European Journal of Nutrition最新文献

{"title":"Examining the link between adherence to the planetary health diet pattern and mortality in the us: a prospective cohort study.","authors":"Shaojie Han, Chao Yan, Zenghui Zhang, Yuchen Han, Qianyun Wang, Siyuan Cheng, Panpan Li, Tongxu Wang, Xiaobing Gong, Jun Guo","doi":"10.1007/s00394-025-03595-z","DOIUrl":"10.1007/s00394-025-03595-z","url":null,"abstract":"<p><strong>Background: </strong>Though the Planetary Health Diet (PHD) is designed to enhance both human and environmental health, there is limited understanding of how adherence to PHD influences the risk of mortality in the general US adult population. This study aimed to evaluate the relationship between the Planetary Health Diet Index for the United States (PHDI-US) and mortality among adults in the overall population of the United States.</p><p><strong>Methods: </strong>The PHDI-US comprises 16 components, assigned scores ranging from 0 to 150, with higher scores signifying a greater level of adherence to the PHD. Data were obtained from the National Health and Nutrition Examination Survey spanning 2005 to 2018, with mortality data linked through December 2019.</p><p><strong>Results: </strong>This study encompassed 30,521 participants (mean [SD] age, 47.02 [17.01] years; 14,817 males [48.0%]). Over an average follow-up period of 8.50 years, there were 3,706 recorded deaths. In the adjusted multivariable model, individuals in the highest quintile of PHDI-US exhibited a reduced risk of all-cause mortality (hazard ratio [HR], 0.64; 95% CI, 0.54-0.75), cardiovascular disease mortality (HR, 0.73; 95% CI, 0.55-0.97), cancer mortality (HR, 0.68; 95% CI, 0.52-0.89), and other-cause mortality (HR, 0.58; 95% CI, 0.46-0.72) compared to those in the lowest quintile.</p><p><strong>Conclusion: </strong>Adherence to a PHD pattern was associated with lower mortality risk in the general US adult population.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"79"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the selenium supply of vegans and omnivores with Brazil nut butter compared to a dietary supplement in a randomized controlled trial.","authors":"Rebecca Simon, Kristina Lossow, Denny Pellowski, Kristin Kipp, Michaela Achatz, Nicole Klasen, Tanja Schwerdtle, Christine Dawczynski, Anna P Kipp","doi":"10.1007/s00394-025-03587-z","DOIUrl":"10.1007/s00394-025-03587-z","url":null,"abstract":"<p><strong>Purpose: </strong>A vegan diet is associated with health benefits but may also lead to inadequate intake of essential nutrients. Due to the lower selenium content in plant-based compared to animal-based foods, many vegans do not reach the recommended selenium intake in Europe. The only plant-based food with high selenium content is the Brazil nut, even though there is also a high variability. Therefore, we investigated the effectiveness of Brazil nut butter compared to a dietary supplement as selenium source to improve the selenium status of vegans and omnivores.</p><p><strong>Methods: </strong>44 vegans and 42 omnivores were randomly assigned to one of three intervention groups, either receiving placebo or consuming additional 55 µg of selenium daily as Brazil nut butter or supplement for two weeks. Serum selenium concentrations, glutathione peroxidase 3 (GPX3), and selenoprotein P (SELENOP) were measured at baseline and after intervention. Additionally, dietary selenium intake was estimated using a five-day dietary protocol.</p><p><strong>Results: </strong>The estimated selenium intake was significantly lower in vegans compared to omnivores and correlated with all three selenium biomarkers. Independent of the dietary pattern (vegan or omnivore), Brazil nut butter as well as supplement significantly increased serum selenium and SELENOP concentrations, while there were no changes in the placebo groups. Both interventions were equally effective in increasing selenium levels, but the upregulation of SELENOP was more pronounced in vegans than in omnivores.</p><p><strong>Conclusion: </strong>Brazil nuts are a plant-based source of selenium suitable for vegans and omnivores to improve their selenium status when consumed once in a while.</p><p><strong>Trial registration number and date of registration: </strong>Clinical trials registration number: NCT05814874, April 18 2023.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"74"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bovine dairy products and flow mediated dilation (FMD): a systematic review of the published evidence.","authors":"Martina Rooney, Joyce Lambe, Aileen O'Connor, Simone Dunne, Andrea Mills, Emma L Feeney, Eileen R Gibney","doi":"10.1007/s00394-024-03574-w","DOIUrl":"10.1007/s00394-024-03574-w","url":null,"abstract":"<p><strong>Purpose: </strong>Evidence suggests bovine dairy products may have neutral or beneficial effects on cardiometabolic health, despite being a source of saturated fat. The dairy matrix, the structure and combination of protein, fat, and other nutrients, and how they interact with each other, is purported to be responsible for these beneficial health effects. Whether this relationship extends to endothelial function, as assessed by flow mediated dilation (FMD), remains to be elucidated.</p><p><strong>Methods: </strong>Three electronic databases (PubMed, Embase and Cochrane Central) were searched from inception until 5th September 2024. This review included randomised controlled trials (RCT) investigating any bovine dairy intervention which considered endothelial function using FMD in humans with a non-dairy or alternative dairy control.</p><p><strong>Results: </strong>Of 4,220 records identified, 18 reports from 11 RCT including 508 (53.3% male) participants, examined endothelial function by FMD and were eligible for evidence synthesis. Eight papers reported an improvement, nine reported no effect and one reported a decrease in FMD. The greatest effects were found in those with impaired health at baseline, with whey protein and high dairy intakes observed to be most beneficial.</p><p><strong>Conclusion: </strong>Bovine dairy intake has neutral or beneficial effects on cardiometabolic health. This review demonstrates that this relationship extends to endothelial function as assessed by FMD. Whey protein and high dairy intakes may be most effective, although further high quality RCT in this area are warranted.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"66"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and substitution analyses of dietary sugars, starch and fiber for indices of body fat and cardiometabolic risk- a NoHoW sub-study.","authors":"Karen A Della Corte, Dennis Della Corte, David Camacho, Graham Horgan, Antonio L Palmeira, James Stubbs, Berit L Heitmann","doi":"10.1007/s00394-025-03583-3","DOIUrl":"10.1007/s00394-025-03583-3","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the associations and substitutions of dietary sugars [extrinsic (free) or intrinsic (non-free)] as well as dietary starch and fiber intakes for indices of body fat and cardiometabolic health.</p><p><strong>Methods: </strong>Dietary intake was assessed at multiple times using multi-day 24-hour recalls over 18-months for indices of body fat (body fat %, waist circumference, BMI, and weight change) (n = 1066) and at baseline and 12 months for cardiometabolic outcomes (LDL, HDL, HbA1c) (n = 736). Bayesian modeling was applied to analyze the probabilistic impact of dietary carbohydrate components using credible intervals for association and substitution analyses with repeated measures random effects modeling.</p><p><strong>Results: </strong>A higher starch intake significantly associated with higher body fat %, BMI and waist circumference (WC) (all CrI > 0). Conversely, intrinsic sugar and fiber intakes were significantly linked to lower body fat indices, while free sugar showed no association. A 20 g substitution of free sugars with intrinsic sugars significantly associated with lower body fat (CrI: -4.2; -1.0%), BMI (CrI: -1.8; -0.4) and WC (CrI: -4.2; -1.0 cm), while substituting intrinsic sugars with starch resulted in significantly higher body fat, BMI, WC and weight change. Replacing starch with fiber associated with higher HDL-C (CrI: -0.0; 0.3) and lower LDL-C (CrI: -0.6; 0.1). Replacing free sugars with starch associated with a higher HbA1c level (CrI: 0.0;0.2).</p><p><strong>Conclusion: </strong>These results underscore the importance of distinguishing between intrinsic versus extrinsic sugars and highlight the potential benefits of increasing intrinsic sugars and fiber while reducing starch for better body fat management and cardiometabolic health.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"68"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.","authors":"Luana Almeida Gonzaga, Andrey Alves Porto, Carolina Takahashi, Rayana Loch Gomes, Luiz Carlos Marques Vanderlei, Vitor Engrácia Valenti","doi":"10.1007/s00394-025-03582-4","DOIUrl":"10.1007/s00394-025-03582-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the acute effects of beetroot extract and resveratrol supplementation (isolated and combined) on cardiac autonomic modulation and cardiovascular parameters recovery after exercise in individuals with coronary artery disease (CAD).</p><p><strong>Methods: </strong>14 males with CAD were submitted to 4 protocols consisting of 30 min (min) of rest, 30 min of aerobic exercise on a treadmill (60% of the heart rate reserve HRR), followed by 30 min of recovery. Before each protocol, the subjects consumed 500 mg of starch (placebo protocol), 500 mg of beetroot (beetroot protocol), or 500 mg of resveratrol (resveratrol protocol), or 500 mg of beetroot and 500 mg of resveratrol (combined protocol). Heart rate variability (HRV) indices and cardiorespiratory parameters were determined at different times during the protocols.</p><p><strong>Results: </strong>Regarding HR, significantly higher values about rest in the placebo protocol at all recovery moments (1st to 30th min) were observed. Significant differences were observed in the other protocols (beetroot, resveratrol and combined) from the first to the 20th min recovery. For SBP, significantly higher values concerning rest were observed at the first minute of recovery for all protocols. No differences were found for the HRV index between time and protocols.</p><p><strong>Conclusions: </strong>The single supplementation of beetroot and resveratrol (isolated and combined) did not alter HRV and cardiovascular parameter responses between protocols. The consumption of beetroot extract and resveratrol enhanced vagal modulation and heart rate recovery compared to rest.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"67"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does physical activity level and total energy expenditure relate to food intake, appetite, and body composition in healthy older adults? A cross-sectional study.","authors":"Dilara Dericioglu, Lisa Methven, Miriam E Clegg","doi":"10.1007/s00394-024-03571-z","DOIUrl":"10.1007/s00394-024-03571-z","url":null,"abstract":"<p><strong>Purpose: </strong>With ageing, older adults (≥ 65 years) may experience decreased appetite, contributing to declines in body weight and muscle mass, potentially affecting physical capabilities. Physical activity (PA) has been suggested as a potential strategy to enhance appetite in older adults, but evidence supporting this is insufficient. This study aimed to investigate the relationship between PA levels, total energy expenditure (TEE), body composition, energy intake (EI) and appetite in older adults.</p><p><strong>Methods: </strong>One hundred and eight healthy older adults (age 70 ± 4 years; BMI 24.3 ± 2.6 kg/m²) were categorised into three groups (low, medium, high) based on accelerometer-measured PA level (AMPA) and TEE from 7-day PA diaries. Body composition was measured using bioelectrical impedance. Energy and nutrient intakes were assessed using 3-day weighed food diaries. Appetite was assessed using the visual analogue scales at 30-min intervals throughout 1 day.</p><p><strong>Results: </strong>TEE was positively correlated with EI and % muscle mass (p < 0.05), with higher % muscle mass and TEE associated with higher EI. Energy and protein intake were significantly higher in the high TEE group than the low group (p = 0.03, p = 0.01; respectively). No significant differences in energy and macronutrient intake were observed across AMPA groups, and appetite components (hunger, fullness, desire to eat, prospective consumption) did not differ significantly in either the AMPA or TEE groups.</p><p><strong>Conclusions: </strong>Higher TEE is associated with higher energy and protein intake, with body composition playing a crucial role. These findings highlight the importance of considering PA, TEE, and body composition in interventions aimed at improving EI in older adults.</p><p><strong>Clinical trail registration: </strong>clinicaltrials.gov as NCT05067036. Registered 2 October 2021, https://classic.</p><p><strong>Clinicaltrials: </strong>gov/ct2/show/NCT05067036.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"71"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dietary phenolic compounds intake on mortality in the \"Seguimiento Universidad De Navarra\" (SUN) Mediterranean cohort.","authors":"Zenaida Vázquez-Ruiz, Estefanía Toledo, Facundo Vitelli-Storelli, Maira Bes-Rastrollo, Miguel Ángel Martínez-González","doi":"10.1007/s00394-025-03581-5","DOIUrl":"10.1007/s00394-025-03581-5","url":null,"abstract":"<p><p>Plant-based dietary patterns have been demonstrated to reduce the risk of non-communicable disease (NCD), including cardiovascular disease (CVD), type 2 diabetes, cancer, and all-cause mortality. Phenolic compounds (PC), abundant in plant-based foods, have been considered as instrumental in this attenuation of NCD risk. We evaluated the association between dietary intake of PC and the risk of all-cause mortality in a relatively young Mediterranean cohort of 18,173 Spanish participants in the \"Seguimiento Universidad de Navarra\" (SUN) project, after a median follow-up of 12.7 years. Intake of PC was estimated at baseline and repeatedly after 10-year follow-up using a 136-item validated food frequency questionnaire and the Phenol-Explorer database. During 236,329 person-years, 544 deaths were confirmed. Cox regression models compared low intake (lowest quintile) vs. high intake (the four upper quintiles merged, as a reference category) of total energy-adjusted PC intake. Adjusted hazard ratios (HR) for low PC intake among those participants aged over 45 years during follow-up were 1.32; 95% CI 1.02-1.71 for all-cause mortality, HR:1.44; 95% CI 1.02-2.02 for cancer mortality; HR: 0.88; 95% CI 0.47-1.66 for CVD mortality and HR: 1.69 95% CI 1.04-2.74 for causes of death other than cancer or CVD. In conclusion, a low intake of total PC was associated with a significantly higher risk of all-cause mortality, and, specifically, a higher risk for cancer in a relatively young cohort. Among PC classes a low intake of flavonoids and phenolic acids showed significant effects for non-cancer/non-CVD mortality. Cherries, chocolate, apples and pears, olives, and coffee, were the major sources of between-person variability for total PC intake in our Mediterranean cohort.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"70"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cross-sectional and longitudinal associations of magnesium intake and cognition in the Healthy Aging Longitudinal Study in Taiwan.","authors":"Meng-Hua Tao, Shu-Chun Chuang, I-Chien Wu, Huei-Ting Chan, Chiu-Wen Cheng, Hui-Ling Chen, Marion M Lee, Hsing-Yi Chang, Chao Agnes Hsiung, Chih-Cheng Hsu","doi":"10.1007/s00394-024-03579-5","DOIUrl":"10.1007/s00394-024-03579-5","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"72"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential impact of the extended vitamin D fortification policy during pregnancy varies by continent of origin - a population-representative Swedish cohort.","authors":"Mathilda Forsby, Anna Winkvist, Ciara Mooney, Frida Dangardt, Jenny M Kindblom, Linnea Bärebring, Hanna Augustin","doi":"10.1007/s00394-025-03584-2","DOIUrl":"10.1007/s00394-025-03584-2","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to explore the potential impact of Sweden's extended fortification policy, launched in 2018, on vitamin D intake during pregnancy, depending on continent of origin.</p><p><strong>Methods: </strong>The population-representative GraviD cohort was conducted within the antenatal care in 2013-2014 in Southwestern Sweden. Background data including country of origin were collected through questionnaires. In the third trimester, participants (N = 1761) answered a vitamin D questionnaire which included intakes of margarine, milk, and fermented milk. Reported vitamin D intake in 2013-2014 was compared to simulated vitamin D intake following the 2018 vitamin D fortification policy expansion.</p><p><strong>Results: </strong>Pre-expansion reported median intake of vitamin D from fortified foods differed by continent of origin (p < 0.001). Pre-expansion intake was highest among participants from Northern Europe (2.4 µg/day) compared to those from Continental Europe (2.0 µg/day, p = 0.002), Asia (1.6 µg/day, p < 0.001), and Africa (2.0 µg/day, p = 0.001). Post-expansion simulated median vitamin D intake from fortified foods was higher among participants from Northern Europe (6.3 µg/day) compared to Asia (5.0 µg/day, p < 0.001) and Africa (5.0 µg/day, p = 0.013). Participants from Continental Europe had the largest change (3.6 µg/day) between pre- and post-expansion, while those born in Asia had the smallest change (2.9 µg/day).</p><p><strong>Conclusion: </strong>The Swedish fortification policy expansion had a positive potential impact on vitamin D intake during pregnancy, but the effect depended on the continent of origin. The potential impact was smallest for participants from Asia and Africa, indicating that the current Swedish fortification policy is most beneficial for individuals of European origin.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"69"},"PeriodicalIF":4.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic acid alleviates DSS-induced ulcerative colitis by inhibiting ROS/NLRP3 pathway activation and modulating gut microbiota in mice.","authors":"Yanling Xiong, Zhentao Cheng, Yangzi Zhang, Ting Liu, Zhiling Wan, Cuiyun Xia, Binlan Zhou, Chunlan Shan, Derong Song, Fujun Miao","doi":"10.1007/s00394-024-03577-7","DOIUrl":"10.1007/s00394-024-03577-7","url":null,"abstract":"<p><p>Ulcerative colitis (UC) can cause severe oxidative stress in the colon, which can lead to tissue damage and an imbalance in the normal gut microbiota. Ellagic acid (EA) is one of the main types of plant polyphenols with improved pharmacological effects such as antioxidant, anti-inflammatory, and antibacterial properties. However, currently, the studies on the impact of EA on the gut microbiota and its potential to alleviate UC in mice through the ROS/NLRP3 pathway are limited. In this study, dextran sodium sulfate (DSS) was used to construct a UC mouse model, which was then treated with EA as an intervention for UC. The results revealed that EA alleviated the trend of liver, spleen, and weight changes in UC mice and improved colon oxidative stress, inflammation, and pathological damage. Mechanistically, DSS-induced UC indicated a significant increase in ROS/NLRP3 pathway-related factors, whereas EA intervention activated the Nrf2 pathway to reduce these factors. Furthermore, the DSS group had a reduced abundance of Firmicutes (59.02%) and an increased abundance of Bacteroides and Proteobacterium by 1.8 times and 10.16%; however, EA intervention reversed these changes, thus alleviating UC. The findings of this study revealed that EA could significantly enhance the composition of gut microbiota in UC and reduce the inflammatory response, colonic damage as well as oxidative stress caused by DSS by regulating the ROS/NLRP3 pathway. These results provide novel perspectives on the prevention and treatment strategies of UC and highlight the therapeutic benefits of EA in managing colitis.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"64"},"PeriodicalIF":4.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}