{"title":"The Kirkendall Effect: its Efficacy in the Formation of Hollow Nanostructures","authors":"R. D. Vais, H. Heli","doi":"10.15412/J.JBTW.01050802","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050802","url":null,"abstract":"\"The Kirkendall effect refers to the formation of the so-called ‘Kirkendall voids’ caused by the difference in diffusion rates between two species. It is a classical phenomenon in metallurgy and since its discovery, the Kirkendall effect has been observed in different alloy systems. The development of the hollow interior consists of two main steps. The first step is the formation of the small Kirkendall voids near the original interface via a bulk diffusion process. The second step is a consequence of the surface diffusion of the core material (the fast-diffusing species) along the pore surface. Since hollow and porous structures have attracted tremendous attention due to their common applications in sensor systems, chemical reactors, catalysis, drug delivery, environmental engineering, biotechnology, etc., the Kirkendall effect dominates in the fabrication of hollow nanostructures. These nanostructures play a key role in the biological applications of hollow materials such as labeling of cellular structures/molecules, drug loading, encapsulation, delivery and release, bio-labeling, biosensors, magnetic resonance imaging, and biomedicine vehicles.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128613883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrochemical Genosensing of Leishmania major using Gold Hierarchical Nanoleaflets","authors":"M. Moradi, N. Sattarahmady, G. Hatam, H. Heli","doi":"10.15412/J.JBTW.01050801","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050801","url":null,"abstract":"\"A label- and PCR-free electrochemical genosensor was fabricated for identification of Leishmania parasites. Gold hierarchical nanoleaflets were synthesized by electrodeposition in the presence of spermidine in the deposition solution. A Leishmania major specific single stranded DNA probe was immobilized on the surface of nanoleaflets and ferrocyanide was employed as a hybridization marker. Hybridization of the immobilized probe with targets was investigated under the selected conditions. The genosensor could detect a synthetic DNA target in a range of 1.0×10-12 to 1.0×10-20 mol L-1 with a limit of detection of 2.98i´10-21 mol L-1, and genomic DNA in a range of 0.5 to 15 ng μL-1 with a limit of detection of 0.11 ng μL-1. The genosensor was successfully applied for detection of Leishmania major in patient samples.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133574759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rezaei, A. Palizban, Setare Zamani-doabi, M. Shojaee
{"title":"Transcription factor 7-like 2 (TCF7L2) Gene Polymorphism rs7903146 is Associated with Lipid Profile and Risk of Cardiovascular Disease in Metabolic Syndrome Subjects","authors":"M. Rezaei, A. Palizban, Setare Zamani-doabi, M. Shojaee","doi":"10.15412/J.JBTW.01050703","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050703","url":null,"abstract":"\"Transcription factor 7-like 2 (TCF7L2) polymorphisms especially rs7903146(C/T) are related to type 2 diabetes (T2D) and other metabolic diseases; Metabolic Syndrome(MetS), atherosclerosis and cardiovascular disease (CVD) risk, this study is performed in order to evaluate the relationship between TCF7L2 polymorphism rs7903146 to Metabolic Syndrome (MetS) and CVD risk. Blood samples were collected from the MetS (n=92) and control (n=80) subjects. The subjects were characterized according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III). Blood DNA was extracted and genotyped by mismatch PCR-RFLP. A logistic regression model was performed to analyze the data. T-TEST and ANOVA (Analysis Of Variance) were used to compare differences between CC and CT+TT rs7903146 genotypes. The biochemical factors showed that BMI, SBP, DBP, FBS, TG levels in the MetS subjects were meaningfully higher than Normal subjects (P=0.001, P=0.000, P=0.000, P=0.031, P=0.000) and HDL level in the MetS subjects was Lower than Normal subjects (P=0.003). The biochemical factors and genotype analysis indicated that FBS and TG levels in the CT+ TT genotypes were significantly higher than that of CC genotype in MetS subjects (P =0.000); The HDL level and BMI in CC genotype were higher (P=0.003, P=0.002). Furthermore, logistic regression analysis of the genotype frequencies for people with a history of cardiovascular disease and people without cardiovascular disease in metabolic syndrome subjects, showed that the odds ratios (OR) of CT+ TT genotypes carriers for CVD risk were higher than those of CC genotypes carriers (OR: 2.8889; 95 % CI : 1.0344 - 8.0680; P = 0.0429). There was relative risk for CT+ TT genotypes versus CC genotype (RR: 1.3542; 95 % CI: 1.0386 - 1.7656; P = 0.0251). Results of this study revealed that the CT+ TT genotypes carriers rs7903146 variation could be predisposed to CVD risk.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125735443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Heidari, M. Taheri, A. P. Ravan, A. Moghimbeigi, M. Mojiri, Yousef Naderi-Khojastehfar, Sahel Paydari-Banyarani, Zahra Hassanpour, M. Eftekharian
{"title":"Assessment of some Immunological and Hematological Factors among Radiation Workers","authors":"S. Heidari, M. Taheri, A. P. Ravan, A. Moghimbeigi, M. Mojiri, Yousef Naderi-Khojastehfar, Sahel Paydari-Banyarani, Zahra Hassanpour, M. Eftekharian","doi":"10.15412/J.JBTW.01050702","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050702","url":null,"abstract":"\"Although the ionizing radiations cause various disorders in different parts of the human body, the importance and extensive application of radiations in medicine are undeniable. In this study, we have tried to evaluate the effect of radiation on immunological and hematological parameters in the radiation workers compared with the control group. Two groups including radiation workers (test group) and a control group were determined. Test and control groups were selected from imaging staffs in teaching hospitals of Hamadan and healthy employees working in other parts of the hospital, respectively. They were matched according to age and sex. The serum levels of cytokines IFN-γ, IL-4, IL-10 and IL-17 were determined and the results were analyzed by using SPSS 18. The obtained results indicated that the level of the IFN-γ and IL-10 in the radiation workers were significantly lower than the control group (P <0.05). There was a statistically significant difference in the white blood cell count and percentage of peripheral blood lymphocytes between the radiation workers and the control group (P <0.05). Based on the results of this study and comparison with the results obtained from other studies, the effects of ionizing radiation (in the radiation workers) appear certain on blood and immune systems. However, type, the exact location and severity of the effect, require more extensive researches on the number of people under study.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117286696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histological Alteration in Different Tissues of Freshwater Teleost Labeo rohita (Hamilton) Induced by Lambda-cyhalothrin 5% EC and Marshal (Carbosulfan 25%EC)","authors":"C. Dey, Samir KumarSaha","doi":"10.15412/J.JBTW.01050701","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050701","url":null,"abstract":"Though synthetic pyrethroids and carbamates have enormous use as pesticides however here we look for the histological effects of sublethal doses of Lambda-cyhalothrin 5% EC (a Synthetic pyrethroid) and Marshal (Carbosulfan 25%EC) [a Carbamate pesticide] on brain, gill, liver and kidney of Labeo rohita. Probit Analysis revels that the LC 50 found to be 0.7μl/L and 10 μl/L for Lambda-cyhalothrin and Marshal respectively. After 10 days of pesticides exposure histopathological studies were performed. Notable changes were observed in brain, liver, gill and kidney.","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125763625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Negar Modirzade-Bami, A. Sayad, Nahid Beladi Moghadam, A. Sattari, S. Arsang-Jang, Seyyed Mojtaba Mohaddes-Ardabili, A. Movafagh
{"title":"Promoter Sequence of IL7RA Gene Reveals an Association with Multiple Sclerosis in Iranian Patients","authors":"Negar Modirzade-Bami, A. Sayad, Nahid Beladi Moghadam, A. Sattari, S. Arsang-Jang, Seyyed Mojtaba Mohaddes-Ardabili, A. Movafagh","doi":"10.15412/J.JBTW.01050602","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050602","url":null,"abstract":"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121331183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Study of Sympathetic Skin Response in Burns with Different Mechanisms","authors":"S. Satari, S. Roshanzamir","doi":"10.15412/J.JBTW.01050601","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050601","url":null,"abstract":"\"Sensory, motor, and autonomic neuropathies have been reported after electrical injuries. In addition subclinical involvement of the sympathetic nervous system during post injury and late clinical manifestations of this involvement have been pointed out in some studies. The present study was done to explore how the clinical and electro-diagnostic manifestations of sympathetic involvement would change over time in burn victims. About 164 patients with electrical, chemical and thermal burn injuries were explored for sympathetic skin response (SSR) and monitoring of automatic system derangement symptoms. The wave amplitude of the sympathetic response of the patients with chemical electrical and thermal burn is reduced, compared with the control group and it is not significant (P>0.05). The latency value of the SSR wave of the patients with the three types of burn injuries indicates that the SSR wave height is reduced and the reduction has been significant compared with the control group (P 0.05). SSR intensity can be used as a predictive test for the automatic system derangement symptoms that occur after burn injury.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114196521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Kalani, Pourandokht Pourkermanian, N. Alimohammadi
{"title":"The Effect of Family Guided Visits on the Level of Consciousness in Traumatic Brain Injury","authors":"Z. Kalani, Pourandokht Pourkermanian, N. Alimohammadi","doi":"10.15412/J.JBTW.01050502","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050502","url":null,"abstract":"\"Sensory stimulation in patients with a decreased level of consciousness in the intensive care unit (ICU) can affect the level of consciousness. Thus, this study was conducted to determine the effect of family guided visits on the level of consciousness in traumatic brain injury patients admitted to ICU. A cluster randomization design was used. Patients were divided into the two groups. The patients in the intervention group were visited daily by a trained member of a family receiving touch and auditory stimulations for 14 days. The control group met the patients regularly every day for 30 minutes each day. The level of consciousness was measured 30 minutes before and 30 minutes after the visits using the Glascow Coma Scale (GCS). The repeated measured ANOVA results revealed that the mean scores of GCS have significantly increased over time (from the first day to the fourteenth day) in the intervention group (p<0.001) and the control group (p<0.001). The increase in the intervention group was significantly higher than the control group (p<0.001). Structured and guided family meeting could improve the level of consciousness of the comatose patients. It is recommended that the closest family members, with adequate training, perform sensory stimulation program at the proper time.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"457 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122600544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Dadpour, A. Bagheri-Moghaddam, V. Dabbagh-Kakhki, M. Arabi, A. H. Tamijani
{"title":"Simultaneous Events and Subsequent Disabilities of Homemade Alcohol Consumption: A Case Report","authors":"B. Dadpour, A. Bagheri-Moghaddam, V. Dabbagh-Kakhki, M. Arabi, A. H. Tamijani","doi":"10.15412/J.JBTW.01050401","DOIUrl":"https://doi.org/10.15412/J.JBTW.01050401","url":null,"abstract":"\"A 42 year old man with heavy drinking of homemade alcohol was referred to our hospital due to acute chest pain. At the onset of admission, he developed a cardio respiratory arrest and CPR was started immediately. Heart rate and respiratory rate returned to normal range after 5 minutes of CPR; however LBBB was detected in ECG. He underwent emergency coronary angiography and normal coronary arteries were reported. After CPR, he was unconscious. Vital signs on admission in emergency department of clinical toxicology were: BP: 100/60, PR: 112/min, and RR: 24/min. He was intubated and underwent mechanical ventilation. Pupils were mydriatic and nonreactive to light. Physical examination revealed no pathologic sign in lungs, heart and abdominal organs. Gasometry on admission revealed: pH: 7.13, p CO2: 26.8, and HCO3: 9. Serum methanol level was: 61 mg/dl. 300 ml of Ethanol 20% as loading dose and then 30 cc per hour was initiated via gavage, folic acid was prescribed; haemodialysis was performed due to loss of consciousness, high methanol serum level and severe metabolic acidosis. Serum Urea and Cr were: 43 and 2.5 mg/dl respectively on admission and increased to 72 and 3.1 mg/dl respectively on second day after admission. He underwent two other sessions of hemodialysis. Brain MRI was carried out and bilateral ischemic hemorrhagic lesions in basal ganglia were reported. He was a case of methanol and ethanol toxicity who developed acute chest pain, loss of consciousness, bilateral hemorrhagic necrosis of Basal ganglia, acute tubular necrosis and finally blindness as a consequence of optic neuritis following methanol toxicity.\"","PeriodicalId":119340,"journal":{"name":"Journal of Biology and Today`s World","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114678215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}