European annals of allergy and clinical immunology最新文献_第9页

Anti-IL5/5R in the treatment of chronic eosinophilic pneumonia and severe asthma 抗IL5/5R治疗慢性嗜酸性粒细胞肺炎和重症哮喘

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2024-01-01 DOI: 10.23822/eurannaci.1764-1489.323

M. Colque-Bayona, D. Laorden, D. Romero, S. Quirce, J. Domínguez-Ortega

引用次数: 0

Nasal challenge with ketorolac: utility and safety in clinical practice. 酮咯酸的鼻腔挑战：临床实践中的实用性和安全性。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-12-20 DOI: 10.23822/EurAnnACI.1764-1489.321

L De Las Vecillas, M Sanchez-Jareño, M Lluch-Bernal, S Quirce, J Domínguez-Ortega, V López-Carrasco, P Barranco

引用次数: 0

Quantity increase and functional affinity/avidity decrease of anti-FcεRI and anti-IgE autoantibodies in chronic spontaneous urticaria. 慢性自发性荨麻疹患者体内抗FcεRI和抗IgE自身抗体的数量增加和功能亲和力/活性降低。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2023-12-13 DOI: 10.23822/EurAnnACI.1764-1489.320

L Jörg, N Müller-Wirth, K Kammermann, O Stalder, W Pichler, O Hausmann

{"title":"Quantity increase and functional affinity/avidity decrease of anti-FcεRI and anti-IgE autoantibodies in chronic spontaneous urticaria.","authors":"L Jörg, N Müller-Wirth, K Kammermann, O Stalder, W Pichler, O Hausmann","doi":"10.23822/EurAnnACI.1764-1489.320","DOIUrl":"10.23822/EurAnnACI.1764-1489.320","url":null,"abstract":"Summary: Background. Patients with autoimmune forms of chronic spontaneous urticaria (aiCSU) exhibit autoantibodies against the high-affinity IgE receptor (FcεRI) and IgE. As the presence of these autoantibodies does not correlate with disease activity, the functional affinity/avidity may be relevant in aiCSU. This exploratory study aimed to characterize the quantity and avidity of autoantibodies against IgE and FcεRI over 6 months. Methods. The serum of 49 patients with CSU and 30 healthy control subjects was obtained at baseline and 6 months. Serum was analyzed by ELISA, to determine the quantity and avidity of anti-IgE and anti-FcεRI autoantibodies, and by basophil activation test (CU-BAT). Results. An increase in the quantity of anti-FcεRI and anti-IgE antibodies and a simultaneous decrease in avidity was found in all patients with CSU after 6 months: median anti-IgE increased from 6.7 ng/mL (IQR 5.1-12.5) to 23.8 ng/mL (IQR 12.3-121.5), p less than 0.001, median anti-FcεRI from 52.4 ng/mL (IQR 26.3-111.4) to 129.5 ng/mL (IQR 73.7-253.7), p less than 0.001. Median anti-IgE avidity decreased from 75.8% (IQR 55.3-90.8) to 56.4% (IQR 30.6-76.2), p=0.019 and median anti-FcεRI avidity from 75.1% (IQR 49.8-90.0) to 52.2 (IQR 38.2-60.1), p less than 0.001. In contrast, the frequency of activated basophils did not change significantly over time. Surprisingly, autoantibody avidity did not correlate with basophil activation. Conclusions. Both the quantity and avidity of anti-FcεRI and anti-IgE antibodies change over time, demonstrating that the CU-BAT is more suitable to diagnose aiCSU. In addition, the avidity of anti-FcεRI and anti-IgE antibodies do not correlate with CU-BAT and disease activity, suggesting that further factors independent of anti-FcεRI and anti-IgE autoantibodies contribute to aiCSU.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed postoperative reactions to metamizole: a diagnostic challenge. 甲氰咪唑术后延迟反应：诊断难题。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-12-05 DOI: 10.23822/EurAnnACI.1764-1489.317

A Lopes, M Paulino, A Spínola Santos, E Pedro, M Branco Ferreira

{"title":"Delayed postoperative reactions to metamizole: a diagnostic challenge.","authors":"A Lopes, M Paulino, A Spínola Santos, E Pedro, M Branco Ferreira","doi":"10.23822/EurAnnACI.1764-1489.317","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.317","url":null,"abstract":"Summary: Background. Metamizole, a non-steroidal anti-inflammatory drug from the pyrazolone group, is a frequent cause of immediate hypersensitivity reactions and, more rarely, of delayed drug hypersensitivity reactions. Due to its favorable pharmacokinetic characteristics, metamizole is widely used in the postoperative period for pain control. Methods. Retrospective study of patients referred for allergological study between January 2012 and June2022 for postoperative hypersensitivity reactions. Clinical and diagnostic data were collected through review of patients' medical records. Twenty patients with postoperative hypersensitivity reactions were referred, of which 10 presented delayed reactions. We analyzed the results of skin prick, intradermal and patch tests performed with an intravenous metamizole solution as well as provocation tests performed with metamizole and acetylsalicylic acid. Cross-reactivity to non-steroidal anti-inflammatory drugs was excluded by confirmation of clinical tolerance to non-steroidal anti-inflammatory drugs or by acetylsalicylic acid provocation test. Results. In 7 of the 10 patients a delayed reaction to metamizole was diagnosed. These reactions were characterized as maculopapular exanthema, occurring in multiple postoperative settings. Skin tests were negative, except in one patient with late mild erythema in the ipsilateral upper limb and no reaction at the site of intradermal injection. Delayed hypersensitivity was demonstrated by late positive metamizole provocation tests. Conclusions. This study demonstrated that for a correct diagnosis a high degree of suspicion about possible delayed hypersensitivity drug reactions to metamizole in the postoperative setting is needed. In the investigation, provocation test with metamizole was decisive for diagnostic confirmation.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polythylene glycol severe allergy and SARS-CoV-2 vaccines: usefulness of testing with PEG 1500 extract. 聚乙二醇严重过敏和严重急性呼吸系统综合征冠状病毒2型疫苗：PEG 1500提取物测试的有用性。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2022-12-02 DOI: 10.23822/EurAnnACI.1764-1489.275

A Gaspar, A L Moura, C Cruz, L M Borrego

{"title":"Polythylene glycol severe allergy and SARS-CoV-2 vaccines: usefulness of testing with PEG 1500 extract.","authors":"A Gaspar, A L Moura, C Cruz, L M Borrego","doi":"10.23822/EurAnnACI.1764-1489.275","DOIUrl":"10.23822/EurAnnACI.1764-1489.275","url":null,"abstract":"Summary: Background. Polyethylene glycol (PEG) is being used for first time as an excipient for mRNA anti-SARS-CoV-2 vaccines containing PEG 2000, highlighting it as a potential cause of anaphylaxis. Methods. We evaluated 126 patients with moderate-high risk of allergy to SARS-CoV-2 vaccines referred to our department from March-December 2021. Skin tests were performed with PEG 1500 extract (Roxall), using a stepwise approach, with readings at 30 minutes: prick tests with 0.1%, 1% and 10% concentrations; if negative, intradermal tests with 0.0001%, 0.001% and 0.01% concentrations. The same protocol was applied to 5 healthy controls Results. Six patients had positive immediate intradermal tests with PEG 1500, all with severe PEG allergy: one with a near-fatal anaphylaxis after glucocorticoid injection containing PEG 3350 and five with systemic allergic reactions after mRNA vaccines containing PEG 2000 (Pfizer-BioNTech or Moderna). One patient developed anaphylaxis during intradermal test. These six patients were negative to polysorbate 80. The remaining 120 patients had negative tests to PEG 1500; seven had positive tests to polysorbate 80. All controls had negative tests. Conclusions. To our knowledge this is the first study describing the allergy work-up testing with PEG 1500 commercial extract in the scope of SARS-CoV-2 vaccination. The algorithm designed for skin tests revealed to be a useful tool. Severe PEG allergy was diagnosed in 5% of patients, contraindicating PEG-containing vaccines. PEG allergy was excluded in one hundred patients that afterwards took SARS-CoV-2 vaccines containing PEG 2000. Investigation should be conducted in specialized drug allergy centers..","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40460235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of the COVID-19 pandemic in Hymenoptera venom immunotherapy: a single center experience. COVID-19大流行对膜翅目毒液免疫治疗的影响:单一中心经验

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2022-06-09 DOI: 10.23822/EurAnnACI.1764-1489.257

D Brandão Abreu, M Bragança, J L Plácido, A Coimbra

引用次数: 0

Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approach. Kikuchi-Fujimoto病和新冠肺炎疫苗接种：药物警戒方法。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2022-11-15 DOI: 10.23822/EurAnnACI.1764-1489.273

A Rodríguez-Ferreras, I Maray, C Coya-Fernández, M M Octavio-Bocigas, M F Fernández-Del Río, S Casares-López, J Ruiz-Salazar

{"title":"Kikuchi-Fujimoto Disease and COVID-19 vaccination: pharmacovigilance approach.","authors":"A Rodríguez-Ferreras, I Maray, C Coya-Fernández, M M Octavio-Bocigas, M F Fernández-Del Río, S Casares-López, J Ruiz-Salazar","doi":"10.23822/EurAnnACI.1764-1489.273","DOIUrl":"10.23822/EurAnnACI.1764-1489.273","url":null,"abstract":"Summary: Background. Kikuchi-Fujimoto Disease (KFD) or histiocytic necrotizing lymphadenitys is a rare disorder characterized by subacute necrotizing regional lymphadenopathy. It is usually presented as painful cervical nodes and associated with fever, headache, night sweats, nausea, vomiting and sore throat. Etiology of KFD is still unclear, two theories have been proposed: infections and autoimmune origin. Due to recent reports of KFD related to COVID-19 vaccination, the novelty of the mechanism of these vaccines and the immunomodulated role of both matters, a literature and adverse event databases review was carried out in order to shed light on the relationship between these two matters. Methods. A search in the Spanish and the European adverse events databases (FEDRA and Eudravigilance) was performed. Search criteria were any drug and the diagnosis \"Histiocytic necrotizing lymphadenitis\" according to the Medical Dictionary for Medical Activities version 25.0. All adverse events registered as June 2, 2022, were included. Results. FEDRA encompassed two KFD reports, one related to a mRNA COVID-19 vaccine. Eudravigilance included a total of 62 KFD cases, 14 of them associated to COVID-19 vaccines and eight to other vaccines. Conclusions. Pharmacovigilance is of utter importance in detecting adverse events caused by new vaccines. More research is needed to establish a final connection between KFD and COVD-19 vaccines, but due to the physiopathology of the condition, how vaccines stimulate the immune system and the high number of reported KFD cases with vaccines given its rare incidence, it is plausible to think that both entities are related.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40461201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Skin atrophy after skin tests with corticosteroids for the diagnosis of SARS-CoV-2 vaccine excipients hypersensitivity. 皮质类固醇皮肤试验诊断严重急性呼吸系统综合征冠状病毒2型疫苗赋形剂超敏反应后的皮肤萎缩。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2023-01-13 DOI: 10.23822/EurAnnACI.1764-1489.282

V Fabbri, V G R Ortolani, L Caron, L Bono, C P Ratti, E Iemoli

引用次数: 0

Prenatal antibiotic exposure increases the risk of infant atopic dermatitis: data from a Greek cohort. 产前接触抗生素会增加婴儿特应性皮炎的风险：来自希腊队列的数据。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2022-09-01 DOI: 10.23822/EurAnnACI.1764-1489.266

E Stefanaki, I Kalaitzidou, M Aristou, J Lakoumentas, E Galanakis, P Xepapadaki

{"title":"Prenatal antibiotic exposure increases the risk of infant atopic dermatitis: data from a Greek cohort.","authors":"E Stefanaki, I Kalaitzidou, M Aristou, J Lakoumentas, E Galanakis, P Xepapadaki","doi":"10.23822/EurAnnACI.1764-1489.266","DOIUrl":"10.23822/EurAnnACI.1764-1489.266","url":null,"abstract":"Summary: Background. The human microbiome is important due to the impact it has on host immunologic development and allergy-associated diseases. This study aimed to investigate the impact of prenatal exposure to antibiotics on the incidence of atopic dermatitis (AD) in children at 18 months of age. Methods. Mothers were interviewed at baseline, in the maternity ward and by phone questionnaire after 18 months. Demographic data, mode of delivery, yoghurt consumption, antibiotic and other drug use during pregnancy, atopic history, diagnosis of AD and history of infections in the offspring were noted. Results. 385 mothers were interviewed at baseline. 231 (60%) mothers with 236 children responded at follow up. Cesarean section was reported in 116 (50.2%) deliveries while antibiotic use during pregnancy in 55/231 (23.8%) women. 43/236 (18.22%) infants were diagnosed with AD. Intravenous antibiotic use was associated with a 7.7 increased risk of AD diagnosis in the offspring (95%CI 1.23-48.27, p = 0.029). An increased odd for AD was recorded for mothers 30-40 years of age (OR 4.50, 95%CI 1.08-18.7, p = 0.039). No significant association between cesarean section and AD (p = 0.70) was recorded. In multivariate analysis, reported food allergy (OR 8.03, 95%CI 2.30-27.97, p = 0.001) and otitis media episodes in children (OR 3.76, 95%CI 1.60-8.83, p = 0.002) were significantly associated with AD diagnosis. Conclusions. An increased risk of AD was recorded only when antibiotics were given prenatally by intravenous route and in women between 30-40 years of age. Children with food allergy had an increased risk for AD. The relatively high percentage of cesarean sections was not a risk factor for AD.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40336512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Overview of asthma patients followed up in a tertiary clinic. 三级诊所随访的哮喘患者综述。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2023-11-01 Epub Date: 2022-06-07 DOI: 10.23822/EurAnnACI.1764-1489.256

Z Çelebi Sözener, B Özdel Öztürk, Ö Aydın, S Bavbek, D Mungan

{"title":"Overview of asthma patients followed up in a tertiary clinic.","authors":"Z Çelebi Sözener, B Özdel Öztürk, Ö Aydın, S Bavbek, D Mungan","doi":"10.23822/EurAnnACI.1764-1489.256","DOIUrl":"10.23822/EurAnnACI.1764-1489.256","url":null,"abstract":"Summary: Background. Asthma is a disease that combines different biological mechanisms, inflammatory pathways, and phenotypic features. Our aim was to investigate the demographic and disease characteristics of patients with asthma and to reveal the distribution with different phenotypes according to endotype groups. Methods. Patients were identified as eosinophilic if the absolute eosinophil count was measured at least once ≥ 300/μL during the oral corticosteroid free period or ≥ 150/μL under oral corticosteroids. Patients sensitive to at least one inhalant allergen with skin prick test and/ or spIgE measurement were defined as allergic. They were categorized into four main endotypes. Results. Data of 405 asthma patients with a median age of 50.9 years were analyzed. The prominent clinical and phenotypic characteristics of the study group were being obese (43.2%) or overweight (32%), severe asthma (49.6%), adult-onset (56.1%) or late-onset asthma (35.3%). The distribution of the four main endotypes according to eosinophilic and/or allergic status, is as follows: 22.7% allergic-eosinophilic (AE), 27.9% nonallergic-eosinophilic (NAE), 22.9% allergic-noneosinophilic (ANE), 26.4% nonallergic-noneosinophilic (NANE). While most severe asthma patients were in the AE and NAE groups, those with early-onset asthma were in AE and ANE, and those with late-onset asthma were in the NAE and NANE groups. The proportion of uncontrolled patients was higher in the NAE group. Among the severe asthma patients, the rate of uncontrolled disease was higher in those with NANE asthma. Conclusions. Different phenotypes were more closely related to some endotypes. This may allow the clinicians to identify patients and predict appropriate treatment modalities and response for individualized care.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48336609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0