consistent with CLL transformation to diffuse large B-cell lymphoma (DLBCL). To our knowledge, this is the first reported case of OP associated with CLL transformation into DLBCL. This case suggests that OP could represent a form of immunological reaction to ongoing Richter transformation.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of autologous dentin matrix in bone defects augmentation - a literature review. 自体牙本质基质在骨缺损增量中的应用--文献综述。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 0.24425/fmc.2024.150155

Ewa Wysłouch, Artur Sipika, Natalia Grabowska-Jasik, Michał Tyrakowski, Tomasz Kaczmarzyk, Mariusz Szuta

引用次数: 0

How to teach students of medical and biological sciences electrophoresis in the spirit of physical chemistry - a laboratory exercise scenario. 如何以物理化学的精神向医学和生物科学专业的学生传授电泳知识--一个实验练习场景。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150148

Kamil Kamiński, Joanna Grudzień, Marta Kaczor-Kamińska

{"title":"How to teach students of medical and biological sciences electrophoresis in the spirit of physical chemistry - a laboratory exercise scenario.","authors":"Kamil Kamiński, Joanna Grudzień, Marta Kaczor-Kamińska","doi":"10.24425/fmc.2024.150148","DOIUrl":"https://doi.org/10.24425/fmc.2024.150148","url":null,"abstract":"Gel electrophoresis is one of the most important and most widely used tools in biomedical sciences. However, when students are acquainted with these techniques, information related to practical applications often neglects the physicochemical foundations of the occurring phenomena. The following article proposes a laboratory exercises scenario conducted in the problem-solving and decision-making strategies, which aims to familiarize beginner students with the physicochemical basis of electrophoresis in a simple and accessible way. By analyzing the scheme presented, students will gain knowledge of the basic sciences, as they will learn about the advantages and limitations of the method in addition to its applications. The experiments are designed in a way that allows students to draw conclusions about the parameters affecting the electrophoresis process and the sources of obvious errors. Moreover, the use of simple ionic dyes eliminates the need for complex apparatus and toxic reagents, which may be harmful. The main outcome of the class is to develop students' skill to design their own simple experiments using this commonly used technique.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"17-28"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol-associated liver disease - a current overview. 酒精相关肝病--当前概述。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150156

Krystian Mirowski, Barbara Balicka-Ślusarczyk, Piotr Hydzik, Małgorzata Zwolińska-Wcisło

{"title":"Alcohol-associated liver disease - a current overview.","authors":"Krystian Mirowski, Barbara Balicka-Ślusarczyk, Piotr Hydzik, Małgorzata Zwolińska-Wcisło","doi":"10.24425/fmc.2024.150156","DOIUrl":"https://doi.org/10.24425/fmc.2024.150156","url":null,"abstract":"Alcohol-associated liver disease (ALD) remains a major and increasingly pressing concern in hepatology. ALD includes spectrum of conditions, each with unique diagnostic and therapeutic challenges. Excessive alcohol intake is a leading preventable cause of physical harm, including ALD. The pathogenesis of ALD involves oxidative stress, inflammation, and lipid metabolism disruptions, with genetic predispositions playing a major role. ALD progresses from hepatic steatosis to steatohepatitis, and finally liver cirrhosis, which is marked by severe fibrosis and impaired liver function. Advanced ALD stages, particularly alcoholic hepatitis and liver cirrhosis, are characterized by high mortality rates. Management of ALD primarily involves strict abstinence from alcohol, which can reverse early-stage disease or halt progression. Nutritional support, vitamin supplementation, and symptomatic treatment are also essential. Liver transplantation is the only definitive treatment for alcoholic liver cirrhosis, but it is difficult for patients with a history of alcohol abuse to qualify for the procedure. Epidemiological data indicate a growing burden of ALD, especially among younger populations, exacerbated by increased alcohol consumption trends and the COVID-19 pandemic's influence on drinking behaviors. Despite ALD's significant impact, current therapies are limited, highlight- ing the need for innovative treatments and comprehensive patient management strategies. Individualized care, enhanced epidemiological research, and new therapeutic approaches are crucial to improving outcomes for ALD patients.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"93-104"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Origin of median sacral artery with fourth pair of lumbar artery - an alert for spine surgeons and interventionalists: A case report and mini literature review. 骶正中动脉与第四对腰动脉的起源--脊柱外科医生和介入医师的警示：病例报告和小型文献综述。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150152

Dibakar Borthakur, Rajesh Kumar, Khusru Nomani, Seema Singh

引用次数: 0

Human Papillomavirus, Cervical Intraepithelial Neoplasia, and Quantitative Blood Loss at Delivery. 人类乳头瘤病毒、宫颈上皮内瘤变和分娩定量失血。

Folia medica Cracoviensia Pub Date : 2024-09-15 DOI: 10.24425/fmc.2024.150150

Makayla Mozey, Joshua Fogel, Petr Itzhak

{"title":"Human Papillomavirus, Cervical Intraepithelial Neoplasia, and Quantitative Blood Loss at Delivery.","authors":"Makayla Mozey, Joshua Fogel, Petr Itzhak","doi":"10.24425/fmc.2024.150150","DOIUrl":"https://doi.org/10.24425/fmc.2024.150150","url":null,"abstract":"Studies using estimated blood loss show the association of either human papillomavirus (HPV) or cervical intraepithelial neoplasia (CIN) with postpartum hemorrhage (PPH). We study the association of HPV or CIN with either blood loss or PPH as measured by the more precise measure of quantitative blood loss (QBL). We retrospectively studied 2,334 peripartum women with a documented Pap smear prior to de- livery. The main predictor variable had categories for HPV and CIN as compared to normal cytology. Covariates included demographics, medical/surgical history, and pregnancy variables. Model 1 included the whole sample. Model 2 included only those with an operative vaginal delivery or a cesarean delivery. Outcome measures were QBL and PPH measured by QBL. We found in model 1 that those HPV positive and those with CIN were each not significantly associated with QBL. In model 2, those HPV positive were significantly associated with increased QBL (B = 0.11, SE = 0.05, p = 0.047), while CIN was not significantly associated with QBL. In model 1, those HPV positive and those with CIN were each not significantly associated with PPH. In model 2, those HPV positive were significantly associated with increased odds for PPH (OR:11.03, 9% CI:1.77, 68.74, p = 0.01) while CIN was not significantly associated with PPH. In conclusion, the presence of HPV was positively associated with an increase in the QBL and PPH at time of delivery for those with operative vaginal and cesarean deliveries. We suggest that clinicians take HPV results of Pap smears into consideration when considering a patient's risk of PPH.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 2","pages":"41-50"},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0