Experimental and Clinical Physiology and Biochemistry最新文献_第10页

Correction of Autonomous Dysfunctions by the Prayama Respiratory Gymnastics in Young People 练习呼吸体操对青少年自主功能障碍的矫正作用

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-11-10 DOI: 10.25040/ecpb2019.03.056

N. Sheiko, V. Feketa, K. Kivezhdi

{"title":"Correction of Autonomous Dysfunctions by the Prayama Respiratory Gymnastics in Young People","authors":"N. Sheiko, V. Feketa, K. Kivezhdi","doi":"10.25040/ecpb2019.03.056","DOIUrl":"https://doi.org/10.25040/ecpb2019.03.056","url":null,"abstract":"Autonomic dysfunction syndrome is a polyetiological syndrome characterized by dysfunction of the autonomic nervous system and functional (inorganic) disorders by all body systems, the prevalence of which ranges from 20 to 56% of all diseases in young people. Most researchers consider heart rate variability as an integral marker that reflects the state of all the body's regulatory systems and is now considered an affordable, non-invasive, reasonably simple and relatively inexpensive method for evaluating the autonomic nervous system. The ability to correct autonomic dysfunction through diaphragmatic breathing in biological feedback using portable computer devices has been demonstrated. However, there is little scientific evidence on the use of breathing exercises in yoga to influence the functional state of the autonomic nervous system. The aim of the study was to investigate the possibility of using “pranayama” breathing exercises to correct autonomic dysfunction in young adults. The study involved 30 healthy young foreigners aged 18 to 24 years. Heart rate variability was recorded using the CardioLab Computer Diagnostic Complex (KhAI-Medica, Ukraine) in the supine position after 10 minutes of adaptation to the registration conditions. The last 5 min utes of registration were used as background metrics. The distribution of the examined into the dependent groups was performed according to the indicators of the output tone of the activity of autonomic system’s regulation. Subsequently, for a period of 30 days, a 15-minute session of respiratory gymnastics was conducted daily, which consisted of 3 periods of 5 minutes, during which the subject performed 5-6 breathing cycles per minute. Each period was completed with 3 spontaneous breathing cycles. The obtained numerical data were processed by the methods of variational statistics using Student's test. The dynamics of heart rate variability was assessed by pairwise comparisons, and intergroup differences were determined using one-way ANOVA. Under the influence of a 30-day course of breathing gymnastics \"pranayama\" indicators of the functional state of the autonomic nervous system have undergone significant changes, in particular in groups of people with initial sympathicotonia. The overall heart rate variability according to TP at the end of the course remained higher than the background values, respec -tively, by 697±101ms2 (p<0.05) in the sympathotonic group and by 398 ± 95ms 2 (p<0,05) in the parasympathicotonic group. Changes in TP in the sympathotonic group occurred mainly due to a decrease in the contribution of the low-frequency (VLF) heart rate regulation (by 98 ± 35ms2 (p <0,05) and a significant increase in the contribution of the high-frequency component of HF (by 682±72 ms2 (p<0,05) There were also significant changes in the structure of the heart rate spectrum according to the percentage contribution of waves of different frequencies at TP. At the end of the course in the sympathotonic g","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78586708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the possibility of hypothermic and subornorthomeric storage of placental mesenchymal stem cells in alginate carriers 评估海藻酸盐载体中胎盘间充质干细胞低温和亚常温储存的可能性

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-11-10 DOI: 10.25040/ecpb2019.03.051

V. Prokopiuk, V. Trifonov, O. Prokopiuk, R. Safonov, V. Lazurenko

引用次数: 0

Assessment of Lead, Cadmium, Copper and Zinc Content in Women’s Blood During II Trimester of Gestation 妊娠中期妇女血液中铅、镉、铜和锌含量的评估

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.005

M. Gzhegotskyi, N. Sukhodolska

{"title":"Assessment of Lead, Cadmium, Copper and Zinc Content in Women’s Blood During II Trimester of Gestation","authors":"M. Gzhegotskyi, N. Sukhodolska","doi":"10.25040/ECPB2019.02.005","DOIUrl":"https://doi.org/10.25040/ECPB2019.02.005","url":null,"abstract":"The global environmental pollution by heavy metals and the imbalance of trace elements has some detrimental effect on pregnancy, fetal development, maternal and newborn’s health with further long-term consequences [1–4]. Heavy metals, particularly lead and cadmium, which are classified as global environmental pollutants, adversely affect the generative function even in low concentrations. Lead excess can cause miscarriage, intrauterine growth retardation, chronic fetal hypoxia, bleeding during pregnancy and labor and the occurrence of birth defects in infants [5,6]. The elevated lead level in pregnant woman’s blood leads to the higher content of this metal in the blood of a newborn child that can cause disorders of the psychological development and child’s mental abilities [6]. The experimental study has shown that the inhalation of cadmium can cause fewer offsprings and higher frequency of congenital malformations, namely embryotoxic and teratogenic effects and in adults – liver damage and alterations in the immune system [7]. The high levels of placental cadmium can result in the reduction of neonatal anthropometric data (weight, height, chest circumference) [8]. Copper as a trace element plays an important in the maturation of hematopoietic cells, in normal pregnancy and embryogenesis, fetal and post-natal growth. Lower plasma copper levels have been found in some conditions diagnosed during the first trimester including a spontaneous, threatened and missed abortion and a blighted ovum [9]. Copper deficiency can result in anemia, neutropenia, bone marrow dysplasia, chronic intrauterine hypoxia, fetal hypotrophy, coagulation abnormalities [9,10]. Serum and placental copper levels and placental lipid peroxides, a marker of oxidative stress, were increased in women with a severe preeclampsia [11]. Zinc deficiency during the pregnancy is associated with preeclampsia, a threatened abortion, a premature birth syndrome, a low birth weight, birth defects, circulatory disorders, impairment of the immune response and disorders of the psychological development [12–14]. Thus, modern ecological situation creates preconditions for increasing the frequency of gestational complications and some negative impact on women and children’s health. In this regard, a scientific search for risk factors of a potential adverse effect on the gestation process for timely implementation of adequate preventive and corrective measures is an important issue. The aim of this study was to evaluate lead, cadmium, copper and zinc levels in women’s blood during II trimester of gestation and to assess the significance of their influence on the gestational process.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75503262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ultrastructural Changes in the Respiratory Section of Rats’ lungs with a Colloid-hyperosmolar Solution Application 胶体-高渗溶液对大鼠肺呼吸切片超微结构的影响

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.031

A. Ocheretniuk, B. Kondratskyi, O. Palamarchuk, V. Kovalchuk, Y. Kondratskyi

引用次数: 0

БОРИС МИХАЙЛОВИЧ ШТАБСЬКИЙ (до 90-річчя від дня народження (1929–2017)

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.077

M. Ghzehotskyi, Y. Fedorenko

引用次数: 0

The Range of Bile Acid Cholates in the Bile of Rats With Steatohepatosis Induced by a High-calorie Diet 高热量饮食致脂肪性肝病大鼠胆汁中胆汁酸胆酸盐的范围

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.024

M. Kondro, S. Veselskyi, T. Dovbynchuk, I. Prybytko

{"title":"The Range of Bile Acid Cholates in the Bile of Rats With Steatohepatosis Induced by a High-calorie Diet","authors":"M. Kondro, S. Veselskyi, T. Dovbynchuk, I. Prybytko","doi":"10.25040/ECPB2019.02.024","DOIUrl":"https://doi.org/10.25040/ECPB2019.02.024","url":null,"abstract":"The effect of a high-calorie diet on the dynamics of choleresis and secretion of free and conjugated fatty acids was studied in experiments on rats. They has shown that in comparison with rats fed with the standard food, in rats that were on a high-calorie diet for 20 weeks, the volume rate of bile secretion increased by 12.4 % (p < 0.05). Using the method of thin layer chromatography, it has been found out that in the bile of rats within a 3-hour experiment the concentration of taurocholic acid mixture of taurochenodeoxycholic and taurodeoxycholic acids, the concentration of the mixture of glycochenodeoxycholic and glycodeoxycholic acids, the concentration of the mixture of chenodeoxycholic and deoxycholic acids increased. At the same time, the concentration of glycocholic acid in the bile of rats decreased after 20 weeks of rats’ staying on HCD, the concentration of cholic acid did not undergo statistically significant changes. In this case, the conjugation coefficient remains unchanged and the hydroxylation coefficient has decreased which indicates the activation of some alternative pathway of biosynthesis of bile acids. The incidence of nonalcoholic steatosis, also called as a nonalcoholic fatty liver disease, is growing rapidly around the world. The growth rate is 30-40 %, which is becoming a huge medical and economic burden for patients and states in the whole [1]. Therefore, the establishment of mechanisms of pathogenesis of steatohepatosis, its consequences and the development of optimal methods of treatment is an urgent problem of our time. Previously, we have shown that the presence of rats on a high-calorie diet No. 11024 (HCD) (diet No. 11024, Research Diets, New Brunswick, NJ) for 20 weeks leads to the development of metabolic syndrome (MS), on the background of which liver steatosis was recorded [2,3]. On the background of structural changes in the liver, there is a change in its functional state, for the assessment of which it is important to determine the spectrum of bile acids in the bile and to establish a ratio between individual bile acids. Under physiological conditions, this spectrum is quite stable. However, in case of impairments of the hepatobiliary system, the content of individual bile acids can vary significantly. Despite the fact that HCD No. 11024 is widely used in experimental studies, the aim of this work was to investigate the range of bile acids cholates in the bile of rats after 20 weeks of their staying on this diet. Materials and methods. Studies were carried out on male white rats with an initial mass of 210-215 grams. During the first week all rats received the standard food and water ad libitum. On the 2nd week the animals were randomized into two groups. Rats of group 1 received the standard food and water ad libitum and served as a control group. Rats of group II were on the HCD (diet No. 11024, Research Diets, New Brunswick, NJ), which consisted","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74229098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Dental Status in Rats with Experimental Hyperhomocysteinemia and its Correction with Choline and Vitamin D 实验性高同型半胱氨酸血症大鼠牙齿状况的评估及胆碱和维生素D的矫正

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.066

O. Kutelmakh

引用次数: 1

The Comparative Characteristics of Aerobic and Anaerobic Productivity of Girls in Lowland and Mountainous Transcarpathian Areas According to the Body Component composition 喀尔巴阡低地和山区女孩有氧和无氧生产能力与身体成分组成的比较特征

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.051

O. Dulo

引用次数: 2

Successful Treatment of Multiple Chronic Leg Wounds - a Case Report 成功治疗多发性慢性腿部伤口1例报告

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.072

I. Terletskyi, M. Verkhola, M. Antoniv, Y. Orel

{"title":"Successful Treatment of Multiple Chronic Leg Wounds - a Case Report","authors":"I. Terletskyi, M. Verkhola, M. Antoniv, Y. Orel","doi":"10.25040/ECPB2019.02.072","DOIUrl":"https://doi.org/10.25040/ECPB2019.02.072","url":null,"abstract":"Chronic wounds constitute a significant challenge confronting patients and health care professionals. In the USA approximately 5.7 million patients are currently suffering from chronic wounds. Expenses on their treatment are estimated at $20 billion annually [1,2]. Lower-extremities ulcers, especially in individuals older than 65 years, are a frequent cause for attending a podiatrist, wound care specialist, primary care physician, vascular surgeon or dermatologist. The bulk of vascular leg ulcers is chronic or recurrent. They can present significant complications among patients with the peripheral vascular disease, including work incapacity. The management of vascular leg ulcers puts a considerable burden on a patient and the health care system. Moreover, these non-healing ulcers increase the risk for lower extremity amputation [3]. Vascular leg ulcers are often multifactorial and can be caused by both arterial and venous diseases. Hypertension and atherosclerosis of peripheral vessels lead to the arterial disease associated with ischemic ulcers. In some cases, difficulties with determining the underlying cause of wound formation complicates treatment and prevents the recurrences. Systemic sclerosis (or scleroderma) is a rare autoimmune connective tissue disorder which is associated with a various degree of systemic manifestations [4]. The organs most frequently affected by scleroderma are skin, gastrointestinal tract, lungs, kidneys, skeletal muscle, and pericardium [5]. One of the challenging complications of systemic sclerosis are non-digital lower extremity ulcers seen both in limited and diffuse scleroderma, with not exactly clear etiology that tends to reflect chronic vasculopathy. They aggravate some pain and ability of the advanced disease. As the incidence of nonhealing lower extremity ulcers in scleroderma has not specifically been studied, more researches are considered to be appropriate in this field of study. The delayed wound healing is typical for systemic sclerosis and, likewise in other chronic leg ulcers, characterized by multifactorial etiology. A role of vascular disease has been proposed, but in spite of restoring the good blood flow and venous drainage, many scleroderma ulcers still remain refractory [6,7]. The 73-year-old female patient V. was sent to the surgical department No 1 of Lviv regional clinical hospital in 2013 due to ulcers on both legs, which she developed 3 years before the clinical attendance. Her medical history was remarkable for myocardial infarction which she suffered in 2009. She suffered from atrial fibrillation (treated by Varfarin 5 mg) and hypertension (treated by Valsartan 80 mg plus Hydrochlorothiazide","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73509268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of the Parameters of EEG in Persons Whose Immune Status is Susceptible or Resistant to Chronic Stress 免疫状态易感或抵抗慢性应激者脑电图参数的特征

Experimental and Clinical Physiology and Biochemistry Pub Date : 2019-07-05 DOI: 10.25040/ECPB2019.02.011

O. Mel’nyk, O. Lukyanchenko, O. Gozhenko, I. Popovych

{"title":"Features of the Parameters of EEG in Persons Whose Immune Status is Susceptible or Resistant to Chronic Stress","authors":"O. Mel’nyk, O. Lukyanchenko, O. Gozhenko, I. Popovych","doi":"10.25040/ECPB2019.02.011","DOIUrl":"https://doi.org/10.25040/ECPB2019.02.011","url":null,"abstract":"In animal experiments and clinical observations, it was found out that the reactions of the immune system to stress are characterized by features of individuality due to the individual reactions of the main stress-realizing systems: sympatho-adrenomedulary and hypothalamic-pituitary-corticoadrenal [1,2,3,4,5,6]. The secondary, but essential role is also played by stress-induced changes in vagus tone, blood levels of sex and thyroid hormones as well as parathyrin and calcitonin [6,7,8,9,10,11,12]. In order to find out the role induced by chronic stress changes in immune parameters of the sympatho-vagal balance in the previous study, we [13,14] compared the individuals who were retrospectively divided into two groups, almost identical to the average value of LF/HF ratio and its dispersion, but with opposite deviations from the standards of the links of immunity. In stress-sensitive individuals the integral state of Phagocytosis as Z-scores was compiled: –1,82 ± 0,39, of Cellular link: –1,69 ± 0,21, of Humoral link: +0,23 ± 0,19 versus +0,76 ± 0,43; +0,23 ± 0,26 and +0,76 ± 0,11 in stress-resistant persons respectively. The immune profiles constructed on Z-scores can be divided into three networks. The first set contains 7 parameters (IL-6, Entropy of Leukocytogram (LCG), Killing Index vs E. coli and Staph. aureus, Microbial Count E. coli, Igg G and M) that are not significantly different from persons who are stress-sensitive or stress-resistant. 18 parameters of the second set (total Leukocytes, Segmented and Stub Neutrophils, Phagocytose Index vs E. coli and Staph. aur., Microbial Count Staph. aur., Bactericidity vs E. coli and Staph. aur., T-active, T-helper, T-cytolytic, Natural Killers and B-Lymphocytes, IgA, CIC, Popovych’s Adaptation Index of LCG as well as Bifidobacterium and Lactobacillus feces) to a greater or lesser degree are higher in stress-resistant persons. The 8 parameters of the third set (total and 0-Lymphocytes, Monocytes and Eosinophils, Popovych’s Strain Index of LCG, TNF-α, IL-1 as well as Hemolytica E. coli) are higher in stress-sensitive persons. Previously, in our laboratory, significant relationships were found between the parameters of phagocytic, cellular and humoral links of immunity, on the one","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87584530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6