嗜酸性粒细胞腹水和嗜酸性粒细胞胃肠道疾病。

IF 2.3 Q2 ALLERGY
D Longhino, I Spinelli, F Fianchi, F Castri, G Ianiro, F R Ponziani, C Caruso, A Buonomo, G Antonio, A Aruanno
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引用次数: 0

摘要

摘要:背景。嗜酸性腹水(EA)以腹水中嗜酸性粒细胞计数高为特征,虽然非常罕见,但主要由嗜酸性胃肠道疾病(EGIDs)、寄生虫感染和嗜酸性高综合征(HES)引起。EGIDs引起的症状是多种多样的,取决于受影响的胃肠道以及所涉及的层;通常,EA意味着浆膜受累。在此,我们报告了三例EGIDs患者EA的单中心经验,并对文献中描述的所有其他病例进行了系统回顾。方法。通过查询到我院就诊的EGIDs患者数据库并提取所有嗜酸性腹水病例来选择患者。为了描述报告的嗜酸性腹水病例,我们在Pubmed上进行了文献综述。结果。我们在我们的中心发现了三名患有EGIDs的EA患者。在系统文献综述中,我们从81篇文献中共发现了105例因EGIDs而发生EA的患者。对于两组患者,我们描述了:人口统计学特征、其他免疫学疾病、胃肠道症状、腹水的诊断、腹水特征、外周嗜酸性粒细胞、胃肠道受影响、治疗和复发。结论。EA是一种罕见的EGIDs表现,应进行适当的评估以做出正确的诊断;排除嗜酸性粒细胞增多症的克隆性和继发性病因是至关重要的,但单器官hes的鉴别诊断往往不明确。类固醇治疗是有效的,针对IL-5的单克隆抗体也可能有效,但需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eosinophilic ascites and eosinophilic gastrointestinal diseases.

Summary: Background. Eosinophilic ascites (EA) is characterised by a high eosinophil count in the ascitic fluid and, although very rare, is mainly caused by eosinophilic gastrointestinal diseases (EGIDs), parasitic infections, and hypereosinophilic syndrome (HES). Symptoms caused by EGIDs are varied and depend on the gastrointestinal tract affected as well as the layer(s) involved; typically, EA implies a serosal involvement. Herein, we report our single Centre experience of three cases of EA in patients suffering from EGIDs together with a systematic review of all the other cases described in the literature. Methods. Patients selection was performed by querying the database containing patients suffering from EGIDs referred to our hospital and extracting all cases with eosinophilic ascites. In order to describe the reported cases of eosinophilic ascites, a literature review was carried out on Pubmed. Results. We identified three patients with EA suffering from EGIDs at our Centre. In the systematic literature review, a total of 105 patients suffering from EA due to EGIDs were identified from 81 literature articles. For both groups, we described: demographic characteristics, other immunological diseases, gastrointestinal symptoms, how ascites was diagnosed, ascitic fluid characteristics, peripheral eosinophils, gastrointestinal tract affected, therapy, and relapses. Conclusions. EA is a rare presentation of EGIDs and proper evaluations should be performed to make a proper diagnosis; it is crucial to exclude clonal and secondary causes of hypereosinophilia, but differential diagnosis with single organ-HES is often unclear. Steroid therapy is effective and monoclonal antibodies directed against IL-5 could be as well, but further studies are needed.

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