Exogenous Dermatology最新文献_第5页

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000092606

J. Vilaplana, M. Alsina, J. Coll, J. Reig, G. Campos, C. Trullás, C. Pelejero, M. Recasens, D. Costa, C. Romaguera

{"title":"Propylene Glycol Today","authors":"J. Vilaplana, M. Alsina, J. Coll, J. Reig, G. Campos, C. Trullás, C. Pelejero, M. Recasens, D. Costa, C. Romaguera","doi":"10.1159/000092606","DOIUrl":"https://doi.org/10.1159/000092606","url":null,"abstract":"Propylene glycol (PG) has been described as responsible for contact allergy and irritant reactions, but there are a lot of non-conclusive studies reporting a different percentage of patients irritated, with diverse concentrations and doses applied. As this substance is contained in a large amount of products, we reviewed its irritant capacity and the appropriate concentration to be tested. PG from two different origins was tested in 230 healthy volunteers. We applied 25 µl of PG at two different concentrations (70 and 100%). PG from origin B (PGB) was tested furthermore with two different qualities. Biophysical measurements were performed in those subjects patch-tested with PGB and its acute dermal irritation was tested in human skin culture. After 48 h results did not show any difference between PG from both origins and qualities. After 96 h PGB was slightly more irritant than PGA. Biophysical measurements only increased significantly in the subjects with a positive allergic reaction and there were no differences in the in vitro test. PG is not valid as pattern of irritation even at 100% concentration because it irritates a small percentage of patients. The recommended concentration should be between 30 and 70% in water, and the 100% concentration could be used in non-reactive patients.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"242 1","pages":"313 - 317"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80509920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunologic Patterns in Allergic and Irritant Contact Dermatitis: Similarities 过敏性和刺激性接触性皮炎的免疫模式:相似之处

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000087149

E. Dika, Nara Branco, H. Maibach

引用次数: 2

Stratum Corneum: An Ideal Osmometer? 角质层:理想的渗透器?

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000093798

F. Pirot, F. Falson, C. Pailler-Mattéi, H. Maibach

{"title":"Stratum Corneum: An Ideal Osmometer?","authors":"F. Pirot, F. Falson, C. Pailler-Mattéi, H. Maibach","doi":"10.1159/000093798","DOIUrl":"https://doi.org/10.1159/000093798","url":null,"abstract":"Water and osmolyte homeostasis is an essential biological function. Remarkably devoid of aquaporin (i.e., water channel protein) expression, the stratumcorneumavoids a substantial transepidermal water loss, compulsory for the adaptation to terrestrial life. In spite of its heterogeneity, the stratum corneumexhibits a homogeneous water transport, whereas highly osmotic endogenous materials control its water-holding capacity and skin’s physical properties (e.g., stiffness, firmness, flexibility) under various conditions. However, the contingent interplay between water homeostasis of the stratum corneumand an exogenous osmotic stress has been not reported, although constituting a cornerstone of skin physiology. Here, we show that an osmotic shock reinforces the endogenous stratum corneumosmolality proportionally to the osmotic pressure exerted against it and, therefore, reduces the magnitude of outward water transfer and net evaporation. The strengthening of endogenous osmolality enhanced the water-holding capacity of the stratum corneum with respect to chemical potentials. This property was found for organic osmolytes, but questioned for mineral electrolytes characterized by minimal stratum corneumpermeability. Besides, straightforward experiments performed using a built-in house osmometer, a so-called ‘corneosmometer’, have confirmed water transfer through the stratum corneumsubmitted to a gradient of osmotic pressure. Thus, the ambivalent function of the stratum corneum, which firstly behaves as an ideal osmometer and secondly adapts its own osmolality to an exogenous gradient of osmotic pressure, has been clearly demonstrated. This duality influences the water-holding capacity of the stratum corneum, by regulating the water transfer proportionally to an initial osmotic stress, and, finally, conditions the further capacity of the stratum corneumto facilitate or impede skin hydration.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"111 1","pages":"339 - 349"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78055475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Effects of Osmosis on Water-Holding Capacity of Stratum corneum and Skin Hydration 渗透对角质层持水能力及皮肤水合作用的影响

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078693

F. Pirot, Bénédicte Morel, G. Peyrot, Tiphaine Vuillet, V. Faivre, Christine Bodeau, F. Falson

引用次数: 16

24-Hour versus 48-Hour Occlusion in Patch Testing 斑块测试中的24小时与48小时遮挡

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078696

S. Ale, H. Maibach

{"title":"24-Hour versus 48-Hour Occlusion in Patch Testing","authors":"S. Ale, H. Maibach","doi":"10.1159/000078696","DOIUrl":"https://doi.org/10.1159/000078696","url":null,"abstract":"Background: Routine patch testing is usually performed with 2-day occlusion. Yet, shortening the application period, without diminishing diagnostic accuracy, would benefit patients. Previous studies document that differences in application time may produce variable results. Objective: Our objective was to determine whether 1-day application elicits similar results to 2-day application in diagnostic patch testing. Methods: Simultaneous duplicate patch test series were applied to the opposite sides of the upper back on 250 consecutive patients, using the TRUE test system. One set of allergens was removed after 24 and the other after 48 h. Results: A total of 221 positive reactions were observed either after 24 or 48 h of occlusion in 113 (46%) patients. Of these, 190 were concordant, i.e. positive, after 24 and 48 h of occlusion, and 31 were discordant. Twenty-nine of the discordant reactions were observed only after 48 h of occlusion and 2 only after 24 h of occlusion. Of the 27 (19%) patients with discordant patch test reactions, the allergen was deemed to be of definite present or past relevance in 16 (6% of the total and 14% of all patients with positive reactions). Conclusion: These data confirm that the overall concordance of results after 24 and 48 h of application is high. However, clinically relevant allergens would have been missed in 16 patients if only the 24-hour occlusion test was performed. In the light of these results, we consider that the standard 48-hour application remains appropriate for diagnostic patch testing.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"47 1","pages":"270 - 276"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84739176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Corrosion Chemistry of Copper: Formation of Potentially Skin-Diffusible Compounds 铜的腐蚀化学:潜在表面扩散化合物的形成

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091906

J. Hostynek,

引用次数: 4

Comparative Clinicopathological Manifestations of Human Aspergillosis 人曲霉病的比较临床病理表现

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000089608

G. Piérard, J. Arrese, P. Quatresooz

引用次数: 9

Is There Evidence that Linalool Causes Allergic Contact Dermatitis? 有证据表明芳樟醇会引起过敏性接触性皮炎吗?

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078688

J. Hostynek,, H. Maibach