Dynamics of changes in hormonal indicators of ovarian reserve in serial application of cyclophosphamide in the experiment

Experimental and Clinical Physiology and Biochemistry Pub Date : 2021-12-27 DOI:10.25040/ecpb2021.03-04.048

V. Shamrai

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Abstract

. The aim of the study was to study the dynamics of changes in hormonal parameters of the ovarian reserve during serial use of cyclophosphamide in the experiment. The experiments were performed on 45 adult female white rats. Levels of antimullerian hormone, estradiol and follicle-© stimulating hormone were studied. In total, 4 courses of chemotherapy were performed with an interval of 3 weeks. After each course of chemotherapy, the hormonal status of the experimental animals was studied twice: during the first proestrus after the course (to determine the acute ovarian toxicity of the drug) and during the last proestrus before the next course of chemotherapy (to study ovarian function). The dynamics of ovarian reserve hormone levels during serial administration of cyclophosphamide was characterized by wavy dynamics with deterioration immediately after chemotherapy and partial recovery during the period between adjacent courses. Ovariotoxicity of cyclophosphamide when administered serially in therapeutic doses in the experiment was manifested by significant changes in the levels of antimullerian hormone, estradiol and follicle-stimulating hormone after the first course of chemotherapy.

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环磷酰胺系列应用对卵巢储备激素指标变化的影响

．本研究的目的是研究在实验中连续使用环磷酰胺期间卵巢储备激素参数的变化动态。实验以45只成年雌性大鼠为实验对象。研究抗苗勒管激素、雌二醇和促卵泡©激素水平。化疗共4个疗程，间隔3周。每个化疗疗程结束后，对实验动物的激素状态进行两次研究:化疗后第一次发情(以确定药物对卵巢的急性毒性)和下一个化疗疗程前最后一次发情(以研究卵巢功能)。连续给药期间卵巢储备激素水平的动态表现为波浪形动态，化疗后立即恶化，相邻疗程间部分恢复。在本实验中，环磷酰胺按治疗剂量连续给药时的卵巢毒性表现为第一个疗程化疗后抗苗勒管激素、雌二醇和促卵泡激素水平的显著变化。

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Experimental and Clinical Physiology and Biochemistry

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