European journal of hospital pharmacy : science and practice最新文献

{"title":"Predicting unplanned hospital revisits among community-dwelling older adults: a dynamic cohort study.","authors":"Julie Hias, Nicolas Saud, Lotte Blocquiaux, Laura Hellemans, Geert Molenberghs, Bert Vaes, Xavier Rygaert, Jos Tournoy, Lorenz Roger Van der Linden","doi":"10.1136/ejhpharm-2025-004622","DOIUrl":"10.1136/ejhpharm-2025-004622","url":null,"abstract":"<p><strong>Objectives: </strong>Unplanned hospital revisits (UHR) among older adults are common and contribute to adverse clinical outcomes, caregiver burden and increased healthcare costs. We aimed to develop and validate a risk prediction model for UHR in older adults to support early identification.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study, following the TRIPOD statement, using a Flemish linked database combining primary care and national health insurance data. Adults aged ≥75 years with an all-cause hospital admission in 2014 were included. The primary outcome was UHR, defined as emergency department visits or unplanned hospital admissions within 6 months post-discharge. We used multivariable logistic regression to identify predictors for UHR and develop a risk prediction model. Model performance was assessed using balanced accuracy. Missing data were handled using multiple imputation by chained equations. The model was validated on a held-out test set and a k-nearest neighbour classifier was used to cross-validate risk categories.</p><p><strong>Results: </strong>Among 3133 patients, 309 (10%) experienced UHR. The best-performing model had a balanced accuracy of 0.56, with a sensitivity of 58% and a specificity of 54%. Predictors were polypharmacy, male sex, haemoglobin level, number of general practitioner contacts and multimorbidity. Excessive polypharmacy (>9 medications) was associated with a 55% increase in UHR odds. Three UHR risk groups were identified: low-risk (5.1%), medium-risk (8.8%) and high-risk (11.6%).</p><p><strong>Conclusions: </strong>UHR are common in older adults, with excessive polypharmacy emerging as a key predictor. The pragmatic model described here provides a valuable tool to stratify older adults into distinct risk groups, identifying a high-risk group that may benefit from targeted interventions.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":"443-449"},"PeriodicalIF":1.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving drug therapy safety through pictograms: opportunities, limitations and future prospects-a survey of healthcare professionals.","authors":"Ines Gebert, Ludwig Leitner, Astrid Bertsche, Thilo Bertsche","doi":"10.1136/ejhpharm-2026-005101","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005101","url":null,"abstract":"<p><strong>Objectives: </strong>Patient safety in drug therapy depends on clear, rapidly comprehensible medication information in routine care. Pictograms depicting selected drug-related problems (DRPs) may support risk management and help healthcare workers reduce medication errors. To be effective, information provided by such pictograms should be intuitive and accessible to the entire healthcare workforce, requiring targeted change management strategies within healthcare professions.</p><p><strong>Methods: </strong>We performed a prospective cross-sectional online survey asking for (1) existing measures and strategies to communicate DRPs, (2) assessments of general benefits and potential of pictograms within routine practice, (3) prioritised DRP categories for pictogram development, (4) intuitive recognisability and comparative evaluation of newly developed pictograms, and (5) ideas for optimising pictograms. All healthcare professions of a university hospital (1451 beds, 61 (poly)clinics, >6000 employees) were invited to participate.</p><p><strong>Results: </strong>In total, n=193 participants took part in the survey (median age 38 years, 67% women; 28% physicians, 32% nurses, 22% other healthcare professionals; median total work experience 14 years). (1) Pictograms or (visual) warning labels were already actively used by 43% of participants. (2) 83% of the participants deemed pictograms as beneficial. Participants mentioned the main advantages were 'faster understanding' (81%) and 'simplified communication across language barriers' (70%). (3) drug-drug interactions' was rated most important overall (82%). (4) Newly developed pictograms achieved the highest correct interpretation rate for 'medication without indication' (90%). (5) The main measure for optimisation was using 'pictograms together with signal words' (56%).</p><p><strong>Conclusions: </strong>Healthcare professionals perceive pictograms as beneficial for DRP communication, yet the risk of misinterpretation is high. Therefore, newly developed pictograms require further optimisation and evaluation before they can be applied in clinical routine. Embedding such pictograms as tools within risk management and change management frameworks may improve DRP communication, help the healthcare workforce prevent medication errors and enhance patient safety.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond documentation: could artificial intelligence (AI) scribes transform hospital pharmacy practice?","authors":"Aron Misa Garcia, Sara Ferro Rodríguez","doi":"10.1136/ejhpharm-2026-005272","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005272","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring treatment satisfaction in rare diseases: challenges and opportunities for hospital pharmacy.","authors":"Sandra Caíña López, Silvia Vázquez-Gómez, Andrea Portela Sotelo, Carmen Dávila Pousa","doi":"10.1136/ejhpharm-2026-005284","DOIUrl":"10.1136/ejhpharm-2026-005284","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148725448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of clinical pharmacist supervision over protocol-based IVIG administration in a paediatric teaching hospital.","authors":"Saeed Nazarian, Behnam Imani, Niloufar Saber-Moghaddam, Ali Ghasemi, Vahid Ghavami, Omid Arasteh","doi":"10.1136/ejhpharm-2025-004887","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004887","url":null,"abstract":"<p><strong>Objectives: </strong>Intravenous immunoglobulin (IVIG) is a high-cost therapy that is widely used in paediatric care for its immunomodulatory effects. However, inappropriate prescribing contributes to resource waste and potential harm. This study aimed to evaluate the impact of clinical pharmacist-led supervision on the rational use of IVIG in a paediatric hospital setting.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted at a paediatric hospital, comparing two 6 month periods: before and after the implementation of a clinical pharmacist-driven prescribing protocol. A total of 248 paediatric patients were systematically selected and assessed for IVIG indication appropriateness, dosing accuracy, and corticosteroid pre-treatment. Statistical analyses were performed to compare clinical variables across the two periods.</p><p><strong>Results: </strong>Following clinical pharmacist intervention, the proportion of appropriate IVIG prescriptions significantly increased from 49.2% to 66.9% (p<0.001), and the number of vials used decreased from 837 to 451. Dosing improvements led to the saving of 199 vials, equating to approximately £15,694 in cost savings. Among patients with immune thrombocytopenic purpura (ITP), the rate of corticosteroid use, as the first-line therapy prior to IVIG administration, increased from 10.5 to 33.3%. Although IVIG use increased in certain departments, its administration became more evidence-based and targeted to appropriate indications.</p><p><strong>Conclusion: </strong>Clinical pharmacist-led supervision significantly improved the appropriateness of IVIG use in paediatric patients, reduced unnecessary dosing, and contributed to substantial cost savings, underscoring the critical role of clinical pharmacists in optimising high-cost medication use. Further prospective studies are recommended to assess long-term clinical outcomes of such interventions.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal muscular atrophy (SMA): early diagnosis, therapy and economic impact.","authors":"Eleonora Castellana, Maria Rachele Chiappetta","doi":"10.1136/ejhpharm-2025-004856","DOIUrl":"https://doi.org/10.1136/ejhpharm-2025-004856","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordant CYP2C19 genotype-phenotype relationship in voriconazole metabolism: impact of inflammation on drug exposure in a Chinese patient.","authors":"Hui Qin Ang, Yi Ching Yuen","doi":"10.1136/ejhpharm-2026-005003","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005003","url":null,"abstract":"<p><p>Voriconazole is commonly used for the treatment of invasive aspergillosis. Its metabolism is influenced by pharmacogenetic polymorphisms of CYP2C19 as well as by inflammatory states. We report a case of a 49-year-old Chinese woman with essential thrombocythaemia who was treated with voriconazole for possible invasive pulmonary aspergillosis. Despite possessing a CYP2C19 *1/*1 normal metaboliser genotype, she required unusually high doses (14.5 mg/kg/day), nearly twice the standard dose, to achieve therapeutic voriconazole concentrations without apparent adverse effects under therapeutic drug monitoring (TDM). Notably, increased C-reactive protein (CRP) levels are associated with decreased CYP2C19 activity and can inform cautious dose titration. Although pharmacogenetics plays an important role in voriconazole metabolism, this report highlights the lack of correlation between genotype and clinical pharmacokinetics, as reflected by TDM results.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of an internal evaluation and monitoring system for pharmaceutical product suppliers: FARMAVIGO-PROV project.","authors":"Iria Sanjuan-Casanova, David Rodríguez-Lorenzo, Susana Castro-Luaces, Luis Otero-Millan, Ana Maria Regueira-Arcay, Adolfo Paradela-Carreiro, Natividad Lago Rivero, Leticia Herrero-Poch, Maria Susana Fortes-Gonzalez, Noemi Martínez-López De Castro","doi":"10.1136/ejhpharm-2026-005037","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005037","url":null,"abstract":"<p><strong>Objective: </strong>To establish an internal system for the approval and monitoring of pharmaceutical product suppliers and, through this, to improve management efficiency and objectivity, reduce logistical incidents and stock shortages and carry out a transparent and objective selection of suppliers.</p><p><strong>Methods: </strong>A multidisciplinary team was set up to define approval criteria and a biannual monitoring system based on the detection of eight agreed types of logistical incidents weighted according to their severity. Throughout the monitoring process, incidents were recorded electronically and downloaded for analysis. Those suppliers with the highest number of incidents, weighted and adjusted to the number of orders, were subjected to an evaluation rubric.</p><p><strong>Results: </strong>In 2023, 200 suppliers and 43 393 orders were analysed, with 443 incidents. In 2024, 206 suppliers and 46 045 orders were evaluated, with 468 incidents. The most frequent incidents in both years were missing delivery notes, missing packages and stock shortages. The rubric was applied to a total of 20 suppliers. In 2023, 70% obtained a 'good' result, 20% an 'intermediate' result and 10% a 'poor' result. In 2024, 90% achieved the 'good' category and 10% obtained an 'excellent' result. The re-evaluated suppliers showed an improvement in their scores.</p><p><strong>Discussion: </strong>The implementation of this system enabled structured monitoring of supplier performance. Despite an increase in order volume, incident rates remained stable, suggesting robustness. The model facilitates the identification of areas for improvement. However, potential subjectivity in the evaluation criteria and the descriptive study design should be considered.</p><p><strong>Conclusions: </strong>This model provides a practical framework for supplier evaluation in hospital pharmacy. It may support quality improvement and could be adaptable to other settings, although further validation is needed.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When simple syrup is not so simple: pH-dependent instability of an extemporaneous oxybutynin oral solution.","authors":"Susana Castro-Luaces, Ana Belén Lago-Blanco, Susana Fortes Gonzalez","doi":"10.1136/ejhpharm-2026-005221","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005221","url":null,"abstract":"","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of professional practices in hospital radiopharmacy using a process-based clinical audit: a quality improvement study.","authors":"Sabri Yasser Zemmouri, Faiza Ferradji, Mehdi Chakouri, El Mansouria Nebchi","doi":"10.1136/ejhpharm-2026-005027","DOIUrl":"https://doi.org/10.1136/ejhpharm-2026-005027","url":null,"abstract":"<p><strong>Objectives: </strong>Hospital radiopharmacy plays a central role in ensuring the quality, safety and regulatory compliance of radiopharmaceuticals used for diagnostic and therapeutic purposes. Given the complexity and multidisciplinary nature of the radiopharmaceutical circuit, professional practice evaluation represents a key tool for continuous quality improvement. This study aimed to evaluate professional practices in hospital radiopharmacy using a structured process-based clinical audit and to identify priority areas for quality improvement.</p><p><strong>Methods: </strong>A prospective professional practice evaluation was conducted in the radiopharmacy unit of a university hospital nuclear medicine department. Eleven audit grids comprising 156 criteria were developed based on national regulations, international guidelines and good radiopharmacy practice standards. The evaluation covered all major stages of the radiopharmaceutical circuit including reception and storage, preparation, quality control, dispensing, cleaning and disinfection and radioactive waste management. Data were collected through direct observation and document review and analysed descriptively. Identified non-conformities were prioritised and addressed through a quality improvement action plan structured according to the Plan-Do-Check-Act (PDCA) cycle.</p><p><strong>Results: </strong>Overall compliance with professional practice standards was 87% across evaluated processes. High compliance was observed for workflow organisation, radiopharmaceutical preparation and quality control activities and radiation protection measures. However, recurrent non-conformities were identified, mainly related to hand hygiene practices, traceability of prepared radiopharmaceuticals, radiological controls at reception, equipment stabilisation procedures and radioactive waste management. Based on these findings, a structured and prioritised action plan was developed, including short-, medium- and long-term corrective measures.</p><p><strong>Conclusions: </strong>Professional practice evaluation using a process-based clinical audit is an effective approach for identifying strengths and areas for improvement in hospital radiopharmacy. Implementation of a structured PDCA-based action plan supports continuous quality improvement, enhances patient and staff safety and promotes compliance with professional and regulatory standards. This methodology may be transferable to other radiopharmacy settings.</p>","PeriodicalId":12050,"journal":{"name":"European journal of hospital pharmacy : science and practice","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}