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Risk factors for lymph node metastasis in women with FIGO 2018 IA cervical cancer with a horizontal spread of > 7 mm 患有 FIGO 2018 IA 宫颈癌且水平扩散范围大于 7 毫米的妇女发生淋巴结转移的风险因素。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-05 DOI: 10.1016/j.ejca.2024.115063
Hans H.B. Wenzel , Tine H. Schnack , Maaike A. Van der Aa , Pernille T. Jensen , Claus K. Høgdall , Anna Norberg Hardie , Henrik Falconer , Ruud L.M. Bekkers , Dutch, dANish and sweDish gynaEcoLogIcal ONcology (DANDELION) research group
{"title":"Risk factors for lymph node metastasis in women with FIGO 2018 IA cervical cancer with a horizontal spread of > 7 mm","authors":"Hans H.B. Wenzel ,&nbsp;Tine H. Schnack ,&nbsp;Maaike A. Van der Aa ,&nbsp;Pernille T. Jensen ,&nbsp;Claus K. Høgdall ,&nbsp;Anna Norberg Hardie ,&nbsp;Henrik Falconer ,&nbsp;Ruud L.M. Bekkers ,&nbsp;Dutch, dANish and sweDish gynaEcoLogIcal ONcology (DANDELION) research group","doi":"10.1016/j.ejca.2024.115063","DOIUrl":"10.1016/j.ejca.2024.115063","url":null,"abstract":"<div><h3>Background</h3><div>In the FIGO 2018 classification, women with cervical cancer and a depth of invasion ≤ 5 mm and a horizontal spread of &gt; 7 mm in excisional biopsy with tumour-free margins, are now classified as stage IA instead of IB. This stage shift may reduce the likelihood of surgical lymph node staging. It is therefore crucial to estimate the risk and risk factors of lymph node metastasis (pN+) in this group.</div></div><div><h3>Methods</h3><div>Women diagnosed with cervical cancer between 2005 and 2022 were identified from nationwide population-based registries from the Netherlands, Denmark, and Sweden. Inclusion criteria were squamous cell carcinoma or adenocarcinoma, FIGO 2009 stage IB1, a depth of invasion ≤ 5 mm and horizontal spread of &gt; 7–≤ 40 mm. All cases underwent radical hysterectomy or radical trachelectomy, and surgical lymph node staging. Logistic regression was used to identify risk factors of pN+.</div></div><div><h3>Results</h3><div>We included 992 women (pN+ 4.1 %; n = 41). Lymphovascular space invasion (LVSI) was a significant risk factor of pN+ (odds ratio 4.26, 95 % confidence interval 2.24–8.32). Accordingly, the risk of pN+ was ≥ 7.3 % in LVSI-positive tumours. The risk was lowest in LVSI-negative tumours with a size of &gt; 7–≤ 20 mm (2.2 %), although this varied by depth of invasion and histological subtype (pN+ range 0.6–5.1 %).</div></div><div><h3>Conclusion</h3><div>Women with LVSI-positive FIGO 2018 IA cervical cancer and a horizontal spread &gt; 7 mm, should undergo surgical lymph node staging. In LVSI-negative tumours, lymph node staging should not be routinely performed; tumour size, depth of invasion and histology should be considered.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short- and long-term immunosuppressive effects of melanoma influence the prognostic value of the sentinel lymph node status 黑色素瘤的短期和长期免疫抑制作用会影响前哨淋巴结状态的预后价值。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-04 DOI: 10.1016/j.ejca.2024.115054
Viola K. DeTemple , Cathrin Ritter , Nalini Srinivas , Ivelina Spassova , Thilo Gambichler , Svea Hüning , Nikolai Gräger , Ralf Gutzmer , Eva-Bettina Bröcker , Selma Ugurel , David Schrama , Jürgen C. Becker
{"title":"Short- and long-term immunosuppressive effects of melanoma influence the prognostic value of the sentinel lymph node status","authors":"Viola K. DeTemple ,&nbsp;Cathrin Ritter ,&nbsp;Nalini Srinivas ,&nbsp;Ivelina Spassova ,&nbsp;Thilo Gambichler ,&nbsp;Svea Hüning ,&nbsp;Nikolai Gräger ,&nbsp;Ralf Gutzmer ,&nbsp;Eva-Bettina Bröcker ,&nbsp;Selma Ugurel ,&nbsp;David Schrama ,&nbsp;Jürgen C. Becker","doi":"10.1016/j.ejca.2024.115054","DOIUrl":"10.1016/j.ejca.2024.115054","url":null,"abstract":"<div><h3>Background</h3><div>Presence of micrometastases in the sentinel lymph node (SLN) is currently used to assess prognosis of melanoma patients. The immunoactivity within the SLN is known to be influenced by the primary tumor (PT), which may in turn impact the SLNs’ metastatic state.</div></div><div><h3>Aim</h3><div>We characterize the temporal dependence and underlying mechanisms of the immunological effects of the PT on the SLN.</div></div><div><h3>Methods</h3><div>The prognostic value of SLN state as a function of PT removal time was evaluated. To put the results into a functional context, selected PTs and corresponding SLNs were analyzed for gene and protein expression patterns.</div></div><div><h3>Results</h3><div>In a cohort of 202 patients with known distant metastasis and similar PT prognostic characteristics, SLNs removed before or within one week after the PT (IM-SLN) had a higher incidence of micrometastases than those removed at least one week after the PT (DEL-SLN).</div><div>The immunoactivity in IM-SLN was found to be lower than in DEL-SLN. Specifically, in IM-SLNs, T helper 17 / regulatory T-cells were predominant, whereas in DEL-SLNs, cytotoxic γδT-cells were more frequent. The higher immune activity in DEL-SLNs was probably facilitated by CD209<sup>+</sup> antigen-presenting cells. Indeed, in PT with high TGFβ expression CD209<sup>+</sup> cells appear to be trapped and no increased immunoactivity was observed in DEL-SLN.</div></div><div><h3>Conclusions</h3><div>Presence of micrometastases in DEL-SLNs have a higher negative prognostic value as in IM-SLNs since they indicate not only a melanoma’s propensity to metastasize, but possibly also its capacity to escape immune responses.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Letter re: Real-world outcomes of Italian patients with advanced non-squamous lung cancer treated with first-line pembrolizumab plus platinum-pemetrexed 对 "关于意大利晚期非鳞状肺癌患者接受彭博利珠单抗加铂类-培美曲塞一线治疗的实际效果 "一文的回复。
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-02 DOI: 10.1016/j.ejca.2024.115057
Alessandro Leonetti, Fabiana Perrone, Matteo Puntoni, Giuseppe Maglietta, Caterina Caminiti, Marcello Tiseo
{"title":"Response to the Letter re: Real-world outcomes of Italian patients with advanced non-squamous lung cancer treated with first-line pembrolizumab plus platinum-pemetrexed","authors":"Alessandro Leonetti,&nbsp;Fabiana Perrone,&nbsp;Matteo Puntoni,&nbsp;Giuseppe Maglietta,&nbsp;Caterina Caminiti,&nbsp;Marcello Tiseo","doi":"10.1016/j.ejca.2024.115057","DOIUrl":"10.1016/j.ejca.2024.115057","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright Page 版权页
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.115025
{"title":"Copyright Page","authors":"","doi":"10.1016/j.ejca.2024.115025","DOIUrl":"10.1016/j.ejca.2024.115025","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
54 (PB042): The Application of Small Molecule ClpP Agonists as Novel Anti-Cancer Agents 54 (PB042)：小分子 ClpP 激动剂作为新型抗癌药物的应用
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114581
L. Graves, S. Daglish, O. Canterbury, A. Mistreanu, P. Graves, E. Iwanowicz
{"title":"54 (PB042): The Application of Small Molecule ClpP Agonists as Novel Anti-Cancer Agents","authors":"L. Graves,&nbsp;S. Daglish,&nbsp;O. Canterbury,&nbsp;A. Mistreanu,&nbsp;P. Graves,&nbsp;E. Iwanowicz","doi":"10.1016/j.ejca.2024.114581","DOIUrl":"10.1016/j.ejca.2024.114581","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A-261 The impact of atopic dermatitis preceding cutaneous T-cell lymphoma and its effect on clinical outcomes: a retrospective review at a single tertiary referral center A-261 皮肤T细胞淋巴瘤前特应性皮炎的影响及其对临床结果的影响：对一家三级转诊中心的回顾性研究
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114412
A. Fleischli, S. Khoshniyati, O. Pierog, J. Weiner, S. Rozati
{"title":"A-261 The impact of atopic dermatitis preceding cutaneous T-cell lymphoma and its effect on clinical outcomes: a retrospective review at a single tertiary referral center","authors":"A. Fleischli,&nbsp;S. Khoshniyati,&nbsp;O. Pierog,&nbsp;J. Weiner,&nbsp;S. Rozati","doi":"10.1016/j.ejca.2024.114412","DOIUrl":"10.1016/j.ejca.2024.114412","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142415896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
37 (PB025): Investigating the Therapeutic Potential of novel STK17A Inhibitor UMF814A in Glioblastoma 37 (PB025)：研究新型 STK17A 抑制剂 UMF814A 在胶质母细胞瘤中的治疗潜力
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114565
J. Castro, D. Seetharam, S. Chaudhry, J. Chander, J. Taylor, A. Shah
{"title":"37 (PB025): Investigating the Therapeutic Potential of novel STK17A Inhibitor UMF814A in Glioblastoma","authors":"J. Castro,&nbsp;D. Seetharam,&nbsp;S. Chaudhry,&nbsp;J. Chander,&nbsp;J. Taylor,&nbsp;A. Shah","doi":"10.1016/j.ejca.2024.114565","DOIUrl":"10.1016/j.ejca.2024.114565","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
83 (PB071): Preclinical characterization of SMARCA2-selective monovalent direct degraders 83 (PB071)：SMARCA2 选择性单价直接降解剂的临床前表征
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114609
G. Parker, G. Leriche, T. Kampert, A. Jamborcic, L. Yang, J. Toth, K. Steadman, J. Chung, D. Tran, L. Luis, F. Barmare, K. Hayashi, G. Liu, J. Ma, A. Campos, M. McCarrick, V. Kumar, K. Freeman-Cook, P. Thompson
{"title":"83 (PB071): Preclinical characterization of SMARCA2-selective monovalent direct degraders","authors":"G. Parker,&nbsp;G. Leriche,&nbsp;T. Kampert,&nbsp;A. Jamborcic,&nbsp;L. Yang,&nbsp;J. Toth,&nbsp;K. Steadman,&nbsp;J. Chung,&nbsp;D. Tran,&nbsp;L. Luis,&nbsp;F. Barmare,&nbsp;K. Hayashi,&nbsp;G. Liu,&nbsp;J. Ma,&nbsp;A. Campos,&nbsp;M. McCarrick,&nbsp;V. Kumar,&nbsp;K. Freeman-Cook,&nbsp;P. Thompson","doi":"10.1016/j.ejca.2024.114609","DOIUrl":"10.1016/j.ejca.2024.114609","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
19 (PB007): The SRG Rat, an immunodeficient model for orthotopic glioblastoma, diffuse intrinsic pontine glioma (DIPG) PDX, and intracranial metastatic breast cancer PDX tumors 19 (PB007)：SRG 大鼠，一种用于正位胶质母细胞瘤、弥漫性桥脑胶质瘤 (DIPG) PDX 和颅内转移性乳腺癌 PDX 肿瘤的免疫缺陷模型
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114548
D. Begemann, N. Fulcher, E. Fenton, C. Dunn, D. Robertson, C. Scutchfield, T. Keener, A. Deweyert, A. Elsaleh, H. Xu, C. De Oliveira, J. Kelly, J.A. Ronald, R.G. Walton, S. Sampathi, V. Steffey, M.J. Schlosser, S. Schmid, M.O. Hebb, F. Noto
{"title":"19 (PB007): The SRG Rat, an immunodeficient model for orthotopic glioblastoma, diffuse intrinsic pontine glioma (DIPG) PDX, and intracranial metastatic breast cancer PDX tumors","authors":"D. Begemann,&nbsp;N. Fulcher,&nbsp;E. Fenton,&nbsp;C. Dunn,&nbsp;D. Robertson,&nbsp;C. Scutchfield,&nbsp;T. Keener,&nbsp;A. Deweyert,&nbsp;A. Elsaleh,&nbsp;H. Xu,&nbsp;C. De Oliveira,&nbsp;J. Kelly,&nbsp;J.A. Ronald,&nbsp;R.G. Walton,&nbsp;S. Sampathi,&nbsp;V. Steffey,&nbsp;M.J. Schlosser,&nbsp;S. Schmid,&nbsp;M.O. Hebb,&nbsp;F. Noto","doi":"10.1016/j.ejca.2024.114548","DOIUrl":"10.1016/j.ejca.2024.114548","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A-136 Effects of Mogamulizumab on CD39, CD73 and CD38 ectonucleotidases expression in T-cells of Sézary syndrome patients A-136 莫干单抗对塞扎里综合征患者 T 细胞中 CD39、CD73 和 CD38 外核苷酸酶表达的影响
IF 7.6 1区 医学
European Journal of Cancer Pub Date : 2024-10-01 DOI: 10.1016/j.ejca.2024.114348
G. Roccuzzo, Y. Yakymiv, S. Marchisio, E. Ortolan, L. Lin, L. Marega, P. Fava, R. Ponti, R. Senetta, S. Ribero, A. Funaro, P. Quaglino
{"title":"A-136 Effects of Mogamulizumab on CD39, CD73 and CD38 ectonucleotidases expression in T-cells of Sézary syndrome patients","authors":"G. Roccuzzo,&nbsp;Y. Yakymiv,&nbsp;S. Marchisio,&nbsp;E. Ortolan,&nbsp;L. Lin,&nbsp;L. Marega,&nbsp;P. Fava,&nbsp;R. Ponti,&nbsp;R. Senetta,&nbsp;S. Ribero,&nbsp;A. Funaro,&nbsp;P. Quaglino","doi":"10.1016/j.ejca.2024.114348","DOIUrl":"10.1016/j.ejca.2024.114348","url":null,"abstract":"","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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