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Corrigendum to "Impact of EDP-M on survival of patients with metastatic adrenocortical carcinoma: A population-based study" [Eur J Cancer 196 (2024) 113424]. EDP-M 对转移性肾上腺皮质癌患者生存期的影响:一项基于人群的研究》[Eur J Cancer 196 (2024) 113424]的更正。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-15 DOI: 10.1016/j.ejca.2024.115123
Pien Debets, Koen M A Dreijerink, Anton F Engelsman, Max Dahele, Harm R Haak, Rebecca V Steenaard, Ellen Kapiteijn, Eleonora Corssmit, C Willemien Menke-van der Houven van Oordt
{"title":"Corrigendum to \"Impact of EDP-M on survival of patients with metastatic adrenocortical carcinoma: A population-based study\" [Eur J Cancer 196 (2024) 113424].","authors":"Pien Debets, Koen M A Dreijerink, Anton F Engelsman, Max Dahele, Harm R Haak, Rebecca V Steenaard, Ellen Kapiteijn, Eleonora Corssmit, C Willemien Menke-van der Houven van Oordt","doi":"10.1016/j.ejca.2024.115123","DOIUrl":"https://doi.org/10.1016/j.ejca.2024.115123","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":" ","pages":"115123"},"PeriodicalIF":7.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the timing of immunotherapy administration on overall survival for resectable non-small cell lung cancer (iACORN study): A systematic review and meta-analysis of randomised trials 免疫疗法给药时机对可切除非小细胞肺癌总生存期的影响(iACORN 研究):随机试验的系统回顾和荟萃分析。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-09 DOI: 10.1016/j.ejca.2024.115118
Akshay J. Patel , Hanan Hemead , Jacie Law , Anuj Wali , Paulo De Sousa , Eric Lim
{"title":"Impact of the timing of immunotherapy administration on overall survival for resectable non-small cell lung cancer (iACORN study): A systematic review and meta-analysis of randomised trials","authors":"Akshay J. Patel ,&nbsp;Hanan Hemead ,&nbsp;Jacie Law ,&nbsp;Anuj Wali ,&nbsp;Paulo De Sousa ,&nbsp;Eric Lim","doi":"10.1016/j.ejca.2024.115118","DOIUrl":"10.1016/j.ejca.2024.115118","url":null,"abstract":"<div><h3>Background</h3><div>We sought to investigate the relative impact of the timing of the administration of immunotherapy on survival in patients with resectable lung cancer.</div></div><div><h3>Methods</h3><div>We conducted a systematic review and meta-analysis of randomised controlled trials in this setting. We searched MEDLINE, EMBASE, LILACS and Cochrane Library databases from 1st January 1980 onwards. We excluded case reports; non-randomised studies; studies without an immunotherapy arm and if there was incomplete reporting on outcome data including conference abstracts. A standardised, pre-piloted form was used to extract data from the included studies for the assessment of study quality and for evidence synthesis. The primary outcome measure was overall survival which was assessed using random-effects meta-analyses (DerSimonian and Laird). The study was registered with PROSPERO (CRD42023407825).</div></div><div><h3>Findings</h3><div>We screened 865 studies and assessed 58 full text articles after removing non-human, non-surgical studies. These studies collectively enrolled 4982 participants and 4425 were included in the respective analyses. Hazard ratios (HRs) for death by timing of administration of immunotherapy, i.e., Neoadjuvant (pre-operative), peri-operative and post-operative were 0.57 (95 % CI 0.302–1.08), 0.67 (95 % CI 0.39–1.13) and 0.94 (95 % CI 0.29–3.06) respectively. The timing of administration accounted for 100 % of the difference in true effect size (test of moderators (Q<sub>M</sub> p = 0.127), residual I<sup>2</sup> 0 %, p = 0.561). OR for adverse events was higher in the neoadjuvant setting compared to the peri-operative setting; 1.49 (0.64–3.47) and 1.34 (1.08–1.66) respectively. Bias assessment found the majority of studies to be low risk with respect to random sequencing, incomplete outcomes, and selective reporting.</div></div><div><h3>Interpretation</h3><div>In resectable non-small cell lung cancer, administration of adjuvant chemo-immunotherapy regimens in clinical trials did not lead to statistically significant survival benefits. Overall survival outcomes of neoadjuvant and peri-operative chemo-immunotherapy were comparable, but given the shorter duration and lower costs, neoadjuvant chemo-immunotherapy can be considered the current multimodality combination of choice.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"214 ","pages":"Article 115118"},"PeriodicalIF":7.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiomic features of primary retroperitoneal sarcomas: a prognostic study 原发性腹膜后肉瘤的放射学特征:预后研究。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-09 DOI: 10.1016/j.ejca.2024.115120
Sandro Pasquali , Sara Iadecola , Andrea Vanzulli , Gabriele Infante , Marco Bologna , Valentina Corino , Gabriella Greco , Raffaella Vigorito , Carlo Morosi , Alessia Beretta , Stefano Percio , Viviana Vallacchi , Paola Collini , Roberta Sanfilippo , Chiara Fabbroni , Silvia Stacchiotti , Marco Fiore , Paul Huang , Matteo Benelli , Luca Mainardi , Dario Callegaro
{"title":"Radiomic features of primary retroperitoneal sarcomas: a prognostic study","authors":"Sandro Pasquali ,&nbsp;Sara Iadecola ,&nbsp;Andrea Vanzulli ,&nbsp;Gabriele Infante ,&nbsp;Marco Bologna ,&nbsp;Valentina Corino ,&nbsp;Gabriella Greco ,&nbsp;Raffaella Vigorito ,&nbsp;Carlo Morosi ,&nbsp;Alessia Beretta ,&nbsp;Stefano Percio ,&nbsp;Viviana Vallacchi ,&nbsp;Paola Collini ,&nbsp;Roberta Sanfilippo ,&nbsp;Chiara Fabbroni ,&nbsp;Silvia Stacchiotti ,&nbsp;Marco Fiore ,&nbsp;Paul Huang ,&nbsp;Matteo Benelli ,&nbsp;Luca Mainardi ,&nbsp;Dario Callegaro","doi":"10.1016/j.ejca.2024.115120","DOIUrl":"10.1016/j.ejca.2024.115120","url":null,"abstract":"<div><h3>Background</h3><div>Risk-stratification of patients with retroperitoneal sarcomas (RPS) relies on validated nomograms, such as Sarculator. This retrospective study investigated whether radiomic features extracted from computed tomography (CT) imaging could <em>i</em>) enhance the performance of Sarculator and <em>ii</em>) identify G3 dedifferentiated liposarcoma (DDLPS) or leiomyosarcoma (LMS), which are currently consider in a randomized clinical trial testing neoadjuvant chemotherapy.</div></div><div><h3>Methods</h3><div>Patients with primary localized RPS treated with curative-intent surgery (2011–2015) and available pre-operative CT imaging were included. Regions of interest (ROIs) were manually annotated on both unenhanced and portal venous phase acquisitions. Top performing radiomic features were selected with outcome-specific random forest models, through generation of replicative experiments (contexts) where patients were split into training and testing sets. Endpoints were overall and disease-free survival (OS, DFS).</div><div>Prognostic models for DFS and OS included the top five selected radiomic features and the Sarculator nomogram score.</div><div>Models accuracy was assessed with Harrell’s Concordance (C-)index.</div></div><div><h3>Results</h3><div>The study included 112 patients, with a median follow-up of 77 months (IQR 65–92 months).</div><div>Sarculator alone achieved a C-index of 0.622 and 0.686 for DFS and OS, respectively. Radiomic features only marginally enhanced the prediction accuracy of Sarculator for OS (C-index=0.726, C-index gain: 0.04) or DFS (C-index=0.639, C-index gain: 0.017). Finally, radiomic features identified patients with G3 DDLPS or LMS with an accuracy of 0.806.</div></div><div><h3>Conclusion</h3><div>Radiomic features marginally improved the performance of Sarculator in RPS.</div><div>However, they accurately identified G3 DDLPS or LMS at diagnosis, potentially improving patients selection for neoadjuvant treatments.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115120"},"PeriodicalIF":7.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from all of us cohort PCCA 变异 rs16957301 是一种新型 AKI 风险基因型,对接受 ICI 治疗的患者具有特异性:来自我们所有人队列的真实世界证据。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-09 DOI: 10.1016/j.ejca.2024.115114
Yanfei Wang , Chenxi Xiong , Weifeng Yu , Minghao Zhou , Tyler Shugg , Fang-Chi Hsu , Michael T. Eadon , Jing Su , Qianqian Song
{"title":"PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from all of us cohort","authors":"Yanfei Wang ,&nbsp;Chenxi Xiong ,&nbsp;Weifeng Yu ,&nbsp;Minghao Zhou ,&nbsp;Tyler Shugg ,&nbsp;Fang-Chi Hsu ,&nbsp;Michael T. Eadon ,&nbsp;Jing Su ,&nbsp;Qianqian Song","doi":"10.1016/j.ejca.2024.115114","DOIUrl":"10.1016/j.ejca.2024.115114","url":null,"abstract":"<div><h3>Introduction</h3><div>Immune checkpoint inhibitors (ICIs) enhance the immune system's ability to target and destroy cancer cells, but can also trigger immune-related adverse events (irAEs), such as acute kidney injury (ICI-AKI), complicating patient management. Limited knowledge of genetic predispositions to ICI-AKI highlights the need for genomic studies to improve therapeutic strategies.</div></div><div><h3>Objective</h3><div>To identify genetic predispositions for ICI-AKI using large-scale real-world data.</div></div><div><h3>Methods</h3><div>A systematic literature search led to 14 candidate variants related to irAEs. We performed a candidate variant association study with these variants using the All of Us cohort. An ICI-treated cohort and a general cohort were established to evaluate ICI-AKI risk. Logistic regression, adjusted for sex, evaluated the impact of each candidate genotype, separately for self-reported and ancestry-estimated race. Kaplan-Meier survival analysis assessed genetic effects on AKI-free survival.</div></div><div><h3>Results</h3><div>The ICI cohort (n = 414) showed a one-year AKI incidence rate of 23.2 %, significantly higher than the general cohort (6.5 %, n = 213,282). The rs16957301 variant (chr13:100324308, T &gt; C) in the <em>PCCA</em> gene was a significant risk genotype for ICI-AKI among self-reported White (Beta=0.93, CI: 0.32 – 1.54, ORs= 2.53, Bonferroni-corrected P-value=0.047) and ancestry estimated Europeans (Beta = 0.94, CI: 0.31 – 1.57, ORs= 2.56, Bonferroni-corrected P-value=0.044). Self-reported White with the rs16957301 risk genotypes (TC/CC) developed AKI significantly earlier (3.6 months) compared to the reference genotype (TT, 7.0 months, log-rank P = 0.04). Consistent results were found in ancestry-estimated Europeans. This variant did not present significant AKI risks in the general cohort (Beta: −0.008–0.035, FDR: 0.75–0.99).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that rs16957301 in PCCA may serve as an ICI-AKI risk marker in Caucasians. Further studies are needed to validate this association and explore risks in other populations.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115114"},"PeriodicalIF":7.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials. 化放疗加诱导或巩固化疗作为直肠癌的整体新辅助治疗:CAO/ARO/AIO-12 和 OPRA 随机 2 期试验的汇总分析。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-06 DOI: 10.1016/j.ejca.2024.115112
Steven Sorscher, Caio Max Sao Padro Rocha Lima
{"title":"Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials.","authors":"Steven Sorscher, Caio Max Sao Padro Rocha Lima","doi":"10.1016/j.ejca.2024.115112","DOIUrl":"https://doi.org/10.1016/j.ejca.2024.115112","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":" ","pages":"115112"},"PeriodicalIF":7.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of immune checkpoint inhibitor plus chemotherapy or ipilimumab plus nivolumab-based therapy for NSCLC patients with PD-L1 TPS (1–49 %): TOPGAN2023-01 比较免疫检查点抑制剂加化疗或伊匹单抗加尼伐单抗治疗PD-L1 TPS(1-49 %)的NSCLC患者:TOPGAN2023-01。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-05 DOI: 10.1016/j.ejca.2024.115117
Hisashi Tanaka , Tomonori Makiguchi , Takehiro Tozuka , Yosuke Kawashima , Tomohiro Oba , Ryosuke Tsugitomi , Junji Koyama , Yuichi Tambo , Shinsuke Ogusu , Masafumi Saiki , Hiroshi Gyotoku , Tsukasa Hasegawa , Eisaku Miyauchi , Tomoaki Sonoda , Ryota Saito , Katsumi Nakatomi , Toshio Sakatani , Keita Kudo , Yuko Tsuchiya-Kawano , Makoto Nishio
{"title":"Comparison of immune checkpoint inhibitor plus chemotherapy or ipilimumab plus nivolumab-based therapy for NSCLC patients with PD-L1 TPS (1–49 %): TOPGAN2023-01","authors":"Hisashi Tanaka ,&nbsp;Tomonori Makiguchi ,&nbsp;Takehiro Tozuka ,&nbsp;Yosuke Kawashima ,&nbsp;Tomohiro Oba ,&nbsp;Ryosuke Tsugitomi ,&nbsp;Junji Koyama ,&nbsp;Yuichi Tambo ,&nbsp;Shinsuke Ogusu ,&nbsp;Masafumi Saiki ,&nbsp;Hiroshi Gyotoku ,&nbsp;Tsukasa Hasegawa ,&nbsp;Eisaku Miyauchi ,&nbsp;Tomoaki Sonoda ,&nbsp;Ryota Saito ,&nbsp;Katsumi Nakatomi ,&nbsp;Toshio Sakatani ,&nbsp;Keita Kudo ,&nbsp;Yuko Tsuchiya-Kawano ,&nbsp;Makoto Nishio","doi":"10.1016/j.ejca.2024.115117","DOIUrl":"10.1016/j.ejca.2024.115117","url":null,"abstract":"<div><h3>Introduction</h3><div>Immune checkpoint inhibitors (ICIs) plus chemotherapy is now a standard treatment for non-small cell lung cancer (NSCLC). Whether ICI plus chemotherapy (ICI-chemo) or ipilimumab plus nivolumab (I-N)-based therapy is superior for patients with NSCLC with a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) of 1–49 % has not been evaluated.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study included NSCLC patients with a TPS score of 1–49 %, who began first-line chemotherapy. Propensity score matching analysis was used to adjust for various confounders and evaluate treatment efficacy.</div></div><div><h3>Results</h3><div>A total of 401 patients were enrolled, of whom 308 received ICI-chemo and 93 received I-N-based therapy. The median OS was 21.0 months in the ICI-chemo group and 20.0 months in the I-N-based therapy group. After propensity score matching, there was no difference in OS or PFS between the ICI-chemo group and the I-N-based therapy group (OS: hazard ratios (HR), 0.83; 95 % confidence interval [CI], 0.54–1.26, PFS: HR, 0.72; 95 % CI, 0.52–1.00). Among PD-L1 TPS 25–49 %, there was a tendency for OS to be favorable for the ICI-chemo group (OS: HR, 0.30; 95 % CI, 0.09–0.85). Treatment discontinuation occurred for 26.2 % of the patients in the ICI-chemo group and 41.9 % in the I-N-based therapy group.</div></div><div><h3>Conclusions</h3><div>Among PD-L1 TPS 1–49 %, there was no significant difference in survival outcomes between the ICI-chemo group and the I-N-based therapy group. Based on the results of a subgroup analysis, ICI-chemo may be superior for treating NSCLC with a TPS of 25–49 %.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115117"},"PeriodicalIF":7.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of invasive lung cancer in pure ground glass nodules less than 30 mm: A systematic review 小于 30 毫米的纯磨碎玻璃结节中浸润性肺癌的发病率:系统综述。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-05 DOI: 10.1016/j.ejca.2024.115116
Abdullah AlShammari , Akshay Patel , Mark Boyle , Chiara Proli , Jose Alvarez Gallesio , Anuj Wali , Paulo De Sousa , Eric Lim
{"title":"Prevalence of invasive lung cancer in pure ground glass nodules less than 30 mm: A systematic review","authors":"Abdullah AlShammari ,&nbsp;Akshay Patel ,&nbsp;Mark Boyle ,&nbsp;Chiara Proli ,&nbsp;Jose Alvarez Gallesio ,&nbsp;Anuj Wali ,&nbsp;Paulo De Sousa ,&nbsp;Eric Lim","doi":"10.1016/j.ejca.2024.115116","DOIUrl":"10.1016/j.ejca.2024.115116","url":null,"abstract":"<div><h3>Background</h3><div>The IASLC TNM proposal suggests that pure ground glass nodules less than 30 mm should be classified as cTis corresponding to pathologic adenocarcinoma in situ implying no invasive malignancy potential. We sought to ascertain the proportion of pure ground glass nodules that harbour tissue confirmed minimally invasive or invasive adenocarcinoma.</div></div><div><h3>Methods</h3><div>We analyzed data from 3874 individuals with pure ground glass nodules less than 30 mm, reported in 28 observational studies identified through a systematic search of electronic databases. The primary outcome was the prevalence of invasive malignancy by random effects meta-analysis, and we used meta-regression to determine the impact of baseline risk, size, and country of investigation on overall effect size. The study was registered with PROSPERO (CRD42021286261).</div></div><div><h3>Results</h3><div>All published studies were retrospective (n = 28) and the majority conducted in Asia (n = 25). Baseline patient cohorts were mainly from published surgical series (n = 22) or lung cancer screening programs (n = 6). The proportion of minimally invasive and invasive cancer ranged from 0.9 % to 100 % with a pooled prevalence of 42.4 % [95 % CI: 0.28, 0.57].</div><div>Considerable heterogeneity was observed (I<sub>2</sub> =99 %) and patient selection was the most significant contribution, accounting for 73 % of the observed heterogeneity (p &lt; 0.0001). Meta-regression based on size selection and country of investigation revealed no significant contribution to effect size effect or heterogeneity.</div></div><div><h3>Conclusions</h3><div>Pure ground glass nodules less than 30 mm harbour a high proportion of invasive malignancy, contrary to the IASLC staging proposals and opinions from numerous guidelines across the world.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115116"},"PeriodicalIF":7.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FIGO 2023 staging for endometrial cancer, when, if it is not now? FIGO 2023 子宫内膜癌分期,如果不是现在,是何时?
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-05 DOI: 10.1016/j.ejca.2024.115115
Xavier Matias-Guiu , Sigurd Lax , Maria Rosaria Raspollini , Jose Palacios , Wenxin Zheng , Congrong Liu , Louise de Brot , Leonardo Lordello , David Hardisson , David Gaffney , David Mutch , Giovanni Scambia , Carien L. Creutzberg , Christina Fotopoulou , Jonathan S. Berek , Nicole Concin
{"title":"FIGO 2023 staging for endometrial cancer, when, if it is not now?","authors":"Xavier Matias-Guiu ,&nbsp;Sigurd Lax ,&nbsp;Maria Rosaria Raspollini ,&nbsp;Jose Palacios ,&nbsp;Wenxin Zheng ,&nbsp;Congrong Liu ,&nbsp;Louise de Brot ,&nbsp;Leonardo Lordello ,&nbsp;David Hardisson ,&nbsp;David Gaffney ,&nbsp;David Mutch ,&nbsp;Giovanni Scambia ,&nbsp;Carien L. Creutzberg ,&nbsp;Christina Fotopoulou ,&nbsp;Jonathan S. Berek ,&nbsp;Nicole Concin","doi":"10.1016/j.ejca.2024.115115","DOIUrl":"10.1016/j.ejca.2024.115115","url":null,"abstract":"<div><div>Incorporation of pathological and (not mandatory) molecular features into the new FIGO 2023 staging system has generated some controversy. Several validations have been published recently that demonstrated the higher prognostic precision of FIGO 2023 compared to the previous FIGO 2009 scheme. In the present article, the authors want to respond to some concerns that were raised by some pathologists and clinicians.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115115"},"PeriodicalIF":7.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The journey of patients affected by metastatic hormone receptor-positive/HER2-negative breast cancer from CDK 4/6 inhibitors to second-line treatment: A real-world analysis of 701 patients enrolled in the GIM14/BIOMETA study 转移性激素受体阳性/HER2 阴性乳腺癌患者从 CDK 4/6 抑制剂到二线治疗的历程:对参加 GIM14/BIOMETA 研究的 701 例患者的实际情况分析。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-04 DOI: 10.1016/j.ejca.2024.115113
Chiara Molinelli , Marco Bruzzone , Eva Blondeaux , Tommaso Ruelle , Chiara Lanzavecchia , Michelino De Laurentiis , Stefania Russo , Ferdinando Riccardi , Valentina Sini , Francesco Cognetti , Grazia Arpino , Alessandra Fabi , Palma Pugliese , Elena Collovà , Andrea Fontana , Fabio Puglisi , Claudia Bighin , Matteo Lambertini , Lucia Del Mastro
{"title":"The journey of patients affected by metastatic hormone receptor-positive/HER2-negative breast cancer from CDK 4/6 inhibitors to second-line treatment: A real-world analysis of 701 patients enrolled in the GIM14/BIOMETA study","authors":"Chiara Molinelli ,&nbsp;Marco Bruzzone ,&nbsp;Eva Blondeaux ,&nbsp;Tommaso Ruelle ,&nbsp;Chiara Lanzavecchia ,&nbsp;Michelino De Laurentiis ,&nbsp;Stefania Russo ,&nbsp;Ferdinando Riccardi ,&nbsp;Valentina Sini ,&nbsp;Francesco Cognetti ,&nbsp;Grazia Arpino ,&nbsp;Alessandra Fabi ,&nbsp;Palma Pugliese ,&nbsp;Elena Collovà ,&nbsp;Andrea Fontana ,&nbsp;Fabio Puglisi ,&nbsp;Claudia Bighin ,&nbsp;Matteo Lambertini ,&nbsp;Lucia Del Mastro","doi":"10.1016/j.ejca.2024.115113","DOIUrl":"10.1016/j.ejca.2024.115113","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study was to evaluate the effectiveness of CDK 4/6 inhibitors (CDK 4–6i) according to HER2 status (low/zero), and endocrine resistance/sensitivity, as well as the efficacy of second-line treatments, in a large real-world cohort.</div></div><div><h3>Methods</h3><div>The GIM14/BIOMETA study (NCT02284581) is a retrospective/prospective study of the Gruppo Italiano Mammella evaluating treatment patterns and survival outcomes in patients with metastatic breast cancer (MBC). We retrieved data on patients with hormone receptor-positive/HER2-negative MBC receiving first-line CDK 4/6i.</div></div><div><h3>Results</h3><div>Among 3832 patients enrolled in the GIM14-BIOMETA study, 701 were eligible. At a median follow-up of 24.80 months, no significant differences were found between HER2-zero and HER2-low subgroups in terms of first-line time to treatment discontinuation (TTD) (26.16 months [IQR 12.84-NR] vs. 27.60 months [IQR 12.12–64.44], p = 0.972) or overall survival (OS) (mOS&gt;60 months for both groups, p = 0.398). Median TTD was 33.24 months (IQR 16.32-NR) for the endocrine sensitive subgroup, 19.92 months (IQR 8.88–51.24) for the secondary endocrine resistant subgroup and 17.40 months (IQR 7.44–24.72) for the primary endocrine resistant subset, respectively (p &lt; 0.001). Among 239 patients receiving second-line treatment, no significant difference (p = 0.188) was found in terms of second-line TTD between those treated with capecitabine (6.11 months, IQR 2.96–11.47), taxane-based chemotherapy (5.06 months, IQR 2.99–9.99), everolimus plus exemestane (5.39 months, IQR 2.53–9.03) or fulvestrant (6.44 months, IQR 3.38-NR).</div></div><div><h3>Conclusions</h3><div>Endocrine therapy plus CDK 4/6i represents an effective treatment, regardless of HER2 status (low/zero). Second-line agents did not differ significantly in terms of TTD. Endocrine resistant cancers exhibit poor response to CDK 4/6i.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115113"},"PeriodicalIF":7.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared decision-making supported by outcome information regarding surveillance after curative treatment for breast cancer: Results of the SHOUT-BC study 乳腺癌根治性治疗后监测结果信息支持的共同决策:SHOUT-BC研究的结果
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-11-02 DOI: 10.1016/j.ejca.2024.115107
J.W. Ankersmid , C.H.C. Drossaert , L.J.A. Strobbe , M.Q.N. Hackert , N. Engels , J.C.M. Prick , S. Teerenstra , Y.E.A. van Riet , R. The , C.F. van Uden-Kraan , S. Siesling , on behalf of the Santeon VBHC Breast Cancer Group
{"title":"Shared decision-making supported by outcome information regarding surveillance after curative treatment for breast cancer: Results of the SHOUT-BC study","authors":"J.W. Ankersmid ,&nbsp;C.H.C. Drossaert ,&nbsp;L.J.A. Strobbe ,&nbsp;M.Q.N. Hackert ,&nbsp;N. Engels ,&nbsp;J.C.M. Prick ,&nbsp;S. Teerenstra ,&nbsp;Y.E.A. van Riet ,&nbsp;R. The ,&nbsp;C.F. van Uden-Kraan ,&nbsp;S. Siesling ,&nbsp;on behalf of the Santeon VBHC Breast Cancer Group","doi":"10.1016/j.ejca.2024.115107","DOIUrl":"10.1016/j.ejca.2024.115107","url":null,"abstract":"<div><h3>Background</h3><div>Integrating outcome information into the process of shared decision-making (SDM) about post-treatment surveillance can enhance its effectiveness. The Breast Cancer Surveillance Decision Aid (BCS-PtDA) integrates risk estimations of patients’ risks for recurrences as well as outcome information on fear of cancer recurrence (FCR). The SHOUT-BC study aimed to evaluate the effectiveness of the implementation of the BCS-PtDA. Patients’ satisfaction with the BCS-PtDA was also evaluated.</div></div><div><h3>Methods</h3><div>As described in a previously published protocol paper, the study employed a Prospective multiple interrupted time series (ITS) design in which the BCS-PtDA was implemented stepwise into the care pathways of eight Dutch hospitals.</div></div><div><h3>Results</h3><div>A total of 507 participants completed a questionnaire after their first surveillance consultation which usually takes place approximately one year after surgery. ITS analysis per hospital and subsequent meta-analysis over hospital effects indicated a significant increase in patient-reported SDM from pre- to post-implementation (overall estimated effect: 27.14, 95 % CI: 22.71 to 31.87, <em>p</em> &lt; .0001). Moreover, post-implementation participants (<em>n</em> = 225) reported a more active role in decision-making, decreased decisional conflict, and increased knowledge on the aim and methods of surveillance. Furthermore, a decrease in FCR was seen post-implementation. The self-reported intensity of surveillance schedules decreased slightly and the BCS-PtDA received highly positive evaluations.</div></div><div><h3>Discussion</h3><div>The implementation of the BCS-PtDA, which integrates outcome information, led to increased patient-reported SDM and an improved quality of decision-making. The BCS-PtDA was evaluated highly positively by participants. Further research should address optimisation of the implementation.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"213 ","pages":"Article 115107"},"PeriodicalIF":7.6,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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