Exogenous Dermatology最新文献_第6页

Anti-Irritants: Myth or Reality? An Overview 抗刺激剂:神话还是现实?概述

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000090352

C. Ford, H. Maibach

引用次数: 1

Exogenous Factors and Psoriasis 外源性因素与银屑病

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091900

E. Dika, H. Maibach

引用次数: 10

Smoking Habits and Alcohol Consumption in Patients with Cutaneous Lichen planus 皮肤扁平苔藓患者的吸烟习惯和饮酒

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000087463

A. Mansur, Z. Kılıç

{"title":"Smoking Habits and Alcohol Consumption in Patients with Cutaneous Lichen planus","authors":"A. Mansur, Z. Kılıç","doi":"10.1159/000087463","DOIUrl":"https://doi.org/10.1159/000087463","url":null,"abstract":"Background: Alcohol intake and smoking have been reported to be risk factors in some inflammatory skin disorders. There is a dearth of published data on the relation between smoking/alcohol intake and oral lichen planus. Moreover, the reports on the relationship of these habits with cutaneous lichen planus (CLP) are lacking. Objective: The aim of this study was to investigate smoking and alcohol as potential risk factors in CLP. Methods: We examined smoking habits and alcohol consumption in 55 patients with CLP, and compared the results with control subjects who had superficial fungal infections, matched for age and sex. Results: There was no statistical difference between the two groups according to the rate of patients that had ever smoked (combining both current and past smokers) and the rate of the patients who had never smoked (p > 0.05). No significant difference was found between CLP patients and controls with respect to current smokers and subjects who never smoked (p > 0.05). The most notable finding was that the rate of subjects who quitted smoking was significantly higher among CLP patients compared to controls (23.6 vs. 5.5%, p < 0.05). Regarding alcohol consumption, there was no significant difference between the groups (p > 0.05). Conclusion: We conclude that alcohol intake and smoking do not appear to be risk factors for CLP. The increased incidence of ex-smokers in patients with CLP was an unexpected and interesting finding. Further epidemiological studies and investigations are warranted to clear up this observation.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"237 1","pages":"126 - 130"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89037740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identifying the Source of Textile Dye Allergic Contact Dermatitis – A Guideline 纺织品染料过敏性接触性皮炎的来源鉴定指南

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078691

K. Hatch, H. Motschi, H. Maibach

引用次数: 9

Monitoring the Penetration and Distribution of Topically Applied Formulations through the Skin in Relation to the Skin Protein/Lipid Morphological Characteristics 监测局部应用配方通过皮肤的渗透和分布与皮肤蛋白质/脂质形态特征的关系

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000088011

P. Garidel

{"title":"Monitoring the Penetration and Distribution of Topically Applied Formulations through the Skin in Relation to the Skin Protein/Lipid Morphological Characteristics","authors":"P. Garidel","doi":"10.1159/000088011","DOIUrl":"https://doi.org/10.1159/000088011","url":null,"abstract":"The ability of topically applied dosage forms to penetrate the skin depends on the interactions of the formulation ingredients with the intrinsic components of the skin. These interactions define the penetration route as well as the distribution of the drug in the skin tissue. The present study focused on monitoring components of externally applied formulations through the skin (ex vivo) via mid-infrared microspectroscopic techniques. Infrared microspectroscopy represents a new bioanalytical method, combining the powerfulness of chemical component analysis by means of infrared spectroscopy and using the high lateral resolution (∼20 µm) as obtained from microscopy. Two methods are applied for analysing tissues: the mapping and the imaging approach. A major breakthrough using infrared microspectroscopy in tissue diagnostics was the development and implementation of so-called focal plane array detectors. Using these detectors, sample areas of about 0.25–16 mm2 can be analyzed. The highest lateral resolution obtained by the transmission techniques approaches the mid-infrared diffraction limit of approximately 6 µm. Using mid-infrared microspectroscopic imaging, a large amount of biochemical information, at high lateral resolution, is generated, not yet available by other methods. Additional advantages are: it is a non-invasive, non-destructive approach, requiring no complex and time-consuming tissue staining procedures. In the present study, mid-infrared microspectroscopic mapping and imaging techniques in transmission are used for the biochemical characterisation of skin samples (e.g. lipid/protein distribution). This information provides new insight into the morphology of the tissue constitution. Additionally, examples are presented concerning the analysis of the distribution of topically applied drugs (e.g. UV B blocker or liposomes) through the skin. The potential as well as the limits of the methods for dermatological research are discussed.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"109 1","pages":"131 - 143"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77645199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Is There Evidence that Anisyl Alcohol Causes Allergic Contact Dermatitis? 有证据表明茴香醇会引起过敏性接触性皮炎吗?

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000078689

J. Hostynek,, H. Maibach

引用次数: 8

Pitted Keratolysis: New Ultrastructural Insight in Keratohyalin Granule and Corneodesmosome Alterations 凹点角化:角膜透明素颗粒和角膜桥粒改变的新超微结构观察

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000086942

T. Hermanns‐Lê, Roy García, J. Arrese, G. Piérard

{"title":"Pitted Keratolysis: New Ultrastructural Insight in Keratohyalin Granule and Corneodesmosome Alterations","authors":"T. Hermanns‐Lê, Roy García, J. Arrese, G. Piérard","doi":"10.1159/000086942","DOIUrl":"https://doi.org/10.1159/000086942","url":null,"abstract":"Background: Pitted keratolysis (PK) is a superficial cutaneous infection caused by different species of bacteria. It is characterized by discrete crateriform and malodorous pits and erosions coalescing to form bizarre figures on the soles. Objective: To investigate the process of corneocyte shedding in PK. Method: Biopsies from typical lesions of 3 patients were investigated by transmission electron microscopy. Results: Microorganisms were found both inter- and intracellularly in corneocytes and keratinocytes of the upper layers of the stratum spinosum. Bacteria exhibited different morphologic aspects related to their localization in the epidermis. Keratohyalin granules were strikingly abnormal, showing sharp segregation between rounded dense areas and more electron-translucent areas. Some keratohyalin granules exhibited only alveolar dense areas. These altered keratohyalin granules were still present inside corneocytes. The corneodesmosomes at the bottom of the pits were in part cleaved leading to partial corneocyte dissociation. Conclusion: It is suggested that proteases secreted by the bacteria alter the structure of both the corneodesmosomes and the keratohyalin granules. The latter appeared more resistant to the normal processing of profilaggrin inside the corneocytes.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"3 1","pages":"107 - 111"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81768241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function 通过破坏屏障功能对特应性皮炎非病变性皮肤干燥的再表征

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091909

Hayato Matsuki, K. Kiyokane, T. Matsuki, Sayuri Sato, G. Imokawa

{"title":"Recharacterization of the Nonlesional Dry Skin in Atopic Dermatitis through Disrupted Barrier Function","authors":"Hayato Matsuki, K. Kiyokane, T. Matsuki, Sayuri Sato, G. Imokawa","doi":"10.1159/000091909","DOIUrl":"https://doi.org/10.1159/000091909","url":null,"abstract":"Background: The etiology of the nonlesional dry and barrier-disrupted skin of patients with atopic dermatitis (AD) is still unclear. Objective: To determine whether disrupted barrier function in the nonlesional skin is associated with inflammatory or postinflammatory events, which are relevant to the severity of AD or local dry skin properties, respectively. Methods: We evaluated the barrier function and the water content of nonlesional forearm skin and compared these with the severity of AD and the intensity of dryness/scaling/itchiness at the same skin sites. Results: The transepidermal water loss (TEWL) significantly increased in proportion to the severity of AD with a markedly high correlation coefficient (r = 0.834, p < 0.0001, n = 106), while the capacitance decreased in proportion to the severity of AD with a relatively lower correlation coefficient (r = –0.720, p < 0.0001, n = 106) compared with TEWL. Relationship between TEWL and capacitance values in association with the AD severity revealed that the two parameters are well distributed, corresponding to the severity of AD, and that the elevated TEWL more adequately reflects the difference between healthy control and the mild group of AD compared with the reduced capacitance. Comparison with dry skin properties revealed that while the capacitance values were highly correlated with dryness (r = –0.752, p < 0.0001, n = 106) and with scaling (r = –0.697, p < 0.0001, n = 106), the TEWL was also related to dryness (r = 0.788, p < 0.0001, n = 106) with a higher correlation coefficient compared with capacitance and to scaling (r = 0.697, p < 0.0001, n = 106). Conclusion: Our results indicate that the barrier disruption in the nonlesional skin is well suited to reflect the severity of AD as well as the dry skin properties, providing a useful insight into understandings of diagnosis and clinical improvement during therapy.","PeriodicalId":12086,"journal":{"name":"Exogenous Dermatology","volume":"12 1","pages":"282 - 292"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80323081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Is There Evidence That Alpha-Iso-Methylionone Causes Allergic Contact Dermatitis? 有证据表明α -异甲基狮子酮引起过敏性接触性皮炎吗?

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000087462

J. Hostynek,, H. Maibach

引用次数: 7

Genetic Determinants of Susceptibility to UV Light-Associated Skin Cancer 紫外线相关皮肤癌易感性的遗传决定因素

Exogenous Dermatology Pub Date : 2004-07-01 DOI: 10.1159/000091899

E. Sprecher

引用次数: 0