Exogenous Dermatology最新文献_第4页

Operational Definition of a Causative Contact Allergen – A Study with Six Fragrance Allergens 一种致病接触过敏原的操作定义——六种芳香过敏原的研究

Exogenous Dermatology Pub Date : 2004-12-01 DOI: 10.1159/000081564

J. Hostynek,, H. Maibach

{"title":"Operational Definition of a Causative Contact Allergen – A Study with Six Fragrance Allergens","authors":"J. Hostynek,, H. Maibach","doi":"10.1159/000081564","DOIUrl":"https://doi.org/10.1159/000081564","url":null,"abstract":"In practice, the clinical diagnosis of allergic contact dermatitis is often highly problematic with the identification of the specific allergen that has actually caused a patient’s particular dermatitic episode being even more difficult. A large number of reports in the literature are able to identify a number of substances to which the patient is allergic without clearly indicating a causal link to the patient’s current problem. For the reader of such reports, it is often difficult to judge if this link has been established, and for this reason, a number of criteria have been proposed to determine if reported positive patch test reactions are clinically relevant. These criteria include the degree of information given on the selection and condition of the patients, patch testing conditions, the intensity and duration of reactions, reactions occurring simultaneously to other patch test materials, the likelihood of confounding factors such as cross-reactions and excited skin occurring, linkage to specific consumer products or environmental sources of the putative allergen and follow-up with appropriate use testing. Criteria are also suggested for evaluating a substance’s allergenic potency from reports of predictive testing. These include the availability of details on the test methodology, maximization procedures, the selection criteria for test and control subjects and of the exact test scores. The applicability of these criteria are tested in separate publications on 6 fragrance allergens, for which information is provided on patch test concentrations.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"19 1","pages":"279 - 285"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87891756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Subject Index Vol. 2, 2003 主题索引第2卷，2003年

Exogenous Dermatology Pub Date : 2004-12-01 DOI: 10.1159/000082691

J. Hostynek,, H. Maibach, H. Zhai, C. D. Villarama, Z. H. Hafeez, A. Ormerod, P. Woo, J. Islam, J. Moran, M. Cals-Grierson, J. Minang, N. Ahlborg, M. Troye-Blomberg, M. Choi

引用次数: 0

Contents Vol. 2, 2003 目录2003年第2卷

Exogenous Dermatology Pub Date : 2004-12-01 DOI: 10.1159/000082692

J. Hostynek,, H. Maibach, H. Zhai, C. D. Villarama, Z. H. Hafeez, A. Ormerod, P. Woo, J. Islam, J. Moran, M. Cals-Grierson, J. Minang, N. Ahlborg, M. Troye-Blomberg, M. Choi

引用次数: 0

Role of Ceramides in Skin Stress: Ultraviolet Light, Tape Stripping and Crowding 神经酰胺在皮肤应激中的作用:紫外线、胶带剥离和拥挤

Exogenous Dermatology Pub Date : 2004-12-01 DOI: 10.1159/000081565

M. Choi, H. Maibach

引用次数: 3

Exogenous Factors in Hair Disorders 头发疾病的外源性因素

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091903

L. Horev

引用次数: 11

Predictive Testing for Irritancy and Allergenicity of Tea Tree Oil in Normal Human Subjects 茶树油对正常人的刺激性和致敏性的预测试验

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078694

Nicholas Aspres, S. Freeman

{"title":"Predictive Testing for Irritancy and Allergenicity of Tea Tree Oil in Normal Human Subjects","authors":"Nicholas Aspres, S. Freeman","doi":"10.1159/000078694","DOIUrl":"https://doi.org/10.1159/000078694","url":null,"abstract":"Background: Topical tea tree oil has become increasingly popular as a general-purpose medicament for various dermatological conditions. Although recent reports of adverse cutaneous reactions have highlighted concerns about the risk of inducing acute allergic contact dermatitis, few published studies have attempted to evaluate objectively the true irritancy and allergenicity potential of this commonly used essential oil. Objective: To perform predictive testing for irritancy and allergenicity of tea tree oil in a large group of human subjects. Methods: Various concentrations of tea tree oil (5, 25, 100%) in different vehicles were applied under occlusive patch testing to the skin of healthy, human volunteers (n = 311) using a protocol based on the Draize human sensitisation test. Patch test sites were assessed every 48 h and scored according to the severity of any resulting cutaneous reaction using a clinical grading scale from 0 to 4 over a 21-day induction period. After a 14-day rest period, subjects underwent challenge testing with the same tea tree oil samples to determine if sensitisation to tea tree oil had occurred. Results: The mean irritancy score for each test sample was low, ranging from 0 for 5% tea tree oil to 0.2505 for neat 100% tea tree oil. However, 3 subjects developed grade 3 skin reactions during the induction period suggestive of an allergic reaction. Conclusions: Topical application of tea tree oil is associated with negligible skin irritancy. In the group of subjects studied, the risk of developing an allergic dermatitis from topical tea tree oil usage was found to be <1%.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"85 1","pages":"258 - 261"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74741416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Vitiligo – Exogenous Factors

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091904

H. Matz, E. Tur

引用次数: 3

Classification of Exogenous Factors Contributing to the Itch Response 引起瘙痒反应的外源因素分类

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091901

Christopher B. Yelverton, G. Yosipovitch

引用次数: 1

Exogenous Factors in Atopic Dermatitis 特应性皮炎的外源性因素

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091902

E. Guttman‐Yassky