European annals of allergy and clinical immunology最新文献

{"title":"Allergy evaluation in hypersensitivity to platinum compounds and taxanes: a 5-year experience.","authors":"D Longhino, C Sarnari, G Andriollo, A Aruanno, A Rizzi, E Nucera, A Buonomo","doi":"10.23822/EurAnnACI.1764-1489.389","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.389","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Platinum compounds (PC) and taxanes (TX) are drugs frequently administered for the treatment of several cancers. In recent years, their increased use has been accompanied by a relatively high prevalence of hypersensitivity reactions (HSRs). In this study, we report our comprehensive experience of allergy skin test (ST) evaluation in 276 patients who experienced HSRs to PC and/or TX. Primary objectives were to determine the clinical characteristics of HSRs, and to assess the role of STs in the diagnosis and prevention of HSRs in order to address the subsequent treatments. Secondary objective was to evaluate any cross-reactivity between PC (cisplatin, oxaliplatin and carboplatin) and among TX (paclitaxel and docetaxel). <b>Methods.</b> A monocentric, retrospective, observational, cohort study including patients who experienced one or more HSR during PC and/or TX chemotherapy was conducted from May 2018 to July 2023 in the Allergy and Clinical Immunology Unit at the \"Fondazione Policlinico Universitario A. Gemelli\" IRCCS, Rome. <b>Results.</b> A total of 114 patients with positive ST were identified: 102 for PC, 11 for TX and one for both. 162 patients were tested negative. Patients with HSR to PC were found to be allergic in 64%, compared to 9,9% of patients with HSR to TX (p < 0.0001). Patients who experience more serious reactions have a higher chance to have a positive result on STs (p < .01). <b>Conclusions.</b> STs to investigate sensitization to TX or PC is a highly valuable diagnostic tool in selecting the appropriate therapy when a hypersensitivity reaction occurs.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis Quality of Life Scale for adults: the validation on the Italian allergic patients.","authors":"V Patella, L Pierro, E Bosco, M S Cuomo, G Florio, M Latempa, A Giuliano, R Zunno","doi":"10.23822/EurAnnACI.1764-1489.390","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.390","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> The aim of this study is to translate and validate the Italian Version of the Anaphylaxis Quality of Life Scale for Adults (A-QoL-Adults), made up of the three subscales Social impact (SQoL), Emotional impact (EQol) and Limitations on Life (LoL) to measure the impact of the risk of anaphylaxis from any cause on patients' quality of life (QoL). <b>Methods.</b> The study involves 30 patients with a history of anaphylaxis who were prescribed epinephrine self-injectable, who compiled the Italian translation of A-QoL-Adults, World Health Organization Quality of life (WHOQoL)-Brief edition, Hospital Anxiety and Depression Scales (HADS-A, HADS-D) and Perceived Stress Scale (PSS) questionnaires to validate the Italian version. <b>Results.</b> The A-QoL-Adults administered in the Italian version had good internal structural validity and internal consistency reliability: Cronbach alpha levels of 0.972 for AQoL, 0.942 for SQoL, 0.939 for EQoL and 0.910 for LoL, and a strong correlation with other generic QoL and psychological scales. A large significant correlation (p<0.005) was found with PSS (r=0,722), HADS-A (r=0.685) and Environmental QoL (r=-0.528). A medium significant correlation (p<0.05) was found with HADS-D (r=0.455), Physical QoL (r=-0.376) and Psychological QoL (r=-0.425). Anxiety, depression, and stress levels in participants were accurately predicted by anaphylaxis-related QoL scores (p<0.001). <b>Conclusions.</b> The Italian version of A-QoL-Adults is a trusted instrument for evaluating the QoL of adults with anaphylaxis at any trigger. It may be used in research and clinical practice. The Italian version values match the original version and accurately predict anxiety, depression, and stress levels..</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could egg yolk be the fırst approach ın oral challenges for egg allergy tolerance?","authors":"S Tekeli, S Doğan, M Özer, S Şirin, S Özmen","doi":"10.23822/EurAnnACI.1764-1489.388","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.388","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Hen's egg allergy is one of the most common pediatric food allergies, requiring accurate diagnosis and management strategies. Oral food challenges (OFCs) are critical in evaluating food allergies; however, limited research has focused on the outcomes of challenges involving egg yolks. This retrospective study aims to assess the outcomes and characteristics of pediatric patients who underwent oral challenges with boiled egg yolk. <b>Methods.</b> We evaluated patients diagnosed with egg allergy who underwent an OFC with egg yolk between 2019 and 2022. <b>Results.</b> The study included 123 patients with a median age of 12 months. The first presentation of symptoms occurred at a mean age of 6 months. Initial symptoms included eczema flare-ups (70%), urticaria (13.8%), and anaphylaxis (8.9%). The median age of the first egg yolk OFC was 12 months. For the first egg white OFC to assess the tolerance, the median age was 16 months.  Of the 123 egg yolk OFCs, 115 (93.4%) patients were tolerant and consumed egg yolk at home. In the egg yolk-tolerant group, the mean duration of egg white tolerance was 4 months post-OFC; for non-tolerant patients, this extended to 11 months. The egg yolk non-tolerant group had higher egg white-specific IgE levels than the tolerant group (28 kU/L [IQR: 2.4-85.9] vs. 4.2 kU/L [IQR: 0.9-8.8], p<0.01). <b>Conclusions.</b> Though mild symptoms may occur, most children with egg allergies can safely consume boiled egg yolk. Consuming hen's egg yolk after a negative OFC could expand dietary options and improve quality of life.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical update on chronic rhinosinusitis and nasal polyposis.","authors":"F S Regateiro, E Barros, J L Plácido, J P Moreira da Silva","doi":"10.23822/EurAnnACI.1764-1489.385","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.385","url":null,"abstract":"<p><strong>Summary: </strong>Chronic rhinosinusitis (CRS) is a complex heterogeneous disease of the nose and paranasal sinuses that presents different phenotypes and endotypes. CRS is a common health problem associated with significant morbidity, as well as with high health care expenditure. As our knowledge on inflammation, tissue remodeling and pathophysiological mechanisms develops, both diagnosis and therapeutic approaches to CRS improve. This review outlines key drivers in the pathogenesis of CRS with and without nasal polyps, current diagnostic tools clinicians can rely on in clinical practice, and current and future treatment options, while providing a general overview of up-to-date guidelines for CRS diagnosis and management. A better understanding of CRS can pave the way for the optimization and development of novel therapies, benefiting patients who suffer with more severe phenotypes and allowing a personalized approach to the disease.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune response to mosquito allergens is associated with cross-reactive bee venom components: the importance of cross-reactive carbohydrate determinants (CCDs) in the Bee-Mosquito Syndrome.","authors":"C G Uasuf, C D'Anna, C Di Sano, V Blanda, E Scala, M Barrale, I Brusca, A Torina","doi":"10.23822/EurAnnACI.1764-1489.386","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.386","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Mosquitoes are a family of the order Diptera. Throughout the world, there are two groups able to suck human blood and transmit diseases: the anophelines and the culicines comprise several genera such as Culex, Aedes and Aedes communis (Ac). Previous study has demostrated a significant relationship between Ac sensitization and either extract or single bee venom components suggesting a \"bee-mosquito syndrome\" occurrence. The aim of the study was to identify bands of cross reactivity between the extracts of Mosquito and Bee venom, with IgE positive sera. <b>Methods.</b> Serum from 21 different Mosquito and A. mellifera allergic individuals were combined with extracts of Mosquito (in house) and A. mellifera. SDS-PAGE and (IB) were carried out with/without CCD inhibitor. <b>Results.</b> The data without CCD inhibitor suggests IgE binding to common bands between Culex male, Culex female and Aedes of approx ~21kDa, ~35kDa, ~40kDa and ~55kDa. Whilst IgE binding has been observed to protein bands from the A. mellifera extract, these bands do not align with any present in the mosquito extracts. Data with CCD inhibitor results in differences in IgE binding. Bands that were previously observed in the A. mellifera venom sample at 40 and 90 kDa, disappeared. No major differences in banding pattern were observed for the mosquito samples, although the blot appears cleaner. <b>Conclusions.</b> IB data suggests that the use of CCD inhibitor prevents binding of IgE from mosquito allergic patients to multiple bands from A. mellifera venom. It may be inferred that bands originally present at 40kDa and 90 kDa may have been due to a CCD interaction. Two bands remain present in the A. mellifera sample between 15-20 kDa, however do not align with any bands present in the mosquito extracts. Further experiments must be done to determine whether the reactive bands from A. mellifera are unrelated proteins or whether the proteins are related homologues of varying MW.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful dupilumab dose spacing in controlled severe atopic dermatitis and predictive factors.","authors":"J Vieira, J Marcelino, M Proença, J Guimarães, D Dias, E Tomaz","doi":"10.23822/EurAnnACI.1764-1489.387","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.387","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety evaluation of Dermatophagoides farinae drops in the treatment of allergic rhinitis with epistaxis.","authors":"J Pei, Z Ding, L Cai, H Yang, Y Tao, C Huang","doi":"10.23822/EurAnnACI.1764-1489.342","DOIUrl":"10.23822/EurAnnACI.1764-1489.342","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Epistaxis is frequently observed in allergic rhinitis (AR) patients. However, few studies focus on the outcome of epistaxis with treatment of AR patients. This study aimed to retrospectively analyze the efficacy and safety of AR patients with epistaxis treated with sublingual immunotherapy (SLIT). <b>Methods.</b> A total of 74 patients aged 4-60 years with house dust mite (HDM)-induced AR accompanied by epistaxis and who completed 1 year of SLIT treatment with standard Dermatophagoides farinae (D. farinae) drops were enrolled in this study. The symptom scores, total medication scores (TMS), combined symptom and medication score (CSMS), visual analog scales (VAS), and bleeding score (BS) were assessed, as well as the nasal endoscopic examinations were performed to observe nasal signs. <b>Results.</b> The levels of symptom scores, TMS, CSMS, VAS, and BS at 0.5 year and 1 year of SLIT treatment were significantly lower than those at the baseline (all p less than 0.01). Also, statistical differences were seen in CSMS (p less than 0.05) and VAS (p less than 0.01) between 0.5 year and 1 year. As expected, BS was positively correlated with CSMS (r = 0.617, 95% CI 0.517-0.699) and VAS (r = 0.777, 95% CI 0.719-0.822) at all three time points. <b>Conclusions.</b> SLIT with D. farinae drops was effective and safe for AR patients with epistaxis, resulting in improving the symptoms of rhinitis while relieving the symptoms of epistaxis.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"68-76"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sIgE/sIgG4 profile in platinum desensitization: is there immunological tolerance?","authors":"R Brás, J Goncalves, C Araújo, A Godinho Santos, L Costa, E Pedro, J Caiado","doi":"10.23822/EurAnnACI.1764-1489.302","DOIUrl":"10.23822/EurAnnACI.1764-1489.302","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"88-90"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity to non-steroidal anti-inflammatory drugs on a pediatric Portuguese cohort.","authors":"M I T Silva, J Cosme, C Lorenzo, J Virtuoso, R Gomes, E Pedro, A M Neves, A Lopes","doi":"10.23822/EurAnnACI.1764-1489.299","DOIUrl":"10.23822/EurAnnACI.1764-1489.299","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Non-steroidal anti-inflammatory drugs (NSAID)/analgesics (paracetamol) are among the most common causes of drug hypersensitivity reactions in children, with a reported prevalence of around 0.3% in the pediatric population. Paracetamol and ibuprofen are the most commonly reported culprits in the pediatric population. Our objective was to describe the allergy workup to NSAID/paracetamol of a pediatric population monitored in an allergy outpatient clinic. <b>Methods.</b> Retrospective observational study by consulting the medical records of patients evaluated in a pediatric outpatient clinic with history of NSAID/paracetamol, between January 2016 to August 2022. <b>Results.</b> A total of 43 patients have been evaluated for NSAID/paracetamol suspected allergy: 53.5% females, mean age of 9.8 ± 5.1 years, 47.7% atopic. The drugs reported as culprits were: ibuprofen (75.6%), paracetamol (17.8%), metamizole (4.4%) and naproxen (2.2%) and clinical manifestations were mainly urticaria/angioedema and maculopapular exanthema. Skin tests were performed in 7 patients: paracetamol (n = 5) and metamizole (n = 2), which were all negative. Fourty-six drug provocation tests were performed: 28 with the culprit drug and 18 with an alternative one; only 2 were positive (ibuprofen - culprit NSAID group): one immediate periorbital angioedema and one delayed lip edema with oropharyngeal tightness. <b>Conclusions.</b> The investigation of allergy to NSAID/paracetamol in children remains a challenge. In our population, ibuprofen was the most common NSAID reported. There were only 2 (4.3%) mild reactions on DPT. We could allow the use of the culprit NSAID/analgesic in 11 patients and an alternative one in 9 patients. This study highlights the importance of DPT in children for a correct diagnosis of NSAID hypersensitivity and selection of an alternative drug.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"77-82"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9540298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clavulanic acid sensitization seems more involved in cutaneous than systemic reactions in amoxicillinclavulanate drug reactions.","authors":"F Rivolta, C Cappelletti, A Sangalli, A Fasiello, V Longoni, V Pravettoni","doi":"10.23822/EurAnnACI.1764-1489.329","DOIUrl":"10.23822/EurAnnACI.1764-1489.329","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Beta-lactams (BLs) allergy is considered a major health issue, as BLs are the most frequently involved in drug allergic reactions. Amoxicillin (AX) is the main sensitizer among all BLs. AX is commercialized alone or combined with clavulanic acid (CLA) in order to increase the antibiotic spectrum. The growing prescriptions of AX-CLA formulations contributed to increase the role of CLA as an allergy inducer. At present, little is known about the clinical characteristics of hypersensitivity reactions to clavulanate. The aim of this study was to assess the difference in the prevalence of cutaneous vs systemic reactions in patients with a documented history of allergic reactions to amoxicillin- clavulanate and tested positive for clavulanate or penicillin/amoxicillin. <b>Methods.</b> Between January 2017 and March 2023, out of 88 outpatients with suspected BLs allergy we selected 59 patients with a reaction to AX-CLA. Hypersensitivity reactions were classified according to onset time as immediate or delayed and according to clinical presentation as mucocutaneous or systemic reactions (anaphylaxis). All patients underwent recommended test protocols for diagnosing BLs hypersensitivity to identify the culprit drug. Sensitization was assessed through serologic and skin tests. <b>Results.</b> Patients whit immediate and delayed mucocutaneous reactions to AX-CLA are more sensitized to CLA 12/41 (29%) than AX or BLs determinants 9/41 (22%); on the opposite patients with immediate systemic reactions are more sensitized to AX or BLs determinants 13/18 (72%) than CLA 2/18 (11%), p less than 0.00. There was no difference in immediate vs delayed reaction regarding CLA or AX and BLs determinants sensitization. <b>Conclusions.</b> Our study suggests that patients who presented only muco-cutaneous reactions were more often sensitized to CLA rather than AX.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"83-87"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}