European annals of allergy and clinical immunology最新文献

Increasing the dosing interval of dupilumab in patients with severe asthma and chronic rhinosinusitis with nasal polyps. 加重dupilumab在严重哮喘和慢性鼻窦炎合并鼻息肉患者中的给药间隔。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-15 DOI: 10.23822/EurAnnACI.1764-1489.413

A Carbonell Martínez, J Carbonell Zamorano

引用次数: 0

Eosinophilic ascites and eosinophilic gastrointestinal diseases. 嗜酸性粒细胞腹水和嗜酸性粒细胞胃肠道疾病。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-12 DOI: 10.23822/EurAnnACI.1764-1489.412

D Longhino, I Spinelli, F Fianchi, F Castri, G Ianiro, F R Ponziani, C Caruso, A Buonomo, G Antonio, A Aruanno

{"title":"Eosinophilic ascites and eosinophilic gastrointestinal diseases.","authors":"D Longhino, I Spinelli, F Fianchi, F Castri, G Ianiro, F R Ponziani, C Caruso, A Buonomo, G Antonio, A Aruanno","doi":"10.23822/EurAnnACI.1764-1489.412","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.412","url":null,"abstract":"Summary: Background. Eosinophilic ascites (EA) is characterised by a high eosinophil count in the ascitic fluid and, although very rare, is mainly caused by eosinophilic gastrointestinal diseases (EGIDs), parasitic infections, and hypereosinophilic syndrome (HES). Symptoms caused by EGIDs are varied and depend on the gastrointestinal tract affected as well as the layer(s) involved; typically, EA implies a serosal involvement. Herein, we report our single Centre experience of three cases of EA in patients suffering from EGIDs together with a systematic review of all the other cases described in the literature. Methods. Patients selection was performed by querying the database containing patients suffering from EGIDs referred to our hospital and extracting all cases with eosinophilic ascites. In order to describe the reported cases of eosinophilic ascites, a literature review was carried out on Pubmed. Results. We identified three patients with EA suffering from EGIDs at our Centre. In the systematic literature review, a total of 105 patients suffering from EA due to EGIDs were identified from 81 literature articles. For both groups, we described: demographic characteristics, other immunological diseases, gastrointestinal symptoms, how ascites was diagnosed, ascitic fluid characteristics, peripheral eosinophils, gastrointestinal tract affected, therapy, and relapses. Conclusions. EA is a rare presentation of EGIDs and proper evaluations should be performed to make a proper diagnosis; it is crucial to exclude clonal and secondary causes of hypereosinophilia, but differential diagnosis with single organ-HES is often unclear. Steroid therapy is effective and monoclonal antibodies directed against IL-5 could be as well, but further studies are needed.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergy to peanuts and peanut oil: a new severe italian phenotype? 对花生和花生油过敏：一种新的严重意大利表型？

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-03 DOI: 10.23822/EurAnnACI.1764-1489.410

S Marziali, M Mazzolini, G Deleonardi

引用次数: 0

Demographic and clinical characteristics of chronic histaminergic angioedema and chronic urticaria with angioedema, a multicenter Italian experience. 慢性组胺能性血管性水肿和慢性荨麻疹伴血管性水肿的人口统计学和临床特征，意大利多中心经验。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-03 DOI: 10.23822/EurAnnACI.1764-1489.411

S Sartorio, F Rivolta, A Tedeschi, G Manzotti, M Piantanida, A M Marra, F Cappiello, M R Yacoub, S Nannipieri, L Maffeis, V Longoni, A Sangalli, V Pravettoni, R Asero

{"title":"Demographic and clinical characteristics of chronic histaminergic angioedema and chronic urticaria with angioedema, a multicenter Italian experience.","authors":"S Sartorio, F Rivolta, A Tedeschi, G Manzotti, M Piantanida, A M Marra, F Cappiello, M R Yacoub, S Nannipieri, L Maffeis, V Longoni, A Sangalli, V Pravettoni, R Asero","doi":"10.23822/EurAnnACI.1764-1489.411","DOIUrl":"10.23822/EurAnnACI.1764-1489.411","url":null,"abstract":"Summary: Background. Chronic spontaneous urticaria (CSU) is a common disorder characterized by the recurrence of wheals and/or angioedema for more than 6 weeks. About 35% of patients experience wheals and angioedema (AE-CSU) and around 6% of patients only present angioedema, also known as chronic histaminergic angioedema (CHA). As few data comparing CHA and AE-CSU are published, we analyzed the differences between demographic and clinical characteristics of these populations. Methods. A multicenter, observational, retrospective study, involving eight Allergology Centers in Lombardy, Italy, including 44 CHA and 34 AE-CSU pediatric and adult patients was performed. Data about sex, age, comorbidities, inflammatory markers, complement fractions, blood count, use of ACE inhibitors or angiotensin receptor blockers, site of angioedema attacks, therapy used to treat attacks, frequency of attacks at diagnosis, after 6 months of therapy and after 12 months of therapy were collected and analyzed. Results. A higher rate of atopy was found in AE-CSU than in CHA (58.8% vs 29.5%, p = 0.01). Hypothyroidism and antithyroid antibodies were more frequently detected in AE-CSU (p < 0.05). Face was the site majorly involved in both populations. Tongue angioedema was more reported in CHA than AE-CSU (22.7% vs 2.9%, p = 0.019). In CHA patients, upper airway involvement was reported mainly in male patients (p = 0.02). Monthly frequency of angioedema attacks at diagnosis was higher in AE-CSU than in CHA (2.1 vs 1.45, p = 0.045). Conclusions. Some characteristics may differentiate CHA from AE-CSU, as the latter experience higher rates of atopy, hypothyroidism and anti-thyroid antibodies positivity, as well as higher frequency of attacks and less tongue involvement.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasal challenge with ketorolac: utility and safety in clinical practice. 酮咯酸的鼻腔挑战：临床实践中的实用性和安全性。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-01 Epub Date: 2023-12-20 DOI: 10.23822/EurAnnACI.1764-1489.321

L De Las Vecillas, M Sanchez-Jareño, M Lluch-Bernal, S Quirce, J Domínguez-Ortega, V López-Carrasco, P Barranco

引用次数: 0

Pollen-induced asthma: diagnostic and therapeutic implications. 花粉诱发哮喘：诊断和治疗意义。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.23822/EurAnnACI.1764-1489.408

L Cecchi, A Musarra, K Jaubashi, A M Marra, M Martini, F Papia, G Valenti, B Yang, A Vaghi, M B Bilò

引用次数: 0

The role of basophil activation test in venom immunotherapy: comparative evaluation with specific IgE and skin prick tests, innovative approaches. 嗜碱性粒细胞活化试验在毒液免疫疗法中的作用：与特异性 IgE 和皮肤点刺试验的比较评估，创新方法。

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-01 Epub Date: 2024-07-31 DOI: 10.23822/EurAnnACI.1764-1489.353

S I Kokcu Karadag, S Özen Çökelez, E Bekar Çepniler, E Abdullayev, O Terzi, D Özçeker, R Sancak, A Yıldıran

{"title":"The role of basophil activation test in venom immunotherapy: comparative evaluation with specific IgE and skin prick tests, innovative approaches.","authors":"S I Kokcu Karadag, S Özen Çökelez, E Bekar Çepniler, E Abdullayev, O Terzi, D Özçeker, R Sancak, A Yıldıran","doi":"10.23822/EurAnnACI.1764-1489.353","DOIUrl":"10.23822/EurAnnACI.1764-1489.353","url":null,"abstract":"Summary: Background. In diagnosing insect venom allergy and making immunotherapy decisions, clinical history, skin tests, and specific serum IgE levels are commonly utilized. This study aims to emphasize the clinical significance of using the basophil activation test in accurately identifying sensitivities in individuals with insect venom allergy and to compare its effectiveness with other testing methods. Methods. This study included a total of 43 patients, who experienced at least one systemic allergic reaction following insect stings and were deemed suitable for immunotherapy.Basophil activation test, specific serum IgE levels, and skin prick test results utilized in making immunotherapy treatment decisions were recorded. Results. Our study determined that the overall clinical sensitivities of the basophil activation test (BAT), specific serum IgE (spIgE), and skin prick test (SPT) for apis mellifera were 95.5%, 95.7%, and 48.4% respectively, while for vespula vulgaris, they were 83.3%, 100%, and 33.3%. Based on these results, the prediction of systemic reactions to bee stings is ordered as spIgE > BAT > SPT. Additionally, early-stage skin prick tests showed a sensitivity of 67% and specificity of 50% at a cut-off value of 1.5 mm, and 33% sensitivity and 83% specificity at 2.5 mm. Conclusions. This study demonstrates that the basophil activation test (BAT) can provide a high positive predictive value in immunotherapy treatment decisions and offer significant insights in clinical practices.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"228-235"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online food allergen labeling: is it a matter of concern? 在线食品过敏原标签：是否值得关注？

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-01 Epub Date: 2024-07-31 DOI: 10.23822/EurAnnACI.1764-1489.354

A Teixeira, F Carvalhosa, M Ferreira Lopes, M Pinheiro, I Pádua

引用次数: 0

Pollen-induced asthma: a specific pheno-endotype of disease? 花粉性哮喘：一种特殊的内源性疾病？

IF 2.3

European annals of allergy and clinical immunology Pub Date : 2025-09-01 Epub Date: 2025-05-13 DOI: 10.23822/EurAnnACI.1764-1489.403

L Cecchi, M Martini, K Jaubashi, A M Marra, A Musarra, F Papia, A Vaghi, G Valenti, B Yang, M B Bilò

引用次数: 0

Clinical and atopic features of patients with wheat allergy dependent on augmentation factors (WALDA) presenting with urticaria: a monocentric study. 小麦过敏患者的临床和特应性特征依赖于荨麻疹的增强因子（WALDA）：一项单中心研究。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-03 DOI: 10.23822/EurAnnACI.1764-1489.407

C M Rossi, S Merli, M V Lenti, M De Amici, A di Sabatino

{"title":"Clinical and atopic features of patients with wheat allergy dependent on augmentation factors (WALDA) presenting with urticaria: a monocentric study.","authors":"C M Rossi, S Merli, M V Lenti, M De Amici, A di Sabatino","doi":"10.23822/EurAnnACI.1764-1489.407","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.407","url":null,"abstract":"Summary: Background. Clinical and laboratory features of wheat allergy dependent on augmentation factor (WALDA) are scarcely characterised as compared to wheat anaphylaxis dependent on augmentation factor (WANDA). In this study we assessed the pattern of comorbid atopic and gastrointestinal diseases and the sensitisation profile in patients with WALDA presenting with intermittent urticaria. Methods. We retrospectively assessed all patients with WALDA-urticaria in a tertiary referral center, with a combined gastrointestinal- allergy unit. WALDA diagnosis was based upon recognised clinical/serological criteria, Clinical, atopic features, allergy tests and gastrointestinal comorbidities were compared to a cohort of O5G negative patients sensitised/allergic to wheat and one of patients allergic to shrimp. Results. Overall, we recruited 11 patients with WALDA presenting with intermittent urticaria (median age 44 years, IQR 29-58, F:M ratio 1.7:1). Atopy was a frequent finding among patients (8/11, 72.7%), with food allergy (6/11, 54.5%) followed by respiratory allergies (5/11, 45.5%). Shrimp sensitisation was present in 8/11 patients (72.7%); half of them were also clinically reactive to shrimp. Irritable bowel syndrome (IBS) was present in 4/11 patients (36.3%). The prevalence of shrimp sensitization was 15.3%, (p=0.01), in a group (n=13) of O5G negative patients with wheat sensitisation/allergy (median age 31 years, IQR 27.7-52.0, F:M ratio 0.4:1), while IBS prevalence was 9% (p=0.12). In the group of patients with shrimp allergy (n=13) with or without allergic rhinitis, the prevalence of O5G positivity was 0% and that of IBS 7.7%. Conclusions. Patients with WALDA-urticaria seems to present specific demographic features (female sex) and atopic (shrimp sensitisation/allergy).","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0