European Journal of Cancer最新文献

{"title":"Digital Interventions for psychosocial risk factors in cancer onset: Systematic review for the iBeChange platform","authors":"M. Masiero , E. Tomezzoli , C. Marzorati , G. Pagani , R. Pietrobon , S. Mattioli , L. Teixeira , M. Serra-Blasco , A. García-Serra , C. Ochoa- Arnedo , D. Monzani , B. Caci , G. Miale , G. Pravettoni","doi":"10.1016/j.ejca.2026.116344","DOIUrl":"10.1016/j.ejca.2026.116344","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116344"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health education in the digital age: Analysing the engagement and impact of breast cancer content on TikTok","authors":"L. Chandrakumar , I. Carty , D. Betal","doi":"10.1016/j.ejca.2026.116345","DOIUrl":"10.1016/j.ejca.2026.116345","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116345"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World evidence of immunotherapy-driven axillary downstaging and surgical de-escalation in triple-negative breast cancer","authors":"L. Pitoni , A.J. Esgueva Colmenarejo , C. Siso Raber , F. Martinez Regueira , N. Rodriguez-Spiteri , B. Olartecoechea , C. Sobrido , L.J. Pina , T. Iscar , A. Lopez Janeiro , I.T. Rubio","doi":"10.1016/j.ejca.2026.116357","DOIUrl":"10.1016/j.ejca.2026.116357","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116357"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac decision impact (CarDI) study for cardiovascular disease risk identification in breast cancer patients undergoing radiotherapy: Protocol of a clinical trial","authors":"S. Jaya-Prakason , E. Benkel , B.B. Irankunda , F. Banning , R. Kates , S.A.M. Gernaat , M.V. Maraldo , E. Batista , H.J.G.D. van den Bongard , T. Spanic , H.M. Verkooijen , N. Harbeck","doi":"10.1016/j.ejca.2026.116342","DOIUrl":"10.1016/j.ejca.2026.116342","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116342"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a telephone-based weight loss intervention on overall dietary quality and dietary lipids intake in overweight and obese breast cancer (BC) survivors: secondary analyses from the MEDEA randomized controlled trial (RCT)","authors":"S. Maccarone , H. Julie , E. Martin , R. Gazan , M. Maillot , D. Soldato , B. Raynard , C. Tracy E , A. Barbier , A. Mangin , B. Pistilli , L. Vanlemmens , C. Segura-Djezzar , C. Bouleuc , O. Tredan , S. Michiels , D. Chaltiel , J.A. Ligibel , I. Vaz-Luis , A. Di Meglio","doi":"10.1016/j.ejca.2026.116377","DOIUrl":"10.1016/j.ejca.2026.116377","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116377"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced cardiac toxicity in breast cancer patients: 15 year results from a large single-center breast cancer database","authors":"A. Van Der Vorst , J. Jacobs , R. Van Lerberghe , V. De Foer , Y. Ickx , W.H. Zhan , L. Delombaerde , A. Laenen , G. Defraene , M. Lambrecht , L. Van Aelst , J. Verhoeven , A. Baten , H. Janssen , C. Weltens","doi":"10.1016/j.ejca.2026.116318","DOIUrl":"10.1016/j.ejca.2026.116318","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116318"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147546700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRAVE-HEART: Clinical and dosimetric validation of active breath control for cardiac sparing in breast cancer radiotherapy","authors":"E. Bonzano , L. Squillace , A. Lancia , J. Saddi , S. Colombo , S. La Mattina , D.A. Santos , P. Pedrazzoli","doi":"10.1016/j.ejca.2026.116319","DOIUrl":"10.1016/j.ejca.2026.116319","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116319"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147547168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is pathological complete response a surrogate for overall survival in neoadjuvant clinical trials for gastroesophageal adenocarcinoma?","authors":"Luís Felipe Leite ,&nbsp;Mariana Macambira Noronha ,&nbsp;Samuel Menezes ,&nbsp;Lucas Diniz da Conceição ,&nbsp;Luiz F. Costa de Almeida ,&nbsp;Anelise Poluboiarinov Cappellaro ,&nbsp;Marcos Belotto ,&nbsp;Renata D.’Alpino Peixoto ,&nbsp;Thais Baccili Cury Megid","doi":"10.1016/j.ejca.2026.116602","DOIUrl":"10.1016/j.ejca.2026.116602","url":null,"abstract":"<div><h3>Background</h3><div>Pathologic complete response (pCR) is frequently used as a surrogate endpoint in neoadjuvant gastroesophageal adenocarcinoma (GEA) trials, yet its validity in predicting overall survival (OS) remains uncertain.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis, follows PRISMA and ReSEEM guidelines, and evaluates pCR as a surrogate for OS in randomized controlled trials (RCTs) of neoadjuvant therapy for GEA. Randomized trials enrolling patients with resectable distal esophageal, gastroesophageal junction (GEJ), or gastric adenocarcinoma were included if both pCR and OS were reported. Individual-level surrogacy was assessed by correlating pCR rates with median OS across trial arms; trial-level surrogacy was evaluated by correlating treatment effects on pCR (odds ratios) with treatment effects on OS (hazard ratios) using weighted linear regression and calculating the coefficient of determination (R²).</div></div><div><h3>Results</h3><div>Twenty-six RCTs including 7452 patients were analyzed. Overall, pCR showed no meaningful correlation with OS at the individual-level (R² = 0.006; p = 0.210), and treatment effects on pCR explained little of the variability in OS effects at the trial level (R² = 0.060; p = 0.206). Most trials evaluated cytotoxic chemotherapy or chemoradiotherapy. Surrogacy varied by subgroup, being strong for esophageal adenocarcinoma (R² = 0.886; p &lt; 0.001), moderate for gastric cancer (R² = 0.386; p = 0.041), and absent for GEJ trials. Trials incorporating radiotherapy demonstrated strong surrogacy, whereas chemotherapy-only trials did not.</div></div><div><h3>Conclusions</h3><div>The interpretation of pCR results in gastroesophageal adenocarcinoma trials requires caution. Surrogacy might need to be reassessed in the upcoming immunotherapy trials.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116602"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment patterns in geriatric patients with melanoma and the effect of age on the efficacy of immunotherapy: Analysis from the real-world multicenter registry ADOREG","authors":"Konstantinos Lallas ,&nbsp;Lena Nanz ,&nbsp;Selma Ugurel ,&nbsp;Peter Mohr ,&nbsp;Friedegund Meier ,&nbsp;Michael Weichenthal ,&nbsp;Imke von Wasielewski ,&nbsp;Patrick Terheyden ,&nbsp;Jessica Hassel ,&nbsp;Alexander Kreuter ,&nbsp;Rudolf Herbst ,&nbsp;Anja Gesierich ,&nbsp;Claudia Pföhler ,&nbsp;Ralf Gutzmer ,&nbsp;Julia Welzel ,&nbsp;Christoffer Gebhardt ,&nbsp;Sebastian Haferkamp ,&nbsp;Jens Ulrich ,&nbsp;Martin Kaatz ,&nbsp;Frank Meiss ,&nbsp;Ulrike Leiter","doi":"10.1016/j.ejca.2026.116582","DOIUrl":"10.1016/j.ejca.2026.116582","url":null,"abstract":"<div><h3>Purpose</h3><div>Data on treatment approaches in geriatric melanoma patients are scant. Efficacy of oncologic treatments across age groups, with special focus on immunotherapy, and the impact of comorbidities were analyzed.</div></div><div><h3>Methods</h3><div>A retrospective multicenter cohort study of the ADOREG registry included patients with cutaneous melanoma, who received oncological drugs at German skin cancer centers between 2013 and 2023. Outcomes were objective response rate (ORR), progression-free survival (PFS), melanoma-specific survival (MSS), toxicities and reasons for treatment discontinuation. Age groups were prespecified as &lt; 75 vs ≥ 75 years (geriatric), comorbidities were summarized by Charlson-Comorbidity-Index (CCI). Comparisons across groups were conducted with X²-test, survival outcomes were compared via log-rank tests.</div></div><div><h3>Results</h3><div>Of 14,356 melanoma patients, 8213 met the inclusion criteria, 6063 and 2150 were &lt; 75 and ≥ 75 years old, respectively. Among the 3646 patients with metastatic disease, older patients received fewer treatment lines and were less likely to undergo surgery, radiotherapy and systemic therapy. However, efficacy of any first-line treatment did not differ between both age groups (p = 0.306). Immunotherapy selection at any line was similar in both groups (p = 0.109), but geriatrics were treated mainly with first-line anti-PD1 monotherapy, whereas combination ICIs was preferred in younger patients. Efficacy was not impaired (PFS and MSS: p &gt; 0.05), while toxicity rates were lower. This pattern persisted across CCI categories.</div></div><div><h3>Conclusion</h3><div>Age influenced treatment selection in melanoma patients. However, in geriatric patients, efficacy was not impaired, and a balanced toxicity profile was noticed, particularly for immunotherapy. Future studies considering biological age and impairment by comorbidities seems important to assess individualized treatment approaches.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116582"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of tumour infiltrating lymphocytes and metabolic activity of the spleen derived from [18F]FDG PET/CT in predicting axillary pathologic complete response in clinically node-positive breast cancer after neoadjuvant chemotherapy","authors":"M. Lenaerts ,&nbsp;L. Kooreman ,&nbsp;F.J.G. van Amstel ,&nbsp;C.C.P. Adang ,&nbsp;F.M. Mottaghy ,&nbsp;P.J. van Diest ,&nbsp;J.M. Simons ,&nbsp;E.J.T. Luiten ,&nbsp;C.C. van der Pol ,&nbsp;L.B. Koppert ,&nbsp;M.L. Smidt ,&nbsp;T.J.A. van Nijnatten","doi":"10.1016/j.ejca.2026.116348","DOIUrl":"10.1016/j.ejca.2026.116348","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"237 ","pages":"Article 116348"},"PeriodicalIF":7.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147554203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}