European annals of allergy and clinical immunology最新文献

Pollen-induced asthma: a specific pheno-endotype of disease? 花粉性哮喘：一种特殊的内源性疾病？

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-13 DOI: 10.23822/EurAnnACI.1764-1489.403

L Cecchi, M Martini, K Jaubashi, A M Marra, A Musarra, F Papia, A Vaghi, G Valenti, B Yang, M B Bilò

引用次数: 0

The crucial role of allergists in the clinical management and treatment of eosinophilic esophagitis. 变态反应科医师在嗜酸性粒细胞性食管炎的临床管理和治疗中的关键作用。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-12 DOI: 10.23822/EurAnnACI.1764-1489.402

D Gargano, L Franceschini, R Polillo, C M Rossi, D Bignardi, D Villalta, F Buzzulini, G Cortellini, E Pinter, M B Bilò, A Farsi

引用次数: 0

Altered serum sphingosine 1 phosphate level in food allergy and its association with disease severity. 食物过敏患者血清鞘氨醇1磷酸水平的改变及其与疾病严重程度的关系

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-09 DOI: 10.23822/EurAnnACI.1764-1489.401

M Maged Amin, R E S Abdel Monem Galal, O M Zeyada

{"title":"Altered serum sphingosine 1 phosphate level in food allergy and its association with disease severity.","authors":"M Maged Amin, R E S Abdel Monem Galal, O M Zeyada","doi":"10.23822/EurAnnACI.1764-1489.401","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.401","url":null,"abstract":"Summary: Background. Allergy is a multifactorial disease in which variant genetic and environmental factors are involved. Pathophysiology of food allergy (FA) and its natural history are poorly understood till now. Novel biomarkers and curative treatment options are strongly required. We aimed to study the significance of serum sphingosine 1 phosphate (S1P) level in food allergy and assess its possible correlation with disease severity. Methods. Study conducted on fifty participants diagnosed to have food allergy and another fifty group matched individuals who served as a control group. Results. The mean food allergy severity score of patients was 2.64±1.06, in which nearly two thirds (70%) are moderate, 18% are mild and about 12% of them are severe. A statistically significant increase in median value of S1P was found in patients with food allergies when compared to the control group. The best S1P cut-off level for the prediction of food allergy was (122.35 ng/L), with a sensitivity of 97.9% and a specificity of 95.7%, with a (97%) accuracy. Regarding Spearman's rho correlation analysis, a positive significant correlation was found between serum S1P level and Food allergy severity score. Conclusions. Sphingosine 1 phosphate (S1P) serum level can be a diagnostic marker for food allergy and its modulation could be a modality treatment for food allergies.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic reactions to spices: a review of sensitivities to pepper, cumin, oregano, anise, mustard and other spices. 对香料的过敏反应：对辣椒、孜然、牛至、茴香、芥末和其他香料的过敏反应综述。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-09 DOI: 10.23822/EurAnnACI.1764-1489.400

M F Lisiecka

{"title":"Allergic reactions to spices: a review of sensitivities to pepper, cumin, oregano, anise, mustard and other spices.","authors":"M F Lisiecka","doi":"10.23822/EurAnnACI.1764-1489.400","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.400","url":null,"abstract":"Summary: Spice allergies are often under-recognized and under-researched, leading to delays in diagnosis and treatment. Cross-reactivity with other plant allergens further complicates accurate diagnosis. This literature review seeks to systematize and analyze current data on hypersensitivity to spices, including pepper, cumin, oregano, anise, mustard, and other seasonings. The review covers research published from 2010 to 2023 in peer-reviewed journals, books, and conference proceedings, sourced from databases such as PubMed, Scopus, Web of Science, and Google Scholar. The main pepper allergens are PR-10 proteins, profilins and defensins. They can cause cross-allergic reactions with pollen and other plant allergens. Cumin allergens belong to the PR-10 family and can provoke allergic reactions. Cross-reactivity between cumin and other umbelliferae is common. Oregano contains Bet v 1 allergens and profilins, often leading to cross-allergies with other spices and plants. Allergies to anise are less common but can be a serious problem due to cross-reactivity with birch pollen. Mustard is one of the most allergenic spices. These proteins can cause severe reactions even in small amounts. Diagnosis is carried out using skin prick tests and blood tests for specific IgE antibodies. Cross-reactivity among spices and other allergens complicates the diagnosis and management of spice allergies. This review will be useful for the development of personalized dietary recommendations for patients, accounting for cross-reactivity and individual sensitization profiles.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probable apixaban-induced purpura. 可能是阿哌沙班引起的紫癜。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2023-08-02 DOI: 10.23822/EurAnnACI.1764-1489.309

G Famularo, F Casorati

引用次数: 0

Clinical spectrum of patients diagnosed with childhood mastocytosis: a retrospective single center experience. 儿童肥大细胞增多症患者的临床表现：单一中心的回顾性经验。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2024-06-24 DOI: 10.23822/EurAnnACI.1764-1489.348

A M Durmaz, Ö Özdemir

{"title":"Clinical spectrum of patients diagnosed with childhood mastocytosis: a retrospective single center experience.","authors":"A M Durmaz, Ö Özdemir","doi":"10.23822/EurAnnACI.1764-1489.348","DOIUrl":"10.23822/EurAnnACI.1764-1489.348","url":null,"abstract":"Summary: Background. Pediatric cutaneous mastocytosis patients diagnosed and followed up by our specialist were enrolled in this study, and clinical and laboratory evaluations were retrospectively analyzed from patients' archived files. Methods. Patients, who applied to the Division of Pediatric Allergy And Immunology Unit of a University Training and Research Hospital between 01.01.2010 and 28.04.2021, were enrolled in this study. Results. Of the 33 patients included in the study, 11 (33.3%) were female and 22 (67.7%) were male. The median age of onset of the patient's complaints was 7 (0-60) months. The median age at diagnosis was 11 (2-64) months. Their complaints' median regression age was 54 (6-192) months. Resistant clinical findings were followed in 13 (39.4%) patients. Itching, redness, gastrointestinal symptoms, and maculopapular eruption were the most common complaints. The rashes were mostly polymorphic and larger than 1 cm. Heat was the most common trigger. Darier's sign was positive in 97% of the patients. Antihistamines were the most commonly used drug for prophylaxis and treatment. The autoinjector prescription rate was 24.2%. Conclusions. Quality of life was mildly affected in 48,5% of the patients based on the CDLQI scores. Thus, patients should be followed up through adolescence for the development of systemic signs and symptoms.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"120-127"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical severity of LTP syndrome is associated with an expanded IgE repertoire, FDEIA, FDHIH, and LTP mono reactivity. LTP综合征的临床严重程度与扩大的IgE库、FDEIA、FDHIH和LTP单反应性有关。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2023-09-15 DOI: 10.23822/EurAnnACI.1764-1489.314

E Scala, D Abeni, V Villella, D Villalta, L Cecchi, V Pravettoni, M Giani, E Caprini, R Asero

{"title":"Clinical severity of LTP syndrome is associated with an expanded IgE repertoire, FDEIA, FDHIH, and LTP mono reactivity.","authors":"E Scala, D Abeni, V Villella, D Villalta, L Cecchi, V Pravettoni, M Giani, E Caprini, R Asero","doi":"10.23822/EurAnnACI.1764-1489.314","DOIUrl":"10.23822/EurAnnACI.1764-1489.314","url":null,"abstract":"Summary: Background. Lipid transfer proteins (LTP) allergy is often a challenge for clinicians. We evaluated a multiplex diagnostic approach with diverse cofactors to stratify LTP syndrome risk. Methods. Of the 1,831 participants screened with 'Allergy Explorer-ALEX-2', 426 had reactions to at least one LTP. Data was gathered and recorded via an electronic database. Results. Reactivity to peach Pru p 3 was found in 77% of individuals with LTP allergy. Higher levels of specific IgE and concurrent sensitization to more than 5 molecules (50% of all LTP-sensitised participants, 62% of symptomatic cases) were significantly associated with an increased risk of severe reactions (p = 0.001). Several cofactors, either alone or in combination, also influenced patients' clinical outcomes. Some cofactors increased the risk of severe reactions, such as mono reactivity to LTP in 44.6% of cases (p = 0.001), Food-Dependent Exercise-Induced Anaphylaxis (FDEIA) in 10.8% of patients (p = 0.001), and Food-dependent NSAID-induced hypersensitivity (FDNIH) in 11.5% (p = 0.005). On the other hand, reactivity to PR10 (24.2%; p = 0.001), profilin hypersensitivity (10.3%; p = 0.001), and/or atopic dermatitis (16.7%; p = 0.001) had a mitigating effect on symptom severity. Conclusions. Clinical severity of LTP syndrome is associated with an expanded IgE repertoire in terms of the number of LTP components recognized and increased IgE levels in individual molecules. Ara h 9, Cor a 8, and Mal d 3 showed the strongest association with clinical severity. In addition, several cofactors may either exacerbate (FDEIA, FDHIH, and LTP monoreactivity) or ameliorate (atopic dermatitis and co-sensitization to profilin and/or PR10) individual patient outcomes. These factors may be utilized for the daily clinical management of LTP syndrome.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"128-139"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pruritus burden assessment in severe atopic dermatitis patients under dupilumab: response predictor? dupilumab治疗严重特应性皮炎患者瘙痒负担评估：反应预测因子？

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2023-07-28 DOI: 10.23822/EurAnnACI.1764-1489.308

R Brás, R Limão, E Pedro, A Lopes

引用次数: 0

The autologous serum skin test predicts the response to anti-IgE treatment in chronic spontaneous urticaria patients: a prospective study. 自体血清皮试 (ASST) 预测慢性自发性荨麻疹患者对抗 IgE 治疗的反应：一项前瞻性研究。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2024-03-14 DOI: 10.23822/EurAnnACI.1764-1489.337

A Palladino, F Villani, E Pinter, M Visentini, R Asero

{"title":"The autologous serum skin test predicts the response to anti-IgE treatment in chronic spontaneous urticaria patients: a prospective study.","authors":"A Palladino, F Villani, E Pinter, M Visentini, R Asero","doi":"10.23822/EurAnnACI.1764-1489.337","DOIUrl":"10.23822/EurAnnACI.1764-1489.337","url":null,"abstract":"Summary: Background. Chronic spontaneous urticaria (CSU), characterized by recurrent itchy wheals and angioedema for > 6 weeks, is a quite common disease that may heavily impair the quality of life. Omalizumab, an anti-IgE mAb, has much improved the management of CSU but patients' response to the drug may vary and predictive markers are still largely missing. We investigated the predictive value of the autologous serum skin test (ASST) on omalizumab response. Methods. 15 patients with severe CSU eligible for omalizumab treatment were prospectively studied submitting them to ASST and to complete blood count, D-dimer, anti-thyroid peroxidase antibodies, and total IgE measurement before the start of the treatment. Results. 14/15 (93%) responded brilliantly to omalizumab at 3 months assessment. 7 responded in less than 1 month (\"early responders\") and 7 only after multiple administrations (\"late responders\"). Of 9 patients scoring positive on ASST, 7 (78%) were late, and 2 (22%) early responders to omalizumab (p = 0.021). Of 6 patients scoring negative on ASST, 5 were early omalizumab responders and 1 did not respond. The PPV and NPV of the ASST for a \"late\" response to omalizumab were 78% and 100%, respectively. Total IgE were significantly higher in early responders. Conclusions. Although larger prospective studies are needed to confirm these results, this study confirms previous retrospective investigations that the positive ASST appears to predict a slow response to omalizumab in CSU patients.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"115-119"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140119169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of patch testing based on clinical response to contact allergen restrictions in allergic contact dermatitis. 根据过敏性接触性皮炎患者对接触过敏原限制的临床反应进行斑贴测试的诊断准确性。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2024-02-20 DOI: 10.23822/EurAnnACI.1764-1489.331

J Sánchez, L Álvarez, S Diez, J Miquel-Miquel, M Velásquez

{"title":"Diagnostic accuracy of patch testing based on clinical response to contact allergen restrictions in allergic contact dermatitis.","authors":"J Sánchez, L Álvarez, S Diez, J Miquel-Miquel, M Velásquez","doi":"10.23822/EurAnnACI.1764-1489.331","DOIUrl":"10.23822/EurAnnACI.1764-1489.331","url":null,"abstract":"Summary: Background. Patch testing (PT) is used to identify substances that cause allergic contact dermatitis (ACD). However, the clinical effects of allergen restrictions following PT have not been thoroughly investigated. This study aims to assess the diagnostic accuracy of PT in patients suspected of having ACD. Methods. Prospective study. PT were performed in patients with clinical diagnosis of ACD. Patients with a positive PT (case group) had a strict restriction of the suspected substance for one month. In patients with negative patch testing (control group), allergen restriction was based in clinical history. Clinical reduction (CR) of at least 50% in disease activity (CR50%) after one month of allergen restriction was considered clinically relevant. Total control was defined as clinical reduction of at least 90% (CR90%). Results. From 400 patients, 66.2% had a positive PT. The sensitivity of PT to identify CR50% was 84%, specificity 47%, PPV 53%, and NPV 81%. Only 10.5% of patients achieved CR90%. Conclusions. The PT had moderate diagnostic accuracy. It could be useful as a screening, but a positive result should be confirmed with controlled allergen restriction. The low number of patients who achieved a 90% CR invites to reconsider the allergens included in PT and the mechanistic processes of the disease.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"107-114"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0