European journal of rheumatology and inflammation最新文献_第5页

Enteric coated naproxen tablets. 肠溶萘普生片。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

O N Gamst

引用次数: 0

The outcome of arthritis: measures of function, X-rays damage, pain and patients' satisfaction. 关节炎的结果:测量功能、x光损伤、疼痛和患者满意度。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

S Donnelly, D L Scott

{"title":"The outcome of arthritis: measures of function, X-rays damage, pain and patients' satisfaction.","authors":"S Donnelly, D L Scott","doi":"","DOIUrl":"","url":null,"abstract":"The outcome of arthritis has several dimensions. These include mortality, morbidity, radiological measures of joint destruction, pain, and patients' satisfaction with therapy. Functional disability measured by health status questionnaires, is directly associated with long-term outcome and mortality. Long term clinical trials should incorporate functional indices as outcome measures. Studies measuring the outcome of arthritis should define clear end-points involving the determination of functional classes and this will allow standardised and sensitive end points. An example would be the time taken to reach a given functional class or increase from baseline by one functional class. Patients' satisfaction with treatment is a different dimension of response. There are considerable advantages in using an index of patients' satisfaction when determining the therapeutic efficacy in short term clinical trials. It gives a different indication of the response to treatment than conventional clinical and laboratory measures of disease activity. Alleviating pain and preservation of function remain the major therapeutic goals, and both reflect the outcome of arthritis. Outcome measures have shifted from laboratory markers and radiographic techniques to measures of health status, pain, and patients' satisfaction. These should become a routine part of patient assessment.","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"12 2","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naproxen: its current place in therapeutics. 萘普生:目前在治疗学中的地位。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

A G Mowat

引用次数: 0

Enteric-coated and plain naproxen tablets in osteoarthritis; tolerability and efficacy. 肠溶萘普生片与普通萘普生片治疗骨关节炎耐受性和有效性。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

O F Lehn, O N Jensen, L A Andersen, K A Christensen, L Solheim, J Barslev, W Mjølstad, G Wiig, H H Ibfelt, T Kjønniksen

{"title":"Enteric-coated and plain naproxen tablets in osteoarthritis; tolerability and efficacy.","authors":"O F Lehn, O N Jensen, L A Andersen, K A Christensen, L Solheim, J Barslev, W Mjølstad, G Wiig, H H Ibfelt, T Kjønniksen","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this 8 week study, was to compare the tolerability and efficacy of enteric-coated (ECT) and plain naproxen tablets (PT). Ninety eight patients (mean age 66 years) with osteoarthritis were included in a randomized, multi-centre, double-blind, cross-over study. Response variables were monitored at 2 week intervals for the duration of the study. Sixteen patients withdrew from the study, eight because of gastrointestinal (GI) adverse events (ECT 5, PT3). There was no significant difference in patients preference. Eighteen patients reported GI adverse events only on PT compared to 9 on ECT (n.s.). In the first treatment period the severity of adverse events was significantly less on ECT (P = 0.015). Both enteric-coated and plain naproxen tablets were effective and well tolerated. In conclusion, the study did not show any clinical significant difference in tolerability or efficacy between the formulations in osteoarthritis of the knee and/or the hip, although some of the variables did show statistical significant difference or tendency in favour of the enteric coated tablets.","PeriodicalId":12056,"journal":{"name":"European journal of rheumatology and inflammation","volume":"12 2","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12537857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NSAID-associated gastrointestinal damage: methodological considerations and a review of the experience with enteric coated naproxen. 非甾体抗炎药相关胃肠道损伤:方法学考虑和肠溶萘普生经验回顾。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

L Aabakken

引用次数: 0

Enteric coated naproxen; a double blind trial comparing the tolerance of enteric coated and standard formulations. 肠溶萘普生;比较肠溶包衣和标准制剂耐受性的双盲试验。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

E C Huskisson, R M Bernstein, J S Coppock, P G Davies, D V Doyle, P R Platt, D L Scott, R H Witherington, J A Wojtulewski

引用次数: 0

Morning stiffness and nightime pain in ankylosing spondylitis. A comparison between enteric-coated and plain naproxen tablets. 强直性脊柱炎的晨僵和夜间疼痛。萘普生肠溶片与普通片的比较。

European journal of rheumatology and inflammation Pub Date : 1992-01-01

V Johnsen, J G Brun, E Fjeld, K Hansen, O A Sydnes, M B Ugstad