T. Wang, M. Ibanez, K. Yu, K. Fan, J. Juan, M. Perez, T. Smith, B. Walsh, V. Kang, J. Tyhonas, N. Alvarez, J. Tran, K.S. Moorefield, A. Phimister, X. Zhu, A. Chi, M.D. Bartberger, E. Murphy
{"title":"8 Oral: ALTA3263: an oral, KRAS isoform-selective, dual ON/OFF state, noncovalent inhibitor induces regressions across KRAS G12V, G12D, and G12C cancer models","authors":"T. Wang, M. Ibanez, K. Yu, K. Fan, J. Juan, M. Perez, T. Smith, B. Walsh, V. Kang, J. Tyhonas, N. Alvarez, J. Tran, K.S. Moorefield, A. Phimister, X. Zhu, A. Chi, M.D. Bartberger, E. Murphy","doi":"10.1016/j.ejca.2024.114537","DOIUrl":"10.1016/j.ejca.2024.114537","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Radzimierski, A. Bobowska, A. Stachowicz, K. Kuś, K. Kozłowska-Tomczyk, A. Ludwig-Słomczyńska, A. Gołas, M. Żukowska, G. Ćwiertnia, K. Brzózka, M. Nowak, A. Bartosik, D. Pez
{"title":"32 (PB020): Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers","authors":"A. Radzimierski, A. Bobowska, A. Stachowicz, K. Kuś, K. Kozłowska-Tomczyk, A. Ludwig-Słomczyńska, A. Gołas, M. Żukowska, G. Ćwiertnia, K. Brzózka, M. Nowak, A. Bartosik, D. Pez","doi":"10.1016/j.ejca.2024.114560","DOIUrl":"10.1016/j.ejca.2024.114560","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Hearn, M. Ahn, L. Bevan, G. Chessari, M. Clark, B. Cons, J. Espana-agusti, K. Ferro, A. Howard, J. Lyons, V. Martins, C. Morgillo, N. Palmer, M. Rapti, A. Shah, T. Smyth, M. Unbekandt, D. Varshney, C. Hamlett
{"title":"42 (PB030): A novel small-molecule CBP/p300 HAT domain inhibitor demonstrates potent in vivo activity and a favorable safety profile in preclinical species","authors":"K. Hearn, M. Ahn, L. Bevan, G. Chessari, M. Clark, B. Cons, J. Espana-agusti, K. Ferro, A. Howard, J. Lyons, V. Martins, C. Morgillo, N. Palmer, M. Rapti, A. Shah, T. Smyth, M. Unbekandt, D. Varshney, C. Hamlett","doi":"10.1016/j.ejca.2024.114570","DOIUrl":"10.1016/j.ejca.2024.114570","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Hollebecque, E. Dotan, C.Y.A. Liao, D. Roda, E. Fontana, H. Babiker, R.D. Kim, D.Y. Oh, F. Ghiringhelli, I. Moreno, J. Liu, V. Subbiah, A. Varkaris, M.J. Borad, P.A. Cassier, A. Deary, F.T. Ramirez, F. Ricard, K.Y. Jen, A.M. Schram
{"title":"58 (PB046): Tumor-agnostic efficacy and safety of lirafugratinib, a highly selective FGFR2 inhibitor, in patients (pts) with advanced solid tumors with FGFR2 fusions or rearrangements (f/r): the ReFocus study","authors":"A. Hollebecque, E. Dotan, C.Y.A. Liao, D. Roda, E. Fontana, H. Babiker, R.D. Kim, D.Y. Oh, F. Ghiringhelli, I. Moreno, J. Liu, V. Subbiah, A. Varkaris, M.J. Borad, P.A. Cassier, A. Deary, F.T. Ramirez, F. Ricard, K.Y. Jen, A.M. Schram","doi":"10.1016/j.ejca.2024.114585","DOIUrl":"10.1016/j.ejca.2024.114585","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Kluitmans, J. Kooijman, J. Melis, E. van den Bossche, J. Dylus, J. de Roos, G. Zaman
{"title":"67 (PB055): Combined cellular and biochemical profiling of BTK inhibitor nemtabrutinib reveals potential application in FGFR-driven cancers","authors":"D. Kluitmans, J. Kooijman, J. Melis, E. van den Bossche, J. Dylus, J. de Roos, G. Zaman","doi":"10.1016/j.ejca.2024.114594","DOIUrl":"10.1016/j.ejca.2024.114594","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Decarvalho, O. Nuga, Y. Meng, A. Berezovsky, L. Poisson, J. Snyder, I. Datta
{"title":"45 (PB033): Assessing the predictive value of genomic drivers for targeted therapy in glioblastoma: Insights from a pre-clinical platform","authors":"A. Decarvalho, O. Nuga, Y. Meng, A. Berezovsky, L. Poisson, J. Snyder, I. Datta","doi":"10.1016/j.ejca.2024.114573","DOIUrl":"10.1016/j.ejca.2024.114573","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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