Experimental and Clinical Physiology and Biochemistry最新文献_第4页

Еxperimental justification of the efficacy of cocarnite for correction of disorders in rat periodont tissues under alcohol neuropathy Еxperimental乙醇性神经病大鼠牙周组织紊乱的校正效果证明

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.031

A. Kotvytska

引用次数: 0

Сharacteristics of oxidative stress and non-enzymatic link of the glutathione system in sperm plasma and spermatozoa in men with different fertilization potential Сharacteristics不同受精潜力男性精子血浆和精子中氧化应激和谷胱甘肽系统的非酶联系

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.005

M. Vorobets

引用次数: 0

IL-6 levels in patients with hypertension in combination with coronavirus disease 高血压合并冠状病毒病患者IL-6水平的变化

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.038

引用次数: 1

Hgf gene expression in rat hepatocytes under conditions of glutamate-induced steatohepatosis and when using drugs with pro- and prebiotic action 谷氨酸诱导的脂肪性肝病及使用益生前和益生元药物时大鼠肝细胞中Hgf基因的表达

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.023

M. Kondro

引用次数: 0

Clinical and microbiological characteristics of biofilm formation on new and reused dental healing abutments during implantation procedure 新的和重复使用的牙愈合基台种植过程中生物膜形成的临床和微生物学特征

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.013

V. Vovk

引用次数: 0

Effects of mitomycin C on pro-/antioxidant system of blood lymphocytes 丝裂霉素C对血液淋巴细胞促抗氧化系统的影响

Experimental and Clinical Physiology and Biochemistry Pub Date : 2022-06-22 DOI: 10.25040/ecpb2022.01-02.053

引用次数: 0

Peculiarities of shifts in the state of proteinase-inhibitory system in periodontal tissues under conditions of formation of experimental periodontitis and immobilization stress 实验性牙周炎和固定应力形成条件下牙周组织蛋白酶抑制系统状态变化的特殊性

Experimental and Clinical Physiology and Biochemistry Pub Date : 2021-12-27 DOI: 10.25040/ecpb2021.03-04.028

Olekshij

{"title":"Peculiarities of shifts in the state of proteinase-inhibitory system in periodontal tissues under conditions of formation of experimental periodontitis and immobilization stress","authors":"Olekshij","doi":"10.25040/ecpb2021.03-04.028","DOIUrl":"https://doi.org/10.25040/ecpb2021.03-04.028","url":null,"abstract":". The aim was to study the state of the proteinase-inhibitory system in periodontal tissues in the dynamics of experimental periodontitis (EP) and immobilization stress (IS). Experimental studies were performed on 40 guinea pigs (males), body weight 0.18-0.21 kg, were divided into four groups (10 in each): the first – intact animals – control; the second (experimental) group – animals with experimental periodontitis under conditions of immobilization stress (3 rd day), the third group included guinea pigs with EP and IS on the 5 th day of the combined model process, to IV – animals with EP and IS 15 th day. Experimental periodontitis was modeled by the method of ZR Jogan (1983). Immobilization stress was reproduced by the method of PD Horizontov (1996). Condition of proteinase-inhibitory system in periodontal tissues was determined by lysis of the azoalbumin, azokasein and azokolagen and mainte-nance content of α1-protease inhibitor (α1-IP), α2-macroglobulin by method of Veremeenko K.N., Goloborodko O.P. (1988). The results of the research showed the activation of lysis processes of all markers identified by us. Thus, a grad-ual intensive growth of azoalbumin, azocasein and azocollagen in periodontal tissues was found throughout the experiment. The dynamics of the activity of proteinase inhibitors is characterized by a decrease in all studied markers in all studied days of EP and IS, which indicates their inhibition. The obtained results give reason to think about the imbalance in the system in the protein-ase-inhibitory system with the predominance of proteinase potential against the background of inhibitor depression.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75350796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of changes in hormonal indicators of ovarian reserve in serial application of cyclophosphamide in the experiment 环磷酰胺系列应用对卵巢储备激素指标变化的影响

Experimental and Clinical Physiology and Biochemistry Pub Date : 2021-12-27 DOI: 10.25040/ecpb2021.03-04.048

V. Shamrai

{"title":"Dynamics of changes in hormonal indicators of ovarian reserve in serial application of cyclophosphamide in the experiment","authors":"V. Shamrai","doi":"10.25040/ecpb2021.03-04.048","DOIUrl":"https://doi.org/10.25040/ecpb2021.03-04.048","url":null,"abstract":". The aim of the study was to study the dynamics of changes in hormonal parameters of the ovarian reserve during serial use of cyclophosphamide in the experiment. The experiments were performed on 45 adult female white rats. Levels of antimullerian hormone, estradiol and follicle-© stimulating hormone were studied. In total, 4 courses of chemotherapy were performed with an interval of 3 weeks. After each course of chemotherapy, the hormonal status of the experimental animals was studied twice: during the first proestrus after the course (to determine the acute ovarian toxicity of the drug) and during the last proestrus before the next course of chemotherapy (to study ovarian function). The dynamics of ovarian reserve hormone levels during serial administration of cyclophosphamide was characterized by wavy dynamics with deterioration immediately after chemotherapy and partial recovery during the period between adjacent courses. Ovariotoxicity of cyclophosphamide when administered serially in therapeutic doses in the experiment was manifested by significant changes in the levels of antimullerian hormone, estradiol and follicle-stimulating hormone after the first course of chemotherapy.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90264235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of experimental acute bronchopneumonia with pulmonary fibrosis 实验性急性支气管肺炎伴肺纤维化模型的建立

Experimental and Clinical Physiology and Biochemistry Pub Date : 2021-12-27 DOI: 10.25040/ecpb2021.03-04.039

D. Ziablitsev

{"title":"Modeling of experimental acute bronchopneumonia with pulmonary fibrosis","authors":"D. Ziablitsev","doi":"10.25040/ecpb2021.03-04.039","DOIUrl":"https://doi.org/10.25040/ecpb2021.03-04.039","url":null,"abstract":". There is currently an urgent need to create an available experimental model to reproduce the main pathogenetic mechanisms of COVID-associated lung injury. Aim – development of the acute bronchopneumonia experimental model with the pulmonary fibrosis. A group of laboratory Wistar rats (n=20) with full observance of bioethical norms under thiopental anesthesia underwent surgery with the introduction into the trachea of sterile nylon thread 2.5 cm long and 0.2 mm thick to a depth of 2.5 cm; in the control group included 5 animals. For 28 days, the animals were observed and performed pathomorphological, cytological, hematological and microscopic examinations. During the observation, the cyanosis increased, breathing became difficult with the active involvement of the respiratory muscles, severe rales and crepitation were heard. Rectal temperature increased by 1–1.5 o C. On sectional examination after 7 days, the lungs were swollen, pale pink in color, had layers of fibrin, severe cyanosis, intra-tissue hemorrhage. After 21 days, these changes were supplemented by the development of atelectasis and fibrosis. On the 21st day, the granulocyte-lymphocyte index increased (1.5 times; p=0.003). Microscopic examination showed the development in the first week of acute exudative bronchopulmonary inflammation, in the second – the formation of peribronchial and alveolar abscesses, with their organization in the third week, with the subsequent development of diffuse parenchymal fibrosis and vascular hyalinosis. The model of acute aspiration bronchopneumonia in rats with the introduction of nylon thread into the trachea allows to obtain the main clinical and morphological manifestations of acute exudative-proliferative damage to the lungs with the development of pulmonary fibrosis.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87902303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of liraglutide on eating disorders in patients with type 2 diabetes 利拉鲁肽对2型糖尿病患者饮食失调的影响

Experimental and Clinical Physiology and Biochemistry Pub Date : 2021-12-27 DOI: 10.25040/ecpb2021.03-04.033

A. Urbanovich

引用次数: 0