European annals of allergy and clinical immunology最新文献_第3页

Hypersensitivity to lipoic acid. 对硫辛酸过敏。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-01 Epub Date: 2023-09-06 DOI: 10.23822/EurAnnACI.1764-1489.310

F Marchi, A Carabelli

引用次数: 0

Delayed postoperative reactions to metamizole: a diagnostic challenge. 甲氰咪唑术后延迟反应：诊断难题。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-01 Epub Date: 2023-12-05 DOI: 10.23822/EurAnnACI.1764-1489.317

A Lopes, M Paulino, A Spínola Santos, E Pedro, M Branco Ferreira

{"title":"Delayed postoperative reactions to metamizole: a diagnostic challenge.","authors":"A Lopes, M Paulino, A Spínola Santos, E Pedro, M Branco Ferreira","doi":"10.23822/EurAnnACI.1764-1489.317","DOIUrl":"10.23822/EurAnnACI.1764-1489.317","url":null,"abstract":"Summary: Background. Metamizole, a non-steroidal anti-inflammatory drug from the pyrazolone group, is a frequent cause of immediate hypersensitivity reactions and, more rarely, of delayed drug hypersensitivity reactions. Due to its favorable pharmacokinetic characteristics, metamizole is widely used in the postoperative period for pain control. Methods. Retrospective study of patients referred for allergological study between January 2012 and June2022 for postoperative hypersensitivity reactions. Clinical and diagnostic data were collected through review of patients' medical records. Twenty patients with postoperative hypersensitivity reactions were referred, of which 10 presented delayed reactions. We analyzed the results of skin prick, intradermal and patch tests performed with an intravenous metamizole solution as well as provocation tests performed with metamizole and acetylsalicylic acid. Cross-reactivity to non-steroidal anti-inflammatory drugs was excluded by confirmation of clinical tolerance to non-steroidal anti-inflammatory drugs or by acetylsalicylic acid provocation test. Results. In 7 of the 10 patients a delayed reaction to metamizole was diagnosed. These reactions were characterized as maculopapular exanthema, occurring in multiple postoperative settings. Skin tests were negative, except in one patient with late mild erythema in the ipsilateral upper limb and no reaction at the site of intradermal injection. Delayed hypersensitivity was demonstrated by late positive metamizole provocation tests. Conclusions. This study demonstrated that for a correct diagnosis a high degree of suspicion about possible delayed hypersensitivity drug reactions to metamizole in the postoperative setting is needed. In the investigation, provocation test with metamizole was decisive for diagnostic confirmation.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"176-183"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local allergic rhinitis in children: identification and characterization in a specialty outpatient clinic. 儿童局部过敏性鼻炎：专科门诊的识别和特征描述。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-01 Epub Date: 2024-01-23 DOI: 10.23822/EurAnnACI.1764-1489.327

F Y Matsumoto, T R Tranquillini Gonçalves, D Solé, G F Wandalsen

{"title":"Local allergic rhinitis in children: identification and characterization in a specialty outpatient clinic.","authors":"F Y Matsumoto, T R Tranquillini Gonçalves, D Solé, G F Wandalsen","doi":"10.23822/EurAnnACI.1764-1489.327","DOIUrl":"10.23822/EurAnnACI.1764-1489.327","url":null,"abstract":"Summary: Background. Local Allergic Rhinitis (LAR) is a phenotype defined by rhinitis symptoms with negative responses to systemic sensitization tests but with an exclusively nasal allergic inflammatory response. Data on the pediatric age group is scarce, and no Latin American data has been published so far. Methods. Nasal Allergen Challenge (NAC) was performed with Dermatophagoides pteronyssinus and Blomia tropicalis in six- to 18-year-old patients diagnosed with rhinitis and no systemic sensitization. NAC was monitored using subjective parameters and acoustic rhinometry. The study aimed to identify LAR in child and adolescent subjects previously diagnosed with non-allergic rhinitis (NAR) in a Brazilian specialty outpatient clinic (Allergy and Immunology). Results. During the study period, we analyzed 758 skin prick tests (SPT). Of those, 517 (68.2%) were diagnosed with rhinitis. Among those, 18.4% (95/517) had a negative SPT, meeting the criteria for inclusion in the study. Twenty-five patients underwent NAC, and 40% (10/25) of them, previously considered to have NAR, had a positive test and were reclassified as having LAR. Based on the analyzed characteristics, clinically differentiating LAR from NAR was impossible. Conclusions. This study represents the first investigation of LAR in child and adolescent subjects in Latin America, contributing significantly to the understanding of its prevalence and characteristics in this geographic area. Among a subgroup of patients lacking systemic sensitization submitted to NAC, 40% (10/25) demonstrated a positive NAC with Dermatophagoides pteronyssinus and Blomia tropicalis, warranting their reclassification to LAR. NAC with multiple allergens has been proven safe and viable in pediatric populations, affirming its critical role in the accurate diagnosis of LAR.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"163-175"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139520264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diet quality, asthma and airway inflammation in school-aged children. 学龄期儿童饮食质量与哮喘和气道炎症的关系。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-01 Epub Date: 2023-06-08 DOI: 10.23822/EurAnnACI.1764-1489.301

M Rodrigues, F de Castro Mendes, I Paciência, R Barros, P Padrão, J Cavaleiro Rufo, D Silva, L Delgado, A Moreira, P Moreira

{"title":"Diet quality, asthma and airway inflammation in school-aged children.","authors":"M Rodrigues, F de Castro Mendes, I Paciência, R Barros, P Padrão, J Cavaleiro Rufo, D Silva, L Delgado, A Moreira, P Moreira","doi":"10.23822/EurAnnACI.1764-1489.301","DOIUrl":"10.23822/EurAnnACI.1764-1489.301","url":null,"abstract":"Summary: Background. Asthma is a major public health problem, with increasing prevalence in most countries, particularly among children. Poor dietary quality is also increasing in children, and evidence of the overall quality of children's food patterns effects on asthma is scarce. Methods. This cross-sectional analysis (660 children: 49.1% females, aged 7-12years) evaluated the association between diet quality and asthma (n = 56) and airway inflammation among school-aged children according to body mass index (BMI). Diet quality was assessed through the Healthy Eating Index (HEI)-2015, and categorized by tertiles. Higher scores represent a healthier diet. A questionnaire was used to enquire about self-reported medical diagnosis of asthma and asthma under medication. Lung function and airway reversibility were measured, and airway inflammation assessed measuring exhaled fractional nitric oxide (eNO). Two categories of BMI were considered: non-overweight/obese (p less than 85th), (n = 491), and overweight/obese (p ≥ than 85th), (n = 169). The associations between diet quality and asthma and airway inflammation were estimated using logistic regression models. Results. Non-overweight/obese children in 2nd tertile of HEI-2015 score had decreased odds of having eNO ≥ 35ppb (OR 0.43, 95%CI 0.19-0.98), medical diagnosis of asthma (OR 0.18; 95%CI 0.04-0.84), and asthma treatment (OR 0.12; 95%CI 0.01-0.95), compared to children in the 1st tertile. Conclusions. Our findings suggest that a higher diet quality associates with lower levels of airway inflammation and reduced prevalence of asthma among non-overweight/obese school-aged children.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"163-175"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9590477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shiitake flagellate dermatitis: a case series from Italy. 鞭毛虫性皮炎：意大利一例系列病例。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-07-01 Epub Date: 2023-06-22 DOI: 10.23822/EurAnnACI.1764-1489.303

S Veraldi, A Cerri, P Bortoluzzi, F Derlino, F Rongioletti

引用次数: 0

The crucial role of allergists in the clinical management and treatment of eosinophilic esophagitis. 变态反应科医师在嗜酸性粒细胞性食管炎的临床管理和治疗中的关键作用。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-12 DOI: 10.23822/EurAnnACI.1764-1489.402

D Gargano, L Franceschini, R Polillo, C M Rossi, D Bignardi, D Villalta, F Buzzulini, G Cortellini, E Pinter, M B Bilò, A Farsi

引用次数: 0

Altered serum sphingosine 1 phosphate level in food allergy and its association with disease severity. 食物过敏患者血清鞘氨醇1磷酸水平的改变及其与疾病严重程度的关系

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-09 DOI: 10.23822/EurAnnACI.1764-1489.401

M Maged Amin, R E S Abdel Monem Galal, O M Zeyada

{"title":"Altered serum sphingosine 1 phosphate level in food allergy and its association with disease severity.","authors":"M Maged Amin, R E S Abdel Monem Galal, O M Zeyada","doi":"10.23822/EurAnnACI.1764-1489.401","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.401","url":null,"abstract":"Summary: Background. Allergy is a multifactorial disease in which variant genetic and environmental factors are involved. Pathophysiology of food allergy (FA) and its natural history are poorly understood till now. Novel biomarkers and curative treatment options are strongly required. We aimed to study the significance of serum sphingosine 1 phosphate (S1P) level in food allergy and assess its possible correlation with disease severity. Methods. Study conducted on fifty participants diagnosed to have food allergy and another fifty group matched individuals who served as a control group. Results. The mean food allergy severity score of patients was 2.64±1.06, in which nearly two thirds (70%) are moderate, 18% are mild and about 12% of them are severe. A statistically significant increase in median value of S1P was found in patients with food allergies when compared to the control group. The best S1P cut-off level for the prediction of food allergy was (122.35 ng/L), with a sensitivity of 97.9% and a specificity of 95.7%, with a (97%) accuracy. Regarding Spearman's rho correlation analysis, a positive significant correlation was found between serum S1P level and Food allergy severity score. Conclusions. Sphingosine 1 phosphate (S1P) serum level can be a diagnostic marker for food allergy and its modulation could be a modality treatment for food allergies.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic reactions to spices: a review of sensitivities to pepper, cumin, oregano, anise, mustard and other spices. 对香料的过敏反应：对辣椒、孜然、牛至、茴香、芥末和其他香料的过敏反应综述。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-09 DOI: 10.23822/EurAnnACI.1764-1489.400

M F Lisiecka

{"title":"Allergic reactions to spices: a review of sensitivities to pepper, cumin, oregano, anise, mustard and other spices.","authors":"M F Lisiecka","doi":"10.23822/EurAnnACI.1764-1489.400","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.400","url":null,"abstract":"Summary: Spice allergies are often under-recognized and under-researched, leading to delays in diagnosis and treatment. Cross-reactivity with other plant allergens further complicates accurate diagnosis. This literature review seeks to systematize and analyze current data on hypersensitivity to spices, including pepper, cumin, oregano, anise, mustard, and other seasonings. The review covers research published from 2010 to 2023 in peer-reviewed journals, books, and conference proceedings, sourced from databases such as PubMed, Scopus, Web of Science, and Google Scholar. The main pepper allergens are PR-10 proteins, profilins and defensins. They can cause cross-allergic reactions with pollen and other plant allergens. Cumin allergens belong to the PR-10 family and can provoke allergic reactions. Cross-reactivity between cumin and other umbelliferae is common. Oregano contains Bet v 1 allergens and profilins, often leading to cross-allergies with other spices and plants. Allergies to anise are less common but can be a serious problem due to cross-reactivity with birch pollen. Mustard is one of the most allergenic spices. These proteins can cause severe reactions even in small amounts. Diagnosis is carried out using skin prick tests and blood tests for specific IgE antibodies. Cross-reactivity among spices and other allergens complicates the diagnosis and management of spice allergies. This review will be useful for the development of personalized dietary recommendations for patients, accounting for cross-reactivity and individual sensitization profiles.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probable apixaban-induced purpura. 可能是阿哌沙班引起的紫癜。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2023-08-02 DOI: 10.23822/EurAnnACI.1764-1489.309

G Famularo, F Casorati

引用次数: 0

Clinical spectrum of patients diagnosed with childhood mastocytosis: a retrospective single center experience. 儿童肥大细胞增多症患者的临床表现：单一中心的回顾性经验。

IF 2.6

European annals of allergy and clinical immunology Pub Date : 2025-05-01 Epub Date: 2024-06-24 DOI: 10.23822/EurAnnACI.1764-1489.348

A M Durmaz, Ö Özdemir

{"title":"Clinical spectrum of patients diagnosed with childhood mastocytosis: a retrospective single center experience.","authors":"A M Durmaz, Ö Özdemir","doi":"10.23822/EurAnnACI.1764-1489.348","DOIUrl":"10.23822/EurAnnACI.1764-1489.348","url":null,"abstract":"Summary: Background. Pediatric cutaneous mastocytosis patients diagnosed and followed up by our specialist were enrolled in this study, and clinical and laboratory evaluations were retrospectively analyzed from patients' archived files. Methods. Patients, who applied to the Division of Pediatric Allergy And Immunology Unit of a University Training and Research Hospital between 01.01.2010 and 28.04.2021, were enrolled in this study. Results. Of the 33 patients included in the study, 11 (33.3%) were female and 22 (67.7%) were male. The median age of onset of the patient's complaints was 7 (0-60) months. The median age at diagnosis was 11 (2-64) months. Their complaints' median regression age was 54 (6-192) months. Resistant clinical findings were followed in 13 (39.4%) patients. Itching, redness, gastrointestinal symptoms, and maculopapular eruption were the most common complaints. The rashes were mostly polymorphic and larger than 1 cm. Heat was the most common trigger. Darier's sign was positive in 97% of the patients. Antihistamines were the most commonly used drug for prophylaxis and treatment. The autoinjector prescription rate was 24.2%. Conclusions. Quality of life was mildly affected in 48,5% of the patients based on the CDLQI scores. Thus, patients should be followed up through adolescence for the development of systemic signs and symptoms.","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"120-127"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0