Features of the Parameters of EEG in Persons Whose Immune Status is Susceptible or Resistant to Chronic Stress

Abstract

In animal experiments and clinical observations, it was found out that the reactions of the immune system to stress are characterized by features of individuality due to the individual reactions of the main stress-realizing systems: sympatho-adrenomedulary and hypothalamic-pituitary-corticoadrenal [1,2,3,4,5,6]. The secondary, but essential role is also played by stress-induced changes in vagus tone, blood levels of sex and thyroid hormones as well as parathyrin and calcitonin [6,7,8,9,10,11,12]. In order to find out the role induced by chronic stress changes in immune parameters of the sympatho-vagal balance in the previous study, we [13,14] compared the individuals who were retrospectively divided into two groups, almost identical to the average value of LF/HF ratio and its dispersion, but with opposite deviations from the standards of the links of immunity. In stress-sensitive individuals the integral state of Phagocytosis as Z-scores was compiled: –1,82 ± 0,39, of Cellular link: –1,69 ± 0,21, of Humoral link: +0,23 ± 0,19 versus +0,76 ± 0,43; +0,23 ± 0,26 and +0,76 ± 0,11 in stress-resistant persons respectively. The immune profiles constructed on Z-scores can be divided into three networks. The first set contains 7 parameters (IL-6, Entropy of Leukocytogram (LCG), Killing Index vs E. coli and Staph. aureus, Microbial Count E. coli, Igg G and M) that are not significantly different from persons who are stress-sensitive or stress-resistant. 18 parameters of the second set (total Leukocytes, Segmented and Stub Neutrophils, Phagocytose Index vs E. coli and Staph. aur., Microbial Count Staph. aur., Bactericidity vs E. coli and Staph. aur., T-active, T-helper, T-cytolytic, Natural Killers and B-Lymphocytes, IgA, CIC, Popovych’s Adaptation Index of LCG as well as Bifidobacterium and Lactobacillus feces) to a greater or lesser degree are higher in stress-resistant persons. The 8 parameters of the third set (total and 0-Lymphocytes, Monocytes and Eosinophils, Popovych’s Strain Index of LCG, TNF-α, IL-1 as well as Hemolytica E. coli) are higher in stress-sensitive persons. Previously, in our laboratory, significant relationships were found between the parameters of phagocytic, cellular and humoral links of immunity, on the one